Claims
- 1. A process for the preparation of a controlled release oral dosage form comprising:
(a) forming granules comprising oxycodone hydrochloride, alkyl cellulose and polymethacrylate, and (b) drying said granules.
- 2. The process of claim 1, further comprising adding aliphatic alcohol and regranulating and compressing said granules into tablets.
- 3. The process of claim 1, wherein said granules are dried at 50° C.
- 4. A process for the preparation of a controlled release oral dosage form comprising:
(a) forming spheroids comprising oxycodone hydrochloride, spheronising agent, alkyl cellulose and polymethacrylate and drying said spheroids
- 5. The process of claim 4, where the spheronising agent is microcrystalline cellulose.
- 6. The process of claim 4, further comprising film coating said spheroids.
- 7. A process for the preparation of a controlled release oral dosage form comprising:
(a) wet granulating oxycodone hydrochloride, alkyl cellulose and polymethacrylate to form granules of said oxycodone hydrochloride, (b) drying said granules, (c) adding aliphatic alcohol, (d) regranulating and compressing said granules into tablets.
Parent Case Info
[0001] This application is a continuation of Ser. No. 08/081,302, filed Jun. 18, 1993, which is a continuation-in-part of Ser. No. 07/800,549, filed Nov. 27, 1991, now. U.S. Pat. No. 5,266,331, hereby incorporated by reference.
Continuations (8)
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