Embodiments of the present disclosure generally relate to the field of plastic bottles and preforms. More specifically, embodiments of the disclosure relate to a tamper evidence container preform that includes a stepped interior surface and is configured for being blow-molded to form a container to store liquid contents.
Plastic containers have been used as a replacement for glass or metal containers in the packaging of beverages for several decades. The most common plastic used in making beverage containers today is polyethylene terephthalate (PET). Containers made of PET are transparent, thin walled, and have the ability to maintain their shape by withstanding the force exerted on the walls of the container by their contents. Advantages of PET containers include lighter weight and decreased breakage as compared to glass, and lower costs overall when taking both production and transportation into account. PET resins are also reasonably priced and easy to process. PET containers are generally made by a process that includes the blow-molding of plastic preforms which have been made by injection molding of the PET resin.
A PET container for storing liquid contents typically includes a base that extends up to a grip portion suitable for affixing a label, as well as providing a location for grasping the container. The grip portion generally transitions into a shoulder, which connects to a bell. The bell has a diameter that generally decreases as the bell extends upward from the shoulder to a neck and a finish portion. The finish portion is adapted to receive a closure, such as a bottle cap, to seal the contents within the interior of the plastic container.
In many instances, the closure includes a tamper evidence band that is disposed around the perimeter of the finish portion. The tamper evidence band generally remains positioned on the finish portion when an end-user loosens the closure to access the contents within the container. As such, the tamper evidence band and the finish portion cooperate to indicate to the end-user whether or not the closure has been previously loosened after being installed by the manufacturer.
Advantages of plastic containers include lighter weight and decreased breakage as compared to glass, and lower costs overall when taking both production and transportation into account. As such, there is a continuous interest in creating the lightest possible plastic container so as to maximize cost savings in both transportation and manufacturing by making and using containers that contain less plastic. Embodiments disclosed herein provide articles, including preforms and containers, that utilize less plastic in their construction while maintaining the ease of processing and excellent structural properties associated with current commercial designs.
The drawings refer to embodiments of the present disclosure in which:
While the present disclosure is subject to various modifications and alternative forms, specific embodiments thereof have been shown by way of example in the drawings and will herein be described in detail. The invention should be understood to not be limited to the particular forms disclosed, but on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the present disclosure.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present disclosure. It will be apparent, however, to one of ordinary skill in the art that the invention disclosed herein may be practiced without these specific details. In other instances, specific numeric references such as “first container,” may be made. However, the specific numeric reference should not be interpreted as a literal sequential order but rather interpreted that the “first container” is different than a “second container.” Thus, the specific details set forth are merely exemplary. The specific details may be varied from and still be contemplated to be within the spirit and scope of the present disclosure. The term “coupled” is defined as meaning connected either directly to the component or indirectly to the component through another component. Further, as used herein, the terms “about,” “approximately,” or “substantially” for any numerical values or ranges indicate a suitable dimensional tolerance that allows the part or collection of components to function for its intended purpose as described herein.
In general, there is a continuous interest in creating the lightest possible plastic container so as to maximize cost savings in both transportation and manufacturing, as well as reducing the amount of plastic waste in the environment, by making and using containers that contain less plastic. Embodiments disclosed herein provide a tamper evidence container preforms and containers that include stepped interior surfaces and utilize less plastic in their construction while maintaining an ease of processing and excellent structural properties associated with current commercial designs.
In the embodiment illustrated in
As shown in
With continuing reference to
The preform 160 includes a finish portion 164 and a body portion 168, formed monolithically (i.e., as a single, or unitary, structure). Advantageously, the monolithic arrangement of the preform 160, when blow-molded into a bottle, provides greater dimensional stability and improved physical properties in comparison to a preform constructed of separate neck and body portions that are bonded together.
The finish portion 164 begins at an opening 172 to an interior of the preform 160 and extends to and includes a tamper evidence ledge 176. The finish portion 164 is further characterized by the presence of one or more threads 180 configured to provide a means to fasten a cap, such as the closure 144 of
With continuing reference to
In some embodiments, a plurality of gaps (not shown) may be disposed in the threads 180 and positioned uniformly around the perimeter of the finish portion 164. Preferably, the gaps of adjacent threads 180 are vertically aligned so as to form channels extending longitudinally along the finish portion 164. The channels advantageously operate to relieve pressure within the container 100 when the closure 144 is loosened. As will be appreciated, the channels may provide a direct route for gases escaping the interior of the container 100, rather than the gases being forced to travel around the finish portion 164 between adjacent threads 180.
The body portion 168 includes a neck portion 192 that extends to a tapered portion 196 of the body portion 168. The tapered portion 196 comprises a smooth transition from a diameter of the neck portion 192 to a relatively smaller diameter of a cylindrical portion 200 of the preform 160. The cylindrical portion 200 is a generally elongate member that culminates in an end cap 204. In some embodiments the body portion 168 may be generally cylindrical, and the end cap 204 may be conical or frustoconical and may also be hemispherical, and the very terminus of the end cap 204 may be flattened or rounded.
