N. Serizawa, et al., "6.alpha.-Hydroxy-ISO-ML-236B (6.alpha.-Hydroxy-ISO-Compactin) and ML-236A, Microbial Transformation products of ML-236B", J. Antibiotics 36(7):918-920 (1983). |
Y. Tsuhita et al., "CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species", Biochimica et Bipphysica Acta 887:50-60 (1986). |
M. Hosobuchi et al., "Morphology Control of Preculture during Production of ML-236B, a Precursor of Pravastating Sodium, by Penicillium citrinum", J. Fermentation and Bioengineering 76(6):476-481 (1993). |
N. Serizawa et al., "Microbial Hydroxylation of ML-236B (Compactin) and Monacolin K (MB-530B0", J. Antibiotics 36(5):604-607 (1983). |
N. Serizawa and T. Matsuoka, "A two component-type cytochrome P-450 monooxygenase system in a prokaaryote that catalyzes hydroxylation of ML-236B to pravastatin, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenyme A reductase", Biochimica et Biophysica Acta 1084:35-40 (1991). |
N. Serizawa et al., "3.alpha.-Hydroxy-ML-236B (3.alpha.-Hydroxycompactin), Microbial Transformation Product of ML-236B (Compactin)", J. Antibiotcs 36(5):608-610 (1983). |
T. Fujioka et al., "The mechanism of lack of hypocholesterolemic effects of pravastatijn sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in rats", Biochimica et Biophysica Acta 1254:7-12 (1995). |
M. Hosobuchi et al., "Fuzzy Control in Microbial Production of ML-236B, a Precursor of Pravastatin Sodium", J. Fermentation and Bioengineering 76(6):482-486 (1993). |
N. Serizawa et al., "Microbial Hydroxylation of ML-236B (Compactin) Studies on Microorganisms Capable of 3.beta.-Hydroxylation of ML-236B", J. Antibiotics 36(7):887-891 (1983). |
T. Matsuoka et al., "Purification and Characterization of cytochrome P-450.sub.sca from Streptomyces carbophilus", Eur. J. Biochem 184:707-713 (1989). |
Y. Kishida et al., "Reasearch and Development of Pravastatin", Yakugaku Zasshi 111(9):469-487 (1991). |
M. Hosobuchi et al. "Application of Computer to Monitoring and Control of Fermentation Process: Microbial Conversion of ML-236B Na to Pravastatin", Biotechnology and Bioengineering 42:815-820 (1993). |
F. Nara et al., "Development of a transformation system for the filamentous, ML-236B (compactin) - producing fungus Pencillium citrinum", Curr. Genet 23:28-32 (1993). |
H. Yamashita et al., "Microbial Hydroxylation of Compactin (ML-236B) and Monacolin K", 38(5):605-609 (1985). |
M. Hosobuchi et al., "Morphology Study in Production of ML-236B, a Precursor o Pravastatin Sodium, by Penicillium citrinum", J. Fermentation and Bioengineering 76(6):470-475 (1993). |
M.A. Wallace et al., "The Synthesis of Carbon-14 Labeled Pravastating", J. Labelled Compounds and Radiopharmaceuticals 33(8):697-702 (1993). |
A. Endo et al., "The Synthesis of Compactin (ML-236B) and Monacolin K in Fungi", J. Antibiotics, 39(11):1609-1610 (1986). |