Patent Application
20230165620
The invention relates to a cryosurgical instrument that operates under utilization of the Joule-Thomson effect.
Prior art has disclosed medical instruments whose working end is being cooled in order to thus generate physiological or therapeutic effects on the tissue of the patient. For example, from publication WO 02/02026 A1 there is known a cryoprobe that comprises a tip for cutting, in which case liquid cooling means is supplied to the tip in order to cool said tip. Publication U.S. Pat. No. 6,830,581 B2 describes a heat transfer element to be inserted into a blood vessel, in which case said element is to cool blood in the vessel in that cooled working agent is supplied to the tip of the instrument.
Instruments for cryosurgery work, for example, with the targeted utilization of the Joule-Thomson effect, in which case a fluid experiences a reduction of its temperature due to being slowed down.
Publication DE 10 2008 024 946 A1, for example, discloses a cryosurgical instrument that comprises a feed line for feeding a fluid, in particular a gas, into an expansion chamber in the head of the probe. On the front side of the feed line there is an aperture with an opening through which the fluid flows out of the feed line into the expansion chamber and is thus expanded, whereby the fluid cools. In doing so, the probe tip is cooled. The cooled fluid flows from the probe tip back through a gas feedback line.
Publication WO 2006/006986 A2 describes a cryosurgical instrument comprising a tube with a closed end. Arranged inside the tube there is a gas feed line, to the end of which a capillary tube is connected, in which case the end of the latter terminates in an expansion chamber in the tip of the probe.
Publication US 2012/0 130 359 A1 describes an instrument for cryotherapy with the use of which nerves at the operating site can be affected with cold for therapeutic purposes. The instrument comprises a shaft, at the end of which a working section is provided. Extending through the shaft in the working section, there is a feed line for feeding coolant back into the working section. At the end of the feed line, there may be provided an aperture or a capillary tube with which the feed line terminates in an expansion chamber in the working region.
Publication US 2005/0 016 188 A1 describes an instrument for the cryosurgical ablation of tissue with a cryocatheter comprising a tube having a closed distal end, wherein a feedback line extends in the tube up to the end of the instrument, in which case a capillary tube is arranged in the end of the feed line, said capillary tube terminating in a chamber on the distal end of the instrument.
It is the object of the present invention to state an improved cryosurgical instrument.
This object is achieved with a cryosurgical instrument described herein that, for example, may be disposed for taking a tissue sample. The cryosurgical instrument according to the invention comprises a feed line for supplying a working fluid, in particular a gas, into an expansion chamber that is preferably arranged on the distal end of the instrument. The feed line has a capillary line section that terminates in the expansion chamber. A return arrangement for returning gas from the expansion chamber is connected to the expansion chamber. The feed line has at least one first section and one second section that form line sections displaying different-size inside cross sections (inside cross-sectional areas). The inside cross-sections determine the flow cross-section for the fluid through the feed line in the first and the second sections. The feed line of the instrument according to the invention is designed in such a manner that the path of flow of the fluid through the feed line tapers in a transition section of the feed line from the first section to the second section in a funnel-shaped manner in the direction toward the expansion chamber. With this funnel-like tapering of the inside cross-section of the feed line in the transition section, it is possible to achieve a stepped progression of the flow cross-section along the feed line with a decrease of the inside cross-section, said decrease being preferably continuous (steady) or step-by-step. As a result of the fact that the inside cross-section of the feed line tapers at least once in a funnel-shaped manner in the direction of flow of the fluid through the feed line in the direction toward the expansion chamber, the fluid is accelerated in the at least one funnel-shaped transition section of the feed line. Due to the funnel-shaped tapering in the transition section the flow cross-section does not decrease suddenly (abruptly) from the flow cross-section of the first section toward the flow cross-section of the second section that is smaller compared to the flow cross-section of the first section. Therefore, due to the funnel shape of the transition-section, pressure fluctuations of the accelerated fluid in the section of the feed line following the funnel-shaped transition section can be largely reduced or prevented.
