Claims
- 1. A compound having the following structure:the following structure (I): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof,wherein: X is nitrogen or CR3; Z is O, S or NR4; Y is N, NR5 or O; A is O, S, or NR6; “----” represents an optional double bond; R is an optional substituent which, at each occurrence, is independently alkyl, aryl, heteroaryl, alkylidenyl, arylalkyl or heteroarylalkyl, wherein m is 0, 1, 2 or 3 and represents the number of R substituents; R1 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; R2 is hydrogen, alkyl, substituted alkyl, alkoxy or thioalkyl; R3 is hydrogen, halogen, alkyl or substituted alkyl; R4 is hydrogen, cyano, nitro, alkyl or substituted alkyl; R5 is hydrogen, alkyl or substituted alkyl; and R6 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl.
- 2. The compound of claim 1 wherein X is CR3.
- 3. The compound of claim 1 wherein X is nitrogen.
- 4. The compound of claim 1 wherein A is O.
- 5. The compound of claim 1 wherein A is S.
- 6. The compound of claim 1 wherein A is NR6.
- 7. The compound of claim 6 wherein R6 is alkyl.
- 8. The compound of claim 1 wherein Y is N.
- 9. The compound of claim 1 wherein Y is NR5.
- 10. The compound of claim 9 wherein R5 is alkyl.
- 11. The compound of claim 1 wherein Y is O.
- 12. The compound of claim 1 wherein Z is O.
- 13. The compound of claim 1 wherein Z is S.
- 14. The compound of claim 1 wherein Z is NR4.
- 15. The compound of claim 1 wherein R1 is substituted aryl.
- 16. The compound of claim 15 wherein R1 is substituted phenyl.
- 17. The compound of claim 1 wherein R2 is alkyl.
- 18. The compound of claim 1 wherein m is O.
- 19. A composition comprising a compound of claim 1 in combination with a pharmaceutically acceptable carrier or diluent.
- 20. A method for treating a disorder manifesting hypersecretion of CRF in a warm-blooded animal, comprising administering to the animal an effective amount of the composition of claim 19.
- 21. The method of claim 20 wherein the disorder is stroke.
- 22. The method of claim 20 wherein the disorder is depression.
- 23. The method of claim 20 wherein the disorder is anxiety.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims the benefit of U.S. Provisional Application No. 60/205,644 filed May 18, 2000 and U.S. Provisional Application No. 60/205,885 filed May 18,2000.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
6121278 |
Jackson et al. |
Sep 2000 |
A |
Foreign Referenced Citations (2)
Number |
Date |
Country |
WO 9808846 |
Mar 1998 |
WO |
WO 0027850 |
May 2000 |
WO |
Provisional Applications (2)
|
Number |
Date |
Country |
|
60/205644 |
May 2000 |
US |
|
60/205885 |
May 2000 |
US |