Tumors, such as brain tumors, may be treated by heat (also referred to as hyperthermia or thermal therapy). In particular, it is known that above 57.degree. C. all living tissue is almost immediately and irreparably damaged and killed through a process called coagulation necrosis or ablation. Malignant tumors, because of their high vascularization and altered DNA, are more susceptible to heat-induced damage than normal tissue. Various types of energy sources may be used, such as laser, microwave, radiofrequency, electric, and ultrasound sources. Depending upon the application and the technology, the heat source may be extracorporeal (i.e., outside the body), extrastitial (i.e., outside the tumor), or interstitial (i.e., inside the tumor). One example treatment of a tissue includes interstitial thermal therapy (ITT), which is a process designed to heat and destroy a tumor from within the tumor itself. In this type of therapy, energy may be applied directly to the tumor rather than passing through surrounding normal tissue, and energy deposition can be more likely to be extended throughout the entire tumor.
Further, tumors and other abnormal cellular masses may be treated using a cryosurgical or cryotherapy technique where extreme cold conditions are applied to damage or destroy tissue. In one example, a coolant, such as liquid nitrogen or liquid argon, may be circulated within a probe device (cryoprobe) while in contact with tumorous tissue to freeze tissue within the vicinity of the cryoprobe.
In one aspect, the present disclosure relates to a variable length probe apparatus having a variable length probe structure including a probe and an adjustable depth stop to facilitate access to both shallow and deep targeted tissue areas. The variable length probe apparatus may be configured to accommodate lesions located at varying depths by repositioning over the adjustable depth stop. The probe portion, in some embodiments, is connected to an umbilical sheath for carrying inputs and outputs (e.g., energy, control signals, cooling gas or fluid, and/or heating gas or fluid) between the probe and a control unit. A transitional part configured for ease of grasping and manipulation of the probe may be disposed at the junction of the probe and the flexible umbilical sheath. The adjustable depth stop may be configured to connect to or otherwise rest upon a probe follower for remote rotational and/or linear positioning of the variable length probe apparatus.
In one aspect, the present disclosure relates to temperature modulation probes configured for modulated application of thermal therapy and cryotherapy using at least one thermal therapy-generating element as well as at least one cryotherapy-generating element disposed within the temperature modulation probe. In use, the temperature modulation probe supplies a modulated temperature output pattern to a target tissue, varying between at least one warmer temperature applied at least in part by the thermal therapy-generating element and at least one colder temperature applied at least in part by the cryotherapy-generating element.
In one aspect, the present disclosure relates to methods for supplying temperature modulation therapy to a tissue using a temperature modulation probe. The method may include identifying a modulation pattern, monitoring temperature(s) of the target tissue, and, where needed, adjusting the modulation pattern in real time to effect a desired temperature or temperature profile goal. The method may include continuously supplying therapy to a tissue while automatically adjusting a probe position in a rotational and/or linear direction.
In one aspect, the present disclosure relates to focal laser probes including a shortened lens region for focusing the laser and reducing manufacturing costs. A focal laser probe may be designed, for example, by exposing only a forward directed tip of the laser fiber and shortening the capsule portion of the respective probe to avoid stray energy transmission, for example due to internal reflections. Focal laser probes may be used for providing focal thermal therapy through at least one of ablation, coagulation, cavitation, vaporization, necrosis, carbonization, and reversible thermal cellular damage. The focal emission supplied by focal laser probes provides precision to protect surrounding tissues during thermal therapy, while resulting in minimal edema which encourages immediate therapeutic benefit.
In one aspect, the present disclosure relates to cryogenic therapy probes configured for interstitial cryoablation of a tissue. Cryogenic therapy probes can include internal thermal monitoring and real time adjustment of pressure, flow, and/or temperature delivery parameters for adjusting an emission temperature and/or emission pattern. Cryogenic therapy probes may employ Joule-Thomson cooling. An aperture of a fluid delivery tube may be designed for different directional deployment depending upon a desired use for a particular cryogenic therapy probe, such as a side-firing cryogenic therapy probe or a focal cryogenic therapy probe. In some embodiments, an adjustable aperture may be mechanically or electrically adjusted to control flow rate, pressure, and/or deployment patterns (e.g., ranging from focal to diffuse).
In one aspect, the present disclosure relates to probes, probe sheaths, and probe sleeves incorporating one or more recording elements. A recording element may include an electrocardiography (ECG) wire and/or an electroencephalography (EEG) wire. A recording element may be used for lesion localization and assessment at the time of cryotherapy, thermal therapy, or temperature modulation therapy. A recording element may be used to provide positioning and monitoring during functional neurosurgery. In the example of epileptic symptoms, the recording element may be used to confirm positioning of therapeutic energy for treatment of seizure activity. A recording element may be used to confirm disruption of the blood-brain barrier. A recording element may be used for monitoring biorhythms while performing an operation or other therapy. A recording element may be used to apply local tissue stimulation responsive to detection of an abnormal event to regulate cellular behaviors during treatment. A recording element may be used to effect deep brain stimulation during a neurosurgical operation.
In one aspect, the present disclosure relates to recording instruments incorporating one or more recording elements for monitoring internal electrical signals and identifying abnormalities. The recording instruments, for example, may be designed for in vivo deployment for hours or days while monitoring and analyzing signals such as deep brain signals. For signal analysis, leads disposed between recording element contact surfaces and along a shaft of the recording instrument may deliver recorded signals from the contact surfaces to a controller external to the patient for analysis. In one example, a recording instrument includes a cooling tube for delivery of cooling gas or fluid to a cooling zone region of the recording instrument. Further to this example, a temperature sensor such as a thermocouple may be disposed within or adjacent to the cooling zone region of the recording instrument for monitoring a temperature of the recording instrument. The temperature sensor, in a particular example, may provide temperature data to a thermal readout external to the patient. In an additional particular example, the temperature sensor may provide temperature data to a controller external to the patient for controlling cooling gas or fluid delivery to the cooling zone region.
In one aspect, the present disclosure relates to reduced profile probe designs. Reducing the profile of a probe is desirable for achieving minimally invasive surgery, performing surgical operations upon small bodies such as infants, juveniles and animals, and reaching otherwise difficult-to-reach in situ locations without negatively impacting surrounding tissues. A reduced profile probe, for example, can allow entry into small and narrow spaces in the brain while reducing patient injury. A low profile probe may include multiple internal lumens. Low profile probes may be configured with selected materials, lumen structures, and layer structures to provide desired and/or selected mechanical properties including straightness, rigidity, torque strength, column strength, tensile strength, kink resistance, and thermal properties such as thermal stability and thermal stress capacity. Low profile probe dimensions may vary, in some examples, based upon the style of the low profile probe (e.g., thermal therapy, cryotherapy, temperature modulation therapy), the anticipated probe deployment (e.g., intracranial, spinal, cardiac, etc.), the required thermal tolerances of the low profile probe, and/or the required structural tolerances of the probe (e.g., flexible vs. rigid). The following are examples of low profile probe dimensions: the inner shaft of a low profile probe may have an outer diameter of 2.0 mm, within a tolerance of 0.03 mm and an inner diameter of 1.5 mm, within a tolerance of 0.03 mm; the outer shaft may have an outer diameter of 2.25 mm, within a tolerance of 0.03 mm and an inner diameter of 2.07 mm, within a tolerance of 0.03 mm; the shaft may have an outer diameter of approximately 2.1 mm, approximately 2.2 mm, or less than approximately 3.2 mm. In additional examples, the shaft of various low profile probe designs may have an outer diameter of approximately 1.0 mm or approximately 1.2 mm.
With any of the apparatus described within, it may be understood that materials used for manufacture may be selected, in some embodiments, for compatibility with thermal imaging systems, such as Magnetic Resonance Imaging. Thermal imaging-compatible materials, in some examples, may include polymeric material such as nylon, ethylene-tetrafluoroethylene, polyamines, polyimides, and other plastics, quartz, sapphire, crystal structures, and/or glass-type structures. Additionally, small amounts of thermal-imaging tolerant (non-ferromagnetic) metal materials such as titanium and titanium alloys may be included, for example in various connectors for stabilizing positioning of neurosurgical instruments relative to introduction equipment. In further embodiments, material selection may be based in part upon compatibility with various imaging or neurosurgical treatment modalities such as, in some examples, radiofrequency (RF), high-intensity focused ultrasound (HiFU), microwave, and/or cryogenic energy.
In some embodiments, the present disclosure describes a system for deploying at least one signal recording electrode proximate a tissue during interstitial therapy to the tissue, the system including: an interstitial therapy instrument including a tip region and a shaft region, where the interstitial therapy instrument includes at least one therapy generating element, where the at least one therapy generating element includes one of a) a thermal therapy-generating element for thermal therapy emission via the tip region and b) a cryotherapy-generating element for cryogenic therapy emission via the tip region; and at least one signal recording element configured for deployment proximate to the tip region, where the at least one signal recording element includes one of an electrocardiography recording element, an electroencephalography recording element, and a stereo electroencephalography recording element.
In some embodiments, the system includes a controller including processing circuitry and a memory having instructions stored thereon, where the instructions, when executed by the processing circuitry, cause the processing circuitry to, while the interstitial therapy instrument is positioned proximate a tissue, receive signal recordings from the at least one signal recording element, analyze the signal recordings to identify an abnormal signal pattern, and responsive to identifying the abnormal signal pattern, cause at least one of i) adjustment of an emissive output of a first therapy generating element of the at least one therapy generating element, ii) adjustment of a therapeutic profile for delivering therapy to the tissue via the interstitial therapy instrument, iii) adjustment of a linear position of the interstitial probe, iv) adjustment of a rotational position of the interstitial therapy instrument, and v) output of at least one of visual information and audible information regarding the abnormal signal pattern for the attention of an operator. The instructions may cause the processing circuitry to, prior to receiving the signal recordings, cause extension of at least a first signal recording element of the at least one signal recording element along the tip region of the interstitial therapy instrument. The first signal recording element may be extended from the shaft portion of the interstitial therapy instrument. The instructions may cause the processing circuitry to, after receiving the signal recordings and prior to adjusting the emissive output of the first therapy generating element, cause retraction of the first signal recording element such that the first signal recording element will not interfere with the first therapy generating element. Identifying the abnormal signal pattern may include identifying a signal pattern associated with a lesion. The instructions may cause the processing circuitry to, before receiving the signal recordings, cause emission of the cryotherapy-generating element directed to the tissue; receive initial signal recordings from the at least one signal recording element, analyze the initial signal recordings to identify a hibernation pattern; and cause cessation of emission of the cryotherapy-generating element; where the signal recordings are captured while the tissue is warming.
In some embodiments, the system includes a flexible sleeve, where the flexible sleeve surrounds the interstitial therapy instrument and includes the at least one signal recording element. The system may include a guide sheath including a number of lumens, where the interstitial probe is disposed within a first lumen of the number of lumens and a first signal recording element of the at least one signal recording element is disposed within a second lumen of the number of lumens.
In some embodiments, the at least one signal recording element includes at least three signal recording elements. The at least three signal recording elements may be provided as rings surrounding a circumference of the interstitial therapy instrument. The rings may be formed along the shaft region of the interstitial therapy instrument.
