TREA

Core D: Neuropathology and Animal Behavior

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Information

  • Research Project
  • 8292294
  • ApplicationId
    8292294
  • Core Project Number
    P01ES016738
  • Full Project Number
    5P01ES016738-04
  • Serial Number
    16738
  • FOA Number
  • Sub Project Id
    9003
  • Project Start Date
    7/1/2011 - 13 years ago
  • Project End Date
    6/30/2013 - 11 years ago
  • Program Officer Name
  • Budget Start Date
    7/1/2011 - 13 years ago
  • Budget End Date
    6/30/2012 - 12 years ago
  • Fiscal Year
    2011
  • Support Year
    4
  • Suffix
  • Award Notice Date
    9/29/2011 - 12 years ago
Organizations
Information

Core D: Neuropathology and Animal Behavior

The mission of the Neuropathology and Animal Behavior Core will be to provide the projects of the NIEHS Center with well-characterized autopsy brain material from human PD cases as well as with transgenic (tg) animal models expressing a-synuclein (a-syn), DJ-1, Parkin and PINK1 for neuropathological, molecular, biochemical and behavioral studies. The Core will provide support with human tissues from PD patients and animal models of PD to Projects 1, 2, and 3; support behavioral studies in Project 3;and help with survival/apoptosis/necrosis analysis of human embryonic stem cell (hESC)-derived developing neurons for Project 4. The Core has developed state of the art techniques for neuropathological analysis of neurodegeneration, biochemical analysis of misfolded protein accumulation, and behavioral analysis of motor and cognitive alterations. Moreover, we have developed unique animal models of PD in which to test and screen new molecular pathways and small molecules. Please note that a human clinical component, as defined in the NIEHS Center RFA, is contained within this Core.

IC Name
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
  • Activity
    P01
  • Administering IC
    ES
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
    100169
  • ARRA Funded
    False
  • CFDA Code
  • Ed Inst. Type
  • Funding ICs
    NIEHS:100169\
  • Funding Mechanism
    Research Projects
  • Study Section
    ZES1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    SANFORD-BURNHAM MEDICAL RESEARCH INSTIT
  • Organization Department
  • Organization DUNS
    020520466
  • Organization City
    LA JOLLA
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    920371005
  • Organization District
    UNITED STATES