Patent Grant
10105036
The present invention relates generally to connector assemblies for use with articulating instruments. More particularly, it relates to connectors and systems for transmitting force to an articulating instrument to move that instrument.
One challenge confronting the use of articulating instruments is the efficient and reliable coupling of the force generated for moving the articulating components of the instrument to the articulating components themselves. It may be desirable to have a single force generator that may be used with a number of individual articulating instruments. In this case, the ability to switch, with ease, between the different individual articulating instruments is desirable. For example, while one articulating instrument is being cleaned or maintained, the force generator could be coupled to another articulating instrument thereby increasing the utilization factor of the force generator.
As the degree of movement and control for an articulating instrument increases, the number, variety and size of articulating components needed to operate the instrument increases. As the variety and size of articulating components increases, so too increases the number of force transmission elements to move those articulating components. As such, there also exists a need for a connector that provides an organized arrangement of the force transmission elements in an effort to reduce complexity at the force transmission/component articulation interface.
Articulating instruments are used in a wide variety of commercial settings including, for example, industrial robotic applications and medical applications. One example of an articulating medical instrument is an endoscope. An endoscope is a medical instrument for visualizing the interior of a patient's body. Endoscopes are used for a variety of different diagnostic and interventional procedures, including colonoscopy, bronchoscopy, thoracoscopy, laparoscopy and video endoscopy. The desire to access remote portions of the body more efficiently or access one area of the body while avoiding other areas along the way increases the complexity of articulating endoscopes and articulating surgical instruments generally.
Insertion of an articulating colonoscope is further complicated by the fact that the colon represents a tortuous and convoluted path. Considerable manipulation of the colonoscope by manipulation of articulating components is often necessary to advance the colonoscope through the colon. However, as the colonoscope is inserted farther into the colon, it becomes more difficult to advance the colonoscope along the selected path. At each turn of the colon, the colonoscope rubs against the mucosal surface of the colon and friction and slack in the articulating components of the colonoscope changes. As such, there also exists a need to provide compensation for changes in the friction and slack of the articulating components as the colonoscope is advanced or withdrawn from the colon.
As such, a need exists for connector assemblies that will organize and simplify the probess of connecting the plurality of elements needed to move and control an articulating instrument with the force generator or actuators that generate the forces to move the articulating instrument.
In one aspect of the present invention, there is a system for moving a controllable article. The system includes a force generator; a first force transmission element having a first end connected to the force generator and a second end having a first connecting element; a second force transmission element having a first end connected to the controllable article and a second end having a second connecting element; and a connector for releasably engaging the first connecting element and the second connecting element. In one aspect of the present invention, the connector releasably engages the first connecting element and the second connecting element using a mechanical coupler.
In one aspect of the present, invention, the force generator generates a mechanical force. In another aspect of the present invention, the force generator generates a hydraulic force. In another aspect of the present invention, the force generator generates a rotational force. In another aspect of the present invention, the rotational force from the force generator is translated into longitudinal motion within the connector. In another aspect of the present invention, the force generator generates a pneumatic force. In one aspect of the present invention provides a connector having a first portion releasably coupled to a second portion. The first portion has a plurality of guideways. Each of the guideways has a carriage assembly and each of the carriage assemblies is coupled to a force generator. The second portion also has a plurality of guideways where each of the guideways has a carriage assembly. Each of the carriage assemblies in the second portion is coupled to an article articulated by moving one or more of the second portion carriage assemblies.
In one aspect of the present invention, the plurality of guideways in the first and/or second portion are parallel. In another aspect of the present invention each of the plurality of guideways in the first portion are parallel to each of the plurality of guideways in the second portion. In another aspect, at least one of the plurality of guideways in the first portion is aligned with at least one of the plurality of guideways in the second portion.
In one aspect of the invention, the force generated by the force generator is coupled to the article.
In another aspect of the invention, at least one carriage assembly in the first portion is engaged with at least one carriage assembly in the second portion. In one aspect, the engaging feature and the complementary engaging feature are engaged by relative movement between the first connector portion and the second connector portion. In another aspect, a carriage assembly of the first portion has an engaging feature and a carriage assembly of the second portion has an engaging feature complementary to the engaging feature of the carriage assembly of the first portion. In one aspect, the engaging feature and the complementary engaging feature include teeth. In another aspect, the engaging feature and the complementary engaging feature include gear teeth. In another aspect, the engaging feature and the complementary engaging feature include a spur gear. In another aspect, the engaging feature and the complementary engaging feature include a shape memory alloy element. In another aspect, the engaging feature and the complementary engaging feature include hooks. In another aspect, the engaging feature and the complementary engaging feature are threaded members. In another aspect, the engaging feature and the complementary engaging feature comprise a slot and pin. In another aspect, the engaging feature and the complementary engaging feature comprise a spline and a rack.
In another aspect, a force generated by the force generator is transmitted to the article when the first portion is coupled to the second portion. In another aspect, the first portion is coupled to the second portion using a lever. In another aspect, the first portion is coupled to the second portion by hydraulically moving one or both of the first portion or the second portion. In another aspect, the first portion is coupled to the second portion by pneumatically moving one or both of the first portion or the second portion. In another aspect, the first portion is coupled to the second portion by moving one or both of the first portion and the second portion utilizing a lead screw, a motor driven lead screw and combinations thereof.
In one specific embodiment, the force generator is a motor. The motor is coupled to a leadscrew assembly, so that when the motor rotates, it transmits torque to the leadscrew. A modified nut on the leadscrew is constrained to prevent rotational motion, so that when the leadscrew is rotated, the nut is translated along the axis of the leadscrew. The torque from the motor is thereby translated into linear motion. In this specific embodiment, a force transmission element is a cable that is connected to the nut on one end and a carriage assembly on the other end. The linear motion of the nut translates into force on the cable. In the present embodiment, 64 of the leadscrew assemblies are arranged in modules for easy organization and maintenance. The modules are supported in a chassis that also houses the first portion of the connector as described herein.
In one aspect, the article is an endoscope. In another aspect, the article is a control surface. In another aspect, the article is a robot. In another aspect, the article is a surgical instrument.
In one aspect, the carriage assemblies are biased to an initial condition. In another aspect, a biasing element is coupled to each one of the plurality of carriage assemblies. In yet another aspect, the carriage assemblies are aligned before engaging the first connector portion and the second connector portion. In yet another aspect, a biasing element aligns the carriage assemblies before engaging the first connector portion and the second connector portion.
In yet another aspect of the invention, a connector for coupling a force to move an article is provided. The connector has a first connector housing having a plurality of guideways and a carriage assembly disposed in each guideway. A force transmission element attached to each carriage assembly. The force transmission elements are adapted for connection to a force generator. A second connector housing having a plurality of guideways and a carriage assembly disposed in each guideway. A force transmission element attached to each carriage assembly. The force transmission elements are adapted for connection to an article. In one aspect, the article is a surgical instrument. In another aspect, the article is an endoscope
In one aspect, at least one of the first connector housing and the second connector housing comprising a slack area. In another aspect, the slack area contains the force transmission elements of the first connector housing arranged in an angular relationship to the guideways in the first connector housing. In yet another aspect, the slack area contains the force transmission elements of the second connector housing arranged in an angular relationship to the guideways in the second connector housing.
In yet another aspect, the connector includes a sensor to detect an operational characteristic of the connector. In one aspect, the operational characteristic of the connector is the engagement of a carriage assembly in the first connector housing to a carriage assembly in the second connector housing. In another aspect, the operational characteristic of the connector is the disengagement of a carriage assembly in the first connector housing to a carriage assembly in the second connector housing. In yet another aspect, the operational characteristic of the connector is the tension in a force transmission element or a position of each or any of the carriage assemblies. In yet another aspect, the operational characteristic of the connector is the torque exerted on a force transmission element. In yet another aspect, the operational characteristic of the connector is a force acting on a force transmission element. In yet another aspect, the operational characteristic of the connector is the time in service of a particular article. In yet another aspect, the operational characteristic of the connector is the range of travel of a carriage assembly. In another aspect, the operational characteristic of the connector is the engagement of a carriage assembly in the first connector housing to a carriage assembly in the second connector housing.
One aspect of the invention is a connection assembly for connecting an articulating instrument to a force generator. The connection assembly has a first portion releasably coupled to a second portion. The first portion includes at least one guideway, a carriage assembly moveable relative to the at least one guideway. A force transmission element is attached to the carriage assembly and coupled to the force generator. The second portion includes at least one guideway, a carriage assembly moveable relative to the at least one guideway. A force transmission element is attached to the carriage assembly and coupled to the articulating instrument. In one aspect, the carriage assembly of the first portion engages the carriage assembly of the second portion when the first portion is coupled to the second portion. In another aspect, the first portion is coupled to the second portion using a first motion and the carriage assembly of the first portion engages the carriage assembly of the second portion using a second motion. In yet another aspect, movement of a carriage assembly in the first portion relative to the at least one guideway in the first portion moves the articulating instrument when the first portion is coupled to the second portion.
In yet another aspect, a carriage assembly of the first portion is engaged to a carriage assembly of the second portion using hooks. In yet another aspect, a carriage assembly of the first portion is engaged to a carriage assembly of the second portion using gears. In yet another aspect, a carriage assembly of the first portion is engaged to a carriage assembly of the second portion using an engaging surface and a complementary engaging surface. In yet another aspect, a carriage assembly of the first portion is engaged to a carriage assembly of the second portion when a shape memory alloy element is activated. In yet another aspect, a carriage assembly of the first portion is engaged to a carriage assembly of the second portion using a pin and a slot. In yet another aspect, a carriage assembly of the first portion is engaged to a carriage assembly of the second portion using a mechanical connector. In yet another aspect, a carriage assembly of the first portion is engaged to a carriage assembly of the second portion using a magnetic field.
In another aspect, the force generator produces rotational energy. In another aspect, the force generator comprises a motor. In another aspect, force generator comprises a pump. In another aspect, the application of force to the force transmission element in the first portion moves the carriage assembly in the first portion relative to the at least one guideway in the first portion. In another aspect, the application of force to the force transmission element in the first portion moves the articulating instrument. In another aspect, the articulating instrument is a medical instrument. In another aspect, the medical instrument is a segmented endoscope. In another aspect, the force transmission element of the second portion is connected to at least one segment of a segmented endoscope.
In another aspect, the connection assembly includes a sensor that indicates an operational condition of the connection assembly. In one aspect, the connection assembly comprises a quick release mechanism. In another aspect, the connection assembly comprises a mechanical interface adapted to transfer force from the first portion to the second portion. In another aspect, a guideway defines a limited range of travel for a carriage assembly. In yet another aspect, a guideway comprises a stop to limit carriage assembly movement. In another aspect, a guideway comprises a protrusion. In another aspect, the protrusion is adapted to retain a carriage assembly. In another aspect, the guideway comprises a recess. In yet another aspect, the recess is adapted to retain a carriage assembly.
In another aspect of the invention, there is provided a system for controlling the movement of an articulating instrument. The system includes a connection assembly having a first portion removably coupled to a second portion. The first portion comprising a carriage assembly connected to a first force transmission element. The second portion comprising a carriage assembly connected to a second force transmission element. An actuator is coupled to the first force transmission element. An articulating instrument is coupled to the second force transmission element. A control system responsive to inputs for controlling movement of the articulating instrument.