In some embodiments, the present disclosure describes a focal laser induced interstitial thermal therapy probe for treatment of a tissue, including: a transparent lens capsule; a laser fiber including a sheath portion and an exposed tip, where the exposed tip is disposed within the transparent lens capsule; a shaft portion fixed to the transparent lens capsule, where the laser fiber extends along the shaft portion; and a cooling supply tube disposed within the shaft portion for delivering at least one of a cooling fluid and a cooling gas to the transparent lens capsule; where the exposed tip is configured to direct focal energy through a tip portion of the transparent lens capsule in a forward direction, and the length of the transparent lens capsule is configured to minimize energy transmissions outside of the forward direction. The tip portion of the transparent lens capsule may be substantially flat in shape. The exposed tip may be substantially flat in shape.
In some embodiments, the present disclosure describes a system for providing interstitial cryotherapy to a tissue, the system including: an interstitial cryogenic probe, including a shaft region and a tip region, where a distal end of the tip region is affixed to a proximal end of the shaft region. The system may include an injection tube disposed within the shaft region for delivering a refrigerant to the tip region, and a temperature sensor disposed within the shaft region. The system may include a controller including processing circuitry and a non-transitory computer readable medium having instructions stored thereon for controlling emission of the interstitial cryogenic probe, where the instructions, when executed by the processing circuitry, cause the processing circuitry to, during cryotherapy of the tissue, receive temperature signals from the temperature sensor, and responsive to the temperature signals, adjust at least one of a pressure, a flow rate, and a temperature of refrigerant delivered to the injection tube. The temperature sensor may be a thermocouple. The injection tube and tip region may be configured for Joule-Thomson cooling. The interstitial cryogenic probe may include a vacuum return lumen to direct evaporated refrigerant towards the shaft region of the interstitial cryogenic probe. An orifice of the injection tube may be configured for side-firing emission of refrigerant. The interstitial cryogenic probe may include a porous plug at an orifice of the injection tube. Adjusting the flow rate may include modulating the flow of refrigerant in an on-off pattern.
In some embodiments, the present disclosure describes an interstitial probe for performing temperature modulation therapy to a tissue, the interstitial probe including: a shaft region; a tip region; at least one thermal therapy-generating element for thermal therapy emission via the tip region; at least one cryotherapy-generating element for cryogenic therapy emission via the tip region; processing circuitry disposed within the shaft region; and a memory disposed within the shaft region, the memory having instructions stored thereon for causing emission of a number of thermal modulation patterns, where each thermal modulation pattern of the number of thermal modulation patterns includes at least one higher thermal output corresponding to activation of a first thermal therapy element of the at least the thermal therapy-generating element for a first time interval, and at least one lower thermal output corresponding to activation of a first cryogenic therapy element of the at least one cryogenic therapy element for a second time interval different than the first time interval. The instructions, when executed by the processing circuitry, may cause the processing circuitry to receive selection of a first thermal modulation pattern of the number of thermal modulation patterns, and activate temperature modulation therapy utilizing the modulation pattern. The memory may include a programmable memory element, the interstitial probe further including at least one communication connection for programming the programmable memory element with one or more additional thermal modulation patterns.
In some embodiments, the present disclosure describes a low profile interstitial probe for effecting at least one of thermal therapy and cryotherapy to a tissue, the low profile interstitial probe including a shaft, including at least one outer layer and at least one inner layer, where an outermost layer of the at least one outer layer has a first set of mechanical properties including at least two of the following: straightness, rigidity, torque strength, column strength, tensile strength, kink resistance, thermal stability, and thermal stress capacity, and an approximate outer diameter of less than 3.2 mm, and an innermost layer of the at least one inner layer has a second set of mechanical properties including at least two of the following: straightness, rigidity, torque strength, column strength, tensile strength, kink resistance, thermal stability, and thermal stress capacity, and an approximate maximum inner diameter of at least 1.5 mm; The low profile interstitial probe may include a transparent lens capsule through which energy is delivered to the tissue during treatment, where a distal end of the transparent lens capsule is connected to a proximal end of the shaft region; and an energy emission element may be disposed at least in part within the transparent lens.
The low profile interstitial probe may include a number of lumens formed within the innermost layer, where the maximum inner diameter corresponds to a widest diameter measurable between two or more adjacent lumens. A first lumen of the number of lumens may be configured to carry an energy emission medium to the energy emission element; and a second lumen of the number of lumens may be configured to deliver cooling gas to the transparent lens capsule.
The outermost layer may be configured to act a protective barrier in case of breakage of a layer of the shaft directly abutting an inner surface of the outermost layer. The outermost layer may be a thin-walled polyether ether keretone (PEEK) plastic; and the outermost layer may partially overlap the transparent lens capsule. The outermost layer may be linearly aligned with the remaining layers of the at least one outer layer and the at least one inner layer to provide a counterbore region, where a distal portion of the transparent lens capsule is permanently affixed to the counterbore region. The transparent lens capsule may be composed of machined sapphire.
The foregoing general description of the illustrative implementations and the following detailed description thereof are merely exemplary aspects of the teachings of this disclosure, and are not restrictive.
A more complete appreciation of this disclosure and many of the attendant features thereof will be readily obtained as the same becomes better understood by reference to the following detailed description when considered in connection with the accompanying drawings, wherein:
In the drawings, like reference numerals designate identical or corresponding parts throughout the several views. Further, as used herein, the words “a,” “an” and the like generally carry a meaning of “one or more,” unless stated otherwise.
Further, in individual drawings figures, the components/features shown are drawn to scale to exemplify a particular implementation. For some drawings, components/features are drawn to scale across separate drawing figures. However, for other drawings, components/features are shown magnified with respect to one or more other drawings.
Measurements and ranges described herein relate to exemplary implementations and can identify a value or values within a range of 1%, 2%, 3%, 4%, 5%, or, preferably, 1.5% of the specified value(s) in some implementations.
Further probes can include temperature modulation probes including at least one thermal therapy-generating element (e.g., RF, HiFu, microwave, laser, electrical heat, heating fluid or supercritical fluid, heating gas, etc.) and at least one cryotherapy-generating element (e.g., cooling gas, cooling fluid, etc.). Each of the at least one thermal therapy-generating element and the at least one cryotherapy-generating element may be configured to emit respective thermal or cryo energy in a side-firing, focal, or diffuse manner. In a particular example, a temperature modulation probe includes a circumferentially emitting thermal therapy-generating element and a circumferentially emitting cryotherapy-generating element.
The temperature modulation probes of the present disclosure may be designed for insertion into a body cavity, insertion into vascular system, or interstitial deployment.
Treatments in accordance with the descriptions provided in this disclosure include treatments that ablate a tissue to destroy, inhibit and/or stop one or more or all biological functions of the tissue. Ablation agents include, but are not limited to, laser, RF, HiFu, microwave, cryogenic, PDT and drug or chemical release. A corresponding probe and/or another instrument, such as a needle, fiber or intravenous line can be utilized to effect treatment by one or more of these ablation agents. Treatments in accordance with the descriptions provided in this disclosure include treatments that create temporary or permanent physical-biological effects to tissue including freezing freeze-thawing, hyperthermia, coagulation, and/or vaporization of tissues. The temporary or permanent physical-biological effects can include alterations in biological function of cells, tissues, and/or body fluids. In a particular example, the treatment may cause the cells, tissues, and/or body fluids to be more receptive or sensitive to additional therapies or manipulations such as, in some examples, radiation therapy or chemotherapy. In a further example, the treatment may cause hemostasis, reduction or dissolution of thrombi or emboli, alteration of functional membranes including the blood-brain barrier, and/or renal filtration. The physical-biological effects may be caused directly by temperature change to the cells, tissues, and/or body fluids or indirectly (e.g., downstream) from the temperature change, such as alterations in heat shock proteins or immune reaction or status.
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An energy output pattern of a temperature modulation probe includes a modulated output pattern, varying between at least one warmer temperature applied at least in part by one or more thermal therapy-generating elements and at least one cooler temperature applied at least in part by one or more cryotherapy-generating elements. In certain embodiments, a particular energy output pattern may be developed based upon the type of thermal therapy-generating elements and cryotherapy-generating element included within the probe, an emission style of the probe tip (e.g., side-firing, focal tip, diffuse tip, etc.), and/or the depth of the region of interest or the targeted tissue area (e.g., based in part on the shape of a tumor region, etc.).
An energy output pattern of a probe, such as a laser probe or HIFU probe, in certain embodiments, includes a pulsed output pattern. For example, a higher power density may be achieved without causing tissue scorching by pulsing a high power laser treatment for x seconds with y seconds break between (e.g., allowing for tissue in the immediate vicinity to cool down by only activating the cryotherapy-generating element). In a particular example, the energy output pattern of a probe may include a ten Watt output of the thermal therapy-generating element for two seconds while maintaining activation of the cryotherapy-generating element, followed by a one second period of inactivity of the thermal therapy-generating element while maintaining activation of the cryotherapy-generating element. Conversely, the thermal therapy-producing element may remain activated, in some pulsed output patterns, while modulating activation of the cryotherapy-generating element.
An energy output pattern of a probe, in certain embodiments, includes a refined temperature modulated pattern, where both the thermal therapy-generating element(s) and the cryotherapy-generating element(s) is/are constantly activated, while power levels, emission levels, flow rates, and/or energy levels are varied between the elements to cycle between cooler and warmer output.
In certain embodiments, a particular energy output pattern may be developed based upon the type of probe (e.g., laser, HIFU, etc.), an emission style of the probe tip (e.g., side-firing, diffuse tip, etc.), and/or the depth of the ROI or the targeted tissue area (e.g., based in part on the shape of a tumor region, etc.).
In certain embodiments, a treatment pattern includes effecting treatment while concurrently or simultaneously moving the probe (e.g., linearly and/or rotationally). For example, a thermal therapy, cryotherapy, or temperature modulation probe may be automatically rotated (e.g., using a commander and follower as described in relation to
An example probe apparatus 100 is shown in
In an example embodiment of probe apparatus as discussed in relation to
As illustrated in
Instead or in addition to the printed gradations, in other embodiments, the shaft of the probe 112 may include a series of mating points for mating with the adjustable depth stop 114. For example, the shaft of the probe 112 may include a series of bumps (e.g., every 5 millimeters, 10 millimeters, etc.) and the adjustable depth stop 114 may include one or more mating depressions for engaging with at least one of the series of bumps. The mating points, for example, may be used to more precisely align the adjustable depth stop 114 with a particular depth setting.
Using the adjustable depth stop 114 with the guidance of the printed gradations upon the shaft of the probe 112, an operator may modify the probe length in situ. For example, during a patient operation, after applying a procedure at a first selected depth, an operator may vary the length or depth relatively rapidly to a second selected depth. To allow for varying the probe length of the probe 112 in-situ while controlling the internal deployment of the probe tip, the shaft of the probe 112 may be configured with a selected kink resistance value, in addition to column strength and/or torque strength and/or tensile strength and/or thermal stability.
