Claims
- 1. A pharmaceutical composition having coronary vasodilator activity comprising a pharmaceutical carrier and, in an amount to produce said activity, a compound of the formula: ##STR7## or a pharmaceutically acceptable acid addition salt thereof, in which: R.sub.1 is hydrogen, halo, trifluoromethyl, nitro, lower alkyl or lower alkoxy;
- R.sub.2 and R.sub.3 are hydrogen, lower alkyl or lower alkoxy;
- R.sub.4 is hydrogen or straight chain lower alkyl;
- R.sub.5 is straight chain lower alkyl;
- R.sub.6 is phenyl, lower alkylphenyl, di-lower alkylphenyl, tri-lower alkylphenyl, lower alkoxyphenyl, di-lower alkoxyphenyl, tri-lower alkoxyphenyl, halophenyl, dihalophenyl, trihalophenyl, trifluoromethylphenyl, benzyl, halobenzyl, lower alkylbenzyl, lower alkoxybenzyl or trifluoromethylbenzyl;
- n is 2 to 4; and
- Z is sulfur.
- 2. A method of producing coronary vasodilation comprising administering to an animal in need of said effect an effective amount of a compound of the formula: ##STR8## or a pharmaceutically acceptable acid addition salt thereof, in which: R.sub.1 is hydrogen, halo, trifluoromethyl, nitro, lower alkyl or lower alkoxy;
- R.sub.2 and R.sub.3 are hydrogen, lower alkyl or lower alkoxy;
- R.sub.4 is hydrogen or straight chain lower alkyl;
- R.sub.5 is straight chain lower alkyl;
- R.sub.6 is phenyl, lower alkylphenyl, di-lower alkylphenyl, tri-lower alkylphenyl, lower alkoxyphenyl, di-lower alkoxyphenyl, tri-lower alkoxyphenyl, halophenyl, dihalophenyl, trihalophenyl, trifluoromethylphenyl, benzyl, halobenzyl, lower alkylbenzyl, lower alkoxybenzyl or trifluoromethylbenzyl;
- n is 2 to 4; and
- Z is sulfur.
- 3. A pharmaceutical composition having antianginal activity comprising a pharmaceutical carrier and, in an amount to produce said activity, 3-[4-(3-diethylaminopropoxy)benzoyl]-2-phenylbenzofuran.
- 4. A pharmaceutical composition having anti-anginal activity comprising a pharmaceutical carrier and, in an amount to produce said activity, 3-[4-(3-diethylaminopropoxy)benzoyl]-2-(4-tolyl)benzofuran.
- 5. A pharmaceutical composition having anti-anginal activity comprising a pharmaceutical carrier and, in an amount to produce said activity, 5-chloro-3-[4-(3-diethylaminopropoxy)benzoyl]-2-phenylbenzofuran.
- 6. A pharmaceutical composition having anti-anginal activity comprising a pharmaceutical carrier and, in an amount to produce said activity, 3-(4-chlorophenyl)-2-[4-(3-diethylaminopropoxy)benzoyl]benzofuran.
- 7. A method of producing anti-anginal activity comprising administering to an animal in need of said activity an effective amount of 3-[4-(3-diethylaminopropoxy)benzoyl]-2-phenylbenzofuran.
- 8. A method of producing anti-anginal activity comprising administering to an animal in need of said activity an effective amount of 3-[4-(3-diethylaminopropoxy)benzoyl]-2-(4-tolyl)benzofuran.
- 9. A method of producing anti-anginal activity comprising administering to an animal in need of said activity an effective amount of 5-chloro-3-[4-(3-diethylaminopropoxy)benzoyl]-2-phenylbenzofuran.
- 10. A method of producing anti-anginal activity comprising administering to an animal in need of said activity an effective amount of 3-(4-chlorophenyl)-2-[4-(3-diethylaminopropoxy)benzoyl]benzofuran.
- 11. A pharmaceutical composition having coronary vasodilator activity comprising a pharmaceutical carrier and, in an amount to produce said activity, a compound of the formula: ##STR9## or a pharmaceutically acceptable acid addition salt thereof, in which the aminoalkoxy side chain is in the para position of the benzoyl ring; R.sub.1 is hydrogen or halo in the 5-position; R.sub.2 and R.sub.3 are hydrogen; R.sub.4 and R.sub.5 are ethyl, n-propyl or n-butyl; R.sub.6 is tolyl, chlorophenyl, bromophenyl, methoxyphenyl, trifluoromethylphenyl, dimethylphenyl, dichlorophenyl, dimethoxyphenyl, trimethoxyphenyl, chlorobenzyl or trifluoromethylbenzyl; n is 2 to 4 and Z is oxygen or sulfur.
- 12. A method of producing coronary vasodilation comprising administering to an animal in need of said effect an effective amount of a compound of the formula: ##STR10## or a pharmaceutically acceptable acid addition salt thereof, in which the aminoalkoxy side chain is in the para position of the benzoyl ring; R.sub.1 is hydrogen or halo in the 5-position; R.sub.2 and R.sub.3 are hydrogen; R.sub.4 and R.sub.5 are ethyl, n-propyl or n-butyl; R.sub.6 is tolyl, chlorophenyl, bromophenyl, methoxyphenyl, trifluoromethylphenyl, dimethylphenyl, dichlorophenyl, dimethoxyphenyl, trimethoxyphenyl, chlorobenzyl or trifluoromethylbenzyl; n is 2 to 4 and Z is oxygen or sulfur.
Parent Case Info
This is a division of application Ser. No. 481,283 filed June 20, 1974, now U.S. Pat. No. 3,947,470.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3248401 |
Tondeur et al. |
Apr 1966 |
|
3658845 |
Posselt et al. |
Apr 1972 |
|
3706747 |
De Angelis et al. |
Dec 1972 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
481283 |
Jun 1974 |
|