In one aspect, the control system controls the articulating instrument movement by regulating the operation of the actuator. In another aspect, the first portion carriage assembly is engaged with the second portion carriage assembly when the first portion is coupled to the second portion. In yet another aspect, the first portion carriage assembly is mechanically engaged with the second portion carriage assembly. In yet another aspect, the first portion carriage assembly is magnetically engaged with the second portion carriage assembly. In yet another aspect, the first portion carriage assembly is pneumatically engaged with the second portion carriage assembly. In yet another aspect, the first portion carriage assembly engaged with the second portion carriage assembly using suction or vacuum. In yet another aspect, the first portion carriage assembly is hydraulically engaged with the second portion carriage assembly.
In yet another aspect of the invention, the first portion carriage assembly is engaged with the second portion carriage assembly using a set of engaging teeth. In another aspect of the invention, the first portion carriage assembly is engaged with the second portion carriage assembly using a set of engaging gear teeth. In another aspect of the invention, the first portion carriage assembly is engaged with the second portion carriage assembly using a spur gear. In another aspect of the invention, the first portion carriage assembly is engaged with the second portion carriage assembly by activating a shape memory alloy element. In another aspect of the invention, the first portion carriage assembly is engaged with the second portion carriage assembly using at least one hook. In another aspect of the invention, the first portion carriage assembly is engaged with the second portion carriage assembly using a threaded member. In another aspect of the invention, the first portion carriage assembly is engaged with the second portion carriage assembly by engaging a slot and a pin. In another aspect of the invention, the first portion carriage assembly is engaged with the second portion carriage assembly using a spline and a rack. In another aspect, the first portion carriage assembly is engaged with the second portion carriage assembly using a rack; a pinion; a spur gear; a worm gear, or combinations thereof. In another aspect, the first portion carriage assembly is engaged with the second portion carriage assembly using an electromagnet and/or permanent magnet or other magnetic forces.
In one aspect of the invention, the first force transmission element or the second force transmission element is a cable. In another aspect of the invention, the first force transmission element or the second force transmission element is a piston. In one aspect of the invention, the first force transmission element or the second force transmission element is a Bowden cable.
In one aspect of the invention, the actuator is a motor. In one aspect of the invention, the actuator is a pump. In another aspect of the invention, the actuator is a vacuum pump. In one aspect of the invention; the actuator is a pneumatic pump.
In another embodiment of the present invention, the first portion carriage assembly is disengaged with the second portion carriage assembly when the first portion is disengaged from the second portion.
In one embodiment of the present invention, there is provided a system for controlling the movement of an articulating instrument and the articulating instrument is a medical instrument. In another aspect of the invention, the medical instrument is a segmented endoscope. In another aspect of the invention, the first portion is coupled to the second portion and movement of the first force transmission element moves a segment of the segmented endoscope. In another aspect of the invention, a control system generates a command to operate the actuator and thereby move a segment of the segmented endoscope in response to an input.
In one aspect of the invention, the input is provided by a user. In another aspect of the invention, the input is provided by a surgical planning program. In another aspect of the invention, the input is provided by an image of the desired path of travel for the segmented endoscope.
In another aspect of the present invention, there is provided a connector for coupling a force to move a segmented medical instrument having a connector having a first connector housing releaseably coupled to a second connector housing. The first connector housing having a plurality of guideways and a carriage assembly disposed in each guideway. The carriage assembly is adapted to be coupled to a force generator. A second connector housing having a plurality of guideways and a carriage assembly disposed in each guideway. A force transmission element attached to each carriage assembly and adapted for connection to a segmented medical instrument. In one aspect of the present invention, a carriage assembly in the first connector housing is adapted to be coupled to the force generator using a force transmission element. In one aspect, a force transmission element attached to a carriage assembly in the second connector housing passes through a proximal segment of the segmented medical instrument and is attached to a distal segment of the segmented medical instrument. In another aspect of the invention, application of a force to a carriage assembly in the first connector housing moves a carriage assembly in the second connector housing. In another aspect, application of a force to a carriage assembly in the first connector housing moves a segment of the segmented medical instrument. In one aspect the carriage assembly in the second connector housing moves along a guideway. In another aspect, at least one of the first connector housing and the second connector housing comprising a slack area. In another aspect, the slack area is in the first connector housing and a portion of the slack area is in a non-linear orientation to the guideways in the first connector housing. In another aspect, the slack area is in the second connector housing and a portion of the slack area is in a non-linear orientation to the guideways in the second connector housing. In yet another aspect, the slack area contains the force transmission element coupled to the first connector housing arranged in an angular relationship to the guideways in the first connector housing. In yet another aspect, the slack area contains the force transmission elements of the second connector housing arranged in an angular relationship to the guideways in the second connector housing.
In another aspect of the present invention, there is provided a connector having a sensor to detect an operational characteristic of the connector. In one aspect, the operational characteristic of the connector is the engagement of a carriage assembly in the first connector housing to a carriage assembly in the second connector housing. In another aspect, the operational characteristic of the connector is the disengagement of a carriage assembly in the first connector housing to a carriage assembly in the second connector housing. In another aspect, the operational characteristic of the connector relates to the operational condition or performance of the connector such as friction losses, wear, component-degradation and the like. In another aspect, the operational characteristic of the connector is the tension in a force transmission element. In another aspect, the operational characteristic of the connector is the torque exerted on a force transmission element. In another aspect, the operational characteristic of the connector is a force acting on a force transmission element. In another aspect, the operational characteristic of the connector is a force acting on a carriage assembly. In another aspect, the characteristic of the connector is the range of travel of a carriage assembly. In another aspect, the connector includes an indicator that provides information about the segmented medical instrument coupled to the connector. In one aspect, the information is related to the time since maintenance was performed on the segmented medical instrument. In another aspect, the information is related to the physical parameters of the segmented medical instrument. In another aspect, the information provided by the indicator alters the manner in which the segmented medical instrument is actuated. In another aspect, the segmented medical instrument is an endoscope.
A connector assembly 1120 completes the transmission of power generated by the force generator 1110 and applied to the controllable article 1100. The two portions 1125, 1130 of the connector assembly 1120 are disengagably coupled. The connector portion 1125 is the first connector portion or the force generation side connector. The connector 1130 is the second connector portion or the controllable article side connector portion. When the connector portions 1125, 1130 are in a coupled condition, the force transmission elements 1135 are joined and force generated by the force generator 1110 is applied to the controllable article 1100. When the connector portions 1125, 1130 are not coupled, the connector portion 1130, force transmission elements 1135 and the controllable article 1100 may be removed, in some embodiments as a single integrated unit, from the connector portion 1125, force transmission elements 1135 and the force generator 1110 or actuators 1115.
The connector assembly 1120 represents one advantage of the present invention. The ability to quickly connect and disconnect the two portions 1125, 1130 allow a single force transmission portion to be used with multiple controllable articles. Currently, articulating instruments such as, for example, endoscopes typically have only 4 cables to provide limited control at the tip of the endoscope. The present invention may be advantageously utilized by existing articulating instruments to allow endoscopes with only a few force transmission elements to be quickly and more readily connected to a force generator. Moreover, connector embodiments of the present invention provide compact organization and efficient coupling of numerous force transmission elements used by highly maneuverable controllable articles. As the degree of control exerted over controllable articles increases, the number of force transmission elements needed to exert that control also increases. Increasing numbers of force transmission elements drive the need for connector solutions such as those presented by embodiments of the present invention that afford a highly compact and organized coupling arrangement of the force transmission elements.
One advantage of the simplified connection/disconnection aspect of the present invention, is that in many instances it may be desirable to have the controllable article easily separable from the actuators, force generators or controllers for cleaning, disinfecting or maintenance. The quick-release characteristic of the connectors of the present invention enable an efficient way to achieve a controllable article that is easily removable, replaceable or interchangeable. In this manner, a single controller and actuator system may be used to articulate multiple controllable instruments. After one instrument is released, another is quickly and easily connected and ready for service.
Another advantage of the connectors of the present invention is that the proximal ends of the force transmission elements attached to the controllable article can be organized to allow predictable attachment point to the corresponding force transmission elements coupled to the actuators. The plurality of force transmission elements may be organized into a bundle, array, or rack. Such organization provides a known attachment point between the force transmission elements of the actuators to the force transmission elements of the articulating instrument. Additionally, as will be seen in the examples that follow, dozens of force transmission elements will be utilized in advanced articulating instruments. Embodiments of the connectors of the present invention provide a scaleable solutions that allows a user, in a single motion, to connect all the force transmission elements coupled to the actuators to those coupled to the controllable article. Moreover, the single action connection feature of some embodiments of the present invention also provides an important safely feature if an unsafe condition arises, the actuators or force generators may be quickly disconnected from the articulating instrument.
As will be detailed below, this organization could also provide other advantages to the controllable article, such as allowing active or passive control of the tendon slack. Furthermore, the proximal ends of each tendon can be modified to allow attachment and manipulation, e.g., the ends of the tendons may be held in a specially configured sheath or casing.
Additionally, the connector 1120 may include sensors and/or safety features to help ensure proper operation and articulation of the controllable article. In the discussion that follows, the connector refers to embodiments of the connector 1120 as well as embodiments of the first and second connector portions 1125, 1130. One sensor or feature may indicate or detect translation or movement of the engaging elements (i.e., carriage assemblies 120 described below) or the force transmission elements 1135 themselves. Another sensor or feature may also detect and measure or otherwise quantify the amount of translation or movement of the engaging elements (i.e., carriage assemblies 120 described below) or the force transmission elements 1135 themselves. Another sensor may be utilized to indicate proper engagement of either the connector portions 1125, 1130 or each of the individual engaging elements (i.e., carriage assemblies 120). Another sensor or indicator may be used to generate a signal based on contacting a limit stop or the length of travel of a particular component. Another sensor may be used to detect component failure within the connector 1120.
Returning to
The controllable article 1100 is connected to the connector portion 1130 by a plurality of force transmission elements 1135. The controllable article may be any of a number of commercial, industrial or medical devices. These force transmission elements have a first end connected to the controllable elements, modules or components within the controllable article. The controllable article may be, for example, a robotic handler having a number of articulating linkages. In this example, the force transmission elements 1135 attached to the connector 1130 are connected to transmit force to the articulating linkages. In another illustrative embodiment, the controllable article may be a segmented, articulating instrument. In this case, the force transmission elements 1135 attached to the connector 1130 will also be connected so as to transmit force to the individual segments to articulate the instrument. The ends of the force transmission elements 1135 within the connector 1120 are adapted to engage one another when the connector portions 1125, 1130 are coupled. In some embodiments, the first and the second elements are mechanically coupled. Other types of coupling configurations are possible and are described in greater detail below.
A controllable article 1100 includes at least one segment or module, and preferably several segments or modules, which are controllable via a computer and/or electronic controller (controller) 1140 located at a distance from the controllable article 1100. Each of the segments has force transmission elements 1135, tendons, mechanical linkages or elements connected to a force generator 1110 or an actuator 1115 to allow for the controlled motion of the segments or modules. The actuators driving the tendons (as a specific example of a force transmission element 1135) may include a variety of different types of mechanisms capable of applying a force to a tendon, e.g., electromechanical motors, pneumatic and hydraulic cylinders, pneumatic and hydraulic motors, solenoids, shape memory alloy wires, electroactive polymer actuated devices, electronic rotary actuators or other devices or methods as known in the art. If shape memory alloy wires are used, they are preferably configured into several wire bundles attached at a proximal end of each of the tendons within the controller. Segment articulation may be accomplished by applying energy, e.g., electrical current, heat, etc., to each of the bundles to actuate a linear motion in the wire bundles which in turn actuate the tendon movement. The linear translation of the actuators within the controller is configured and scaled in conformity with the desired movement of the controllable article and may vary depending upon application of the controllable article. Some commercial applications may include controllable articles articulating in large movements measured in feet. Still other applications, such as for example, medical applications, may find that the controllable article is configured for tighter control to enable more precise movement over a relatively short distance, e.g., within a few inches or less such as ±1 inch, to accomplish effective articulation depending upon the desired degree of segment movement and articulation.