In some embodiments, the probe apparatus 110 is compatible with a low profile trajectory guide (e.g., as described in U.S. patent application Ser. No. 14/661,194 entitled “Image-Guided Therapy of a Tissue” and filed Mar. 18, 2015 and U.S. patent application Ser. No. 14/661,212, entitled “Image-Guided Therapy of a Tissue” and filed Mar. 18, 2015, the contents of each of which is incorporated herein by reference in its entirety) and a minibolt (as described in U.S. Provisional Patent Application No. 62/132,970 entitled “Apparatus and Methods for Neurological Intervention” and filed Mar. 13, 2015, the contents of which is incorporated herein by reference in its entirety). The probe-side end of the adjustable depth stop 114, in some examples, may be designed to fit over and/or mate with a minibolt mounted to the skull of a patient or a probe driver (as described in U.S. patent application Ser. No. 14/659,488 filed Mar. 16, 2015, U.S. patent application Ser. No. 14/661,194 filed Mar. 18, 2015, and U.S. patent application Ser. No. 14/661,212 filed Mar. 18, 2015, each being entitled “Image-Guided Therapy of a Tissue,” the contents of each of which are incorporated herein by reference in their entireties). For example, the adjustable depth stop 114, as illustrated in the enlarged view of
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Twin snap style depth locking elements 1630a and 1630c of
To release the probe, for twin snap style depth locking elements 1630a and 1630b of
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In some embodiments, a shaft portion of the probe 112 including windings 132 (e.g., at least beginning at a point above the gradations and abutting or extending beyond the transitional part 120, if not continuing throughout the entirety of the shaft portion of the probe 112) may be composed of one or more materials selected at least in part for flexibility of the shaft portion such that the shaft portion may bend away from the skull. Probe shaft materials may include, in one example, polyimide for rigidity in a first shaft portion designed for interstitial deployment, and PTFE for flexibility in a second shaft portion interfacing with the windings 132. Additionally, the first shaft portion and/or the second shaft portion may be composed of multiple layers of material, such as polyimide under an etched layer of PTFE, to provide for better bonding characteristics at the interface between the first shaft portion and the second shaft portion.
The probe driver 200 can be mounted to an interface platform, such as the interface platform disclosed in U.S. Pat. No. 8,979,871 to Tyc, entitled “Image-Guided Therapy of a Tissue” and filed Mar. 15, 2013, incorporated by reference in its entirety. The position feedback plug 208, for example, can connect to the interface platform in order to communicate the probe's position to the system. The probe driver 200 is used to rotate or translate (extended or retract) the probe. The probe driver 200 in this illustrated implementation can provide, at a minimum, a translation of 20-80 mm, 30-70 mm, 40-60 mm or 40 mm, with a maximum translation of 60 mm, 80 mm, 100 mm, 120 mm or 60-150 mm. The probe driver 200 in this illustrated implementation can also provide, at a minimum, a rotation of 300.degree.-340.degree., with a maximum rotation of 350.degree., 359.degree., 360.degree., 540.degree., 720.degree. or angles therebetween. Included with the probe driver 200 can be a rotary test tool that can be used during a self-test procedure to simulate an attachment of a probe to the follower 206.
The umbilicals 204 may include sheathed wires that independently control rotational and longitudinal motion of a probe or other device held by the follower 206. Independent control of the rotational and longitudinal motion may be provided, for example, by rotating a respective one of the knobs or dials 210 provided at either side of the commander 202. An example structure for the corresponding mechanisms that provide the rotational and longitudinal motion is described and shown in U.S. Pat. No. 8,728,092, entitled “Stereotactic Drive System” and filed Aug. 13, 2009, the entirety of which is incorporated herein by reference.
In various implementations, the probe driver 200 provides full remote control to an operator that is located either: (1) in the proximity of the imaging apparatus and an interface platform that the probe driver is connected to, or (2) in a remote room, such as a control room, at a workstation, where the workstation sends positioning signals to the interface platform to actuate corresponding movements by the commander 202. Full remote control of the probe driver 200 is thus provided, which reduces procedure time.
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In an implementation illustrated in
Multiple different probes can be utilized and swapped into the follower 206 or follower 222 during treatment so as to provide different therapeutic patterns from different probes. For example, a symmetrical ablation probe can be used, followed by a side-fire (asymmetrical) ablation probe. A diffused tip probe can also be utilized.
A process of advancing probe, asymmetrically treating, measuring, advancing probe and repeating is provided, such that the process does not require the interruption of a user-intervention in the surgical room to change probes or probe position.
Further, in some implementations, the follower 222 includes a low profile design with a short stem to enable wider skull access and/or multiple concurrent probe trajectories.
As illustrated in
The locking sleeve 248 in some implementations, includes a poka-yoke design 250 such that the locking sleeve 248 naturally aligns with a thread opening 252 of the locking sleeve 248 with the hole 246 of the short stem 244.
The follower 222 with low profile design may be manufactured of thermal imaging compatible materials, such as MRI-compatible materials. Additionally, the locking sleeve 248 and/or thumb screw 254 may be manufactured of thermal imaging compatible materials. In some embodiments, at least a portion of the follower 222 may include imaging system-identifiable material such as a thermal imaging identifiable fiducial marker for use in identifying the location and/or orientation of the follower 222 through medical imaging. In a particular example, a fiducial marker 258, as illustrated in
As illustrated, the temperature modulation probe 300 includes a laser 302 with a side-firing tip 304 as a thermal-therapy generating element. The side-firing tip 304 may further include a side-firing diffuser capable of focal ablation with a lower power density. Examples of side-firing tips and various diffusing patterns for side-firing probes are described in U.S. Pat. No. 8,979,871 to Tyc, entitled “Image-Guided Therapy of a Tissue” and filed Mar. 15, 2013, incorporated by reference in its entirety.
Although the temperature modulation probe 300 is illustrated with the side-firing laser 302, in other embodiments, the temperature modulation probe 300 includes a forward firing probe tip, such as a probe tip 322 illustrated in relation to the laser probe 320 of
In further embodiments, rather than or in addition to the laser fiber 304, the temperature modulation probe 300 may include one or more ultrasound elements and/or ultrasonic transducers capable of focal or diffuse heating using HiFU. The ultrasonic beam of a HIFU probe can be geometrically focused (e.g., using a curved ultrasonic transducer or lens) or electronically focused (e.g., through adjustment of relative phases of the individual elements within an array of ultrasonic transducers). In an ultrasonic transducer array, the focused beam can be directed at particular locations, allowing treatment of multiple locations of a region of interest without mechanical manipulation of the probe. The depth of treatment can be controlled by adjusting the power and/or frequency of the one or more transducers of the HIFU probe. Example HiFU probes are described in U.S. patent application Ser. No. 14/661,170, entitled “Image-Guided Therapy of a Tissue” and filed Mar. 18, 2015, the contents of which are incorporated by reference herein in its entirety.
In additional embodiments, the temperature modulation probe 300 may include a microwave, RF, heating gas, heating fluid, or electrical heat thermal therapy-generating element in lieu of or in addition to the laser 302. A heating fluid thermal therapy-generating element, for example, may circulate a fluid such as helium or hydrogen. Each of the at least one thermal therapy-generating element may be configured to emit thermal energy in a side-firing, focal, or diffuse manner. In a particular example, a temperature modulation probe includes a circumferentially emitting thermal therapy-generating element. The temperature modulation probes of the present disclosure may be designed for insertion into a body cavity, insertion into vascular system, or interstitial deployment.
The temperature modulation probe 300 further includes a cryotherapy-generating element 306 (e.g., cooling gas, cooling fluid, etc.) for supplying cryotherapy to the effected tissue. In some examples, the cryotherapy-generating element 306 may include a flow of fluid such as gaseous carbon dioxide, liquid nitrogen, or liquid argon. The supplied fluid/gas may utilize Joule-Thomson cooling via Joule-Thomson expansion. As described in relation to
The cryotherapy-generating element 306 may be configured to emit cryotherapeutic energy in a focal, circumferential, or diffuse manner. In some configurations, a probe may include multiple cryotherapy-generating elements 306 and/or multiple supply orifices for a single cryotherapy-generating element 306 to provide a particular deployment shape or pattern. In some examples, multiple orifices may be arranged in a line, a cluster, and/or a circular pattern to form a longer and/or wider cooling pattern at a distal tip of the temperature modulation probe 300. For example, arranging several orifices along the probe tip may provide an ellipsoidal three-dimensional cooling zone extending from the distal tip of the temperature modulation probe 300. In some embodiments, the multiple orifices may be provided via multiple perforations or other openings of a distal tip of the cryotherapy-generating element 306. In other embodiments, each orifice may include a separate venturi nozzles or other release valve, such that the cryotherapy-generating element 306 may produce two or more delivery patterns (e.g., based upon which release valve(s) of a number of release valves is placed in an open position). A controller, such as software and/or firmware, may control the patterning of a multi-nozzle, multi-pattern cryotherapy-generating element 306.
The cryotherapy-generating element 306, in some embodiments, is designed for compatibility with the thermal therapy-generating element. For example, the fluid or gas supplied by the cryotherapy-generating element 306 may be selected to avoid interference with the transmission of heat energy by the thermal therapy-generating element (e.g., will not alter laser light attenuation due to absorption by the coolant fluid).
In some implementations, an energy output pattern of the temperature modulation probe 300 includes simultaneous activation of at least one cryotherapy-generating element and at least one thermal therapy-generating element. For example, emissions of both a cryotherapy-generating element and a thermal therapy-generating element may be combined to refine control of temperature emission of the temperature modulation probe. Modulation may further be achieved by varying output of at least one cryotherapy-generating element relative to at least one thermal therapy-generating element. For example, laser power, pulse timing, RF cycling, HiFU element frequency and/or power, fluid or gas pressure, fluid or gas temperature, and/or flow rate may each be varied to obtain temperature modulating output and/or controlled temperature output.
Temperature production of the temperature modulation probe 300, in some implementations, is refined based upon temperature measurements obtained by a temperature sensor element 308 such as the temperature sensor element 408 described in relation to the probe 400 of
In some implementations, an on-board processor of the temperature modulation probe 300 controls temperature modulation. Temperature modulation control can be managed by the temperature modulation probe 300, in one example, based upon activation of one or more pre-set patterns programmed into the temperature modulation probe 300. In another example, the temperature modulation probe may maintain or vary a probe temperature (e.g., at the tip of the temperature modulation probe 300) by monitoring temperature measurements gathered by the temperature sensor element 308.
A controller, such as a workstation or computing device, in some implementations, manages temperature modulation of the temperature modulation probe 300 through successively (or concurrently) activating cryotherapy-generating element(s) 306 and thermal therapy-generating element(s) 302 via remotely supplied commands. In additional implementations, the controller may manage temperature modulation of the temperature modulation probe 300 through modifying fluid or gas flow rates, fluid or gas temperatures, laser power and pulse timing, etc.
Further, in some implementations, the controller may manage temperature modulation by modifying output of a fluid or gas within the temperature modulation probe through remotely controlling a release aperture through which the fluid or gas is delivered. For example, as discussed in relation to the probe 400 of
Turning to
The thermal therapy temperature 608 of the example modulation pattern may be applied to the tissue by one or more thermal therapy-generating elements of a temperature modulation probe. In alternative embodiments, the thermal therapy temperature 608 is applied to the tissue by one or more thermal therapy-generating elements of the temperature modulation probe during simultaneous application to the tissue by one or more cryotherapy-generating elements of the temperature modulation probe. In one example, simultaneous application may reduce an overall temperature of the therapy, for example maintaining thermal output in a range of reversible cellular damage or other non-ablative therapy. In another example, simultaneous application may be used to protect tissue within close proximity to the probe from undesirable damage (e.g., charring) while using the thermal therapy-generating elements to cause irreversible cellular damage (e.g., during laser ablation application).