In some embodiments, a wall thickness of the cylindrical portion 200 may be substantially uniform throughout the cylindrical portion 200 and the end cap 204. A wall thickness of the tapered portion 196, however, generally decreases from the wall thickness of the cylindrical portion 200 to a relatively thinner wall thickness of the neck portion 192. As will be appreciated, the wall thickness of the cylindrical portion 200 is relatively greater than the wall thickness of the neck portion 192 so as to provide a wall thickness at the desired dimensions of a finished product after the preform 160 is blow-molded into the shape and size of a bottle. As such, the wall thickness throughout most of the body portion 168 will depend upon the overall size of the preform 160 and the wall thickness and overall size of the resulting container.
As will be appreciated, the sealing surface 212 must comprise a sufficiently smooth surface capable of cooperating with the plug seal to retain contents under pressure, such as carbonated contents, within the container 100. To this end, it is contemplated that the sealing surface 212 may be highly polished so as to be substantially free of surface defects and thus conditioned to form a tight seal with the plug seal of the closure 144. Preferably, the sealing surface 212 is to be polished to a degree of smoothness that is commonly associated with a mirror finish. As such, it is contemplated that the sealing surface 212 comprises a mirror polished region along the interior of the finish portion 164. Further, in some embodiments, the bevel 208 may also be conditioned to comprise a mirror polished region at the beginning of the opening 172. Any of various techniques may be used to mirror polish either or both of the sealing surface 212 and the bevel 208, without limitation.
As shown in
It is contemplated that the transition surface 216 is to be capable of cooperating with the plug seal of the closure 144 to form a tight seal between the closure 144 and the container 100. In some embodiments, the concave portion 224 may be configured to forcibly receive an end of the plug seal so as to form a tight seal therebetween. Further, in some embodiments, the convex portion 228 may be configured to forcibly receive the end of the plug seal. As such, the transition surface 216 may include a smooth surface that is polished similarly to the sealing surface 212. It is envisioned that the transition surface 216 may be mirror polished, as described hereinabove with respect to the sealing surface 212.
Moreover, in some embodiments, the plug seal of the closure 144 may be configured to extend into the opening 172 such that the plug seal cooperates with the handling surface 220 to seal the container 100. In such embodiments, the plug seal may include a sidewall shape that mates with the concave and convex portions 224, 228. As will be appreciated, therefore, the handling surface 220 may be mirror polished similarly to the sealing surface 212 and the transition surface 216. It is contemplated that mirror polished surface may be achieved by way of any of various suitable polishing techniques, such as mechanical machining and buffing, chemical treatments, plasma treatments, and the like, without limitation.
In some embodiments, such as the illustrated embodiment of
In some embodiments, the secondary transition surface 244 may be configured to cooperate with the plug seal of the closure 144 to form a tight seal between the closure 144 and the container 100 suitable for storing pressurized contents, such as carbonated beverages, within the container 100. As such, the concave portion 252 may be configured to tightly receive an end of the plug seal to form a tight seal therebetween. In some embodiments, the convex portion 256 may be configured to forcibly receive and compress the end of the plug seal. To this end, the secondary transition surface 244 may include a smooth surface that is polished similarly to the sealing surface 212. It is envisioned that the secondary transition surface 244 may be mirror polished, as described hereinabove with respect to the sealing surface 212.
In some embodiments, the plug seal of the closure 144 may be configured to extend into the opening 172 such that the plug seal extends beyond the secondary transition surface 244 and thus cooperates with the portion of the interior surface 248 near the convex portion 256. In some embodiments, the interior surface 248 may have a diameter that tightly compresses the end of the plug seal to seal the pressurized contents within the container 100. It is contemplated that, in some embodiments, the plug seal may include a sidewall profile that mates with the concave and convex portions 252, 256. As such, the interior surface 248 preferably is mirror polished similarly to the mirror polish of the sealing surface 212. As disclosed hereinabove, the mirror polished surface may be achieved by way of any of various suitable polishing techniques, such as mechanical machining and buffing, chemical treatments, plasma treatments, and the like, without limitation.
In the embodiment illustrated in
In some embodiments, the stepped interior may be configured to compressibly receive a plug seal of the closure 144 that comprises graduated seals configured to tightly engage with the graduated narrowing of the opening 172. For example, the stepped interior can include one or more sealing surfaces that are each configured to tightly engage with one of the graduated seals of the plug seal to contribute to forming a tight seal between the closure 144 and the container 100. As will be appreciated, therefore, the graduated seals of the plug seal generally include diameters that are suitable for engaging with the graduated narrowing of the opening 172 so as to seal pressurized contents, such as carbonated beverages, within the container 100. It is contemplated that the one or more sealing surfaces comprise mirror-polished surfaces that are joined together by transition surfaces. Further, the transition surfaces 216, 244 are contemplated to comprise mirror-polished surfaces that cooperate with the one or more seals of the plug seal so as to contribute to forming the tight seal between the closure 144 and the container 100. It is contemplated that such a seal may also be formed by configuring an interference fit between the plug seal and the finish portion 164 such that the interference accommodates a range of environments in which the seal must perform. Those environments can include a range of internal pressures, a range of temperatures that can impact either or both pressure and dimensions of the closure 144 and container 100, or a range of tolerances arising due to injection molding and assembling the closure 144 and container 100.