In one specific embodiment, the force generator is a motor. The motor is coupled to a leadscrew assembly, so that when the motor rotates, it transmits torque to the leadscrew. A modified nut on the leadscrew is constrained to prevent rotational motion, so that when the leadscrew is rotated, the nut is translated along the axis of the leadscrew. The torque from the motor is thereby translated into linear motion. In this specific embodiment, the force transmission element is a cable that is connected to the nut on one end and a carriage assembly 120 on the other end. The linear motion of the nut translates into force on the cable. As such, the leadscrew movement is translated into linear movement of a carriage assembly in one connector hence to another carriage assembly in another connector assembly connected to the controllable article. In one specific embodiment, 64 of the leadscrew assemblies are arranged in modules for easy organization and maintenance. The modules are supported in a chassis that also houses the first portion of the connector described above. More or fewer leadscrew assemblies may be used depending upon application.
The housing 109 provides a structural base for supporting the connector assembly 110. In this embodiment, the first connector portion 112 (not shown) is secured within the housing 109. The first connector portion and its carriage assemblies are connected via force transmission elements 130 to actuators 105. While four actuators 105 are illustrated, it is to be appreciated that more actuators may be used to drive a corresponding number of carriage assemblies. The housing 109 also provides a opening 107 configured to receive the second connector portion 114. Optionally, either one or both of the opening 107 or a portion of the second connector portion 114 may be keyed to ensure correct orientation prior to connection. When the second connector portion 114 is placed within the opening 107, the first and second connector portions 112, 114 are brought into engagement using an appropriate quick release mechanism, such as for example a cam actuated lever or other engagement device as known to those of ordinary skill in the art. When the first and second connector portion 112, 114 are engaged, forces generated by actuators 105 are transmitted to the controllable article. In one embodiment, relative movement between the first connector portion and the second connector portion is used to couple the first connector portion to the second connector portion. In one embodiment, nearly vertical movement between the first connector portion and the second connector portion is used to engage the first and second connector portions. In another embodiment, the coupling force between the first and second connection portions acts nearly orthogonal to the direction of movement of the individual connection elements (i.e., carriage assemblies 120) within the first and second connection portions.
The connector 110 embodiment of
It is to be appreciated that both double and single sided connector portions are possible. For example, the double-sided second connector portion may be coupled to two single sided first connector portions (i.e., one single sided first connector engages with the second connector upper face and the other engages with the lower face, for example
The connectors and housing 109 may be formed from any suitable material having sufficient strength to transmit the forces or energy used. Suitable materials include metals, plastics, extrusions, injection molded parts, forged, and/or metal injection molded parts, In addition, the bearing surfaces may be coated with suitable low friction coatings to reduce friction losses within the connectors such as between the carriage assemblies and the guideways. One or more surfaces within the connector assembly may be coated as desired. Suitable coatings include, for example, Teflon, PTFE, and other low friction coatings. In addition, the bearing surfaces may include a viscous coating or include other bearing structure or surfaces such as, for example, ball bearings, linear bearings, or air bearings and the like.
Connector assembly portion 114 has a plurality of guideways 118 for organizing the array of tensioning members and/or cables 121 used to control a controllable article, Guideway 118 may be a U-shaped channel formed integrally within housing 114 as illustrated or it may be manufactured separately and attached onto housing 114. As described in greater detail below with regard to
As illustrated in
Guideway 118 may be configured to provide a limited range of travel for the translational movement of cable carriage assemblies 120. For instance, guideway 118 may have a frame stop 119 defined at one end of the guideway 118 so that carriage assemblies 120 may be securely seated and aligned with each rail. Frame stop 119 may define a portion of the guideway that is discontinuous such that a carriage assembly 120 may be seated within the discontinuity. Although the discontinuity is shown in
In the illustrated embodiment of the second connector portion 114, the second connector portion 114 includes a cable passageway or slack area 116. Slack area 116 is an area sufficiently spacious to allow for the inclusion of slack in the tendons and/or cables which may be routed through and/or bend within the passageway 116, as described in further detail below. The passageway 116 may be curved such that controllable article interface 113 and guideway 118 are angled relative to one another, such as the illustrated angle of about 90° but may range between 0° to 180°. The slack area angle is measured between a line representing the direction of movement of the carriage assembles—i.e., direction of travel 126—and a line directed towards the articulating instrument through interface 113. The size and exact configuration of the slack area, if included, will depend upon the number size, shape and flexibility of the force transmission elements used in a particular application. As such, the slack area may have any of a wide variety of shapes or curvature to provide an accommodation for the excess or slack cable length temporarily created during movement or manipulation of the controllable article.
In the illustrated embodiment of
One potential problem when engaging connector portions 112, 114 is the proper alignment of the carriage assemblies prior to engagement. Any number of mechanical alignment features and techniques may be used to align the carriage assemblies into a zero or alignment position prior to engagement between a first and a second connector portion.
Also shown in
Although the embodiments of
This feature is not limited to pins and receptacles, since virtually any convenient mechanism for transferring force from the actuator to the force transmission elements would work.
Any of the above connection embodiments may be modified to include sensors to provide added functionality to embodiments of the connector of the present invention. Sensors may be located in either or both of the connector portions 112, 114 or in any of the connection and release mechanisms described herein. Any of a wide variety of commonly available sensors may be used to accomplish the functionalities described below such as, for example, reed switches, electro-optical switches, resistive switches, contact switches, optical indicators, strain gauges, stress gauges, measurement indicators and the like. Examples of added functionality, include without limitation, detection of cable or carriage assembly translation, position, or engagement With regard to engagement, sensors may be used to indicate proper or improper engagement between carriage assemblies or connectors or whether components have become or are about to become disengaged. Sensors may be used to measure component performance or failure. For example, a sensor detects when a cable becomes slack when it should be under tension as an indication of cable failure or, if a carriage assembly suddenly locks into a position, a sensor may indicate an obstruction of the controllable article and/or obstruction or abnormal occurrence elsewhere in the force transmission pathway. Additionally, the output or signal from a sensor may be integrated into the control system. For example, sensors within the connector could be used to measure carriage assembly movement as the indication for position of the controllable article. The sensor could be coupled to or in communication with a portion of the connector assembly and have an output that indicates the position of the instrument. Furthermore, the control system could be adapted to use the output of the sensor, in place of or in addition to encoders on the instrument to control and/or monitor the position, shape, movement etc. of the instrument.
In a specific example where the controllable article is a steerable endoscope, the tip of the endoscope and different segments or positions of the endoscope could be controlled using the position of the carriage assembly/assemblies and cables used to control those segments. In another example, a sensor may be used as limit switch for the length of travel of a carriage assembly. In this example, the carriage assembly length of travel corresponds to a physical or operational limitation of the system or of the controllable article. As such when the carriage assembly reaches the limit switch the control system may respond appropriately by, for example, shutting off power, sounding an alarm or otherwise providing an indication that the limit switch sensor had been activated. In addition, sensors may be used to identify a particular controllable article being provided to the connector. The identifying information could be used to recall stored maintenance or performance information about the particular controllable article. If for example, a particular component was beginning to wear or if a particular cable required additional force for proper movement such unique variability for the article could be provided to and accounted for by the control signals generated by the control system. Likewise, the control system may have recording capabilities to record the amount of time the device was used and performance criteria met or not met by the article. In another example, a connector portion attached to a controllable article may include a sensor, other readable feature, mark or other identifying characteristic or a user may enter a serial number or the connector may have a bar code identifier read by a bar code reader associated with the system. The system could automatically read the identifying feature of the connector and adjust control signals according to the stored maintenance, performance and/or service information related to that article.
Embodiments of the connector of the present invention allow for determination of position and provide control of the various segments or modules of a controllable article using the position and/or movement of the cables or carriage assemblies or other components within the connector. For example, the position, shape, and/or movement of the tip of a steerable endoscope or portion thereof could be controlled using the position of the cables, carriage assemblies or other components used to control the tip. The amount of within connector movement of the more or more cables, carriage assemblies or components is correlated to an amount, degree or type of tip movement. A such, by monitoring and controlling within connector movements, the tip and other sections or modules of a controllable article may be controlled. Additionally, linear motion of the cable within the connector may be used to indicate segment position including the position and movement of the instrument tip. Sensors to detect movement may be placed in one or both connector portions 112, 114 (or in other connector assemblies such as
In addition, sensors incorporated into the connector may be used to measure or indicate the operational condition of the cables, cable wear or changes in friction loads in the instrument. For example, sensors in the connector may be used to detect, for example, increases in cable wear or friction within the instrument, in specific cables and sections of the instrument. Information regarding the operating condition of the cables and instrument may be used in a number of ways to improve overall system performance. For example, measurements indicating increasing friction losses over a period of time may be used as an indication that maintenance or service of the instrument is advisable. Alternatively, measurements indicating an immediate friction increase may be an indication of mechanical binding in the force transmission pathway, instrument failure or that the instrument has encountered an obstruction. The signal indications could be used by the system in a number of ways, such as for example, a warning indication, a safety shut-offs, or a “service needed” indicator.
The automatically controlled portion 2520 is segmented, and each segment is capable of bending through a full range of steerable motion. The distal portion 2516 is also a controllable segment. A more detailed description on the construction and operation of the segmented endoscope may be found in U.S. patent application Ser. No. 10/229,577 filed Aug. 27, 2002, which is incorporated herein by reference in its entirety.
The selectively steerable distal portion 2516 can be selectively steered or bent up to, e.g., a full 180° bend in any direction 2518, as shown. A fiber optic imaging bundle 2534 and one or more illumination fibers 2532 may extend through the body 2512 from the proximal portion 2514 to the distal portion 2516. Alternatively, the endoscope 2510 may be configured as a video endoscope with a miniaturized video camera, such as a CCD or CMOS camera, positioned at the distal portion 2516 of the endoscope body 2512. The images from the video camera can be transmitted to a video monitor by a transmission cable or by wireless transmission where images may be viewed in real-time and/or recorded by a recording device onto analog recording medium, e.g., magnetic tape, or digital recording medium, e.g., compact disc, digital tape, etc. LEDs or other light sources could also be used for illumination at the distal tip of the endoscope.
The body 2512 of the endoscope 2510 may also include one or more access lumens 2528 that may optionally be used for illumination, fibers for providing a light source, insufflation or irrigation, air and water channels, and vacuum channels. Generally, the body 2512 of the endoscope 2510 is highly flexible so that it is able to bend around small diameter curves without buckling or kinking while maintaining the various channels intact. When configured for use as a colonoscope, the body 2512 of the endoscope 2510 may range typically from 135 to 185 cm in length and about 13-19 mm in diameter. The endoscope 2510 can be made in a variety of other sizes and configurations for other medical and industrial applications.