The cryotherapy temperature 610 of the modulation pattern may be applied to the tissue by one or more cryotherapy-generating elements of the temperature modulation probe. Application of a temperature modulation enabled therapy using a temperature modulation probe such as the probe 300 is described in greater detail below in relation to
In some implementations, the method 800 begins with determining a thermal dose for effecting temperature controlled therapy treatment at a present position of the temperature modulation probe (802). The present position, for example, corresponds to a particular region of interest of tissue. The thermal dose may include a goal temperature, a goal thermal dose profile, or a goal energy dose profile. Thermal dose profiles, with respect to a specified time period, can include one or more temperatures or temperature gradients for effecting treatment to the particular region of interest. The thermal dose profiles and/or the temperature gradients may permit the determination of an extent of cellular damage in the targeted tissue area and/or other effects upon the targeted tissue area occurring as a result of the temperature modulation therapy. Energy dose profiles may describe energy emissions, over time, which are calculated to cause a particular thermal effect upon the targeted tissue. The thermal dose, for example, may correspond to a desired effect upon the targeted tissue, such as altering normal biological function (e.g., electrical impulse carrying capacity, cytoplasmic enzyme activity, etc.), altering abnormal biological function (e.g., oncogenes, etc.), or influencing cellular activity by an external agent (e.g., drug, chemical, biochemical, etc.). A workstation or computing device, in some embodiments, may determine the thermal dose based upon properties of the region of interest, the desired effect upon the targeted tissue, and/or a type of secondary treatment to be applied at the region of interest (e.g., drug, chemical, biochemical, radiation, etc.).
In some implementations, a modulation pattern of thermal therapy-generating element activation and cryotherapy-generating element activation is identified for applying the thermal dose (804). The modulation pattern may be pre-programmed (e.g., corresponding to the desired thermal dose and/or desired effect) or independently calculated (e.g., using particular properties of the region of interest, desired effect upon the targeted tissue, and/or type of secondary treatment to be applied at the region of interest). Further, the modulation pattern may be static (e.g., applied during the entire temperature modulation therapy) or dynamic (e.g., capable of real-time adjustment based upon temperature monitoring of the tissue during temperature modulation therapy). In other implementations, the modulation may be user-controlled (e.g., user entered and/or user-activated switching between thermal therapy-generating element(s) and cryotherapy-generating element(s).
In some implementations, temperature modulation therapy is initiated (806). In some examples, an operator may physically activate (e.g., depress a button, switch a control) or electronically activate (e.g., via a graphical user interface control element) functionality of the temperature modulation probe. In a particular example, an operator at a workstation may activate temperature modulation therapy by depressing a foot pedal operatively connected to the workstation to activate the first energy or temperature emission of the modulation pattern (e.g., via a corresponding thermal therapy-generating element or cryotherapy-generating element of the temperature modulation probe).
In some implementations, temperature(s) of the targeted tissue is monitored (808). Initiating temperature modulation therapy may further include initiating thermal monitoring of the targeted tissue. In other embodiments, thermal monitoring is initiated separately from temperature modulation therapy. For example, thermal monitoring may begin prior to temperature modulation therapy to establish a baseline temperature and verify functionality of temperature monitoring equipment prior to activation of temperature modulation therapy. One or more temperatures within the target tissue may be monitored. For example, if the thermal dose included a temperature profile corresponding to a desired temperature gradient, multiple temperatures at multiple locations within and/or abutting the target tissue may be monitored. In one example, temperature monitoring includes receiving temperature data from a temperature sensor element built into the temperature modulation probe. In another example, temperature monitoring includes receiving temperature-sensitive imaging data from an imaging device capturing images including the targeted tissue. In a particular example, utilizing MRI imaging in real time guidance may provide controlled accuracy, while contemporaneous thermography may provide accurate temperature information in determining whether a tissue has achieved a goal temperature or temperature profile to producing a desired therapeutic effect.
In some embodiments, temperatures are monitored throughout the temperature modulation therapy. In other embodiments, temperatures are monitored periodically during temperature modulation therapy. For example, due to potential interference with a particular style of emission element, temperature monitoring may be activated during de-activation of that particular style of emission element. In a particular example, temperature monitoring may be activated during emission of the cryotherapy-generating element of the temperature modulation probe but suspended during emission of an RF style thermal therapy-generating element of the temperature modulation probe. Temperature monitoring of a tissue is discussed in greater detail in U.S. Pat. No. 8,979,871 to Tyc, entitled “Image-Guided Therapy of a Tissue” and filed Mar. 15, 2013, incorporated by reference herein in its entirety.
In some implementations, if the temperature(s) is not in line with the thermal dose goal (810), the modulation pattern is adjusted accordingly (812). Depending on the ability of the tissue or surrounding environment to absorb, conduct, or moderate heating or cooling, for example, the actual temperature changes within the target tissue may fail to correspond with the planned tissue temperature(s). For example, temperature(s) in the target tissue may be lower or higher than desired according to the thermal dose. In this circumstance, the modulation pattern driving emission of the temperature modulation probe may be adjusted to effect the desired change (e.g., increase or decrease in target tissue temperature(s)). The workstation or other computing device, for example, may adjust modulation parameters based upon analysis of temperature data.
Temperature modulation therapy may be suspended, in some embodiments, prior to modulation pattern adjustment. For example, if tissue temperatures are outside of a range associated with a desired therapeutic effect (e.g., moving from temperatures associated with reversible cellular damage to temperatures associated with cellular death), temperature modulation therapy may be temporarily suspended while adjusting the temperature modulation pattern. In other embodiments, temperature modulation therapy may continue during the adjustment period.
In some implementations, if the temperature is in line with the thermal dose goal (810), it may be determined that the thermal dose is concluded (814). For example, the thermal dose may correspond to a particular temperature (or temperatures) for a particular period of time or a series of such temperature profiles or temperature gradients. Temperature monitoring may include analyzing historic temperature measurements of the target tissue to verify that the target tissue has reached a particular temperature (or a particular temperature range) for a particular length of time. In other embodiments, determining conclusion of thermal dose includes analyzing the target tissue for evidence of a desired physical-biological effect. The evidence, in one example, may be derived through analysis of image data. In another example, the evidence may be derived through an invasive analysis element, such as the recording elements described in relation to
In some implementations, if the thermal dose is concluded (814), and an additional probe position is desired (816), the probe is moved to a next position (820). In some embodiments, a rotational and/or linear position of the probe may be adjusted by translating or rotating the probe via automated probe manipulation equipment, such as the commander and follower described in relation to
After adjusting the probe position, in some embodiments, the method 800 returns to determining a thermal dose for effecting temperature controlled therapy treatment at the present probe position (802) and identifying a modulation pattern (804). In other embodiments, the method 800 may continue to use the previously determined thermal dose and/or modulation pattern while proceeding with temperature modulation therapy (806) at the next probe position. The method 800 may thus continue until an entire volume of interest within the targeted tissue has been treated, at which time temperature modulation therapy is concluded (818).
Although described as a particular series of steps, in other implementations, the method 800 may include more or fewer steps. For example, after determining that the thermal dose is concluded (814), and prior to determining whether an additional probe position is desired (816), an additional therapy may be applied to the temperature modulation therapy-treated tissue at the present position. For example, upon preparing the tissue for increased sensitivity to a particular drug or radiation treatment via temperature modulation therapy, the method 800 may include deploying the particular drug or radiation treatment at the present position prior to moving the probe to the next position (820). Secondary treatment, in this example, may be performed by the same probe or an additional instrument. For example, the temperature modulation probe may be retracted into a shared sheath, while a pharmaceutical therapy instrument is supplemented at the same position for performing the secondary treatment. In this example, moving the probe to the next position 820 may involve moving the sheath containing both the probe and the secondary instrument to the next position.
Additionally, in other implementations, steps of the method 800 may be performed in a different order. For example, as discussed above, temperature monitoring of the targeted tissue (808) may begin prior to initiating temperature modulation therapy (806).
As illustrated in
In designing the focal laser probe 320, a tip portion 324 of the lens 322, in some implementations, is shaped to best direct the focal energy of the tip of the laser fiber. For example, the tip portion 324 may be substantially flat in shape (e.g., potentially with some rounding to enable better penetration of the probe into the tissue region). In another example, the tip portion 324 may be substantially rounded to encourage a substantially even diffuse pattern of focal energy throughout the entire tip portion 324 of the probe 320. In designing the focal laser probe 320 to direct energy from the tip portion 324 of the lens 322 to create ablation zones directly ahead of the probe rather than from the side, the tip portion of the laser fiber itself can be plain (e.g., flat) cut so the energy directly exits the tip of fiber along its axis.
In some implementations, the probe 400 may include multiple cryotherapy-generating elements and/or multiple supply orifices for a single cryotherapy-generating element to provide a particular deployment shape or pattern. In some examples, multiple orifices may be arranged in a line, a cluster, or a circular pattern to form a longer and/or wider cooling pattern at a distal tip of the probe 400. In some embodiments, the multiple orifices may be provided via multiple perforations or other openings at an aperture of the injection tube 404. In other embodiments, each orifice may include a separate nozzle (e.g., venturi nozzle, etc.) or other release valve, such that the probe 400 may produce two or more delivery patterns (e.g., based upon which release valve(s) of a number of release valves is placed in an open position). A controller, such as software and/or firmware, may control the patterning of a multi-nozzle, multi-pattern probe 400.
Further, the sizing and/or shape of the orifice(s) may be selected to produce differing effects, such as expanding or contracting (e.g., focusing) deployment of cryotherapy energy. For example, in the circumstance where multiple perforations or release valves are arranged along a length of a tip portion of the probe, the perforations or release valves may include a vent shaping to direct the cryotherapeutic stream in a direction other than perpendicular to the surface of the injection tube 404 at which the particular orifice is positioned.
In some embodiments, the aperture at the orifice of the injection tube 414 and/or individual release valves arranged upon may be mechanically and/or electrically adjustable to vary flow rate of the refrigerant within the probe 400 itself. Further, the size or patterning of the aperture may be adjusted to vary focal diameter of the refrigerant 402 at the tip region 414 of the probe 400, for example by maintaining a flow rate (e.g., via an external control unit) while adjusting the outlet available to the refrigerant at the tip of the injection tube 414.
The aperture, in some examples, may include an adjustable valve or a porous plug. In a particular example, to avoid use of components which may interfere with the imaging system and/or energy producing elements of the cryoablation probe 400, a deflection wire 410 may be used to mechanically manipulate the aperture of the orifice of the injection tube 404. In other embodiments, the deflection wire 410 is used to direct the tip of the injection tube 414 in an offset direction (e.g., in the circumstance of a flexible probe body).