In the exemplary embodiment shown in
Turning again to
The flat lower portion 236 may be configured to retain the tamper evidence band 148 positioned below the tamper evidence ledge 176 during loosening of the closure 144. For example, when the closure 144 is initially installed onto the container 100 by a manufacturer, the tamper evidence band 148 easily passes over the tamper evidence ledge 176 due to the rounded upper portion 232. When an end-user later loosens the closure 144, the flat lower portion 236 retains the tamper evidence band 148 below the tamper evidence ledge 176, causing the tamper evidence band 148 to break loose from the closure 144. Thus, the flat lower portion 236 of the tamper evidence ledge 176 and the tamper evidence band 148 of the closure 144 cooperate to indicate to the end-user that the closure 144 has not been previously loosened after being installed by the manufacturer. It should be understood, however, that the tamper evidence ledge 176 is not limited to being coupled with tamper evidence bands, as described above, but rather the tamper evidence ledge 176 may be configured to operate with any of various devices for indicating whether or not the container has been previously opened. For example, it is contemplated that including a flat upper portion, as mentioned above, facilitates incorporating a tamper evidence band that remains coupled with the tamper evidence ledge 176, thereby preventing the tamper evidence band from falling down the neck portion 192 onto the top of the bell 128 of the container 100.
Disposed between the tamper evidence ledge 176 and the threads 180 is a handling valley 240 that extends circumferentially around the finish portion 164. The handling valley 240 comprises a portion of the finish portion 164 that has a wall thickness and a diameter that are substantially similar to the wall thickness and diameter of the neck portion 192, below the tamper evidence ledge 176. As such, the handling valley 240 and the neck portion 192 advantageously enable gripping fingers to engage with and support the container 100 when conveying the container 100 along a manufacturing assembly line. For example, a first pair of gripping fingers can extend into the handling valley 240 to support the container 100 at a first station of a manufacturing line. Then, upon being conveyed to a second station, a second pair of gripping fingers can extend around the neck portion 192, below the tamper evidence ledge 176, while the first pair of gripping fingers are removed from the handling valley 240. Similarly, upon arriving at a third station, a third pair of gripping fingers can engage with the handling valley 240 while the second pair of gripping fingers are removed from the neck portion 192. Thus, the container 100 can be transported along the manufacturing line by alternatingly engaging gripping fingers with the handling valley 240 and the neck portion 192. As will be appreciated, the flat lower portion 236 comprises a surface area that is substantial enough for air-conveying the container 100 along the manufacturing line, although many modern manufacturing lines no longer require surfaces for air-conveyance.
As will be appreciated, the handling valley 240 provides a separation between the tamper evidence ledge 176 and the threads 180 suitable for receiving the pair of gripping fingers, as described above. In general, the separation must be large enough to allow the gripping fingers to easily pass between the tamper evidence ledge 176 and the threads 180. As such, any of various separations, greater than the width of the gripping fingers, may be disposed between the tamper evidence ledge 176 and the threads 180, without limitation and without deviating beyond the scope of the present disclosure.
Once the preform 160 has been blow-molded to form the container 100 and then the container 100 has been filled with liquid contents, the closure 144 is installed onto the finish portion 164, by way of suitable equipment, to seal the contents in the interior of the container 100. In general, the threads 180 disposed around the finish portion 164 are engaged with similar threads comprising the closure 144 and then the closure 144 is rotated in a clockwise direction to advance the closure 144 toward the tamper evidence ledge 176. The closure 144 preferably is tightened until the tamper evidence band 148 is pushed over the tamper evidence ledge 176 and a plug seal comprising the closure 144 extends into the opening 172 of the finish portion 164, thereby sealing the liquid contents within the container 100.
In an assembly-line environment, a multiplicity of containers 100 are filled with liquid contents and sealed by closures 144 as the containers 100 are conveyed along the assembly-line. Each closure 144 must be optimally threaded and tightened onto the finish portion 164 of the container 100. If the closure 144 is under-tightened, the container 100 may be left unsealed and the liquid contents may leak out of the container 100. Alternatively, if the closure 144 is over-tightened, the closure 144 and the finish portion 164 may be damaged, again allowing the liquid contents to leak out of the containers 100. Moreover, if the threads of the closure 144 are improperly engaged with the threads 180, cross-threading and/or damaging of the threads 180 and the threads of the closure 144 may result, leading again to unsealed containers that may leak. In general, closures 144 must be optimally threaded and tightened onto finish portions 164 of the containers 100 by way of suitable installation equipment.
