Claims
- 1. A composition for the controlled release of interferon from a polymeric matrix, comprising:a) a biocompatible polymer; and b) particles of metal cation-complexed interferon, with a metal cation-to-interferon molar ratio between about 1:1 and 10:1, wherein said particles are dispersed within the biocompatible polymer.
- 2. The controlled release composition of claim 1 wherein the metal cation-to-interferon molar ration is about 2:1.
- 3. The controlled release composition of claim 1 wherein the metal cation of said metal cation-complexed interferon contains at least one type of biocompatible multivalent cation, wherein said cation is not significantly oxidizing to interferon.
- 4. The controlled release composition of claim 3 wherein said multivalent cation is selected from the group consisting of Zn+2, Ca+2, Cu+2, Mg+2 and combinations thereof.
- 5. The controlled release composition of claim 1 wherein the interferon is interferon-α.
- 6. The controlled release composition of claim 1 wherein the biocompatible polymer is biodegradable.
- 7. A controlled release composition of claim 6 wherein the biodegradable polymer is selected from the group consisting of poly(lactides), poly(glycolides), poly(lactide-co-glycolides), poly(lactic acid)s, poly(glycolic acid)s, poly(lactic acid-co-glycolic acid)s, polycaprolactone, polycarbonates, polyesteramides, polyanhydrides, poly(amino acids), polyorthoesters, polyacetals, polycyanoacrylates, polyetheresters, poly(dioxanone)s, poly(alkylene alkylate)s, copolymers of polyethylene glycol and polyorthoester, biodegradable polyurethanes, blends thereof and copolymers thereof.
- 8. A controlled release composition of claim 7 wherein said polymer comprises poly(lactide-co-glycolide).
- 9. A controlled release composition of claim 1 further comprising a second metal cation component, wherein the second metal cation component is not contained in said interferon particles, and wherein the second metal cation component is dispersed within the biocompatible polymer to modulate the release of interferon from the polymeric matrix.
- 10. A controlled release composition of claim 9 wherein the second metal cation component is selected from the group consisting of magnesium hydroxide, magnesium carbonate, calcium carbonate, zinc carbonate, magnesium acetate, zinc acetate, magnesium sulfate, zinc sulfate, magnesium chloride, zinc chloride, zinc citrate, magnesium citrate and a combination thereof.
RELATED APPLICATIONS
This application is a continuation of U.S. patent application Ser. No. 08/765,558, now U.S. Pat. No. 6,165,508, entitled “Controlled Release of Metal Cation-Stabilized Interferon” which is the U.S. National Phase of International Application Number PCT/US95/07348 having an International Filing Date of Jun. 7, 1995 which is a Continuation-in-Part of U.S. patent application Ser. No. 08/279,784 filed on Jul. 25, 1994 now U.S. Pat. No. 5,711,968. The entire content of U.S. patent application Ser. No. 08/765,558 is hereby incorporated by reference.
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Continuations (1)
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Continuation in Parts (1)
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