A vacuum return lumen 406, in some embodiments, allows a return cycle of the refrigerant from the expansion region of the probe 400. Thus, the refrigerant is pumped through the injection tube 404 and escapes from the end of the injection tube 404 into the tip region 414 of the probe 400, and then the evaporated refrigerant is returned through the vacuum return lumen 406. From the vacuum return lumen 406, the evaporated refrigerant may be released to the atmosphere or connected to a return tube (not illustrated) to direct the evaporated refrigerant to a return collection. In a particular example, as illustrated in
In some implementations, the probe 400 includes a temperature sensor 408 such as one or more thermocouple wires or a fiber optic thermometer. The temperature data generated by the temperature sensor 408, for example, may be provided to a control unit (not illustrated) for monitoring temperature at the tip region 414 of the probe 400. The control unit, responsive to temperature fluctuations may modulate delivery of the refrigerant 402 to maintain (or controllably fluctuate) a temperature at the exterior of the tip region 414. In some implementations, the probe 400 includes at least one electroencephalography (EEG), stereo EEG (SEEG), or electrocardiography (ECG) recording element (e.g., wire, electrode, coil, etc.) 412 for monitoring biological rhythms or electrical signals or activity (e.g., within the brain) during positioning of the probe 400 and/or during cryotherapy using the probe 400. The pulse data generated by the recording element 412, for example, may be provided to a control unit. Uses for the data collected by the recording element 412 are described in relation to
In some embodiments, a recording element is incorporated into a recording instrument or therapeutic probe for recording signals used to detect abnormal neurological, cardiac, spinal, and/or other in vivo tissue response signals. The recording instrument or probe, for example, may include the ability to electrically stimulate nearby tissue then detect abnormal signals issued by the tissue responsive to stimulation. In another example, the recording instrument may include the ability to thermally stimulate nearby tissue then detect abnormal signals issued by the tissue responsive to stimulation. Detection may involve sub chronical recording and stimulation to detect abnormal signals.
A recording element incorporated into a therapeutic probe, in some embodiments, is used for lesion localization and assessment at the time of cryotherapy or thermal therapy. In lesions without sclerosis, the lesion may not be visually detectable. As such, to appropriately position a probe including a recording element, the recording element may be used detect a signal pattern indicative of the position of the lesion.
In some embodiments, a recording element incorporated into a therapeutic probe is used for detection of critical structures surrounding a target tissue area prior and/or during cryotherapy or thermal therapy. For example, identification of arteries, nerves, functional motor strip within motor cortex, corticospinal track and other critical neural pathways.
In some embodiments, a recording element is incorporated into a recording instrument or probe with a cryogenic energy element and/or thermal energy element for thermally stimulating the tissue. For example, the tissue proximate to the recording instrument or probe may be cooled using a cryogenic energy element to modify signal activity, such as causing brain signal activities detected by an EEG recording element to go into a hibernation pattern (e.g., at less than 10.degree. C.). Through warming (naturally or aided with a thermal energy element), the “wake-up” patterns triggered within the tissue may be detected by the EEG recording element, thus allowing detection of a signal pattern indicative, in some examples, the position of a lesion or an epileptogenic region (e.g., epilepsy onset spot). In another example, the tissue proximate to the recording instrument or probe may be warmed using a thermal energy element to modify signal activity of the effected tissue. In further examples, tissue temperature may be modulated (e.g., cooled and warmed, or vice-versa, two or more times) while identifying epilepsy onset spots or lesions.
A recording element, in some implementations, is incorporated into a recording instrument or therapeutic probe for detecting blood brain barrier (BBB) changes (e.g., effected at about 43.degree. C.). For example, the recording element may detect BBB disruption by identifying Gadolinium presence. In a particular example, electro-chemical sensing of a total amount of charge or electrical current generated by the BBB disruption may be measured to detect the BBB disruption event.
In some embodiments, a recording element of a therapeutic probe provides monitoring during functional neurosurgery. In the example of epileptic symptoms, the recording element may be used to confirm positioning of therapeutic energy for treatment of seizure activity. In another example, a recording element may be used to confirm disruption of the blood-brain barrier. In an additional example, a recording element may be used for monitoring while performing an operation or other therapy, such as monitoring patient biorhythms or electrical activity in the brain and adjusting or suspending therapy if an abnormal event is detected. In another example, the recording element may be used to apply local tissue stimulation responsive to detection of an abnormal event to regulate cellular behaviors during treatment. In particular, the recording element may effect deep brain stimulation during a neurosurgical operation. Further to this example, the recording element may be used to verify efficacy of the local tissue stimulation in modifying the abnormal signals previously detected.
Turning to
Turning to
As illustrated in
In some embodiments, the probe 510 may be extended and retracted within the sleeve 520. For example, when the probe 510 is inactive and signals collected by the recording element rings 522 are being monitored, the probe 510 may be retracted within the sleeve 520 such that the recording element rings 522 are deployed as close as possible to the tissue near a tip region 524 of the probe 510.
In some embodiments, a recording element/array may be included inside a probe. For example, the recording element/array may be included within a same lumen as one or more other elements of the probe, such as the temperature sensor 408 described in relation to
As illustrated in
As illustrated in
The recording instrument 540, in some implementations, includes an outer tubing 552 of an insulating material, such as the signals recorded by the recording element contact surfaces 542a, 543a are isolated from each other. In a particular example, the outer tubing 552 is formed of a flexible polymer. The contact surfaces, for example, may be integrated with the flexible polymer material.
In some implementations, the recording instrument 540 includes a coolant supply tube 546 for delivery cooling fluid or gas to a cooling zone region 544 of the recording instrument 540 (as illustrated in
The connection unit 562, in some implementations, includes a control module for regulating coolant pressure and/or flow rate to provide a desired temperature to the cooling zone region 544 of the recording instrument 540. The control module, for example, may monitor temperature within the cooling zone region 544 through temperature sensor signals supplied by a temperature sensor 548 (e.g., thermocouple) and modulate coolant feed accordingly to maintain a desired temperature or temperature modulation pattern. Additionally or alternatively, coolant pressure may be manually adjusted via a manual pressure control valve 566 of the connection unit 562.
In a particular example, the connection unit 562 may modulate temperatures of tissue within 0.8 and 1.22 mm of the cooling zone region 544 of the recording instrument 540 by first cooling the tissues using the cooling gas (e.g., via JT cooling as discussed, for example, in relation to
In some implementations, the connection unit 562 includes a temperature readout display 564. For example, the control module may translate temperature signals supplied by the temperature sensor 548 into digits for presentation upon the temperature readout display 564 for review by a medical professional.
Although illustrated as connecting to a single recording instrument 540, in other implementations, the connection unit 562 may be configured to provide input/output connections for two or more recording instruments 540. For example, between two and ten recording instruments 540 may be positioned at various locations within a patient, and the recording instruments 540 may be configured for thermal modulation control and/or analysis via the single connection unit 562.
In some implementations, the method 580 begins with disposing at least one signal recording element proximate a target tissue (582). The tissue, in some examples, may include brain tissue, spinal tissue, or pericardial tissue. In some embodiments, the signal recording element is a separate device (or, optionally, a set of signal recording elements may be included within a single device). For example, as illustrated in
In some implementations, signal recordings are received from the signal recording element(s) (584). The signals may be recorded in a continuous or periodic manner. For example, signals may be recorded opposite an energy emission pattern of a probe deployed with (e.g., proximate to, coupled to, or integrated with) the signal recording element(s) such that the energy emission pattern is not disrupted by the signal recording element(s) or vice versa. The signals recordings may include discrete signal measurements and/or signal patterns sensed over a period of time. The signals, in some examples, may optionally be filtered, amplified, or otherwise adjusted prior to receipt by the method 580. Further, in some embodiments, the signal recordings may be provided with contemporaneous data such as, in some examples, time stamp data, tissue temperature recording data, probe temperature recording data, therapeutic emission pattern data, and/or biometric data (e.g., heart rate, pulse rate, breathing rate, etc.) of the patient.
In some implementations, the signal recordings are analyzed to detect an abnormal signal pattern (586). Analysis may include monitoring for abnormal signal patterns indicative of one or more of a brain tissue hibernation pattern, a brain tissue warm-up (e.g., post hibernation) pattern, a seizure activity pattern or pre-seizure activity pattern (e.g., epilepsy onset spot), location of a lesion, location of a critical structure (e.g., artery, nerve, functional motor strip within motor cortex, corticospinal track, and/or other critical neural pathways, etc.), alterations in the blood brain barrier (e.g., disruption of the BBB), abnormal biorhythms, or other electrical activity markedly different from a baseline for the tissue region (e.g., brain, thoracic cavity, spinal region). In some embodiments, analysis includes coordinating signal data with additional brain activity measurement data, for example derived non-invasively through imaging or other means. For example, analyzing the signal recordings may include analyzing the signal recordings in light of magnetoencephalography (MEG) data or in an effort to confirm MEG data. Further, in some embodiments, analyzing the signal recordings includes analyzing the signal recordings in light of historic signal recording data. For example, detecting an abnormal signal pattern may include detecting movement from previously recorded abnormal signal pattern to a desirable (e.g., normal, healthy, or indicative of success of a therapeutic treatment) or baseline signal pattern.
In some implementations, if an abnormal signal pattern is detected (588) and the recording elements are part of an automated system for therapeutic treatment using an interstitial therapy instrument, an appropriate adjustment to at least one of an emissive output, a therapeutic profile, and a therapeutic instrument position is determined (592). In a first example, the abnormal signal pattern may identify position of a lesion, and adjustment of the emissive output may include delivery of treatment (e.g., thermal therapy, cryotherapy, and/or pharmacological therapy, etc.) to the lesion. In another example, the abnormal signal pattern may identify disruption of the blood brain barrier, and adjustment of therapeutic profile may include shortening a timeframe for delivery of a therapeutic treatment. In an example related to therapeutic instrument position, the abnormal signal pattern may be indicative of location of a critical structure, and the position (e.g., linear position, rotational position, etc.) may be adjusted to avoid damage to the critical structure. The examples are provided for illustrative purposes only, and are in no way mean to be limiting to the opportunities for automated response to detection of an abnormal signal pattern recorded by the signal recording element(s).
In some implementations, after determining the appropriate adjustment, the appropriate adjustment is effected (594). As presented in greater detail, for example, in U.S. Pat. No. 8,979,871 entitled “Image-Guided Therapy of a Tissue” and filed Mar. 15, 2013 (incorporated by reference herein in its entirety), a probe driver may be activated to adjust physical position of the thermal therapy instrument. In another example, as discussed in greater detail in relation to
In some embodiments, if the system is not designed for automated adjustment (590), an alert may be issued for attention of a system operator (596). For example, a visual output including a signal pattern display (e.g., graph, chart, or other illustration indicative of the received signal recordings) and/or signal pattern identifier (e.g., visual arrangement and/or text indicative of particular type of abnormal signal pattern) may be presented upon a display device provided for the system operator. In another example, an audible alert, such as a verbal message, a warning tone, or a series of intonations representative of an abnormal signal pattern may be output for the system operator via a speaker device.
Whether or not an abnormal signal pattern was detected 588, in some implementations, the method 580 proceeds to continue to receive signal recordings (584).
Although described as a particular series of steps, in other implementations, the method 580 may include more or fewer steps. For example, after disposing the signal recording element(s) proximate a target tissue (582) and prior to analyzing the signal recordings (586), the method 580 may receive additional data recordings (e.g., as described in relation to step 586) separate from the signal recordings (e.g., from one or more separate instruments or systems). In another example, after detecting the abnormal signal pattern (588), rather than issuing an alert or determining an adjustment, the method 580 may simply log the abnormal signal pattern (e.g., for later use as historic signal pattern data).
Additionally, in other implementations, steps of the method 580 may be performed in a different order. For example, the method 580 may initially deliver therapeutic output, then receive (584) and analyze (586) signal recordings in an effort to determine success of the delivered therapeutic emission. Other modifications of the method 580 are possible while remaining within the scope and purpose of the method 580.