The controllable portion 2520 is composed of at least one segment 2522, and preferably several segments 2522, which are controllable via a computer and/or electronic controller 2540 located at a distance from the endoscope 2510. Each, or at least a majority, of the segments 2522 may have forces transmission elements or tendons mechanically connected to force generators or actuators to allow for the controlled motion of the segments 2522 in space. The actuators driving the tendons may include a variety of different types of mechanisms capable of applying a force to a tendon, e.g., electromechanical motors, pneumatic and hydraulic cylinders, pneumatic and hydraulic motors, solenoids, shape memory alloy wires, electronic rotary actuators or other devices or methods as known in the art. If shape memory alloy wires are used, they are preferably configured into several wire bundles attached at a proximal end of each of the tendons within the controller. Segment articulation may be accomplished by applying energy, e.g., electrical current, heat, etc., to each of the bundles to actuate a linear motion in the wire bundles which in turn actuate the tendon movement. The linear translation of the actuators within the controller may be configured to move over a relatively short distance, e.g., within a few inches or less such as ±1 inch, to accomplish effective articulation depending upon the desired degree of segment movement and articulation.
It is preferable that the length of the insertable portion of the endoscope comprises controllable segments 2522, although a passive proximal portion 2514 can also be optionally used. This proximal portion 2514 is preferably a flexible tubing member that may conform to an infinite variety of shapes, and may be made from a variety of materials such as thermoset and thermoplastic polymers which are used for fabricating the tubing of conventional endoscopes.
Each segment 2522 preferably defines at least one lumen running throughout to provide an access channel through which wires, optical fibers, air and/or water channels, various endoscopic tools, or any variety of devices and wires may be routed. A polymeric covering, or sheath, 2530 may also extend over the body of the endoscope 2512 including the controllable portion 2520 and steerable distal portion 2516. This sheath 2530 can preferably provide a smooth transition between the controllable segments 2522, the steerable distal portion 2516, and the flexible tubing of proximal portion 2514.
A handle 2524 may be attached to the proximal end of the endoscope. The handle 2524 may include an ocular connected to the fiber optic imaging bundle 2534 for direct viewing. The handle 2524 may otherwise have a cable 2552 for connection to a video monitor; camera, e.g., a CCD or CMOS camera, or a recording device 2550. The handle 2524 may be connected to an illumination source 2536 by an illumination cable 2538 that is connected to or continuous with the illumination fibers 2534. Alternatively, some or all of these connections could be made at the controller 2540. Luer lock fittings 2526 may be located on the handle 2524 and connected to the various instrument channels.
The handle 2524 may be connected to a motion controller 2540 by way of a controller cable 2542. A steering controller 2544 may be connected to the motion controller 2540 by way of a second cable 2546 or it may optionally be connected directly to the handle 2524. Alternatively, the handle may have the steering control mechanism integrated directly into the handle, e.g., in the form of a joystick, conventional disk controllers such as dials, pulleys or wheels, etc. The steering controller 2544 allows the user to selectively steer or bend the selectively steerable distal portion 2516 of the body 2512 in the desired direction 2518. The steering controller 2544 may be a joystick controller as shown, or other steering control mechanism, e.g., dual dials or rotary knobs as in conventional endoscopes, track balls, touchpads, mouse, or sensory gloves. The motion controller 2540 controls the movement of the segmented automatically controlled proximal portion 2520 of the body 2512. This controller 2540 may be implemented using a motion control program running on a microcomputer or using an application-specific motion controller. Alternatively, the controller 2540 may be implemented using, e.g., a neural network controller.
The actuators applying force, to the tendons may be included in the motion controller unit 2540, as shown, or may be located separately and connected by a control cable. The tendons controlling the steerable distal portion 2516 and the controllable segments 2522 extend down the length of the endoscope body 2512 and connect to the actuators.
An axial, motion transducer (also called a depth referencing device or datum) 2548 may be provided for measuring the axial motion, i.e., the depth change, of the endoscope body 2512 as it is advanced and withdrawn. The depth referencing device 2548 can be made in many possible configurations. For example, the axial motion transducer 2548 in
The device is then advanced again in
In addition to measuring tendon displacement, the motion controller alone, a connector of the present invention alone or the controller and the connector operating together can also adjust for tendon stretch or compression. For example, the motion controller can control the “slack” in the tendons, particularly in tendons that are not actively under tension or compression. Allowing slack in inactive tendons reduces the amount of force that is required to articulate more proximal segments. In variations described above, the umbilicus at the distal end of the endoscope may contain space to allow slack in individual tendons.
The bending and advancing process can be done in a stepwise or continuous manner. If stepwise, e.g., as the tendon is advanced by a segment length, the next proximal segment 706 is bent to the same shape as the previous segment or distal steerable portion. A more continuous process could also result by bending the segment incrementally as the tendon is advanced. This could be accomplished by the computer control; for example when the segments are smaller than the navigated curve.
Controllable segments, including the steerable distal portion, can be selected to have different dimensions, e.g., different diameters or lengths, even within the same endoscope. Segments of different dimensions may be desirable because of considerations of space, flexibility and method of bending. For example, the more segments in an endoscope, the further it can be steered within a body cavity; however, more segments require more tendons to control the segments.
The tendons that articulate the segments are in mechanical communication with the actuators. However, it may be desirable to have the insertable distal portion of the endoscope be removable from the actuators and controller, e.g., for cleaning or disinfecting. A quick-release mechanism, such as a connector embodiment described in this application, between the proximal end of the endoscope and the actuators is an efficient way to achieve an endoscope that is easily removable, replaceable or interchangeable. For example, the proximal ends of the tendons can be organized to allow predictable attachment to corresponding actuators, such as for example, through the utilization of embodiments of connector portions 112, 114 or the connectors described with regard to
The steerable distal portion, as well as the endoscope and the controllable segments are bendable but preferably not compressible or expansible. Thus, in
In one variation, three tendons are used to actuate each segment, including the steerable distal portion, although four or more tendons could be used. Three tendons can reliably articulate a segment in any direction without having to rotate the segment or endoscope about its longitudinal axis. The three cable tendons 3012 are preferably attached at the distal end of the segment 3020 close to the segment's edge, spaced equally apart. In
As shown in
In all these variations, the circumferential locations of the tendons and/or biasing elements are illustrative and are not intended to be limited to the examples described herein. Rather, they may be varied according to the desired effects as understood by one of skill in the art.
Steerable endoscopes and colonoscopes may utilize a plurality of individual tensioning or control members, as described in greater detail in U.S. patent application Ser. No. 10/229,577 filed Aug. 27, 2002, which is incorporated herein by reference in its entirety. However, when a relatively large number of tensioning members are used to manipulate an endoscope for traversing a tortuous path, the organization and management for each of these tensioning members may be optimized according to embodiments of the methods and apparatus described herein.
Although the endoscope connectors and assemblies have been described for use with colonoscopes, the connector and engagement assemblies of the present invention may be configured for the efficient control of a wide variety of controllable articles in, the a number of other medical and industrial applications. In addition, they can also be configured for use with catheters, cannulas, surgical instruments, interluminal instruments, and/or introducer sheaths that use the principles described above for navigating through body channels or within the body. They may also be used for industrial applications such as inspection and exploratory applications within tortuous regions, e.g., machinery, pipes, difficult to access'enclosures and the like.
In yet another variation, the motion controller assemblies can be used to control the automatically controlled proximal portion to follow the selected path and, if necessary, to return to a desired location using the three-dimensional model in the electronic memory of the controller. While the above illustrative embodiments have described mechanical connections and force transmissions of the first and second connector portions, it is to be appreciated that alternative embodiments of the connector of the present invention may be modified and adapted to accommodate other forms of energy, position, or force transfer including but not limited to, electrical, pneumatic, hydraulic and the like. Modification of the above-described assemblies and methods for carrying out the invention, and variations of aspects of the invention that are obvious to those of skill in the art are intended to be within the scope of the claims.
This application is a continuation of U.S. patent application Ser. No. 10/988,212 (filed Nov. 12, 2004, pending), which is a continuation-in-part of U.S. patent application Ser. No. 10/229,577 (filed Aug. 27, 2002, now U.S. Pat. No. 6,858,005), which is a continuation-in-part of U.S. patent application Ser. No. 09/790,204 (filed Feb. 20, 2001, now U.S. Pat. No. 6,468,203), which claims the benefit of U.S. Provisional Application No. 60/194,140 (filed Apr. 3, 2000), all of which are incorporated herein by reference in their entirety.
