Patent Application
20100031685
The present application claims priority to European Patent Application No. 08161793.8, filed Aug. 5, 2008, the entire contents of which are herein incorporated by reference in its entirety.
The present invention relates to a convection barrier as well as a freezer comprising such convection barrier.
In clinical studies a wide variety of assays can be carried out to answer questions related to diagnosis (e.g. biomarker), treatment (e.g. efficacy of a drug) and prevention of diseases.
Large sample collections of biological samples can be established e.g., within the context of clinical studies. Such biological samples can be, e.g., blood samples (whole blood, plasma, serum), urine samples, tissue samples, or samples containing cells (e.g. primary cells, stem cells), proteins, DNA, RNA (RNAi, mRNA), or antibodies.
An automated facility for storing biological samples at −80° C. is used in the UK biobank and is described, for example, in the article “Designing and implementing a large-scale automated −80° C. archive” by Justin M. Owen and Peter Woods, published in the International Journal of Epidemiology 2008; 37: i56-i61 (doi: 10.1093/ije/dym293), herein incorporated by reference. The store described therein comprises a system of drawers arranged in a manner so as to form a shelf, which allows robotic access to the biological samples whilst maintaining storage conditions. The drawers can be opened individually by the robot pulling the respective drawer outwards so as to allow access to the interior of the drawer where the biological samples are stored.
However, this system has some disadvantages. Firstly, at its front surface each drawer is provided with a block made of styrene in a manner such that the styrene blocks of adjacently arranged drawers abut against one another. Upon opening an individual drawer by pulling the said drawer outwardly, this does inherently bear the risk that an adjacently arranged drawer is also pulled out although this is not intended and may cause an unwanted temperature rise of the stored samples. Also, the small but continuous leakage of cold air (or cold nitrogen) at the butt faces of adjacent styrene blocks is in total comparatively high, since the −80° C. storage compartments do not have front doors permitting a tight separation of the −80° C. areas from the −20° C. areas in the system.
Cooling of a complete humidity controlled room for storing biological samples as described above to about −80° C. (or below) is generally feasible. However, at said temperatures standard handling devices, such as for example robots, usually do not work properly. Therefore, particularly for long-term storage of biological samples, specific −80° C. freezers are typically used.
Such freezers for long term storage of samples usually have a tight and thermally insulating door which separates the environment outside the freezer from the −80° C. interior of the freezer. In a so-called “robotic store”, a plurality of such freezers are arranged in a −20° C. room as well as a robot for taking the samples out of the respective freezer. As mentioned above, the robot cannot be arranged in a −80° C. environment, since this simply is not economically feasible in such an environment, and in addition, maintenance of the robot would be difficult then. Instead, the robot is arranged outside the freezers in the −20° C. environment where it is capable of working properly. However, particularly with conventional upright standing freezers, certain problems may arise. Firstly, upon having opened the door in order to allow the robot to access the interior of the freezer, the −80° C. cooled air flows out of the interior of the freezer while at the same time −20° C. air flows from the environment into the interior of the freezer thus leading to a rise in temperature and humidity within the freezer. This is all the more the case, since the door of the freezer usually must remain open for a considerable period of time until the desired sample (or a number of samples) has been taken out by the robot. Secondly, opening and closing of the door results in a negative pressure inside the freezer which makes the door extremely difficult to get opened again until the negative pressure is equalized by inflowing air, e.g. through the sealing of the door of the freezer or through a pressure equilibration valve in the wall of the freezer. This usually takes a considerable period of time which may amount up to 30 minutes, for example. In addition, the cooling down of the −20° C. air which is more humid than the −80° C. air results in formation of ice within the freezer. Accordingly, defrosting of the freezer is required more often.
It is therefore an object of at least some of the embodiments of the invention to overcome the afore-mentioned disadvantages and to suggest suitable measures to avoid or at least greatly reduce the above-described scenarios. Also, loss of energy should be reduced to a minimum while at the same time frequent access to the stored biological samples should be possible.
This objective may be achieved through a convection barrier as it is specified by the features of the independent claim directed to such convection barrier, and through a freezer comprising such convection barrier. Specific advantageous embodiments are specified by the features of the dependent claims.
In particular, the convection barrier for a freezer in accordance with some embodiments of the invention comprises:
In some embodiments, the curtain formed by the individual flaps covers the opening which allows access to the freezer, so that the −80° C. air may not flow out of the freezer as the door of the freezer is open. On the other hand, it must also be possible to get access to the desired sample or samples stored in the interior of the freezer. This can be achieved according to some embodiments, by allowing an actuator (such as a robot or a part thereof) to open an individual flap so as to generate a row-like opening to the interior of the freezer. Depending on where the sample to be accessed is stored in the interior of the freezer, only one of the flaps need be opened so as to allow the robot to get access to the sample. Thus, outflow of −80° C. air from the interior of the freezer and inflow of −20° C. air to the interior of the freezer is prevented or at least greatly reduced. Accordingly, the above-identified disadvantages of temperature rise in the interior of the freezer, generation of negative pressure making the door of the freezer extremely difficult to open, etc., may be prevented or at least greatly reduced.