The embodiment of the preform 160 illustrated in
While the invention has been described in terms of particular variations and illustrative figures, those of ordinary skill in the art will recognize that the invention is not limited to the variations or figures described. In addition, where methods and steps described above indicate certain events occurring in certain order, those of ordinary skill in the art will recognize that the ordering of certain steps may be modified and that such modifications are in accordance with the variations of the invention. Additionally, certain of the steps may be performed concurrently in a parallel process when possible, as well as performed sequentially as described above. To the extent there are variations of the invention, which are within the spirit of the disclosure or equivalent to the inventions found in the claims, it is the intent that this patent will cover those variations as well. Therefore, the present disclosure is to be understood as not limited by the specific embodiments described herein, but only by scope of the appended claims.
This continuation-in-part application claims the benefit of and priority to U.S. patent application Ser. No. 16/525,890; filed on Jul. 30, 2019 and U.S. Provisional Application, entitled “Container Preform With Threaded Tamper Evidence Finish,” filed Jul. 30, 2018 and having application Ser. No. 62/712,115, the entirety of said application being incorporated herein by reference.
Number | Name | Date | Kind |
---|---|---|---|
2947432 | Marcel | Aug 1960 | A |
3029963 | Heinz | Apr 1962 | A |
3032809 | Willard | May 1962 | A |
3303249 | Strauss | Feb 1967 | A |
3335889 | Brumme | Aug 1967 | A |
3438578 | Peterson et al. | Apr 1969 | A |
3769394 | Latrielle | Oct 1973 | A |
3773205 | Keller et al. | Nov 1973 | A |
3809365 | Loffler | May 1974 | A |
3850328 | Guala | Nov 1974 | A |
3850329 | Robinson | Nov 1974 | A |
3901403 | Menke | Aug 1975 | A |
D252530 | Budish | Jul 1979 | S |
4197955 | Luenser | Apr 1980 | A |
4316551 | Belokin, Jr. | Feb 1982 | A |
4374878 | Jakobsen et al. | Feb 1983 | A |
4436212 | Alejandro Llera | Mar 1984 | A |
4579241 | Hayes | Apr 1986 | A |
4674643 | Wilde et al. | Jun 1987 | A |
D294462 | Ota et al. | Mar 1988 | S |
4744478 | Hahn | May 1988 | A |
4744479 | Schottli | May 1988 | A |
4744480 | Luch et al. | May 1988 | A |
4756439 | Perock | Jul 1988 | A |
4818575 | Hirata et al. | Apr 1989 | A |
4847129 | Collette et al. | Jul 1989 | A |
4850850 | Takakusaki et al. | Jul 1989 | A |
4863046 | Collette et al. | Sep 1989 | A |
4895265 | Luch et al. | Jan 1990 | A |
4907709 | Abe et al. | Mar 1990 | A |
4927680 | Collette et al. | May 1990 | A |
4948001 | Magly | Aug 1990 | A |
5011648 | Garver et al. | Mar 1991 | A |
D315869 | Collette | Apr 1991 | S |
5009324 | Ochs | Apr 1991 | A |
D321830 | York et al. | Nov 1991 | S |
5067622 | Garver et al. | Nov 1991 | A |
5092475 | Krishnakumar et al. | Mar 1992 | A |
5097974 | Rozenberg | Mar 1992 | A |
5103991 | Collins | Apr 1992 | A |
5133468 | Brunson et al. | Jul 1992 | A |
5137163 | Moore | Aug 1992 | A |
5178289 | Krishnakumar et al. | Jan 1993 | A |
5199588 | Hayashi | Apr 1993 | A |
5213225 | King et al. | May 1993 | A |
5248050 | Janousch et al. | Sep 1993 | A |
5255889 | Collette et al. | Oct 1993 | A |
5279433 | Krishnakumar et al. | Jan 1994 | A |
5281387 | Collette et al. | Jan 1994 | A |
D345693 | Edstrom | Apr 1994 | S |
5303833 | Hayashi et al. | Apr 1994 | A |
5303834 | Krishnakumar et al. | Apr 1994 | A |
