CONSOLIDATED, MULTIINSTITUTIONAL PROPOSAL DISCOVERY

Information

  • Research Project
  • 2063057
  • ApplicationId
    2063057
  • Core Project Number
    U01AI025696
  • Full Project Number
    5U01AI025696-08
  • Serial Number
    25696
  • FOA Number
    RFA-AI-91-113
  • Sub Project Id
  • Project Start Date
    9/30/1987 - 37 years ago
  • Project End Date
    4/30/1996 - 28 years ago
  • Program Officer Name
  • Budget Start Date
    5/1/1994 - 30 years ago
  • Budget End Date
    4/30/1995 - 29 years ago
  • Fiscal Year
    1994
  • Support Year
    8
  • Suffix
  • Award Notice Date
    3/22/1994 - 30 years ago

CONSOLIDATED, MULTIINSTITUTIONAL PROPOSAL DISCOVERY

A multi-institutional group seeks to renew funding of a very successful ongoing collaboration that has already identified a clinical candidate for treating HIV-1 infection, i.e., U-87201E, a nonnucleoside inhibitor of the HIV-1 reverse transcriptase (RT). This proposal contains 4 projects that represent an integrated, rational plan to identify, evaluate, and optimize novel inhibitors of HIV replication. Four of the project at Upjohn Laboratories will principally seek to identify and optimize the antiviral and pharmaceutical properties of inhibitors of the essential ribonuclease H (RNase H) activity of the HIV RT. These projects will integrate with one another and use a "Structure- Driven Drug Design Paradigm" to develop lead inhibitors into drug candidates. Studies investigating RT subunit interaction as it relates to the control of reverse transcription will be performed. Work on new classes of RT inhibitors already identified in the Upjohn chemical inventory will be evaluated for novel mechanisms of inhibiting the HIV RT. Together these projects represent a group of research talents not attainable at any single institution. The experience of this group and their documented productivity in the AIDS research area, insure this program will continue to be successful.

IC Name
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
  • Activity
    U01
  • Administering IC
    AI
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    856
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    SRC
  • Study Section Name
  • Organization Name
    PHARMACIA AND UPJOHN, INC.
  • Organization Department
  • Organization DUNS
  • Organization City
    KALAMAZOO
  • Organization State
    MI
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    49001
  • Organization District
    UNITED STATES