For example, the arrangement of flaps forming the closed curtain may be achieved in some embodiments by arranging the flaps in a manner such that the butt faces of adjacently arranged flaps form the tight seal when they are in the closed position. Alternatively, and also by way of example, the arrangement of flaps forming the closed curtain may be achieved by arranging the flaps in a manner such that the flaps at least partially overlap and form the tight seal when they are in the closed position (similar to the tiles of a roof).
In some embodiments of the convection barrier according to the invention, the individual flaps are provided with a bi-stable locking means being connected to the actuation means for releasably locking the individual flaps in the closed or in the open position, respectively. Such embodiments are advantageous since the respective flap can be stably locked in the open or the closed position respectively. In one specific embodiment of the convection barrier according to the invention, the bi-stable locking means comprises a spring, which keeps the flap locked in the open or the closed position with the aid of tensioning forces.
In some further embodiments of the convection barrier according to the invention, at least on the edges abutting or overlapping the adjacently arranged flap, lips are attached to the individual flaps. Preferably, a lip is attached to at least one of the edges abutting or overlapping the adjacently arranged flap. Such lips may serve a plurality of purposes. First, the lips further improve the seal of the interior of the freezer. Second, they form protection for the material the flaps are made of. And third, they simplify the process of opening and closing the flap, since the frictional coefficient of the material the lips are made of is low. A particularly suitable material for the lips is Teflon(& (polytetrafluoroethylene).
In some embodiments of the convection barrier according to the invention, the individual flaps are made of glass ceramics. Glass ceramics is a material which has a low thermal conductivity. Thus, the interior of the freezer is additionally protected against the comparatively “high” temperatures (−20° C.) outside the interior of the freezer (where the temperature is about −80° C.). Since the glass ceramics has a very small thermal expansion coefficient, the temperature gradient perpendicular to the flaps does not cause bending of the flaps which could give rise to a leakage between adjacent flaps.
As already mentioned further above, some embodiments of the invention relate to a freezer comprising a housing and a door, the housing having an opening allowing access to the interior of the freezer through the opening as the door of the freezer is open. The freezer may further comprise a convection barrier as it has already been described with respect to the various embodiments discussed above. The convection barrier may be arranged such that the opening allowing access to the interior of the freezer is covered by the flaps of the convection barrier. The advantages of this management correspond to those already discussed above in connection with the various embodiments of the convection barrier, so that they need not be reiterated here.
Further advantageous aspects of the invention will become apparent from the following description of embodiments of the invention with the aid of the schematic drawings in which:
The embodiment of the convection barrier 2 according to the invention shown in
In
On the longitudinal edges of flaps 20 which abut the longitudinal edges of the respective adjacently arranged flaps 20 lips 22 are attached to the flaps 20. By way of example only, lips 22 may be made of Teflon® while flaps 20 may be made of glass ceramics such as those offered under the trademark ROBAX® by Schott AG, Mainz, Germany. Lips 22 serve various purposes, for example they protect the glass ceramics of flaps 20, they improve the thermal seal provided by the convection barrier 2 and they simplify opening and closing of flaps 20 due to the low frictional coefficient of the Teflon® material.
Flaps 20 may be mounted to holders 23 which themselves are fixed to or are an integral part of an actuation means 24 which allows the flap 20 to be pivoted from the closed position to the open position and vice versa. Bi-stable locking means in form of a spring 25 may be provided whereby flaps 20 can be locked either in the open or in the closed position. To achieve this, one end of spring 25 is attached to a pin 26 which is fixedly mounted to frame 21 while the other end of spring 25 is mounted to actuation means 24.
In some embodiments, in order to access a specific sample, the flap 20 which allows access to the respective drawer in which the specific sample is stored in a tray must be pivoted from the closed position (the first stable position) to the open position (the second stable position). This may be done with the aid of actuator 40 of the robot which engages the actuation means 24 attached to the respective flap 20. For that purpose, actuator 40 may comprise a slot 400 and actuation means 24 may comprise a pin 240. To perform the pivotal movement of flap 20 indicated by double-headed arrows 5 in
Having described specific embodiments of the convection barrier according to the invention and of the freezer according to the invention, the invention is not limited to the specific embodiments described. Rather, various modifications are conceivable without departing from the teaching of the invention. The scope of protection is intended to be defined by the following appended claims. Other claims directed to the currently claimed embodiments, or other unclaimed embodiments, may be presented in the subject application during prosecution, as well as in subsequent child applications of the subject application.
| Number | Date | Country | Kind |
|---|---|---|---|
| 08161793.8 | Aug 2008 | EP | regional |
