Claims
- 1. A method of administering a fluid pharmacological agent to a solid tissue through direct convective interstitial infusion and over a predetermined time comprising:
- inserting a catheter directly into said tissue; and
- administering said agent under pressure through said catheter into the interstitial space at a flow rate of from about 0.5 .mu.l/min to about 15 .mu.l/min.
- 2. The method of administering a fluid pharmacological agent according to claim 1, wherein the fluid pressure is increased in one or more steps.
- 3. The method of administering a fluid pharmacological agent according to claim 1, wherein the fluid pressure is continuously increased over at least part of said predetermined time.
- 4. The method of administering a fluid pharmacological agent according to claim 1, wherein the fluid pressure is continuously increased over all of said predetermined time.
- 5. The method of administering a fluid pharmacological agent according to claim 1, wherein said pharmacological agent comprises a macromolecule.
- 6. The method of administering a fluid pharmacological agent according to claim 1, wherein said pharmacological agent is selected from the group consisting of a protein toxin, an immunotoxin, an antibody, a protein, a growth factor, a virus, a DNA, a RNA, an imaging agent and mixtures thereof.
- 7. The method of administering a fluid pharmacological agent according to claim 1, wherein said solid tissue is brain tissue.
- 8. The method of administering a fluid pharmacological agent according to claim 1, wherein said solid tissue is a tumor.
- 9. The method of administering a fluid pharmacological agent according to claim 1, wherein the fluid pressure is increased by means of a programmable pump.
- 10. The method of administering a fluid pharmacological agent to a solid tissue according to claim 1, further comprising increasing the pressure of said fluid agent at least once over the predetermined time.
- 11. A method for treating a solid tumor comprising:
- inserting a catheter into said tumor; and,
- administering a fluid pharmacological agent directly into interstitial spaces of said tumor through said catheter at a flow rate of from about 0.5 .mu.l/min to about 15 .mu.l/min.
- 12. The method of treating a solid tumor according to claim 11, further comprising increasing the pressure of said fluid agent at least once over a predetermined time of administration.
- 13. In a method of administering a fluid pharmacological agent to a dense tissue, the improvement comprising administering said agent directly into an interstitial space of said tissue through a catheter at a rate of from about 0.5 .mu.l/min to about 15 .mu.l/min over a predetermined time, wherein the fluid pressure is increased at least once over said predetermined time.
Parent Case Info
This is a continuation of application Ser. No. 08/112,370 filed Aug. 27, 1993, now abandoned.
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Non-Patent Literature Citations (1)
Entry |
Lamb, S., Interstitial Radiation for Treatment of Primary Brain Tumors Using the Brown-Roberts-Wells Stereotaxic System, J. Neurosurgical Nursing, vol. 17, pp. 22-29 (1985). |
Continuations (1)
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Number |
Date |
Country |
Parent |
112370 |
Aug 1993 |
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