Claims
- 1. Cross-linked high amylose starch having functional groups, prepared by a process comprising the steps of:(a) reacting high amylose starch with a cross-linking agent cross-linked a concentration of about 0.1 g to about 40 g of cross-linking agent per 100 g of high amylose starch to afford cross-linked amylose; and (b) reacting the cross-linked high amylose starch with a functional group-attaching reagent at a concentration of about 75 g to about 250 g of functional group-attaching reagent per 100 g of cross-linked amylose to afford the cross-linked amylose having functional groups, wherein the functional group attaching reagent is selected from the group consisting of monochloroacetic acid and chloroethylamine hydrochloride.
- 2. The cross-linked amylose of claim 1, wherein the cross-linking agent is selected from the group consisting of 2,3-dibromopropanol, epichlorohydrin, sodium trimetaphosphate, linear mixed anhydrides of acetic and di- or tribasic carboxylic acids, vinyl sulfone, diepoxides, cyanuric chloride, hexahydro-1,3,5-trisacryloyl-s-triazine, hexamethylene diisocyanate, toluene 2,4-diisocyanate, N,N-methylenebisacrylamide, N,N′-bis (hydroxymethyl)ethyleneurea, phosgene, tripolyphosphate, mixed carbonic-carboxylic acid anhydrides, imidazolides of carbonic and polybasic carboxylic acids, imidazolium salts of polybasic carboxylic acids, guanidine derivatives of polycarboxylic acids, and esters of propanoic acid.
- 3. The cross-linked high amylose starch of claim 2, wherein the cross-linking agent is epichlorohydrin.
- 4. The cross-linked high amylose starch of claim 1, wherein the reacting of step (a) is carried out at a concentration of about 35 g of epichlorohydrin per 100 g of high amylose starch.
- 5. The cross-linked high amylose starch of claim 1, wherein the reacting of step (b) is carried out at a concentration of about 100 g of monochloracetic acid per 100 g of high amylose starch.
- 6. The cross-linked high amylose starch of claim 1, wherein the reacting of step (b) is carried out at a concentration of about 122.5 g of 2-chloroethylamine hydrochloride per 100 g of high amylose starch.
Parent Case Info
This is a continuation-in-part of application Ser. No. 09/028,385, filed Feb. 24, 1998, now U.S. Pat. No. 6,284,273, which is incorporated herein in its entirety.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5830884 |
Kasica et al. |
Nov 1998 |
A |
Non-Patent Literature Citations (2)
Entry |
Lenaerts et al., Controlled release of theophylline from cross-linked amylose tablets, 15 (1991), pp. 39-46.* |
Mateescu et al., “A new amyloclastic method for the selective detemrination of alpha-amylase using cross-linked amylose as an insoluble substrate”, 124 (1983), pp. 319-323. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09/028385 |
Feb 1998 |
US |
Child |
09/257090 |
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US |