Claims
- 1. A continuous method for producing separate tablets of an extrudable pharmaceutical mixture which comprises:
- mixing a pharmaceutically active compound and an N-vinylpyrrolid-2-one (NVP) polymer containing 30 to 100% by weight NVP in an extruder to form a melt, said polymer having a K value of from 10 to 100, said mixture having a glass transition point of less than 180.degree. C.;
- extruding the melt and pressing the still deformable extrudate between the surfaces of two rollers driven in opposite directions, the surfaces of said rollers having opposed depressions, whereby, separate tablets having the shape of the opposed depressions are formed.
- 2. The method of claim 1, wherein an active compound-containing melt of an N-vinylpyrrolid-2-one (NVP) polymer is extruded and pressed, the NVP polymer being prepared either in an organic solvent or using an organic peroxide in water.
- 3. The method of claim 1, wherein the K value of the polymer is from 12 to 35 and the mixture has a softening or melting point of from 60.degree. to 130.degree. C. and a glass transition point of less then 130.degree. C.
Priority Claims (1)
Number |
Date |
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Kind |
3612211 |
Apr 1986 |
DEX |
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Parent Case Info
This application is a continuation application Ser. No. 034,939 filed Apr. 6, 1987, now abandoned, which is a continuation-in-part of application Ser. No. 923,870, filed Oct. 28, 1986, now abandoned.
US Referenced Citations (18)
Foreign Referenced Citations (2)
Number |
Date |
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1766546 |
Sep 1971 |
DEX |
537444 |
May 1922 |
FRX |
Continuations (1)
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Number |
Date |
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Parent |
34939 |
Apr 1987 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
923870 |
Oct 1986 |
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