In some embodiments, single-layer low profile probe shafts are designed with a thermoplastic material having a glass transition temperature higher than 100.degree. C. and a Young's Modulus of higher than 2 GPa for effecting thermal therapy by delivering energy to a targeted tissue area, such as brain tissue. In an exemplary embodiment, the energy modality is laser light and the thermal therapy is laser induced interstitial thermal therapy (LITT). The low profile probes described below, for example, may be used to effect reversible cellular damage and/or cellular death (ablation) as discussed above.
As discussed in further detail below, low profile probes may be configured with selected materials, lumen structures, and layer structures to provide desired and/or selected mechanical properties including straightness, rigidity, torque strength, column strength, tensile strength, kink resistance, and thermal properties such as thermal stability and thermal stress capacity. In some embodiments, the low profiled probes are MR-compatible. Maintaining the desired and/or selected mechanical and/or thermal properties, for example, can allow for remotely controlling and operating the low profile probe in a rotational and/or axial direction. In particular implementations, low profile probes are designed such that the tensile strength, torque strength, and column strength are greater than approximately 15 N and the kink resistance is such that no damage to the probe results at curvature radiuses higher than approximately 40 mm. In some embodiments, the low profile probe shaft is air-tight to support modulated heating and cooling operations, such as the temperature-modulation probe designs and uses described above.
Low profile probe dimensions may vary, in some examples, based upon the style of the low profile probe (e.g., thermal therapy, cryotherapy, temperature modulation therapy), the anticipated probe deployment (e.g., intracranial, spinal, cardiac, etc.), the required thermal tolerances of the low profile probe, and/or the required structural tolerances of the probe (e.g., flexible vs. rigid). The wall thickness of the probe shaft, in particular, is related to the stiffness of the low profile probe, which helps the low profile probe stay on trajectory (or allows the probe to deflect therefrom). The following are examples of low profile probe dimensions. In a first example, the inner shaft of a low profile probe has an outer diameter of 2.0 mm, within a tolerance of 0.03 mm and an inner diameter of 1.5 mm, within a tolerance of 0.03 mm; in this embodiment, the sapphire lens has the same inner diameter. In a second example, the outer shaft of the low profile probe has an outer diameter of 2.25 mm, within a tolerance of 0.03 mm and an inner diameter of 2.07 mm, within a tolerance of 0.03 mm. In further examples, the shaft of various low profile probe designs may have an outer diameter of approximately 2.1 mm, approximately 2.2 mm, or less than approximately 3.2 mm. In additional examples, the shaft of various low profile probe designs may have an outer diameter of approximately 1.0 mm or approximately 1.2 mm.
In some implementations, a low profile probe includes multiple internal lumens. The multi-lumen structure, for example, can provide a greater cross-sectional lumen area relative to the profile of the low profile probe while, at the same time, maintaining desired and/or selected mechanical properties including, for example, straightness, rigidity, torque strength, column strength, tensile strength, kink resistance, and thermal properties such as, for example, thermal stability and thermal stress capacity.
The multi-lumen structure, in some implementations, contains one or more thermal therapy-generating elements and one or more cryotherapy-generating elements for temperature modulation therapy. In addition, the multi-lumen structure may contain a temperature sensor, such as a thermocouple (laser or fiber), to monitor internal temperatures during temperature modulation therapy. The thermal therapy-generating element, in a particular example, is a laser fiber. The laser fiber may be optionally selectively etched with a pattern to achieve a desired lasing pattern. Further to the particular example, the cryotherapy-generating element is a Joule-Thompson cooling apparatus. As discussed in greater detail above (e.g., in relation to
In some embodiments of a laser-based low profile temperature modulation probe designed for LITT, a sapphire lens is utilized for the optimal laser transparency, and robust thermal (e.g., hot and cold) stress capacity. The multi-lumen structure of the low profile probe, in this example, provides comparable modulated lasing and cooling ability when compared with a probe having a larger profile and/or a single lumen.
Turning to
Lumen 1310a, in some embodiments, acts as a venting port for a cooling gas (or evaporated cooling liquid) that is delivered via lumen 1310b. A flexible cooling line, for example, may be connected to the distal end of the rod 1318 (not illustrated) and high pressure gas may flow through lumen 1310b, expanding in a tip region 1304 of the low profile probe 1300, and then flowing back through lumen 1310a.
As illustrated in
Extending from and integral with the tip 1304 of the low profile probe 1300, in some embodiments, is a lens 1306. The lens 1306, for example, may be composed of machined sapphire. As illustrated, the lens 1306 is bonded to the proximal end of the rod 1318 and is also inserted into the end of the PEEK plastic tube 1316. The energy delivery occurs via the lens 1306. As illustrated, the tip 1304 of the lens 1306 has a torpedo-like nose shape. In another embodiment (not illustrated), the tip 1304 of the lens 1306 has a rounded nose shape.
As discussed above, in the example embodiment illustrated, the components of the probe shaft 1302 are composed of heterogeneous materials (e.g., PEEK and ceramic). In other embodiments, homogenous materials form the components of the probe shaft 1302. Each material may be selected to achieve the desired and/or selected mechanical and/or thermal properties for the low profile probe 1300. In some embodiments, the shaft 1302 and the PEEK tube 1316 are bonded together.
Turning to
The layers 1506 of the shaft 1502, as illustrated in
Turning to
The support tube 903, as illustrated in
Returning to
While tubing may be available which provides the required dimensions and rigidity, in many cases, the tubing is however flexible so that it bends side to side and also will torsionally twist. The support tube 903, in some embodiments, is therefore mounted within an optional stiffening tube or sleeve 914, which extends from an end 915 remote from the tip 902 to a second end 916 adjacent to the tip 902. The second end 916 is however spaced rearwardly from the end 904 of the support tube 903, which in turn is spaced from the tip 902. The distance from the second end 916 to the tip 902 may be arranged to be less than a length of the order of 1 inch. The stiffening tube 914 may be formed of a suitable stiff material that is non-ferro-magnetic so that it is MRI compatible. The support tube 903 may be bonded within the stiffening tube 914 so that it cannot rotate within the stiffening tube 914 and cannot move side to side within the stiffening tube 914. The stiffening tube 914, in some embodiments, is manufactured from titanium, ceramic or other material that can accommodate the magnetic fields of MRI. Titanium generates an artifact within the MRI image. For this reason, the second end 916 may spaced as far as practicable from the tip 902 so that the artifact is removed from the tip 902 to allow proper imagining of the tissues.
In some embodiments, a capsule 920 in the form of a sleeve 921 and domed or pointed end 922 is provided at the second end 916 of the stiffening tube 914. The sleeve 921 may surround the second end 916 of the stiffening tube 914 and be bonded thereto so as to provide a sealed enclosure around the exposed part of the support tube 903. The capsule 920, in some embodiments, is formed of quartz crystal so as to be transparent to allow the escape of the disbursed light energy from the tip 902. The distance of the end of the stiffening tube 914 from the tip 902 may be arranged such that the required length of the capsule 920 does not exceed what can be reasonably manufactured in the transparent material required.
In some embodiments, supply tube 911 is connected to a supply 925 of a cooling fluid and the supply tube 912 is connected to a return collection 926 for the cooling fluid. Thus, the cooling fluid is pumped through the duct 905 and escapes from the end 904 of the support tube 903 into the capsule 920 and then is returned through the duct 906. The cooling fluid can simply be liquid nitrogen allowed to expand to nitrogen gas at cryogenic temperatures and then pumped through the duct 905 and returned through the duct 906 where it can be simply released to atmosphere at the return 926.
In other embodiments, the supply 925 and the return 926 form parts of a refrigeration cycle where a suitable coolant is compressed and condensed at the supply end and is evaporated at the cooling zone at the capsule 920 so as to transfer heat from the tissue surrounding the capsule 920 to the cooling section at the supply end.
The arrangement set forth above allows the effective supply of the cooling fluid in gaseous or liquid form through the ducts 905 and 906 and also effectively supports the fiber 901 so that it is held against side to side or rotational movement relative to the stiffening tube 914. The location of the tip 902 of the fiber 901 is therefore closely controlled relative to the stiffening tube 914. In some embodiments, the stiffening tube 914 is driven by couplings 930 and 931, shown schematically in
Turning to
In some embodiments, the probe includes a rigid extruded tube 1100 of a suitable material, for example titanium, that is compatible with MRI (non-ferromagnetic) and suitable for invasive medical treatment. The probe further includes a smaller cooling fluid supply tube 1102 which may be separately formed, for example by extrusion, and may be attached by adhesive to the inside surface of the outer tube 1100. An optical fiber 1104 is also attached by adhesive to the inside surface the outer tube 1100 so that the fiber 1104 is preferably diametrically opposed to the cooling supply tube 1102.
The cooling supply tube 1102 is swaged at its end to form a neck section 1105, which projects beyond the end of the tube 1101, to form a neck section of reduced diameter at the immediate end of the tube 1102. Thus in manufacture the extruded tube 1101 may be cut to length so as to define a tip end 1107 at which the outer tube terminates in a radial plane. At the tip end 1107 beyond the radial plane, the outer of the inner tube 1102 may be swaged by a suitable tool so as to form the neck section 1105 having an internal diameter, for example, of the order of 0.003 to 0.005 inch.
The fiber 1104, in some embodiments, is attached to the tube 1101 so that a tip portion 1108 of the fiber 1104 projects beyond the tip end 1107 to a chamfered end face 1109 of the fiber. As illustrated, the chamfered end face 1109 is cut at approximately 45 degrees to define a reflective end plane of the fiber 1104.
The tip end 1107, in some embodiments, is covered and encased by an end cap 1110 (e.g., molded quartz) that includes a sleeve portion 1111 closely surrounding the last part of the tube 1100 and extending beyond the tip end 1107 to an end face 1112, which closes the capsule. The end face 1112 is tapered to define a nose 1113, which allows the insertion of the probe to a required location. The end of the tube 1101 may be reduced in diameter so that the capsule has an outer diameter matching that of the main portion of the tube 1101. However in the arrangement shown in
A temperature sensor 1114 (e.g., thermocouple, fiber optic thermometer, etc.), in some embodiments, is attached to the inside surface of the outer tube 1100 at the tip end 1107 and includes connecting wires 1115 which extend from the temperature sensor 1114 to a control unit 1126. Thus the temperature sensor 1114 provides a sensor to generate an indication of the temperature at the tip end 1107 within the capsule. A fiber optic thermometer, in one example, may provide the benefit of being fully immune to RF environments and therefore require no electromagnetic compatibility (EMC) filtering. The capsule may be welded to or bonded to the outer surface of the tube as indicated at 1118 so as to form a closed expansion chamber within the capsule beyond the tip end 1107. In some embodiments, an inner surface 1116 of the capsule is of the same diameter as the outer surface of the tube 1100 so that the expansion chamber beyond the end of the tube 1100 has the same exterior dimension as the tube 1100.
The capsule, in some embodiments, is transparent so as to allow the reflected beam of the laser light from the end face 1109 of the fiber 1104 to escape through the transparent capsule in the limited angular direction substantially at right angles to the longitudinal axis of the fiber 1104 and within the axial plane defined by that longitudinal axis.