| Number | Name | Date | Kind |
|---|---|---|---|
| 616672 | Kelling | Dec 1898 | A |
| 1590919 | Wahl et al. | Jun 1926 | A |
| 2241576 | Charles | May 1941 | A |
| 2510198 | Tesmer | Jun 1950 | A |
| 2533494 | Mitchell, Jr. | Dec 1950 | A |
| 2767705 | Moore | Oct 1956 | A |
| 3060972 | Sheldon | Oct 1962 | A |
| 3071161 | Ulrich | Jan 1963 | A |
| 3096962 | Meijs | Jul 1963 | A |
| 3162214 | Wilfred, Jr. | Dec 1964 | A |
| 3168274 | Street | Feb 1965 | A |
| 3190286 | Stokes | Jun 1965 | A |
| 3266059 | Stelle | Aug 1966 | A |
| 3430662 | Guarnaschelli | Mar 1969 | A |
| 3497083 | Victor et al. | Feb 1970 | A |
| 3546961 | Marton | Dec 1970 | A |
| 3610231 | Takahashi et al. | Oct 1971 | A |
| 3625084 | Siebert | Dec 1971 | A |
| 3643653 | Nagashige et al. | Feb 1972 | A |
| 3739770 | Mori | Jun 1973 | A |
| 3773034 | Burns et al. | Nov 1973 | A |
| 3780740 | Rhea | Dec 1973 | A |
| 3858578 | Milo | Jan 1975 | A |
| 3871358 | Fukuda et al. | Mar 1975 | A |
| 3897775 | Furihata | Aug 1975 | A |
| 3913565 | Kawahara | Oct 1975 | A |
| 3946727 | Okada et al. | Mar 1976 | A |
| 3990434 | Free | Nov 1976 | A |
| 4054128 | Seufert et al. | Oct 1977 | A |
| 4176662 | Frazer | Dec 1979 | A |
| 4233981 | Schomacher | Nov 1980 | A |
| 4236509 | Takahashi et al. | Dec 1980 | A |
| 4240435 | Yazawa et al. | Dec 1980 | A |
| 4272873 | Dietrich | Jun 1981 | A |
| 4273111 | Tsukaya | Jun 1981 | A |
| 4286585 | Ogawa | Sep 1981 | A |
| 4327711 | Takagi | May 1982 | A |
| 4366810 | Slanetz, Jr. | Jan 1983 | A |
| 4393728 | Larson et al. | Jul 1983 | A |
| 4418688 | Loeb | Dec 1983 | A |
| 4432349 | Oshiro | Feb 1984 | A |
| 4483326 | Yamaka | Nov 1984 | A |
| 4489826 | Dubson | Dec 1984 | A |
| 4494417 | Larson et al. | Jan 1985 | A |
| 4499895 | Takayama | Feb 1985 | A |
| 4503842 | Takayama | Mar 1985 | A |
| 4517652 | Bennett et al. | May 1985 | A |
| 4534339 | Collins | Aug 1985 | A |
| 4543090 | McCoy | Sep 1985 | A |
| 4551061 | Olenick | Nov 1985 | A |
| 4559928 | Takayama | Dec 1985 | A |
| 4566843 | Iwatsuka et al. | Jan 1986 | A |
| 4577621 | Patel | Mar 1986 | A |
| 4592341 | Omagari et al. | Jun 1986 | A |
| 4601283 | Chikama | Jul 1986 | A |
| 4601705 | McCoy | Jul 1986 | A |
| 4601713 | Fuqua | Jul 1986 | A |
| 4621618 | Omagari | Nov 1986 | A |
| 4624243 | Lowery et al. | Nov 1986 | A |
| 4630649 | Oku | Dec 1986 | A |
| 4643184 | Mobin-Uddin | Feb 1987 | A |
| 4646722 | Silverstein et al. | Mar 1987 | A |
| 4648733 | Merkt | Mar 1987 | A |
| 4651718 | Collins et al. | Mar 1987 | A |
| 4655257 | Iwashita | Apr 1987 | A |
| 4683773 | Diamond | Aug 1987 | A |
| 4686963 | Cohen et al. | Aug 1987 | A |
| 4696544 | Costella | Sep 1987 | A |
| 4712969 | Kimura | Dec 1987 | A |
| 4726355 | Okada | Feb 1988 | A |
| 4753222 | Morishita | Jun 1988 | A |
| 4753223 | Bremer | Jun 1988 | A |
| 4754909 | Barker et al. | Jul 1988 | A |
| 4784117 | Miyazaki | Nov 1988 | A |
| 4787369 | Allred, III et al. | Nov 1988 | A |
| 4788967 | Ueda | Dec 1988 | A |
| 4790624 | Van Hoye et al. | Dec 1988 | A |
| 4793326 | Shishido | Dec 1988 | A |
| 4796607 | Allred, III et al. | Jan 1989 | A |
| 4799474 | Ueda | Jan 1989 | A |
| 4800890 | Cramer | Jan 1989 | A |
| 4807593 | Ito | Feb 1989 | A |
| 4815450 | Patel | Mar 1989 | A |
| 4832473 | Ueda | May 1989 | A |
| 4834068 | Gottesman | May 1989 | A |
| 4846573 | Taylor et al. | Jul 1989 | A |
| 4873965 | Danieli | Oct 1989 | A |
| 4873990 | Holmes et al. | Oct 1989 | A |
| 4879991 | Ogiu | Nov 1989 | A |
| 4884557 | Takehana et al. | Dec 1989 | A |
| 4890602 | Hake | Jan 1990 | A |
| 4895431 | Tsujiuchi et al. | Jan 1990 | A |
| 4899731 | Takayama et al. | Feb 1990 | A |
| 4904048 | Sogawa et al. | Feb 1990 | A |
| 4917114 | Green et al. | Apr 1990 | A |
| 4919112 | Siegmund | Apr 1990 | A |
| 4930494 | Takehana et al. | Jun 1990 | A |
| 4949927 | Madocks et al. | Aug 1990 | A |
| 4957486 | Davis | Sep 1990 | A |
| 4969709 | Sogawa et al. | Nov 1990 | A |
| 4971035 | Ito | Nov 1990 | A |
| 4977886 | Takehana et al. | Dec 1990 | A |
| 4977887 | Gouda | Dec 1990 | A |
| 4987314 | Gotanda et al. | Jan 1991 | A |
| 5005558 | Aomori | Apr 1991 | A |
| 5005559 | Blanco et al. | Apr 1991 | A |
| 5014709 | Bjelkhagen et al. | May 1991 | A |
| 5018509 | Suzuki et al. | May 1991 | A |
| 5025778 | Silverstein et al. | Jun 1991 | A |
| 5025804 | Kondo | Jun 1991 | A |
| 5050585 | Takahashi | Sep 1991 | A |
| 5060632 | Hibino | Oct 1991 | A |
| 5083549 | Cho | Jan 1992 | A |
| 5090956 | McCoy | Feb 1992 | A |
| 5092901 | Hunter et al. | Mar 1992 | A |
| 5103403 | Chhayder et al. | Apr 1992 | A |
| 5125395 | Adair | Jun 1992 | A |
| 5127393 | McFarlin et al. | Jul 1992 | A |
| 5159446 | Hibino | Oct 1992 | A |
| 5166787 | Irion | Nov 1992 | A |
| 5174276 | Crockard | Dec 1992 | A |
| 5174277 | Matsumaru | Dec 1992 | A |
| 5179935 | Miyagi | Jan 1993 | A |
| 5188111 | Yates et al. | Feb 1993 | A |
| 5203319 | Danna et al. | Apr 1993 | A |
| 5207695 | Trout, III | May 1993 | A |
| 5217001 | Nakao et al. | Jun 1993 | A |
| 5218280 | Edwards | Jun 1993 | A |
| 5220911 | Tamura | Jun 1993 | A |
| 5228429 | Hatano | Jul 1993 | A |
| 5234448 | Wholey et al. | Aug 1993 | A |
| 5239982 | Trauthen | Aug 1993 | A |
| 5243967 | Hibino | Sep 1993 | A |
| 5250058 | Miller et al. | Oct 1993 | A |
| 5250167 | Adolf et al. | Oct 1993 | A |
| 5251611 | Zehel et al. | Oct 1993 | A |
| 5253647 | Takahashi et al. | Oct 1993 | A |
| 5254809 | Martin | Oct 1993 | A |
| 5257617 | Takahashi | Nov 1993 | A |
| 5259364 | Bob et al. | Nov 1993 | A |
| 5268082 | Oguro et al. | Dec 1993 | A |
| 5269289 | Takehana et al. | Dec 1993 | A |
| 5271381 | Ailinger et al. | Dec 1993 | A |
| 5271382 | Chikama | Dec 1993 | A |
| 5279610 | Park et al. | Jan 1994 | A |
| 5297443 | Wentz | Mar 1994 | A |
| 5324284 | Imran | Jun 1994 | A |
| 5325845 | Adair | Jul 1994 | A |
| 5337732 | Grundfest et al. | Aug 1994 | A |
| 5337733 | Bauerfeind et al. | Aug 1994 | A |
| 5343874 | Picha et al. | Sep 1994 | A |
| 5347987 | Feldstein et al. | Sep 1994 | A |
| 5348259 | Blanco et al. | Sep 1994 | A |
| 5368015 | Wilk | Nov 1994 | A |
| 5370108 | Miura et al. | Dec 1994 | A |
| 5383467 | Auer et al. | Jan 1995 | A |
| 5383852 | Stevens-Wright | Jan 1995 | A |
| 5389222 | Shahinpoor | Feb 1995 | A |
| 5394864 | Kobayashi et al. | Mar 1995 | A |
| 5396879 | Wilk et al. | Mar 1995 | A |
| 5400769 | Tanii et al. | Mar 1995 | A |
| 5402768 | Adair | Apr 1995 | A |
| 5411508 | Bessler et al. | May 1995 | A |
| 5413108 | Alfano | May 1995 | A |
| 5421337 | Richards-Kortum et al. | Jun 1995 | A |
| 5421338 | Crowley et al. | Jun 1995 | A |
| 5425738 | Gustafson et al. | Jun 1995 | A |
| 5429118 | Cole et al. | Jul 1995 | A |
| 5431645 | Smith et al. | Jul 1995 | A |
| 5439000 | Gunderson et al. | Aug 1995 | A |
| 5451221 | Cho et al. | Sep 1995 | A |
| 5456714 | Owen | Oct 1995 | A |
| 5460166 | Yabe et al. | Oct 1995 | A |
| 5460168 | Masubuchi et al. | Oct 1995 | A |
| 5469840 | Tanii et al. | Nov 1995 | A |
| 5479930 | Gruner et al. | Jan 1996 | A |
| 5482029 | Sekiguchi et al. | Jan 1996 | A |
| 5486182 | Nakao et al. | Jan 1996 | A |
| 5487385 | Avitall | Jan 1996 | A |
| 5487757 | Truckai et al. | Jan 1996 | A |
| 5489256 | Adair | Feb 1996 | A |
| 5492131 | Galel | Feb 1996 | A |
| 5503616 | Jones | Apr 1996 | A |
| 5507287 | Palcic et al. | Apr 1996 | A |
| 5507717 | Kura et al. | Apr 1996 | A |
| 5522788 | Kuzmak | Jun 1996 | A |
| 5531664 | Adachi et al. | Jul 1996 | A |
| 5535759 | Wilk | Jul 1996 | A |
| 5551945 | Yabe et al. | Sep 1996 | A |
| 5556370 | Maynard | Sep 1996 | A |
| 5556700 | Kaneto et al. | Sep 1996 | A |
| 5558619 | Kami et al. | Sep 1996 | A |
| 5558665 | Kieturakis | Sep 1996 | A |
| 5577992 | Chiba et al. | Nov 1996 | A |
| 5586968 | Grundl et al. | Dec 1996 | A |
| 5590660 | MacAulay et al. | Jan 1997 | A |
| 5601087 | Gunderson et al. | Feb 1997 | A |
| 5602449 | Krause et al. | Feb 1997 | A |
| 5620408 | Vennes et al. | Apr 1997 | A |
| 5624380 | Takayama et al. | Apr 1997 | A |
| 5624381 | Kieturakis | Apr 1997 | A |
| 5626553 | Frassica et al. | May 1997 | A |
| 5631040 | Takuchi et al. | May 1997 | A |
| 5645064 | Littmann et al. | Jul 1997 | A |
| 5645520 | Nakamura et al. | Jul 1997 | A |
| 5647368 | Zeng et al. | Jul 1997 | A |
| 5647840 | Damelio et al. | Jul 1997 | A |
| 5651366 | Liang et al. | Jul 1997 | A |
| 5651769 | Waxman et al. | Jul 1997 | A |
| 5653690 | Booth et al. | Aug 1997 | A |
