Core E: High-Throughput Screening and Chemical Library Core

Information

  • Research Project
  • 8292295
  • ApplicationId
    8292295
  • Core Project Number
    P01ES016738
  • Full Project Number
    5P01ES016738-04
  • Serial Number
    16738
  • FOA Number
  • Sub Project Id
    9004
  • Project Start Date
    7/1/2011 - 12 years ago
  • Project End Date
    6/30/2013 - 10 years ago
  • Program Officer Name
  • Budget Start Date
    7/1/2011 - 12 years ago
  • Budget End Date
    6/30/2012 - 11 years ago
  • Fiscal Year
    2011
  • Support Year
    4
  • Suffix
  • Award Notice Date
    9/29/2011 - 12 years ago

Core E: High-Throughput Screening and Chemical Library Core

The mission of the High-Throughput Screening and Chemical Library (HTSCL) Core is to support the high-throughput screening, medicinal chemistry, automated microscopy and image analysis needs of the individual Projects. The Burnham Institute for Medical Research (BIMR) has collaborated with neighboring academic institutions to establish the San Diego Center for Chemical Genomics (SDCCG). The SDCCG will provide the projects access to state-of-the-art robotics and instrumentation for HTS for the purpose of discovering novel therapeutics for Parkinson's disease (PD), which will be a major function of Core E. HTS will be conducted in vitro against biochemical targets or cellular responses (Projects 2 3, and 4). A second major function of the core will be the automated acquisition and analysis of images of cells to quantify marker or phenotypic responses (Projects 2 and 3) using the sophisticated and proprietary automated microscopy platforms and algorithms developed within the center. In addition, the core will assume the responsibility of converting primary validated hits to leads through medicinal chemistry and nuclear magnetic resonance (NMR)-based and computational modeling strategies for compound optimization (Projects 2, 3, and 4). Core E will provide these functions for the Parkinson's Disease (PD) researchers in this Center.

IC Name
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
  • Activity
    P01
  • Administering IC
    ES
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
    123803
  • ARRA Funded
    False
  • CFDA Code
  • Ed Inst. Type
  • Funding ICs
    NIEHS:123803\
  • Funding Mechanism
    Research Projects
  • Study Section
    ZES1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    SANFORD-BURNHAM MEDICAL RESEARCH INSTIT
  • Organization Department
  • Organization DUNS
    020520466
  • Organization City
    LA JOLLA
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    920371005
  • Organization District
    UNITED STATES