5314084 | Flota et al. | May 1994 | A |
5337909 | Vailliencourt | Aug 1994 | A |
5340302 | Ingram | Aug 1994 | A |
5341946 | Vailliencourt et al. | Aug 1994 | A |
D352238 | Vailliencourt et al. | Nov 1994 | S |
D352245 | Krishnakumar et al. | Nov 1994 | S |
5360126 | Snyder et al. | Nov 1994 | A |
5366774 | Pinto et al. | Nov 1994 | A |
5381910 | Sugiura et al. | Jan 1995 | A |
5407086 | Ota et al. | Apr 1995 | A |
D358766 | Vailliencourt et al. | May 1995 | S |
5411699 | Collette et al. | May 1995 | A |
D364565 | Vailliencourt et al. | Nov 1995 | S |
D366416 | Semerskv | Jan 1996 | S |
D366417 | Semerskv | Jan 1996 | S |
5487481 | Sander et al. | Jan 1996 | A |
5494174 | Rohr et al. | Feb 1996 | A |
5509552 | Eguchi et al. | Apr 1996 | A |
5511677 | Oder | Apr 1996 | A |
5498152 | Uterlander et al. | May 1996 | A |
5632397 | Fandeux et al. | May 1997 | A |
5645183 | Slat et al. | Jul 1997 | A |
5669520 | Simpson | Sep 1997 | A |
5704503 | Krishnakumar et al. | Jan 1998 | A |
D391168 | Qqq | Feb 1998 | S |
D393802 | Collette et al. | Apr 1998 | S |
5740932 | Bettegazzore | Apr 1998 | A |
5743419 | King | Apr 1998 | A |
5749201 | Cochrane | May 1998 | A |
5756172 | Semersky | May 1998 | A |
5762221 | Tobias et al. | Jun 1998 | A |
5792491 | Chaure | Aug 1998 | A |
D397614 | Krishnakumar et al. | Sep 1998 | S |
5804016 | Schmidt | Sep 1998 | A |
D402895 | Takahashi et al. | Dec 1998 | S |
5850681 | La Barre | Dec 1998 | A |
D404308 | Takahashi et al. | Jan 1999 | S |
5888598 | Brewster | Mar 1999 | A |
D407649 | McCallister et al. | Apr 1999 | S |
D407650 | Takahashi et al. | Apr 1999 | S |
D411453 | Piccioli et al. | Jun 1999 | S |
5908128 | Krishnakumar et al. | Jun 1999 | A |
5915579 | Przytulla et al. | Jun 1999 | A |
D413519 | Eberle et al. | Sep 1999 | S |
5971184 | Krishnakumar et al. | Oct 1999 | A |
5988417 | Chena et al. | Nov 1999 | A |
6016932 | Gaydosh et al. | Jan 2000 | A |
D419882 | Bretz et al. | Feb 2000 | S |
D420592 | Bretz et al. | Feb 2000 | S |
6036037 | Scheffer et al. | Mar 2000 | A |
D423365 | Eberle et al. | Apr 2000 | S |
6044996 | Carew et al. | Apr 2000 | A |
6044997 | Oaa | Apr 2000 | A |
6062409 | Eberle | May 2000 | A |
D426460 | Krishnakumar et al. | Jun 2000 | S |
D427905 | Eberle | Jul 2000 | S |
6092688 | Eberle et al. | Jul 2000 | A |
D429647 | Warner et al. | Aug 2000 | S |
D430493 | Weick | Sep 2000 | S |
6112925 | Nahill et al. | Sep 2000 | A |
D434330 | Rowe et al. | Nov 2000 | S |
D440157 | Lichtman et al. | Apr 2001 | S |
D440158 | Bretz et al. | Apr 2001 | S |
D440877 | Lichtman et al. | Apr 2001 | S |
D441294 | Lichtman et al. | May 2001 | S |
6230912 | Rashid | May 2001 | B1 |
6248413 | Barel et al. | Jun 2001 | B1 |
D445033 | Bretz et al. | Jul 2001 | S |
6257433 | Ogg et al. | Jul 2001 | B1 |
6260723 | Bergholtz | Jul 2001 | B1 |
D446126 | Bretz et al. | Aug 2001 | S |
D447411 | Lichtman et al. | Sep 2001 | S |
6296131 | Rashid | Oct 2001 | B2 |
6347717 | Eberle | Feb 2002 | B1 |
D454500 | Bretz et al. | Mar 2002 | S |
6382444 | Nyman | May 2002 | B1 |
D465158 | Peek et al. | Nov 2002 | S |
D466021 | Thierjung et al. | Nov 2002 | S |
D466819 | Darr et al. | Dec 2002 | S |
6494333 | Sasaki et al. | Dec 2002 | B2 |
D469358 | Bryant et al. | Jan 2003 | S |
D469359 | Bryant et al. | Jan 2003 | S |
D469695 | Bryant et al. | Feb 2003 | S |
D469696 | Bryant et al. | Feb 2003 | S |
D470773 | Darr et al. | Feb 2003 | S |
6523710 | Hidding et al. | Feb 2003 | B1 |
D472470 | Bretz et al. | Apr 2003 | S |