| 5658238 | Suzuki et al. | Aug 1997 | A |
| 5662585 | Willis et al. | Sep 1997 | A |
| 5662587 | Grundfest et al. | Sep 1997 | A |
| 5662621 | Lafontaine | Sep 1997 | A |
| 5665050 | Benecke | Sep 1997 | A |
| 5667476 | Frassica et al. | Sep 1997 | A |
| 5679216 | Takayama et al. | Oct 1997 | A |
| 5681260 | Ueda et al. | Oct 1997 | A |
| 5704898 | Kokish | Jan 1998 | A |
| 5720718 | Rosen et al. | Feb 1998 | A |
| 5725475 | Yasui et al. | Mar 1998 | A |
| 5728044 | Shan | Mar 1998 | A |
| 5733245 | Kawano | Mar 1998 | A |
| 5746694 | Wilk et al. | May 1998 | A |
| 5749828 | Solomon et al. | May 1998 | A |
| 5752912 | Takahashi et al. | May 1998 | A |
| 5759151 | Sturges | Jun 1998 | A |
| 5762613 | Sutton et al. | Jun 1998 | A |
| 5765561 | Chen et al. | Jun 1998 | A |
| 5769792 | Palcic et al. | Jun 1998 | A |
| 5771902 | Lee et al. | Jun 1998 | A |
| 5772597 | Goldberger et al. | Jun 1998 | A |
| 5773835 | Sinofsky | Jun 1998 | A |
| 5779624 | Chang | Jul 1998 | A |
| 5807241 | Heimberger | Sep 1998 | A |
| 5810715 | Moriyama | Sep 1998 | A |
| 5810716 | Mukherjee et al. | Sep 1998 | A |
| 5810717 | Maeda et al. | Sep 1998 | A |
| 5810776 | Bacich et al. | Sep 1998 | A |
| 5813976 | Filipi et al. | Sep 1998 | A |
| 5819749 | Lee et al. | Oct 1998 | A |
| 5827190 | Palcic et al. | Oct 1998 | A |
| 5827265 | Glinsky et al. | Oct 1998 | A |
| 5842973 | Bullard | Dec 1998 | A |
| 5848972 | Triedman et al. | Dec 1998 | A |
| 5855565 | Bar-Cohen et al. | Jan 1999 | A |
| 5857962 | Bracci et al. | Jan 1999 | A |
| 5860581 | Robertson et al. | Jan 1999 | A |
| 5860914 | Chiba et al. | Jan 1999 | A |
| 5868760 | McGuckin, Jr. | Feb 1999 | A |
| 5873817 | Kokish et al. | Feb 1999 | A |
| 5876329 | Harhen | Mar 1999 | A |
| 5876373 | Giba et al. | Mar 1999 | A |
| 5885208 | Moriyama | Mar 1999 | A |
| 5893369 | Lemole | Apr 1999 | A |
| 5897417 | Grey | Apr 1999 | A |
| 5897488 | Ueda | Apr 1999 | A |
| 5902254 | Magram | May 1999 | A |
| 5906591 | Dario et al. | May 1999 | A |
| 5908381 | Aznoian et al. | Jun 1999 | A |
| 5911715 | Berg et al. | Jun 1999 | A |
| 5916146 | Allotta et al. | Jun 1999 | A |
| 5916147 | Boury | Jun 1999 | A |
| 5921915 | Aznoian et al. | Jul 1999 | A |
| 5928136 | Barry | Jul 1999 | A |
| 5941815 | Chang | Aug 1999 | A |
| 5941908 | Goldsteen et al. | Aug 1999 | A |
| 5957833 | Shan | Sep 1999 | A |
| 5957969 | Warner et al. | Sep 1999 | A |
| 5968052 | Sullivan, III | Oct 1999 | A |
| 5971767 | Kaufman et al. | Oct 1999 | A |
| 5976074 | Moriyama | Nov 1999 | A |
| 5989182 | Hori et al. | Nov 1999 | A |
| 5989230 | Frassica | Nov 1999 | A |
| 5993381 | Ito | Nov 1999 | A |
| 5993447 | Blewett et al. | Nov 1999 | A |
| 5993462 | Pomeranz et al. | Nov 1999 | A |
| 5996346 | Maynard | Dec 1999 | A |
| 6016440 | Simon et al. | Jan 2000 | A |
| 6033359 | Doi | Mar 2000 | A |
| 6036636 | Motoki et al. | Mar 2000 | A |
| 6036702 | Bachinski et al. | Mar 2000 | A |
| 6042155 | Lockwood | Mar 2000 | A |
| 6048307 | Grundl et al. | Apr 2000 | A |
| 6059718 | Taniguchi et al. | May 2000 | A |
| 6063022 | Ben-Haim | May 2000 | A |
| 6066102 | Townsend et al. | May 2000 | A |
| 6066132 | Chen et al. | May 2000 | A |
| 6068629 | Haissaguerre et al. | May 2000 | A |
| 6068638 | Makower | May 2000 | A |
| 6071234 | Takada | Jun 2000 | A |
| 6096023 | Lemelson | Aug 2000 | A |
| 6096289 | Goldenberg | Aug 2000 | A |
| 6099464 | Shimizu et al. | Aug 2000 | A |
| 6099465 | Inoue | Aug 2000 | A |
| 6099485 | Patterson | Aug 2000 | A |
| 6099524 | Lipson et al. | Aug 2000 | A |
| 6106510 | Lunn et al. | Aug 2000 | A |
| 6109852 | Shahinpoor et al. | Aug 2000 | A |
| 6117296 | Thomson | Sep 2000 | A |
| 6119913 | Adams et al. | Sep 2000 | A |
| 6129667 | Dumoulin et al. | Oct 2000 | A |
| 6129683 | Sutton et al. | Oct 2000 | A |
| 6141577 | Rolland et al. | Oct 2000 | A |
| 6149581 | Klingenstein | Nov 2000 | A |
| 6162171 | Ng et al. | Dec 2000 | A |
| 6174280 | Oneda et al. | Jan 2001 | B1 |
| 6174291 | McMahon et al. | Jan 2001 | B1 |
| 6178346 | Amundson et al. | Jan 2001 | B1 |
| 6179776 | Adams et al. | Jan 2001 | B1 |
| 6185448 | Borovsky | Feb 2001 | B1 |
| 6201989 | Whitehead et al. | Mar 2001 | B1 |
| 6203493 | Ben-Haim | Mar 2001 | B1 |
| 6203494 | Moriyama | Mar 2001 | B1 |
| 6210337 | Dunham et al. | Apr 2001 | B1 |
| 6221006 | Dubrul et al. | Apr 2001 | B1 |
| 6233476 | Strommer et al. | May 2001 | B1 |
| 6241657 | Chen et al. | Jun 2001 | B1 |
| 6249076 | Madden et al. | Jun 2001 | B1 |
| 6264086 | McGuckin, Jr. | Jul 2001 | B1 |
| 6270453 | Sakai | Aug 2001 | B1 |
| 6293907 | Axon et al. | Sep 2001 | B1 |
| 6306081 | Ishikawa et al. | Oct 2001 | B1 |
| 6309346 | Farhadi | Oct 2001 | B1 |
| 6315714 | Akiba | Nov 2001 | B1 |
| 6319197 | Tsuji et al. | Nov 2001 | B1 |
| 6327492 | Lemelson | Dec 2001 | B1 |
| 6332089 | Acker et al. | Dec 2001 | B1 |
| 6348058 | Melkent et al. | Feb 2002 | B1 |
| 6352503 | Matsui et al. | Mar 2002 | B1 |
| 6364876 | Erb et al. | Apr 2002 | B1 |
| 6366799 | Acker et al. | Apr 2002 | B1 |
| 6371907 | Hasegawa et al. | Apr 2002 | B1 |
| 6402687 | Ouchi | Jun 2002 | B1 |
| 6408889 | Komachi | Jun 2002 | B1 |
| 6425535 | Akiba | Jul 2002 | B1 |
| 6428203 | Danley | Aug 2002 | B1 |
| 6428470 | Thompson | Aug 2002 | B1 |
| 6443888 | Ogura et al. | Sep 2002 | B1 |
| 6447444 | Avni et al. | Sep 2002 | B1 |
| 6453190 | Acker et al. | Sep 2002 | B1 |
| 6459481 | Schaack | Oct 2002 | B1 |
| 6468203 | Belson | Oct 2002 | B2 |
| 6468265 | Evans et al. | Oct 2002 | B1 |
| 6482148 | Luke | Nov 2002 | B1 |
| 6482149 | Torii | Nov 2002 | B1 |
| 6485413 | Boppart et al. | Nov 2002 | B1 |
| 6485496 | Suyker et al. | Nov 2002 | B1 |
| 6490467 | Bucholz et al. | Dec 2002 | B1 |
| 6503259 | Huxel et al. | Jan 2003 | B2 |
| 6511417 | Taniguchi et al. | Jan 2003 | B1 |
| 6511418 | Shahidi et al. | Jan 2003 | B2 |
| 6514237 | Maseda | Feb 2003 | B1 |
| 6517477 | Wendlandt | Feb 2003 | B1 |
| 6527706 | Ide | Mar 2003 | B2 |
| 6537211 | Wang et al. | Mar 2003 | B1 |
| 6544215 | Bencini et al. | Apr 2003 | B1 |
| 6547723 | Ouchi | Apr 2003 | B1 |
| 6554793 | Pauker et al. | Apr 2003 | B1 |
| 6569084 | Mizuno et al. | May 2003 | B1 |
| 6569173 | Blatter et al. | May 2003 | B1 |
| 6589163 | Aizawa et al. | Jul 2003 | B2 |
| 6610007 | Belson et al. | Aug 2003 | B2 |
| 6616600 | Pauker | Sep 2003 | B2 |
| 6638213 | Ogura et al. | Oct 2003 | B2 |
| 6641528 | Torii | Nov 2003 | B2 |
| 6650920 | Schaldach et al. | Nov 2003 | B2 |
| 6656110 | Irion et al. | Dec 2003 | B1 |
| 6664718 | Pelrine et al. | Dec 2003 | B2 |
| 6679836 | Couvillon, Jr. et al. | Jan 2004 | B2 |
| 6690963 | Ben-Haim et al. | Feb 2004 | B2 |
| 6699183 | Wimmer | Mar 2004 | B1 |
| 6719685 | Fujikura et al. | Apr 2004 | B2 |
| 6761685 | Adams et al. | Jul 2004 | B2 |
| 6783491 | Saadat et al. | Aug 2004 | B2 |
| 6790173 | Saadat et al. | Sep 2004 | B2 |
| 6793621 | Butler et al. | Sep 2004 | B2 |
| 6800056 | Tartaglia et al. | Oct 2004 | B2 |
| 6808499 | Churchill et al. | Oct 2004 | B1 |
| 6808520 | Fourkas et al. | Oct 2004 | B1 |
| 6817973 | Merril et al. | Nov 2004 | B2 |
| 6835173 | Couvillon, Jr. | Dec 2004 | B2 |
| 6837846 | Jaffe et al. | Jan 2005 | B2 |
| 6837847 | Ewers et al. | Jan 2005 | B2 |
| 6837849 | Ogura et al. | Jan 2005 | B2 |
| 6843793 | Brock et al. | Jan 2005 | B2 |
| 6850794 | Shahidi | Feb 2005 | B2 |
| 6858005 | Ohline et al. | Feb 2005 | B2 |
| 6869396 | Belson | Mar 2005 | B2 |
| 6875170 | Francois et al. | Apr 2005 | B2 |
| 6890297 | Belson | May 2005 | B2 |
| 6902528 | Garibaldi et al. | Jun 2005 | B1 |
| 6942613 | Ewers et al. | Sep 2005 | B2 |
| 6960161 | Amling et al. | Nov 2005 | B2 |
| 6960162 | Saadat et al. | Nov 2005 | B2 |
| 6960163 | Ewers et al. | Nov 2005 | B2 |
| 6974411 | Belson | Dec 2005 | B2 |
| 6984203 | Tartaglia et al. | Jan 2006 | B2 |
| 6997870 | Couvillon, Jr. | Feb 2006 | B2 |
| 7018331 | Chang et al. | Mar 2006 | B2 |
| 7044907 | Belson | May 2006 | B2 |
| 7087013 | Belson et al. | Aug 2006 | B2 |
| 7125403 | Julian et al. | Oct 2006 | B2 |
| 7167180 | Shibolet | Jan 2007 | B1 |
| 7285088 | Miyake | Oct 2007 | B2 |
| 7297142 | Brock | Nov 2007 | B2 |
| 7371210 | Brock et al. | May 2008 | B2 |
| 7447534 | Kingsley et al. | Nov 2008 | B1 |
| 8062212 | Belson | Nov 2011 | B2 |
| 8226546 | Belson | Jul 2012 | B2 |
| 8517923 | Belson et al. | Aug 2013 | B2 |
| 8641602 | Belson | Feb 2014 | B2 |
| 8721530 | Ohline et al. | May 2014 | B2 |