The instrument according to the invention works, for cooling the working section of the instrument, by utilizing the Joule-Thomson effect that manifests itself on the fluid when the fluid expands in the expansion chamber. Due to the uniform acceleration in the transition section and the use of the capillary line section as the distal end section of the feed line, it is accomplished that the distance over which the fluid particles remain largely together upon exiting from the mouth opening into the expansion chamber is lengthened compared to an instrument that does not comprise the described funnel-shaped taper and capillary line section. In doing so, it can be prevented, in particular, that the jet will widen excessively after the mouth and thus impede the backflow of the gas out of the expansion chamber. As a result of this, the instrument head that contains the expansion chamber and that may contain at least one section of the return system, can be designed in a slim manner. This smoothes the path to obtain miniaturized instrument heads. The use of the capillary line as aperture for the fluid, as well as the largely pressure-surge-free acceleration of the fluid in the at least one transition section in which the flow cross-section tapers in a funnel-shaped manner, in particular, smooth the path to a particularly slim instrument head with which, for example, a safe tissue sample removal can be simplified.
Particularly preferably, the feed line is configured in such a manner that the inside cross-section of the feed line tapers in a funnel-shaped manner in the transition section toward the capillary line section. As a result of this, the fluid can be accelerated and pressure fluctuation at the time of entry into capillary line section can be largely reduced or prevented on entry into the capillary line section, this leading to a large free path length of the fluid, over which length the fluid particles largely remain together upon leaving the capillary line section into the expansion chamber. Preferably, the tapering of the inside cross-section is continuous in a transition region that extends from ahead of the transition section toward the capillary line section—through the transition section and into the capillary line section. The inside wall surface of the feed line in the transition region is preferable free of edges so that, within the transition region along the flow path, there do not exist any sudden changes of the gradient of the inside cross-section.
Preferably, the tapering angle with which the inside cross-section of the feed line tapers at least in the transition section toward the capillary line section in a funnel-like manner is 15° at minimum and 40° at maximum. The tapering angle is included by opposing sections of the inside wall surface of the transition section that determines the flow cross-section through the transition section.
The length of the capillary line section is preferably between a minimum of 1 mm and a maximum of 15 mm. The inside diameter of the capillary line section that determines the flow cross-section of the capillary line section is preferably between a 60 micrometers at minimum and 200 micrometers at maximum.
Preferably, the feed line has at least two transition sections in which the flow path through the feed line tapers in a funnel-shaped manner in the direction of flow toward the expansion chamber.
The first section and the second section preferably form step sections of a series of two, three or more than three step sections of the feed line, wherein a transition section is provided between each two step sections, said transition section being adjacent to the two step sections. As described, the flow cross-section through the at least one transition section, preferably in each transition section, decreases as in a funnel in the direction of the mouth opening of the feed line toward the expansion chamber. The area contents of the inside cross-sectional areas of each step section belong to an inside cross-section step, wherein the area contents of the inside cross-sectional areas of an inside cross-section step of a step section area are greater than the area contents of the inside cross-sectional areas of the inside cross-section step of the step section adjacent—in the direction toward the mouth of the capillary line section downstream—to the same transition section. As a result of this, a stepped progression of the flow cross-section of the feed line up to the mouth of the feed line is provided, in which case the flow path in the transition sections having the funnel-shaped taper is not reduced abruptly—due to the funnel shape—from one cross-section step to the subsequent cross-section step, but is preferably reduced continuously or step-by-step or, in at least one longitudinal section of the transition section, continuously and, in at least another longitudinal section of the transition section, step-by-step in the direction toward the expansion chamber and may advantageously remain largely constant in the step sections along the step sections. The capillary line section may form the last step section of the sequence in flow direction toward the mouth of the last step section. Due to the acceleration in the funnel-shaped transition sections, the fluid particles are imparted with a high speed that carries the fluid jet—upon exiting from the mouth—far into the expansion chamber, as a result of which the expansion range of the fluid is enlarged and the effectiveness of cooling can be improved. Due to the funnel-like taper and the provided step sections, the acceleration of the fluid in the direction toward the expansion chamber—viewed over the course of the sequence—occurs in steps, thereby making possible a reduction of pressure surges and turbulences in the fluid. As a result of this, the range of expansion of the gas in the pressure chamber is enlarged.
During the transition from the mouth opening of the capillary section into the expansion chamber, the flow cross-section for the fluid preferably surges. This promotes a strong formation of the Joule-Thomson effect on the expanding fluid. In addition, a section of the expansion chamber may be available as part of the return system.
The feed line is preferably arranged in the return line, and/or the return line is arranged, for example, next to the feed line. The particularly preferred ratio of the flow cross-section in the return line next to the capillary line section and/or around the capillary line section with respect to the inside cross-section of the capillary line section is greater than or equal to 5.