6554146 | DeGroff et al. | Apr 2003 | B1 |
D476236 | Ungrady et al. | Jun 2003 | S |
6585125 | Peek | Jul 2003 | B1 |
D479690 | DeGroff | Sep 2003 | S |
6616001 | Saito et al. | Sep 2003 | B2 |
D480957 | Mooney et al. | Oct 2003 | S |
D485765 | ThieriunQ et al. | Jan 2004 | S |
6722514 | Renz | Apr 2004 | B2 |
6739467 | Saito et al. | May 2004 | B2 |
D494475 | ThieriunQ et al. | Aug 2004 | S |
D497551 | Gamel et al. | Oct 2004 | S |
6830158 | Yourist | Dec 2004 | B2 |
6841262 | Beck et al. | Jan 2005 | B1 |
D502108 | Gamel et al. | Feb 2005 | S |
D503625 | Nelson et al. | Apr 2005 | S |
D503885 | Bretz et al. | Apr 2005 | S |
D504063 | Bretz et al. | Apr 2005 | S |
D506675 | Bretz et al. | Jun 2005 | S |
D506676 | Bretz et al. | Jun 2005 | S |
D506677 | Bretz et al. | Jun 2005 | S |
D507491 | Bretz et al. | Jul 2005 | S |
D507609 | Bretz et al. | Jul 2005 | S |
D507749 | Bretz et al. | Jul 2005 | S |
D508857 | Bretz et al. | Aug 2005 | S |
6932230 | Pedmo et al. | Aug 2005 | B2 |
6938787 | Shinozaki | Sep 2005 | B2 |
D510526 | Bretz et al. | Oct 2005 | S |
7025219 | Heisner et al. | Apr 2006 | B2 |
7032770 | Finlav et al. | Apr 2006 | B2 |
D525530 | Livingston et al. | Jul 2006 | S |
D527643 | Gottlieb | Sep 2006 | S |
7172087 | Axe et al. | Feb 2007 | B1 |
D538660 | Gatewood | Mar 2007 | S |
7198164 | Yourist et al. | Apr 2007 | B2 |
D548106 | Martinez et al. | Aug 2007 | S |
7258244 | Unqradv | Aug 2007 | B2 |
D551081 | Ohara et al. | Sep 2007 | S |
7267242 | Tanaka et al. | Sep 2007 | B2 |
D555499 | Ross | Nov 2007 | S |
7334695 | Bvsick et al. | Feb 2008 | B2 |
7334696 | Tanaka et al. | Feb 2008 | B2 |
7347339 | Banqi et al. | Mar 2008 | B2 |
7364046 | Joshi et al. | Apr 2008 | B2 |
7416089 | Kraft et al. | Aug 2008 | B2 |
7416090 | Mooney et al. | Aug 2008 | B2 |
D579339 | Shmagin | Oct 2008 | S |
7451886 | Lisch et al. | Nov 2008 | B2 |
D584627 | Leooitevin | Jan 2009 | S |
7510094 | Willis et al. | Mar 2009 | B1 |
D598779 | Leooitevin | Aug 2009 | S |
7637384 | Price et al. | Dec 2009 | B2 |
D610015 | Yourist et al. | Feb 2010 | S |
7694842 | Melrose | Apr 2010 | B2 |
7699183 | Matsuoka et al. | Apr 2010 | B2 |
7748551 | Gatewood et al. | Jul 2010 | B2 |
7748552 | Livingston et al. | Jul 2010 | B2 |
7757874 | Ross | Jul 2010 | B2 |
D621271 | Soni | Aug 2010 | S |
7780025 | Simpson, Jr. et al. | Aug 2010 | B2 |
D623529 | Yourist et al. | Sep 2010 | S |
D624427 | Yourist et al. | Sep 2010 | S |
7798349 | Maczek et al. | Sep 2010 | B2 |
7819264 | Brozell et al. | Oct 2010 | B2 |
D630515 | Bretz et al. | Jan 2011 | S |
7861876 | Stowitts | Jan 2011 | B2 |
7927678 | Mitadera et al. | Apr 2011 | B2 |
7980404 | Trude et al. | Jul 2011 | B2 |
8020717 | Patel | Sep 2011 | B2 |
8047388 | Kelley et al. | Nov 2011 | B2 |
8091720 | Colloud | Jan 2012 | B2 |
8141793 | Wallis et al. | Mar 2012 | B2 |
8268216 | Meador | Sep 2012 | B2 |
8308002 | Penny | Nov 2012 | B2 |
8308007 | Mast et al. | Nov 2012 | B2 |
8328033 | Mast | Dec 2012 | B2 |
8381496 | Trude et al. | Feb 2013 | B2 |
8528759 | Pucci | Sep 2013 | B2 |
8663761 | Kwirandt et al. | Mar 2014 | B2 |
8728601 | Hutts et al. | May 2014 | B2 |
8794461 | Major | Aug 2014 | B2 |
8815356 | Huettner | Aug 2014 | B2 |
8827688 | Maki et al. | Sep 2014 | B2 |
9033168 | Darr | May 2015 | B2 |
9221596 | Patel et al. | Dec 2015 | B2 |
9233771 | Siegl | Jan 2016 | B2 |
9815604 | Ekkert | Nov 2017 | B2 |
9994350 | Labadie et al. | Jun 2018 | B2 |
10118724 | Hanan | Nov 2018 | B2 |
10329043 | Hanan | Jun 2019 | B2 |
10377534 | Hanan | Aug 2019 | B2 |