| 8888688 | Julian et al. | Nov 2014 | B2 |
| 9427282 | Belson et al. | Aug 2016 | B2 |
| 20010031983 | Brock | Oct 2001 | A1 |
| 20010041887 | Crowley | Nov 2001 | A1 |
| 20020016607 | Bonadio et al. | Feb 2002 | A1 |
| 20020032437 | Andrews et al. | Mar 2002 | A1 |
| 20020045778 | Murahashi et al. | Apr 2002 | A1 |
| 20020120252 | Brock | Aug 2002 | A1 |
| 20020129508 | Blattner et al. | Sep 2002 | A1 |
| 20020130673 | Pelrine et al. | Sep 2002 | A1 |
| 20020151767 | Sonnenschein et al. | Oct 2002 | A1 |
| 20020169361 | Taniguchi et al. | Nov 2002 | A1 |
| 20020183592 | Suzuki et al. | Dec 2002 | A1 |
| 20030065373 | Lovett et al. | Apr 2003 | A1 |
| 20030073992 | Sliwa et al. | Apr 2003 | A1 |
| 20030083550 | Miyagi | May 2003 | A1 |
| 20030130598 | Manning et al. | Jul 2003 | A1 |
| 20030163128 | Patil et al. | Aug 2003 | A1 |
| 20030167007 | Belson | Sep 2003 | A1 |
| 20030182091 | Kukuk | Sep 2003 | A1 |
| 20030187460 | Chin et al. | Oct 2003 | A1 |
| 20030195387 | Kortenbach et al. | Oct 2003 | A1 |
| 20030233056 | Saadat et al. | Dec 2003 | A1 |
| 20030236455 | Swanson et al. | Dec 2003 | A1 |
| 20030236505 | Bonadio et al. | Dec 2003 | A1 |
| 20030236549 | Bonadio et al. | Dec 2003 | A1 |
| 20040019254 | Belson et al. | Jan 2004 | A1 |
| 20040044270 | Barry | Mar 2004 | A1 |
| 20040049251 | Knowlton | Mar 2004 | A1 |
| 20040097788 | Mourlas et al. | May 2004 | A1 |
| 20040106852 | Windheuser et al. | Jun 2004 | A1 |
| 20040176683 | Whitin et al. | Sep 2004 | A1 |
| 20040186350 | Brenneman et al. | Sep 2004 | A1 |
| 20040193008 | Jaffe et al. | Sep 2004 | A1 |
| 20040193009 | Jaffe et al. | Sep 2004 | A1 |
| 20040210109 | Jaffe et al. | Oct 2004 | A1 |
| 20040220450 | Jaffe et al. | Nov 2004 | A1 |
| 20040230096 | Stefanchik et al. | Nov 2004 | A1 |
| 20050085693 | Belson et al. | Apr 2005 | A1 |
| 20050124855 | Jaffe et al. | Jun 2005 | A1 |
| 20050137454 | Saadat et al. | Jun 2005 | A1 |
| 20050137455 | Ewers et al. | Jun 2005 | A1 |
| 20050137456 | Saadat et al. | Jun 2005 | A1 |
| 20050154258 | Tartaglia et al. | Jul 2005 | A1 |
| 20050154261 | Ohline et al. | Jul 2005 | A1 |
| 20050165276 | Belson et al. | Jul 2005 | A1 |
| 20050168571 | Lia et al. | Aug 2005 | A1 |
| 20050203339 | Butler et al. | Sep 2005 | A1 |
| 20050209506 | Butler et al. | Sep 2005 | A1 |
| 20050222497 | Belson | Oct 2005 | A1 |
| 20050250990 | Le et al. | Nov 2005 | A1 |
| 20060009678 | Jaffe et al. | Jan 2006 | A1 |
| 20060015009 | Jaffe et al. | Jan 2006 | A1 |
| 20060015010 | Jaffe et al. | Jan 2006 | A1 |
| 20060089528 | Tartaglia et al. | Apr 2006 | A1 |
| 20060089529 | Tartaglia et al. | Apr 2006 | A1 |
| 20060089530 | Tartaglia et al. | Apr 2006 | A1 |
| 20060089531 | Tartaglia et al. | Apr 2006 | A1 |
| 20060089532 | Tartaglia et al. | Apr 2006 | A1 |
| 20060100642 | Yang et al. | May 2006 | A1 |
| 20060235457 | Belson | Oct 2006 | A1 |
| 20060235458 | Belson | Oct 2006 | A1 |
| 20060258912 | Belson et al. | Nov 2006 | A1 |
| 20060259029 | Utley et al. | Nov 2006 | A1 |
| 20070043259 | Jaffe et al. | Feb 2007 | A1 |
| 20070093858 | Gambale et al. | Apr 2007 | A1 |
| 20070135803 | Belson | Jun 2007 | A1 |
| 20070161291 | Swinehart et al. | Jul 2007 | A1 |
| 20070161857 | Durant et al. | Jul 2007 | A1 |
| 20070249901 | Ohline et al. | Oct 2007 | A1 |
| 20070270650 | Eno et al. | Nov 2007 | A1 |
| 20080045794 | Belson | Feb 2008 | A1 |
| 20080154288 | Belson | Jun 2008 | A1 |
| 20080214893 | Tartaglia et al. | Sep 2008 | A1 |
| 20080248215 | Sauer et al. | Oct 2008 | A1 |
| 20090099420 | Woodley et al. | Apr 2009 | A1 |
| 20090216083 | Durant et al. | Aug 2009 | A1 |
| 20100094088 | Ohline et al. | Apr 2010 | A1 |
| 20110065993 | Belson et al. | Mar 2011 | A1 |
| 20120041262 | Belson | Feb 2012 | A1 |
| 20140046324 | Belson et al. | Feb 2014 | A1 |
| 20150320295 | Belson | Nov 2015 | A1 |
| 20170027419 | Belson et al. | Feb 2017 | A1 |
| Number | Date | Country |
|---|---|---|
| 2823025 | Feb 1986 | DE |
| 3707787 | Sep 1988 | DE |
| 4102211 | Aug 1991 | DE |
| 19626433 | Jan 1998 | DE |
| 19729499 | Jan 1999 | DE |
| 165718 | Dec 1985 | EP |
| 382974 | Aug 1990 | EP |
| 497781 | Jan 1994 | EP |
| 0993804 | Apr 2000 | EP |
| 1101442 | May 2001 | EP |
| 1681013 | Jul 2006 | EP |
| 2048086 | Mar 1994 | ES |
| 2062930 | Dec 1994 | ES |
| 2732225 | Oct 1996 | FR |
| 2807960 | Oct 2001 | FR |
| 2347685 | Sep 2000 | GB |
| 20000559 | Jul 2000 | IE |
| 20020170 | Mar 2002 | IE |
| 4712705 | May 1972 | JP |
| 61205912 | Sep 1986 | JP |
| 63136014 | Jun 1988 | JP |
| 63272322 | Nov 1988 | JP |
| S63503365 | Dec 1988 | JP |
| 1152413 | Jun 1989 | JP |
| H01153292 | Jun 1989 | JP |
| 1229220 | Sep 1989 | JP |
| 1262372 | Oct 1989 | JP |
| 2246986 | Oct 1990 | JP |
| 2296209 | Dec 1990 | JP |
| 3004830 | Jan 1991 | JP |
| 3109021 | May 1991 | JP |
| 3136630 | Jun 1991 | JP |
| 3139325 | Jun 1991 | JP |
| 3170125 | Jul 1991 | JP |
| 4002322 | Jan 1992 | JP |
| 4054970 | Feb 1992 | JP |
| 5001999 | Jan 1993 | JP |
| 5011196 | Jan 1993 | JP |
| 5111458 | May 1993 | JP |
| 5177002 | Jul 1993 | JP |
| 5184531 | Jul 1993 | JP |
| 5305073 | Nov 1993 | JP |
| 6007287 | Jan 1994 | JP |
| H0670940 | Mar 1994 | JP |
| H06142106 | May 1994 | JP |
| H06285043 | Oct 1994 | JP |
| H06285009 | Nov 1994 | JP |
| H06510439 | Nov 1994 | JP |
| 7088788 | Apr 1995 | JP |
| 7116104 | May 1995 | JP |
| 7120684 | May 1995 | JP |
| 8010336 | Jan 1996 | JP |
| 8066351 | Mar 1996 | JP |
| 8322783 | Dec 1996 | JP |
| 8322786 | Dec 1996 | JP |
| 9028662 | Feb 1997 | JP |
| 10014863 | Jan 1998 | JP |
| 10337274 | Dec 1998 | JP |
| 11042258 | Feb 1999 | JP |
| 11048171 | Feb 1999 | JP |
| H11509436 | Aug 1999 | JP |
| H11313827 | Nov 1999 | JP |
| 2000279367 | Oct 2000 | JP |
| 21046318 | Feb 2001 | JP |
| 21096478 | Apr 2001 | JP |
| 2001519199 | Oct 2001 | JP |
| 2001521773 | Nov 2001 | JP |
| 2002017746 | Jan 2002 | JP |
| 3322356 | Sep 2002 | JP |
| 2002264048 | Sep 2002 | JP |
| 2002531164 | Sep 2002 | JP |
| 2003504148 | Feb 2003 | JP |
| 2003525688 | Sep 2003 | JP |
| 2003528677 | Sep 2003 | JP |
| 2005507731 | Mar 2005 | JP |
| 871786 | Oct 1981 | SU |
| 1256955 | Sep 1986 | SU |
| 1301701 | Apr 1987 | SU |
| WO-199219147 | Nov 1992 | WO |
| WO-9315648 | Aug 1993 | WO |
| WO-199317751 | Sep 1993 | WO |
| WO-199419051 | Sep 1994 | WO |
| WO-199504556 | Feb 1995 | WO |
| WO-9509562 | Apr 1995 | WO |
| WO-9605768 | Feb 1996 | WO |
| WO-9639963 | Dec 1996 | WO |
| WO-199710746 | Mar 1997 | WO |
| WO-9725101 | Jul 1997 | WO |
| WO-9729701 | Aug 1997 | WO |
| WO-9729710 | Aug 1997 | WO |
| WO-199811816 | Mar 1998 | WO |
| WO-199824017 | Jun 1998 | WO |
| WO-9849938 | Nov 1998 | WO |
| WO-199916359 | Apr 1999 | WO |
| WO-199933392 | Jul 1999 | WO |
| WO-199951283 | Oct 1999 | WO |
| WO-199959664 | Nov 1999 | WO |
| WO-0010456 | Mar 2000 | WO |
| WO-200010466 | Mar 2000 | WO |
| WO-200027462 | May 2000 | WO |
| WO-200054653 | Sep 2000 | WO |
| WO-200074565 | Dec 2000 | WO |
| WO-200149353 | Jul 2001 | WO |
| WO-200158973 | Aug 2001 | WO |
| WO-200167964 | Sep 2001 | WO |
| WO-200170096 | Sep 2001 | WO |
| WO-200170097 | Sep 2001 | WO |
| WO-0174235 | Oct 2001 | WO |
| WO-200180935 | Nov 2001 | WO |
| WO-200224058 | Mar 2002 | WO |
| WO-200239909 | May 2002 | WO |
| WO-200247549 | Jun 2002 | WO |
| WO-200264028 | Aug 2002 | WO |
| WO-200268988 | Sep 2002 | WO |
| WO-200269841 | Sep 2002 | WO |
| WO-200289692 | Nov 2002 | WO |
| WO-200296276 | Dec 2002 | WO |
| WO-03028547 | Apr 2003 | WO |
| WO-03073920 | Sep 2003 | WO |
| WO-200373921 | Sep 2003 | WO |
| WO-03086498 | Oct 2003 | WO |
| WO-03092476 | Nov 2003 | WO |
| WO-2004000403 | Dec 2003 | WO |
| WO-200406980 | Jan 2004 | WO |
| WO-2004019769 | Mar 2004 | WO |
| WO-2004049905 | Jun 2004 | WO |
| WO-200471284 | Aug 2004 | WO |
| WO-200480313 | Sep 2004 | WO |
| WO-2004084702 | Oct 2004 | WO |
| WO-2005072445 | Aug 2005 | WO |
| WO-200584542 | Sep 2005 | WO |
| WO-2006136827 | Dec 2006 | WO |
| Entry |
|---|
| “Active endoscope (ELASTOR, shape memory alloy robot),” 9 pages including 3 figures and 4 photographs. Accessed Feb. 21, 2002. Internet: http://mozu.mes.titech.ac.jp/research/medical/endoscope/endoscope.html. |
| Bar-Cohen, J., “EAP applications, potential, and challenges,” Chapter 21 in Electroactive Polymer (EAP) Actuators as Artificial Muscles, Bar-Cohen, Ed., SPIE Press, 2001, pp. 615-659. |