Preferably, the feed line is configured in such a manner that the outside cross-section (outside cross-sectional area) of the feed line does not decrease abruptly at the funnel-shaped transition sections from the outside cross-section of a step section to the outside cross-section of the step section adjacent to the same transition section but, preferably, decreases continuously or step-by-step or, in at least one subsection of the section of the feed line whose outside cross-section tapers, step-by-step and, in another subsection of the section, continuously in the direction toward the mouth of the capillary line section. Viewed in the direction of flow of the gas flowing away from the expansion chamber following expansion, the outside cross-section of the feed line preferably, accordingly does not increase abruptly but, preferably, continuously and/or step-by-step. If the wall of the feed line, at the same time, forms a wall of the return system, in particular a return line, the return of the gas from the expansion region through the space provided by the outside cross-section reduction can be improved. Different from an abrupt decrease of the outside cross-section of the feed line in the direction toward the mouth, the outside diameter of the flow cross-section for the gas that flows back is not changed abruptly; it is, for example, tapered. As a result of this, the flow resistance of the return system, in particular a return line may be decreased.
The instrument may be configured in such a manner that the flow cross-section of the return line in the direction of flow of the gas during the return away from the expansion chamber decrease, in the transition sections, continuously or step-by-step or, in the transition sections in at least one length section, continuously and, in at least one other length section, step-by-step.
Preferably, at least the section of the feed line having the capillary line section and the transition section adjacent to the capillary line section is configured without seams. This simplifies a reliable process of manufacturing the instrument in order to avoid problems and abrupt changes of the flow cross-section of the feed line up to its mouth. Particularly preferably, at least the section of the feedback line having the capillary line section and the funnel-shaped transition section is configured in one piece without seam, so that a reliable process of producing the transition sections and the capillary line section is simplified.
Overall, the feed line may be manufactured using a rotary swaging process. Preferably, at least the section of the feed line having the capillary line section and the transition section adjacent to the capillary line section are produced by means of a rotary swaging process. Particularly preferably, at least the section of the feed line with the capillary line section and the funnel-shaped transition sections is produced by means of the rotary swaging process. By using the rotary swaging process, it is possible to reliably achieve a high quality with low surface roughness and lower surface waviness of the inside surface of the feed line that determines the flow cross-section.
The wall thickness of the capillary line section may be equal to or less than the wall thickness of the feed line section that is adjacent to the transition section upstream toward the capillary line section. This facilitates the provision of a large space next to the capillary line section or around the capillary line section for the return of the gas from the expansion zone. In addition, the heat transfer between the gas returned next to or around the capillary line section and the gas supplied through the capillary line section can be increased.
The ratio of the inside diameter of the capillary line section with respect to the length of the capillary line section is preferably between 0.004 at minimum to 0.2 at maximum.
Preferably, the mouth opening of the capillary line section through which the fluid exits from the feed line and enters into the expansion chamber is located on the front side of the capillary line section. Preferably, the jacket of the capillary line section that encloses the lumen of the capillary line section and that conveys the fluid is free of lateral openings.
The distance between the mouth opening and the opposing wall surface of the expansion chamber, said wall delimiting the lumen of the expansion chamber, is preferably between 0.5 mm at minimum and 5 mm at maximum.
Further advantageous features of the cryosurgical instrument according to the invention can be inferred from the dependent claims, as well as from the description hereinafter and the figures. They show in
The capillary line section 21 forms the n-th step section 30n of a series of at least n=2, preferably n>2, for example, and as shown in
It is advantageous when the flow cross-section in the transition section(s) 32n−2, 32n−1 of the feed line 15 does not decrease abruptly from the flow cross-section in the step section 30n−2 or 30n−1 of the feed line 15, said step section being arranged in front of the transition section 32n−2 or 32n−1 and being adjacent to the transition section 32n-2 or 32n−1, toward the flow cross-section in the step section 30n−1 or 30n of the feed line 15, said section being adjacent to the transition section 32n−2 or 32n−1 in the flow path in the transition section(s) 32n−2, 32n−1, but when the flow path in the transition section(s) 32n−2, 32n−1 tapers beyond a path section of the flow path toward the mouth 22. It is this that reduces any eddying of the fluid and the pressure fluctuations of the fluid in the step section 30n−1, 30n of the feed line 15 following the transition section 32n−2 or 32n−1.