10647465 | Hanan | May 2020 | B2 |
10829260 | Hanan | Nov 2020 | B2 |
10919671 | Hanan | Feb 2021 | B2 |
10987851 | Hanan | Apr 2021 | B2 |
20010000602 | Luch | May 2001 | A1 |
20010030166 | Ozawa et al. | Oct 2001 | A1 |
20020030031 | Druitt et al. | Mar 2002 | A1 |
20020090473 | Lee et al. | Jul 2002 | A1 |
20020134747 | Babcock et al. | Sep 2002 | A1 |
20030077349 | Derouault et al. | Apr 2003 | A1 |
20030127418 | Schweigert et al. | Jul 2003 | A1 |
20040000533 | Kamineni et al. | Jan 2004 | A1 |
20040121038 | Seki et al. | Jun 2004 | A1 |
20050048235 | Dygert | Mar 2005 | A1 |
20050067365 | Hanafusa et al. | Mar 2005 | A1 |
20050175731 | Chiang | Aug 2005 | A1 |
20050279728 | Finlay et al. | Dec 2005 | A1 |
20060021959 | Falzoni | Feb 2006 | A1 |
20060065992 | Hutchinson et al. | Mar 2006 | A1 |
20060070977 | Howell et al. | Apr 2006 | A1 |
20060113274 | Keller et al. | Jun 2006 | A1 |
20060131257 | Gatewood et al. | Jun 2006 | A1 |
20060157439 | Howell | Jul 2006 | A1 |
20060169666 | Nyman et al. | Aug 2006 | A1 |
20070023299 | Clarkson | Feb 2007 | A1 |
20070131644 | Melrose | Jun 2007 | A1 |
20070210026 | Darr et al. | Sep 2007 | A1 |
20080050546 | Kitano | Feb 2008 | A1 |
20080053949 | Farrar et al. | Mar 2008 | A1 |
20080073382 | Higgins | Mar 2008 | A1 |
20080087628 | Bangi et al. | Apr 2008 | A1 |
20080116162 | Penny | May 2008 | A1 |
20080197102 | Farrar et al. | Aug 2008 | A1 |
20080257855 | Patel | Oct 2008 | A1 |
20090020497 | Tanaka et al. | Jan 2009 | A1 |
20090065468 | Hata et al. | Mar 2009 | A1 |
20090084751 | Pucci | Apr 2009 | A1 |
20090184127 | Mooney | Jul 2009 | A1 |
20090188888 | Penny | Jul 2009 | A1 |
20090261058 | Pritchett, Jr. | Oct 2009 | A1 |
20090261059 | Pritchett, Jr. | Oct 2009 | A1 |
20090266785 | Sieal | Oct 2009 | A1 |
20090283495 | Lane et al. | Nov 2009 | A1 |
20090321383 | Lane | Dec 2009 | A1 |
20100023378 | Ratnam | Jan 2010 | A1 |
20100028577 | Siegl | Feb 2010 | A1 |
20100089865 | Oauchi et al. | Apr 2010 | A1 |
20100151073 | Daniel | Jun 2010 | A1 |
20100163513 | Pedmo | Jul 2010 | A1 |
20100176081 | Kamineni et al. | Jul 2010 | A1 |
20100206837 | Deemer et al. | Aug 2010 | A1 |
20100206838 | Mast et al. | Aug 2010 | A1 |
20100206839 | Tanaka et al. | Aug 2010 | A1 |
20100206892 | Mast | Aug 2010 | A1 |
20100213204 | Melrose | Aug 2010 | A1 |
20100270259 | Russell et al. | Oct 2010 | A1 |
20100286837 | Jiao et al. | Nov 2010 | A1 |
20100304168 | Dambach | Dec 2010 | A1 |
20100304169 | Dambach | Dec 2010 | A1 |
20100314348 | Zoppas et al. | Dec 2010 | A1 |
20100320218 | Tanaka | Dec 2010 | A1 |
20110017700 | Patcheak et al. | Jan 2011 | A1 |
20110073559 | Schlies et al. | Mar 2011 | A1 |
20110115135 | Siegl | May 2011 | A1 |
20110278313 | Labadie et al. | Nov 2011 | A1 |
20120031870 | Porter et al. | Feb 2012 | A1 |
20120091091 | Steinberger | Apr 2012 | A1 |
20120091134 | Sadiq et al. | Apr 2012 | A1 |
20120027966 | Siegl | Sep 2012 | A1 |
20120248003 | Hunter et al. | Oct 2012 | A1 |
20120263902 | Hanan | Oct 2012 | A1 |
20120305516 | Kuzma et al. | Dec 2012 | A1 |
20130113143 | Favre et al. | May 2013 | A1 |
20140076838 | Siegi | Mar 2014 | A1 |
20140190927 | Lane | Jul 2014 | A1 |
20140314984 | Lehner et al. | Oct 2014 | A1 |
20140346135 | Melrose | Nov 2014 | A1 |
20150144587 | Hanan | May 2015 | A1 |
20150190975 | Yokobayashi et al. | Jul 2015 | A1 |
20150375887 | Van Dijck et al. | Dec 2015 | A1 |
20160137331 | Hanan | May 2016 | A1 |
20160176566 | Hanan | Jun 2016 | A1 |
20160193750 | Gaiotti et al. | Jul 2016 | A1 |