| Bar-Cohen, Y., “EAP history, current status, and infrastructure,” Chapter 1 in Electroactive Polymer (EAP) Actuators as Artificial Muscles, Bar-Cohen Ed., SPIE Press, 2001, pp. 3-44. |
| Bar-Cohen, Y. Ed., Worldwide ElectroActive Polymers (Artificial Muscles) Newsletter, Jun. 2001, vol. 3, issue 1, pp. 1-14. |
| Bar-Cohen, Y., “Transition of EAP material from novelty to practical applications—are we there yet” Smart Structures and Materials 2001: Electroactive Polymer Actuators and Devices, Yoseph Bar-Cohen Ed., Proceedings of SPIE, Mar. 5-8, 2001, vol. 4329, pp. 1-6. |
| Berger, W. L. et al., “Sigmoid Stiffener for Decompression Tube Placement in Colonic Pseudo-Obstruction,” Endoscopy, 2000, vol. 32, Issue 1, pp. 54-57. |
| Brock, D.L., “Review of artificial muscle based on contractile polymers,” MIT Artificial Intelligence Laboratory, A.I.Memo No. 1330, Nov. 1991, 10 pages. Accessed Jun. 23, 2005. Internet: http://www.ai.mit.edu/projects/muscle/papers/memo1330/memo1330.html. |
| Cho, S. et al., “Development of micro inchworm robot actuated by electrostrictive polymer actuator,” Smart Structures and Materials 2001: Electroactive Polymer Actuators and Devices, Yoseph Bar-Cohen Ed., Proceedings of SPIE, Mar. 5-8, 2001, vol. 4329, pp. 466-474. |
| Office Action issued in corresponding Japanese Application No. P2006-551580, Dispatch Date: Aug. 21, 2012, Dispatch No. 568236. |
| Duntgen, C., “Walking machines: 0-legged-robots: A compilation by Christian Duntgen,” Aug. 26, 2000, 16 pages. |
| EP03791924 Supplementary Partial Search Report, dated Feb. 27, 2009, 4 pages. |
| EP11175098 Extended EP Search Report dated Dec. 1, 2011, 7 pages. |
| European Search Report for Application No. EP05002014, dated Mar. 31, 2005, 3 pages. |
| Extended European Search Report for Application No. EP05824444, dated Apr. 13, 2011, 6 pages. |
| Grecu, E. et al., “Snake-like flexible Micro-robot,” Copernicus project presentation, financed by European Community, Project start May 1, 1995, 6 pages. Accessed Dec. 27, 2001; Internet: http://www.agip.sciences.univ-metz.fr/˜mihalach/Copernicus_project_engl.html. |
| Hasson, H.M., “Technique of Open Laparoscopy,” (from step 1 to step 9), May 1979, 2424 North Clark Street, Chicago, Illinois 60614, 3 pages. |
| Ikuta, Koji et al., “Shape memory alloy servo actuator system with electric resistance feedback and application for active endoscope,” Proc. IEEE International Conference on Robotics and Automation, 1988, pp. 427-430, vol. 1, IEEE. |
| International Preliminary Examination Report for Application No. PCT/US2001/10907, dated Jan. 21, 2003, 3 pages. |
| International Search Report and Written Opinion for Application No. PCT/US2004/026948, dated Dec. 29, 2005, 4 pages. |
| International Search Report and Written Opinion for Application No. PCT/US2005/03140, dated May 6, 2008, 6 pages. |
| International Search Report for Application No. PCT/US2001/10907, dated Aug. 28, 2001, 3 pages. |
| Ireland Application No. 2000/0225 filed on Mar. 22, 2000, Inventor Declan B., et al. |
| Jager, E.W.H. et al., “Microfabricating conjugated polymer actuators,” Science, Nov. 24, 2000, vol. 290, pp. 1540-1545. |
| Japanese application No. 2007-541342 Office Action dated May 17, 2011, 7 pages, including translation. |
| Jeon, J.W. et al., “Electrostrictive polymer actuators and their control systems,” Smart Structures and Materials 2001: Electroactive Polymer Actuators and Devices, Yoseph Bar-Cohen Ed., Proceedings of SPIE, Mar. 5-8, 2001, vol. 4329, pp. 380-388. |
| Klaassen, B., “GMD-SNAKE: Robot snake with a flexible real-time control,” AiS—GMD-Snake, last updated Oct. 17, 2001, 3 pages, accessed Dec. 27, 2001; Internet: http://ais.gmd.de/BAR/snake.html. |
| Kornbluh, R. et al., “Application of dielectric elastomer EAP actuators,” Chapter 16 in Electroactive Polymer (EAP) Actuators as Artificial Muscles, Yoseph Bar-Cohen, Ed., SPIE Press, 2001, pp. 457-495. |
| Kubler, C. et al., “Endoscopic robots,”Proceedings of 3rd International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2000), Oct. 11-14, 2000, in Lecture Notes in Computer Science, Springer, vol. 1935, pp. 949-955. |
| Laptop Magazine, Science & Technology section, Oct. 2002, pp. 98, 100, and 102. |
| Lee, Thomas S. et al., “A highly redundant robot system for inspection,” Proceedings of Conference on Intelligent Robotics in Field, Factory, Service, and Space (CIRFFSS '94). Mar. 21-24, 1994. vol. 1, pp. 142-148. Houston, Texas. |
| Lightdale, C.J., “New developments in endoscopy,” American College of Gastroenterology 65th Annual Scientific Meeting, Day 1, Oct. 16, 2000, pp. 1-9. |
| Madden, J.D.W., Abstract of “Conducting polymer actuators,” Smart Structures and Materials 2001: Electroactive Polymer Actuators and Devices, Yoseph Bar-Cohen Ed., Proceedings of SPIE, Mar. 5-8, 2001, vol. 4329, 1 page. |
| Madden, J.D.W. et al., “Polypyrrole actuators: modeling and performance”, Smart Structures and Materials 2001: Electroactive Polymer Actuators and Devices, Yoseph Bar-Cohen Ed., Proceedings of SPIE, Mar. 5-8, 2001, vol. 4329, pp. 72-83. |
| Mazzoldi, A., “Smart Catheters,” Internet: http://www.piaggio.ccii.unipi.it/cathe.htm, printed Aug. 27, 2001, 2 pages. |
| McKernan, J.B. et al., “Laparoscopic general surgery,” Journal of the Medical Association of Georgia, Mar. 1990, vol. 79, Issue 3, pp. 157-159. |
| Nam, J.D., “Electroactive polymer (EAP) actuators and devices for micro-robot systems,” Nov. 28, 2000, 1 page. |
| Office Action dated Jul. 30, 2013 for Japanese Application No. 20110200974 filed Sep. 14, 2011. |
| PCT/US02/29472 International Search Report , dated Mar. 6, 2003, 3 pages. |
| PCT/US03/06078 International Search Report , dated Aug. 13, 2003, 1 page. |
| PCT/US03/13600 International Search Report, dated Dec. 12, 2003, 1 page. |
| PCT/US03/27042 International Search Report, dated Feb. 4, 2004, 2 pages. |
| PCT/US03/37778 International Search Report, dated Feb. 8, 2005, 1 page. |
| PCT/US2005/040893 International Search Report and Written Opinion of the International Searching Authority, dated Jun. 23, 2008, 5 pages. |
| Peirs, J. et al., “Miniature parallel manipulators for integration in a self-propelling endoscope,” IUAP P4/24 IMechS Workshop, Organized by UCL/PRM, Oct. 27, 1999, 2 pages. |
| Pelrine, R. et al., “Applications of dielectric elastomer actuators,” Smart Structures and Materials 2001: Electroactive Polymer Actuators and Devices, Yoseph Bar-Cohen Ed., Proceedings of SPIE, Mar. 5-8, 2001, vol. 4329, Issue 1, pp. 335-349. |
| Sansinena, J.M. et al., “Conductive polymers,” Chapter 7 of Electroactive Polymer (EAP) Actuators as Artificial Muscles, Bar-Cohen Ed., SPIE Press, 2001, pp. 193-221. |
| Slatkin, A.B. et al., “The development of a robotic endoscope,” Proceedings 1995 IEEE/RSJ International Conference on Intelligent Robots and Systems, Aug. 5-9, 1995, vol. 2, pp. 162-171, Pittsburgh, Pennsylvania. |
| Supplementary European Search Report for Application No. EP03790076, dated Dec. 28, 2007, 4 pages. |
| Supplementary European Search Report for Application No. EP04781605, dated Jul. 23, 2010, 3 pages. |
| Supplementary European Search Report for Application No. EP05712548, dated Jul. 6, 2012, 3 pages. |
| Supplementary European Search Report of EP Patent Application No. EP03728638, dated Oct. 27, 2005, 2 pages total. |
| U.S. Appl. No. 12/425,272 Office Action dated Mar. 11, 2011, 7 pages. |
| Vertut, Jean and Phillipe Coiffet, Robot Technology: Teleoperation and Robotics Evolution and Development, English translation, Prentice-Hall, Inc., Inglewood Cliffs, NJ, USA 1986, vol. 3A, 332 pages. |
| Zuccaro, G., “Procedural sedation in the GI suite,” A conference co-sponsored by the American Society of Anesthesiologists, 16th Annual Meeting 2001, May 3-6, 2001, pp. 162-171. |
| Japanese Notice of Reason's for Rejection for Patent Application No. JP2014-249104 dated Oct. 30, 2015. |
| Summons to Attend Oral Proceedings mailed Mar. 31, 2016 for European Application No. 05824444.3 filed Nov. 8, 2005, 5 pages. |
| Number | Date | Country | |
|---|---|---|---|
| 20150133858 A1 | May 2015 | US |
| Number | Date | Country | |
|---|---|---|---|
| 60194140 | Apr 2000 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 10988212 | Nov 2004 | US |
| Child | 14537127 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 10229577 | Aug 2002 | US |
| Child | 10988212 | US | |
| Parent | 09790204 | Feb 2001 | US |
| Child | 10229577 | US |