The tube 1102, in some embodiments, is connected at its end opposite to the neck section 1105 to a fluid supply 1119, which forms a pressurized supply of a suitable cooling fluid such as carbon dioxide or nitrous oxide. The fluid supply 1119, in some embodiments, is controlled by the control unit 1126 to generate a predetermined pressure within the fluid supply to the supply tube 1102 which can be varied so as to vary the flow rate of the fluid through the neck section 1105. The fluid may be supplied at normal or room temperature without cooling. The fluid, in some embodiments, is a gas at this pressure and temperature but fluids that are liquid can also be used provided that they form a gas at the pressures within the expansion chamber and thus go through an adiabatic gas expansion through the restricted orifice into the expansion chamber to provide the cooling effect.
Thus the restricted orifice has a cross-sectional area very much less than that of the expansion chamber and the return duct provided by the inside of the tube 1101. The items that reduce the effective cross-sectional area of the return tube 1101 may include, in some examples, the optical fiber 1104, the supply tube 1102, the thermocouple wires 1115, a shrink tube that fixes the thermocouple wires 1115 to the optical fiber 1104, and/or adhesives used to bond the items into place (e.g., at the inlet of the discharge duct).
Without the area of the adhesives included in the calculation, in some embodiments the exhaust duct area is about 300 times larger than a target size of the delivery orifice diameter (e.g., about 0.004″). When considering the area occupied by the adhesives, the exhaust duct inlet area may be approximately 200 to 250 times larger than the delivery orifice diameter. Considering the manufacturing tolerance range of the supply tube orifice diameter alone, the exhaust duct area may be anywhere between 190 to 540 times larger than the orifice area (without considering the area occupied by adhesives). Therefore, it is estimated that about a 200/l gas expansion may be required to achieve appropriate cooling. This may allow the gas as it passes into the expansion chamber beyond the neck section 1105, in the particular example, to expand as a gas thus cooling the capsule and the interior thereof at the expansion chamber to a temperature in the range of approximately −20 C to 0 C. This range has been found to be suitable to provide the required level of cooling to the surface of the capsule so as to extract heat from the surrounding tissue at a required rate. Variations in the temperature in the above range can be achieved by varying the pressure from the supply 1119 so that, in one example, the pressure would be of the order of 700 to 850 psi at a flow rate of the order of 5 liters per min. The tube 1102, in some embodiments, has an outside diameter of the order of 0.014 inch OD, while a tube 1103 has a diameter of the order of 0.079 inch. Thus a discharge duct for the gas from the expansion chamber is defined by the inside surface of the tube 1100 having a flow area which is defined by the area of the tube 1100 minus the area taken up by the tube 1102 and the fiber 1104. This allows discharge of the gas from the expansion chamber defined within the capsule at a pressure of the order of 50 psi so that the gas can be simply discharged to atmosphere if inert or can be discharged to an extraction system or can be collected for cooling and returned to the fluid supply 1119 if economically desirable. Tip cooling may be necessary, in certain uses, for optimum tissue penetration of the laser or heating energy, reduction of tissue charring and definition of the shape of the coagulated zone. The gas expansion thus provides an arrangement that is suitable for higher power densities required in this probe to accommodate the energy supplied by the laser heating system.
The tip portion 1108 of the fiber 1104, in some embodiments, is accurately located within the expansion zone since it is maintained in fixed position within the capsule by its attachment to the inside surface of the outer tube 1100. The fiber 1104 may be located forwardly of the tip end 1107 sufficiently that the MRI artifact generated by the tip end 1107 is sufficiently removed from the plane of the fiber tip portion 1108 to avoid difficulties in monitoring the temperature within the plane of the fiber tip portion 1108. The outlet orifice of the tube 1102 may also be located forwardly of the tip end 1107 so as to be located with the cooling effect generated thereby at the plane of the fiber tip portion 1108 or end face 1109 thereof.
The end face 1109, in some embodiments, is located within the expansion chamber so that it is surrounded by the gas with no liquid within the expansion chamber. Thus, in practice there is no condensate on the end face 1109 nor any other liquid materials within the expansion chamber that would otherwise interfere with the reflective characteristics of the end face 1109.
The end face 1109, in some embodiments, is coated with a reflective coating such as a dual dielectric film. This may provide a reflection at the two wavelengths of the laser light used as a visible guide beam and as the heat energy source, such as He—Ne and Nd:YAG respectively. An alternative coating is gold, which can alone provide the reflections at the two wavelengths.
The arrangement of the probe of
In some embodiments, in operation, the temperature within the expansion zone is monitored by the temperature sensor 1114 so as to maintain that temperature at a predetermined temperature level in relation to the amount of heat energy supplied through the fiber 1104. Thus the pressure within the fluid supply is varied to maintain the temperature at that predetermined set level during the hyperthermic process.
As described previously, the probe may moved to an axial location within the volume to be treated and the probe may rotated in steps so as to turn the heating zone generated by the beam B into each of a plurality of segments within the disk or radial plane surrounding the end face 1109. Within each segment of the radial plane, heat energy is supplied by the beam B that is transmitted through the capsule into the tissue at that segment. The heat energy is dissipated from that segment both by reflection of the light energy into adjacent tissue and by conduction of heat from the heated tissue to surrounding tissue. As stated previously, those skilled in the art will appreciate that the probe used with the cooling system in accordance with the description above may include circumferential fibers having point-of-source energy.
The surface of the capsule, in some embodiments, is cooled to a temperature so that it acts to extract heat from the surrounding tissue at a rate approximately equal to the dissipation or transfer of heat from the segment into the surrounding tissue. Thus the net result of the heating effect is that the segment alone is heated and surrounding tissue not in the segment required to be heated is maintained without any effective heating thereon, that is no heating to a temperature which causes coagulation or which could otherwise interfere with the transmission of heat when it comes time to heat that tissue in another of the segments. In this way when a first segment is heated to the required hyperthermic temperature throughout its extent from the probe to the peripheral surface of the volume, the remaining tissues in the areas surrounding the probe are effectively unheated so that no charring or coagulation has occurred which would otherwise prevent dissipation of heat and in extreme cases completely prevent penetration of the beam B.
Thus when each segment in turn has been heated, the probe can be rotated to the next segment or to another segment within the same radial plane and further heating can be effected of that segment only.
In practice in one example, the laser energy can be of the order of 12 to 15 watts penetrating into a segment having an angle of the order of 60 to 80 degrees to a depth of the order of 1.5 cm. In order to achieve this penetration without causing heating to the remaining portions of the tissue not in the segment, cooling of the outside of the capsule to a temperature of the order of −5.degree. C. may be required.
Next, a hardware description of the computing device, mobile computing device, or server according to exemplary embodiments is described with reference to
Further, a portion of the claimed advancements may be provided as a utility application, background daemon, or component of an operating system, or combination thereof, executing in conjunction with CPU 1700 and an operating system such as Microsoft Windows 7, UNIX, Solaris, LINUX, Apple MAC-OS and other systems known to those skilled in the art.
CPU 1700 may be a Xenon or Core processor from Intel of America or an Opteron processor from AMD of America, or may be other processor types that would be recognized by one of ordinary skill in the art. Alternatively, the CPU 1700 may be implemented on an
FPGA, ASIC, PLD or using discrete logic circuits, as one of ordinary skill in the art would recognize. Further, CPU 1700 may be implemented as multiple processors cooperatively working in parallel to perform the instructions of the inventive processes described above.
The computing device, mobile computing device, or server in
The wireless network can also be Wi-Fi, Bluetooth, or any other wireless form of communication that is known.
The computing device, mobile computing device, or server further includes a display controller 1708, such as a NVIDIA GeForce GTX or Quadro graphics adaptor from NVIDIA Corporation of America for interfacing with display 1710, such as a Hewlett Packard HPL2445w LCD monitor. A general purpose I/O interface 1712 interfaces with a keyboard and/or mouse 1714 as well as a touch screen panel 1716 on or separate from display 1710. General purpose I/O interface also connects to a variety of peripherals 1718 including printers and scanners, such as an OfficeJet or DeskJet from Hewlett Packard.
A sound controller 1720 is also provided in the computing device, mobile computing device, or server, such as Sound Blaster X-Fi Titanium from Creative, to interface with speakers/microphone 1722 thereby providing sounds and/or music.
The general purpose storage controller 1724 connects the storage medium disk 1704 with communication bus 1726, which may be an ISA, EISA, VESA, PCI, or similar, for interconnecting all of the components of the computing device, mobile computing device, or server. A description of the general features and functionality of the display 1710, keyboard and/or mouse 1714, as well as the display controller 1708, storage controller 1724, network controller 1706, sound controller 1720, and general purpose I/O interface 1712 is omitted herein for brevity as these features are known.
One or more processors can be utilized to implement various functions and/or algorithms described herein, unless explicitly stated otherwise. Additionally, any functions and/or algorithms described herein, unless explicitly stated otherwise, can be performed upon one or more virtual processors, for example on one or more physical computing systems such as a computer farm or a cloud drive.
Reference has been made to flowchart illustrations and block diagrams of methods, systems and computer program products according to implementations of this disclosure. Aspects thereof are implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks.
These computer program instructions may also be stored in a computer-readable medium that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable medium produce an article of manufacture including instruction means which implement the function/act specified in the flowchart and/or block diagram block or blocks.
The computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide processes for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks.
A number of implementations have been described. Nevertheless, it will be understood that various modifications may be made without departing from the spirit and scope of this disclosure. For example, preferable results may be achieved if the steps of the disclosed techniques were performed in a different sequence, if components in the disclosed systems were combined in a different manner, or if the components were replaced or supplemented by other components. The functions, processes and algorithms described herein may be performed in hardware or software executed by hardware, including computer processors and/or programmable circuits configured to execute program code and/or computer instructions to execute the functions, processes and algorithms described herein. Additionally, some implementations may be performed on modules or hardware not identical to those described. Accordingly, other implementations are within the scope that may be claimed.
This application is a continuation of U.S. patent application Ser. No. 14/841,109, filed on Aug. 31, 2015, allowed; which claims priority to U.S. Provisional patent application Ser. No. 62/141,612, filed Apr. 1, 2015; the entireties of which are incorporated by reference herein.