The tapering angle 37 of the inside cross-section 33 in the transition section 32n−1 toward the capillary tube section 21, 30n is preferably 15° at minimum to 40° at maximum. The tapering angle 37 is determined by the inside wall surface 35 of the transition section 32n−1 that laterally delimits the flow cross-section through the transition section 32n−1. The inside wall surface 35 of the transition sections 32n−2, 32n−1—viewed in longitudinal section through the feed line 15 along the direction of flow 34—is preferably arranged inclined with respect to the direction of flow 34. The inside wall surface 35 may be, for example, the lateral surface of a truncated cone or a truncated pyramid. The transition section 32n−2 toward the next to last step section 30n−1 and/or the transition section 32n−1 toward the capillary line section 21 may be symmetrical relative to a plane parallel to the direction of flow 34. The centers of the flow cross-sectional areas in the transition section 32n−2 toward the next to last step section 30n−1 and/or the centers of the flow cross-sectional areas in the transition section 32n−2 in the transition section 32n−1 on the capillary line section 21 can be located—as in a symmetrical funnel—on a straight line that extends perpendicularly to the flow cross-sectional area in the inlet in the respective transition section 32n−1, 32n−2. As an alternative to a symmetrical funnel-shaped tapering of the flow cross-section in one or more transition sections 32n−2, 32n−1, the flow cross-section of the transition section 32n−2 may taper toward the next to last step section 30n−1 and/or the transition section 32n−1 toward the last step section 30n, for example as in an asymmetrical funnel.
The step sections 30n−2, 30n−1, 30n define the inside cross-sectional steps. In a step section 30n−2, 30n−1, 30n, the inside cross-sections belong to an inside cross-sectional step. Inside each step section 30n−2, 30n−1, 30n the inside cross-section of the feed line 15 remains within a specific size range (step). Within a step section 30n−1, 30n, the flow cross-section may be constant, for example. The inside cross-sections in the size range of a step section 30n−2, 30n−1 are greater than the inside cross-sections in the size range of the respectively downstream (toward the mouth) step section 30n. The feed line 15 displays, accordingly, not a surge-like stepped progression of the inside cross-section between the steps in the transition sections 32n−2m 32n−1, but, preferably displays a continuous or step-by-step transition of the flow cross-section to the next step. It is also possible that the flow cross-section tapers step-by-step in at least in one transition section 32n−2, 32n−1 in at least one first longitudinal section of the transition section 32n−2, 32n−1 and continuously in at least one other longitudinal section of the transition section 32n−2, 32n−1 that is located upstream or downstream of the first longitudinal section, so that the flow cross-section in the transition section 32n−2, 32n−1 overall tapers continuously and step-by-step toward the next step. In particular, the feed line 15 may be configured in such a manner that the inside cross-section of the feed line 15 decreases monotonously from the start of the series of step sections 30n−2, 30n−1, 30n in the direction of flow 34 up to the mouth 22 of the feed line 15. This means that the inside cross-section decreases—at least in some sections—strictly monotonously and may optionally remain the same in some sections.
In one embodiment, the inside wall surface 35 of the feed line 15 in the transition section 30n−1 toward the capillary line section 21, into the capillary line section 21 up to the mouth of the feed line 15, may be free of edges or bends oriented transversely with respect to the direction of flow 34 through the feed line 15, said edges or bends potentially meaning an abrupt change of the gradient of the flow cross-section of the feed line 15.