20170217646 | Niagara | Aug 2017 | A1 |
20180043603 | Smith et al. | Feb 2018 | A1 |
20180044072 | Asakawa et al. | Feb 2018 | A1 |
20180133948 | Suyama et al. | May 2018 | A1 |
20180229881 | Jarman et al. | Aug 2018 | A1 |
20180297752 | Mai | Oct 2018 | A1 |
20180327131 | Hanan | Nov 2018 | A1 |
20190367203 | Okuyama et al. | Dec 2019 | A1 |
20190375556 | Hanan | Dec 2019 | A1 |
20200031530 | Hanan | Jan 2020 | A1 |
20200031531 | Hanan | Jan 2020 | A1 |
20200071035 | Hanan | Mar 2020 | A1 |
20200095007 | Jarman et al. | Mar 2020 | A1 |
20200198855 | Sterling et al. | Jun 2020 | A1 |
20200269484 | Hanan | Aug 2020 | A1 |
20200298461 | Hanan et al. | Sep 2020 | A1 |
20200298462 | Hanan | Sep 2020 | A1 |
20210039823 | Hanan | Feb 2021 | A1 |
20210039824 | Hanan | Feb 2021 | A1 |
20210101707 | Hanan | Apr 2021 | A1 |
Number | Date | Country |
---|---|---|
101234688 | Aug 2008 | CN |
102012001229 | Jul 2013 | DE |
0199576 | Oct 1986 | EP |
2687450 | Jan 2014 | EP |
2846946 | Mar 2005 | FR |
2899204 | Jun 2008 | FR |
S5486560 | Jul 1979 | JP |
H072263 | Jan 1995 | JP |
H07149357 | Jun 1995 | JP |
H07164436 | Jun 1995 | JP |
H0848321 | Feb 1996 | JP |
H09240647 | Sep 1997 | JP |
H1029614 | Feb 1998 | JP |
2004090425 | Mar 2004 | JP |
2006232392 | Sep 2006 | JP |
2008189721 | Aug 2008 | JP |
2009045877 | Mar 2009 | JP |
2010285162 | Feb 2010 | JP |
2015182789 | Oct 2015 | JP |
WO2004080828 | Sep 2004 | WO |
2005073096 | Nov 2005 | WO |
WO2006005413 | Jan 2006 | WO |
WO2006027092 | Mar 2006 | WO |
WO2007033722 | Mar 2007 | WO |
WO2007124894 | Nov 2007 | WO |
WO2009122144 | Oct 2009 | WO |
WO2010113079 | Oct 2010 | WO |
2011079917 | Jul 2011 | WO |
WO2011160748 | Dec 2011 | WO |
WO2012095285 | Jul 2012 | WO |
WO2012156048 | Nov 2012 | WO |
WO2015032897 | Mar 2015 | WO |
WO2015189436 | Dec 2015 | WO |
2016103563 | Jun 2016 | WO |
WO2017035267 | Mar 2017 | WO |
WO2017136584 | Aug 2017 | WO |
WO2017183952 | Oct 2017 | WO |
Entry |
---|
An-Sofie Schoonjans et al, “Cardiovascular safety of low-dose fenfluramine in Dravet syndrome: a review of its benefit-risk profile in a new patient population”, Current Medical Research and Opinion, vol. 33, No. 10, Jul. 31, 2017, pp. 1773-1781. |
An-Sofie Schoonjans, “Low-dose fenfluramine in the treatment of neurologic disorders: experience in Dravet syndrome”, Jan. 1, 2015 pp. 328-338. |
Jake Remaly, “Fenfluramine Reduces Convulsive Seizure Frequency in Dravet Syndrome | Epilepsy Resource Center”, Jan. 1, 2018 https://www.mdedge.com/neurology/epilepsyresourcecenter/article/153865/epilepsy-seizures/fenfluramine-reduces. |
Brenot et al., “Primary pulmonary hypertension and fenfluramine use.”, HEART, vol. 70, No. 6, Dec. 1, 1993 (Dec. 1, 1993), p. 537-541. |
International Search Report with Written Opinion for related Application No. PCT/US2019/044203 dated Oct. 24, 2019 (6 Pages). |
International Search Report with Written Opinion for related Application No. PCT/US2021/035483 dated Sep. 1, 2021 (19 Pages). |
European Patent Office Extended Search Report for Related Application No. 20763607.7 dated Oct. 5, 2022 (5 pages). |
European Patent Office Extended Search Report for Related Application No. 20774670.2 dated Oct. 21, 2022 (11 pages). |
Number | Date | Country | |
---|---|---|---|
20210031962 A1 | Feb 2021 | US | |
20220185528 A9 | Jun 2022 | US |
Number | Date | Country | |
---|---|---|---|
62712115 | Jul 2018 | US |
Number | Date | Country | |
---|---|---|---|
Parent | 16525890 | Jul 2019 | US |
Child | 16894726 | US |