Number | Name | Date | Kind |
---|---|---|---|
3021842 | Flood | Feb 1962 | A |
3139990 | Jelatis et al. | Jul 1964 | A |
4111209 | Wolvek et al. | Sep 1978 | A |
4233979 | Naser | Nov 1980 | A |
4360028 | Barbier et al. | Nov 1982 | A |
4378016 | Loeb | Mar 1983 | A |
4402694 | Ash et al. | Sep 1983 | A |
4568559 | Nuwayser et al. | Feb 1986 | A |
4609174 | Nakatani | Sep 1986 | A |
4622953 | Gordon | Nov 1986 | A |
4623588 | Nuwayser et al. | Nov 1986 | A |
4646752 | Swann et al. | Mar 1987 | A |
4671254 | Fair | Jun 1987 | A |
4733660 | Itzkan | Mar 1988 | A |
4733929 | Brown | Mar 1988 | A |
4832024 | Boussignac et al. | May 1989 | A |
4914608 | LeBihan et al. | Apr 1990 | A |
4986628 | Lozhenko et al. | Jan 1991 | A |
5059415 | Neuwelt | Oct 1991 | A |
5078140 | Kwoh | Jan 1992 | A |
5085219 | Ortendahl et al. | Feb 1992 | A |
5092891 | Kummer et al. | Mar 1992 | A |
5102410 | Dressel | Apr 1992 | A |
5116344 | Sundqvist | May 1992 | A |
5154723 | Kubota et al. | Oct 1992 | A |
5192278 | Hayes et al. | Mar 1993 | A |
5196005 | Doiron et al. | Mar 1993 | A |
5201742 | Hasson | Apr 1993 | A |
5207669 | Baker et al. | May 1993 | A |
5207681 | Ghadjar et al. | May 1993 | A |
5217441 | Shichman | Jun 1993 | A |
5222953 | Dowlatshahi | Jun 1993 | A |
5230338 | Allen et al. | Jul 1993 | A |
5242438 | Saadatmanesh et al. | Sep 1993 | A |
5246436 | Rowe | Sep 1993 | A |
5247935 | Cline et al. | Sep 1993 | A |
5263956 | Nobles | Nov 1993 | A |
5269777 | Doiron et al. | Dec 1993 | A |
5275165 | Ettinger et al. | Jan 1994 | A |
5281213 | Milder et al. | Jan 1994 | A |
5284144 | Delannoy et al. | Feb 1994 | A |
5291890 | Cline et al. | Mar 1994 | A |
5292320 | Brown et al. | Mar 1994 | A |
5307144 | Hiroshi et al. | Apr 1994 | A |
5307812 | Hardy et al. | May 1994 | A |
5312351 | Gerrone | May 1994 | A |
5320617 | Leach | Jun 1994 | A |
5323779 | Hardy et al. | Jun 1994 | A |
5327884 | Hardy et al. | Jul 1994 | A |
5343543 | Novak, Jr. et al. | Aug 1994 | A |
5344418 | Ghaffari | Sep 1994 | A |
5344419 | Spears | Sep 1994 | A |
5348048 | Schirado et al. | Sep 1994 | A |
5354293 | Beyer et al. | Oct 1994 | A |
5354294 | Chou | Oct 1994 | A |
5366456 | Rink et al. | Nov 1994 | A |
5368031 | Cline et al. | Nov 1994 | A |
5368032 | Cline et al. | Nov 1994 | A |
5370649 | Gardetto et al. | Dec 1994 | A |
5374266 | Kataoka et al. | Dec 1994 | A |
5387220 | Pisharodi | Feb 1995 | A |
5388580 | Sullivan et al. | Feb 1995 | A |
5409493 | Greenberg | Apr 1995 | A |
5433717 | Rubinsky et al. | Jul 1995 | A |
5443068 | Cline et al. | Aug 1995 | A |
5445166 | Taylor | Aug 1995 | A |
5454794 | Narciso, Jr. et al. | Oct 1995 | A |
5454807 | Lennox et al. | Oct 1995 | A |
5454897 | Vaniglia | Oct 1995 | A |
5469353 | Pinsky et al. | Nov 1995 | A |
5474564 | Clayman et al. | Dec 1995 | A |
5476461 | Cho et al. | Dec 1995 | A |
5490840 | Uzgiris et al. | Feb 1996 | A |
5492122 | Button et al. | Feb 1996 | A |
5496308 | Brown et al. | Mar 1996 | A |
5499313 | Kleinerman | Mar 1996 | A |
5509917 | Cecchetti et al. | Apr 1996 | A |
5526814 | Cline et al. | Jun 1996 | A |
5530780 | Ohsawa | Jun 1996 | A |
5534000 | Bruce | Jul 1996 | A |
5537499 | Brekke | Jul 1996 | A |
5553618 | Suzuki et al. | Sep 1996 | A |
5562688 | Riza | Oct 1996 | A |
5568503 | Omori | Oct 1996 | A |
5571099 | Purcell, Jr. et al. | Nov 1996 | A |
5589233 | Law et al. | Dec 1996 | A |
5590653 | Aida et al. | Jan 1997 | A |
5620479 | Diederich | Apr 1997 | A |
5632767 | Sinofsky | May 1997 | A |
5636259 | Khutoryansky et al. | Jun 1997 | A |
5638819 | Manwaring et al. | Jun 1997 | A |
5643179 | Fujimoto | Jul 1997 | A |
5647361 | Damadian | Jul 1997 | A |
5655084 | Pinsky et al. | Aug 1997 | A |
5657760 | Ying et al. | Aug 1997 | A |
5663646 | Kuth et al. | Sep 1997 | A |
5671353 | Tian et al. | Sep 1997 | A |
5672171 | Andrus et al. | Sep 1997 | A |
5672172 | Zupkas | Sep 1997 | A |
5695501 | Carol et al. | Dec 1997 | A |
5711300 | Schneider et al. | Jan 1998 | A |
5715823 | Wood et al. | Feb 1998 | A |
5716369 | Riza | Feb 1998 | A |
5719975 | Wolfson et al. | Feb 1998 | A |
5728106 | Misko et al. | Mar 1998 | A |
5733277 | Pallarito | Mar 1998 | A |
5735846 | Panescu et al. | Apr 1998 | A |
5749362 | Funda et al. | May 1998 | A |
5749549 | Ashjaee | May 1998 | A |
5752962 | D'Urso | May 1998 | A |
5762066 | Law et al. | Jun 1998 | A |
5769790 | Watkins et al. | Jun 1998 | A |
5772657 | Hmelar et al. | Jun 1998 | A |
5782824 | Abela et al. | Jul 1998 | A |
5785704 | Bille et al. | Jul 1998 | A |
5792110 | Cunningham | Aug 1998 | A |
5807383 | Kolesa et al. | Sep 1998 | A |
5814008 | Chen et al. | Sep 1998 | A |
5817036 | Anthony et al. | Oct 1998 | A |
5823941 | Shaunnessey | Oct 1998 | A |
5824005 | Motamedi et al. | Oct 1998 | A |
5830209 | Savage et al. | Nov 1998 | A |
5848967 | Cosman | Dec 1998 | A |
5855582 | Gildenberg | Jan 1999 | A |
5855583 | Wang et al. | Jan 1999 | A |
5861020 | Schwarzmaier | Jan 1999 | A |
5873845 | Cline et al. | Feb 1999 | A |
5874955 | Rogowitz et al. | Feb 1999 | A |
5876342 | Chen et al. | Mar 1999 | A |
5890897 | Kruger et al. | Apr 1999 | A |
5891100 | Fleckenstein | Apr 1999 | A |
5891157 | Day et al. | Apr 1999 | A |
5897495 | Aida et al. | Apr 1999 | A |
5916161 | Ishihara et al. | Jun 1999 | A |
5928145 | Ocali et al. | Jul 1999 | A |
5944663 | Kuth et al. | Aug 1999 | A |
5945827 | Gronauer et al. | Aug 1999 | A |
5947958 | Woodard et al. | Sep 1999 | A |
5949929 | Hamm | Sep 1999 | A |
5959246 | Gretz | Sep 1999 | A |
5961466 | Anbar | Oct 1999 | A |
5978541 | Doiron et al. | Nov 1999 | A |
5989246 | Kaufmann et al. | Nov 1999 | A |
5993463 | Truwit | Nov 1999 | A |
6004315 | Dumont | Dec 1999 | A |
6006126 | Cosman | Dec 1999 | A |
6019724 | Gronningsaeter et al. | Feb 2000 | A |
6022309 | Celliers et al. | Feb 2000 | A |
6039728 | Berlien et al. | Mar 2000 | A |
6047216 | Carl et al. | Apr 2000 | A |
6050943 | Slayton et al. | Apr 2000 | A |
6053912 | Panescu et al. | Apr 2000 | A |
6058323 | Lemelson | May 2000 | A |
6067371 | Gouge et al. | May 2000 | A |
6071288 | Carol et al. | Jun 2000 | A |
6081533 | Laubach et al. | Jun 2000 | A |
6086532 | Panescu et al. | Jul 2000 | A |
6106516 | Massengill | Aug 2000 | A |
6117143 | Hynes et al. | Sep 2000 | A |
6123719 | Masychev | Sep 2000 | A |
6128522 | Acker et al. | Oct 2000 | A |
6131480 | Yoneyama | Oct 2000 | A |
6132437 | Omurtag et al. | Oct 2000 | A |
6133306 | Beal | Oct 2000 | A |
6143018 | Beuthan et al. | Nov 2000 | A |
6148225 | Kestler et al. | Nov 2000 | A |
6151404 | Pieper | Nov 2000 | A |
6152933 | Werp et al. | Nov 2000 | A |
6159150 | Yale et al. | Dec 2000 | A |
6162052 | Kokubu | Dec 2000 | A |
6164843 | Battocchio | Dec 2000 | A |
6167295 | Cosman | Dec 2000 | A |
6179831 | Bliweis | Jan 2001 | B1 |
6195579 | Carroll et al. | Feb 2001 | B1 |
6206873 | Paolini et al. | Mar 2001 | B1 |
6206885 | Ghahremani et al. | Mar 2001 | B1 |
6206890 | Truwit | Mar 2001 | B1 |
6226680 | Boucher et al. | May 2001 | B1 |
6241725 | Cosman | Jun 2001 | B1 |
6246200 | Blumenkranz et al. | Jun 2001 | B1 |
6246896 | Dumoulin et al. | Jun 2001 | B1 |
6246912 | Sluijter et al. | Jun 2001 | B1 |
6254043 | Schwarzler | Jul 2001 | B1 |
6263229 | Atalar et al. | Jul 2001 | B1 |
6267769 | Truwit | Jul 2001 | B1 |
6267770 | Truwit | Jul 2001 | B1 |
6280384 | Loeffler | Aug 2001 | B1 |
6283958 | Vogl et al. | Sep 2001 | B1 |
6283988 | Laufer et al. | Sep 2001 | B1 |
6286795 | Johnson | Sep 2001 | B1 |
6293282 | Lemelson | Sep 2001 | B1 |
6320928 | Vaillant et al. | Nov 2001 | B1 |
6321266 | Yokomizo et al. | Nov 2001 | B1 |
6332891 | Himes | Dec 2001 | B1 |
6334847 | Fenster et al. | Jan 2002 | B1 |
6353445 | Babula et al. | Mar 2002 | B1 |
6355028 | Castaneda et al. | Mar 2002 | B2 |
6368329 | Truwit | Apr 2002 | B1 |
6368330 | Hynes et al. | Apr 2002 | B1 |
6397098 | Uber, III et al. | May 2002 | B1 |
6398778 | Gu et al. | Jun 2002 | B1 |
6409722 | Hoey et al. | Jun 2002 | B1 |
6413253 | Koop et al. | Jul 2002 | B1 |
6413263 | Lobdill et al. | Jul 2002 | B1 |
6416520 | Kynast et al. | Jul 2002 | B1 |
6418337 | Torchia et al. | Jul 2002 | B1 |
6419648 | Vitek et al. | Jul 2002 | B1 |
6423057 | He et al. | Jul 2002 | B1 |
6423077 | Carol et al. | Jul 2002 | B2 |
6425867 | Vaezy et al. | Jul 2002 | B1 |
6440127 | McGovern et al. | Aug 2002 | B2 |
6447505 | McGovern et al. | Sep 2002 | B2 |
6451015 | Rittman, III et al. | Sep 2002 | B1 |
6454774 | Fleckenstein | Sep 2002 | B1 |
6461314 | