SUMMARY Core A is the administrative core facility responsible for overall administration in support of the research aims and goals of the program, and is further responsible for meeting all programmatic administrative requirements of the multiple institutions involved. Core A will provide services that are essential for the completion of research goals addressing the central hypothesis of the overall program: Protein glycosylation and glycoprotein remodeling alter the coagulopathy and inflammation of sepsis. Core A provides administrative functions that are needed by all of the projects, core facilities, and program-funded personnel. Core A will be the nexus of programmatic communications among program participants including project leaders, core leaders, advisory board members, collaborators and consultants, and laboratory and research personnel. The overall administrative goal of Core A is to establish and maintain essential programmatic administrative functions in the most efficient and optimal manner possible. In addition, Core A will continue to establish and maintain effective inter-departmental and inter-institutional communications with multiple offices and staff as needed to achieve the administrative duties required. The Core A administrative facility will maintain records of relevant program activities in fulfilling the administrative requirements as detailed in the application. The administrative functions of Core A include maintaining an effective office infrastructure with multiple routine modes of communication, monitoring project and core expenditures, assistance with orientation and administration of program personnel, execution and record keeping of relevant programmatic meetings and progress reports, composing and maintaining program personnel communication lists, assistance to program personnel regarding program publications and compositionand submission of program reporting, organization of meetings of program investigators, staff, and advisory board members, and organization and execution of program personnel off-site travel including annual program retreats. Core A will further operate in assistance with project personnel as a liaison with Santa Barbara Cottage Hospital physicians and research office staff in facilitating communications and documents transfers enabling accreditation regarding human subjects use with Internal Review Board certification in support of the program. The structure and organization of Core A includes a Core Leader and Program Assistant whom together will provide the administrative functions in support of program project and core personnel and activities.