Next to the feed line 15 and/or around the feed line 15, there is preferably formed the flow cross-section of the return line 19. In the depicted exemplary embodiment, the feed line 15 is arranged, at least in some sections, in the return line 19. The flow cross-section of the return line 19 is delimited, on the one hand, by the wall 38a of the shaft as well as the wall 38b of the head 12, and on the other hand, by the wall 39 of the feed line 15. In
Preferably, the outside cross-section 40 of the feed line 15 in the transition sections 32n−2, 32n−1, as illustrated, does not decrease abruptly in the direction 34 toward the mouth 22 but, preferably, continuously or step-by-step. In at least one transition section 32n−2, 32n−1 the outside cross-section of the feed line 15 may decrease continuously in longitudinal sections and step-by-step in longitudinal sections—in the direction toward the mouth 22. As a result of this, the flow cross-section 41 of the return line 19—as shown by the exemplary embodiment according to
Preferably, the step sections 30n−2, 30n−1, 30n determine the outside cross-section steps. In one step section 30n−2, 30n−1, 30n the outside cross-sections (outside cross-sectional areas) of the feed line 15 belong to one outside cross-section step. Within each step section, the outside cross-section of the feed line remains within a specific size range (step). Along one step section 30n−2, 30n−1, 30n the outside cross-sections of the step section 30n−2, 30n−1, 30n, may be constant, for example. The outside cross-sections in the size range of one step section 30n−2, 30n−1 are greater than the outside cross-sections in the size range of the respectively downstream (toward the mouth) following step section 30n−1, 30n. Accordingly, the feed line 15 shows preferably a stepped progression of the outside cross-section displaying—between the steps in the transition sections 32n−2, 32n−1—a non-abrupt transition of the outside cross-section toward the next step. Rather, the transition extends preferably over the length of the transition section 32n−2, 32n−1 and/or the transition of the outside cross-section toward the next step is preferably continuous, or occurs—viewed from the flowing fluid—step-by-step. The outside cross-section of the feed line 15 between the transition sections 32n−2, 32n−1 shown by
As can be seen with reference to
The ratio of the area content of the flow cross-section of the return line 19 next to the capillary line section 21 and/or around the capillary line section 21 with respect to the area content of the flow cross-section of the capillary line section 21 is preferably greater than or equal to 5. The inside diameter 28 (for purposes of clarity, drawn in an exemplary manner in
The section of the feed line 15 having the transition sections 32n−2, 32n−1, the step section 30n−1 between the transition sections 32n−2, 32n−1 and the capillary line section 21, 30n is preferably formed without seams in one piece. For example, the section can be made by using the rotary swaging process. The cap 24 of the shaft forming the head 12 having the adhesion surface 14 may consist of stainless steel, for example. For example, the shaft 11 may consist of PEEK, PA, PUR or PTFE. The shaft 11 may be rigid or flexible.
During operation of the cryosurgical instrument 10, the following takes place:
With the use of a fluid source (not illustrated) connected to the feed line 15, the feed line 15 is loaded with a fluid, in particular gas, for example N2O or CO2, in which case the fluid flows on the distal working end 43 of the cryosurgical instrument 10 from a tube-shaped step section 30n−2, 30n−1, 30n through the adjacent transition section 32n−2, 32n−1 in the direction of the mouth 22 and the expansion chamber 18 into the subsequent tube-shaped step section 30n−2, 30n−1, 30n. Due to the funnel-like decrease of the inside cross-section 33 and thus the flow cross-section of the feed line 15 in the transition sections 32n−2, 32n−1 in the direction of the expansion chamber 18, the fluid is accelerated in the transition sections 32n−2, 32n−1. Due to the reduction that is not abrupt in the transition sections but—extending over a certain length—preferably continuous or step by step of the flow cross-section 33 from step to step, eddying and/or pressure fluctuations in the step section 32n−2, 32n−1 due to accelerations in each transition section 32n−2, 32n−1 are largely prevented. Preferably, the step sections 30n−2, 30n−1, 30n each have one length, so that eddies and/or pressure fluctuations in step the section 30n−2, 30n−1, 30n following the transition section 32n−2, 32n−1 abate largely or completely. The gas flows from the (n−1)st step section through the (n−1)st transition section into the capillary tube section 21 (nth step section). Potential pressure fluctuations in the gas due to the transition from the (n−1)st step section to the capillary tube section 21 preferably abate completely due to the formation of the capillary tube section 21. In the capillary tube section 21, there results a laminar flow in the direction of flow 34 toward the mouth 22 exhibiting the corresponding velocity profile that—due to the abating of the pressure fluctuations in the capillary tube section 21 in the distal end section of the capillary tube section 21 adjacent to the mouth opening 22 preferably does no longer change in the direction of flow 34 (undisturbed flow profile). The capillary tube section 21 forms the aperture for the gas for the formation of the Joule-Thomson effect. Therefore, an aperture 16—as in prior art according to
Accordingly, the backflow of the cooled gas is not impeded by the out-flowing gas. The expanded gas from the expansion chamber rather preferably flows parallel to the fluid leaving the feed line 21 through the mouth opening 22 into the expansion chamber 18 in the opposite sense of flow direction out of the expansion chamber 18 into the return line 19. This large-volume back flow is illustrated by arrows in
The backflowing gas may escape through lateral openings (not shown) in the shaft 11, for example.
