Claims
- 1. In a pharmaceutical composition comprising an active ingredient and a pharmaceutically acceptable carrier, the improvement wherein the carrier comprises a cross linked product of chitosan obtained by reacting chitosan with a carboxylic acid dianhydride or carboxylic acid polyanhydride.
- 2. The pharmaceutical composition according to claim 1, wherein the cross linked product of chitosan is obtained by reacting chitosan with pyromellitic anhydride.
- 3. The pharmaceutical composition according to claim 1, wherein the cross linked product of chitosan is obtained by reacting chitosan with a polymaleic anhydride.
- 4. The pharmaceutical composition according to claim 1, wherein the chitosan which is reacted with a carboxylic acid di- or polyanhydride is in a solution of acetic acid in aqueous acetone.
- 5. The pharmaceutical composition according to claim 4, wherein the chitosan is reacted with pyromellitic dianhydride.
- 6. The pharmaceutical composition according to claim 4, wherein the chitosan is reacted with polymaleic anhydride.
- 7. The pharmaceutical composition according to claim 3, wherein the polymaleic anhydride has a molecular weight of up to 1000.
- 8. The pharmaceutical composition according to claim 6, wherein the polymaleic anhydride has a molecular weight of up to 1000.
- 9. In a pharmaceutical capsule comprising an active ingredient and a support material, the improvement wherein the support material comprises a cross linked product of chitosan, obtained by reacting chitosan with a carboxylic acid dianhydride or carboxylic acid polyanhydride.
- 10. In a medical implant, the improvement wherein the implant comprises a cross linked product of chitosan, obtained by reacting chitosan with a carboxylic acid dianhydride or carboxylic acid polyanhydride.
- 11. In a suture material, the improvement wherein the suture material comprises a cross linked product of chitosan, obtained by reacting chitosan with a carboxylic acid dianhydride or carboxylic acid polyanhydride.
- 12. In a wound covering, the improvement wherein the wound covering comprises a cross linked product of chitosan, obtained by reacting chitosan with a carboxylic acid dianhydride or carboxylic acid polyanhydride.
Priority Claims (1)
Number |
Date |
Country |
Kind |
196 04 706 |
Feb 1996 |
DE |
|
Parent Case Info
This is a continuation, of application Ser. No. 09/125,072 filed Aug. 7, 1998, now abandoned.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3296155 |
Mink |
Jan 1967 |
A |
4808313 |
Michizuki et al. |
Feb 1989 |
A |
5201945 |
Shimizu et al. |
Apr 1993 |
A |
5874551 |
Glasser et al. |
Feb 1999 |
A |
Foreign Referenced Citations (1)
Number |
Date |
Country |
4034871 |
Jul 1992 |
DE |
Non-Patent Literature Citations (3)
Entry |
File caplus on Stn. An No. 1994:486143. Baba, Yoshimi, Modified Chitosans, Their Prepartion and Uses, JP 05331204, Dec. 14, 19993. Abstract Only.* |
File Caplus on Stn. An. No. 1994:227002. Myazaki et al. Sustained Release Pharmaceutical Suspensions Containing Crosslinked Chitosan. JP 05339149, Dec. 21, 1993. Abstract only.* |
Chemical Abstracts (1990), vol. 112, No. 24 Abstract No. 223161. |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09/125072 |
|
US |
Child |
09/621343 |
|
US |