The feed line 15 and the return line 19 are formed next to each other in the shaft 11 of the instrument 10. The capillary tube section 21 of the feed line 15 is inserted in the section of the feed line 15 provided in the shaft 11. The capillary tube section 21 reaches into the cap 24 of the instrument 10, said cap enclosing the expansion chamber 18.
The feed line 15 has at least three step sections 30n−2, 30n−1, 30n, wherein the last step section 30n is formed by the capillary tube section 21. At least in the transition section 32n−2 on the next to last step section 30n−1, the inside cross-section of the feed line 15 decreases in a funnel-shaped manner in the direction toward the mouth 22 in the expansion chamber 18 in the shape of a funnel.
The flow cross-section of the return line 19 connected to the expansion chamber 18 in the shaft 11 decreases in the transition sections 19m−2, 19m−1 of the return line 19 in the form of a funnel. Between the transition sections 19m−2, 19m−1 of the return line 19, the flow cross-section in the return line 19 is preferably largely constant. The number of transition sections 19m−2, 19m−1 of the return line 19 may correspond to the number of transition sections 32n−3, 32n−2, 32n−1 in the feed line 15.
Disclosed herein is a cryosurgical instrument 10 that comprises a feed line 15 for conveying fluid into an expansion chamber 18 of the instrument 10. The feed line 15 has a capillary line section 21 that terminates in the expansion chamber 18 and that forms an aperture for the fluid to form the Joule-Thomson effect during the expansion of the fluid in the expansion chamber 18. The flow cross-section of the feed line 15 decreases in at least one transition section 32n−2, 32n−1, preferably in two or more transition sections 32n−2, 32n−1, of the feed line 15 in the form of a funnel in the direction of flow 34 toward the expansion chamber 18. Following each transition section 32n−2, 32n−1—viewed in the direction of flow 34—there preferably follows, adjacent to the transition section 32n−2, 32n−1, a step section 30n−1, 30n of the feed line 15, in which latter section the flow cross-section is preferably largely constant. The last step section 30n−1, 30n is preferably formed by the capillary line section 21. Pressure fluctuations in the fluid can abate in the step sections 30n−1, 30n. Due to the acceleration of the fluid in the transition sections 32n−2, 32n−1 and due to the abating of pressure fluctuations in the capillary tube section 21 and, optionally in the additional step sections 30n−1, 30n−2, the expansion range in the expansion chamber 18 is increased, without impeding the backflow of the expanded gas out of the expansion chamber 18.
Due to the use of the capillary tube section 21, as well as the funnel-shaped transition section(s) 30n−2, 30n−1, the free path length of the fluid jet is greatly increased without widening the fluid jet in the instrument 10 according to the invention compared to a cryosurgical instrument having an aperture at the end of the feedback line 15, so that the interaction between the fluid flowing from the mouth opening 22 away into the expansion chamber 18 and the gas flowing back from the expansion chamber 18 can be greatly reduced. Preferably, the pressure fluctuations and/or eddies of the fluid flowing through the feed line 15 in the direction toward the mouth 22 abate in one embodiment of the instrument 10 according to the invention in the capillary tube section 21 to such an extent that they no longer define the free path length of the fluid jet without widening in the expansion chamber 18. The free path length of the fluid jet without widening is measured from the mouth opening 22 in the direction of flow 34 of the fluid up to the point in the expansion chamber 18 at which the fluid jet diameter exceeds a size that is equal to the size of the outside diameter of the capillary line section 21 at the mouth opening 22, or the free path length of the fluid jet without widening is measured from the mouth opening 22 in the direction of flow 34 of the fluid up to the point in the expansion chamber 18 at the level (in flow direction 34) where an interaction of the fluid jet flowing away from the mouth opening 22 into the expansion chamber 18 with the gas flowing back to the feedback line 19 sets in.
| Number | Date | Country | Kind |
|---|---|---|---|
| 17184993.8 | Aug 2017 | EP | regional |
This application is a continuation of U.S. application Ser. No. 16/051,902, filed Aug. 1, 2018, which claims the benefit of European Patent Application No. 17184993.8, filed Aug. 4, 2017, the contents of each application being incorporated herein by reference as if fully rewritten herein.
| Number | Date | Country | |
|---|---|---|---|
| Parent | 16051902 | Aug 2018 | US |
| Child | 18157235 | US |
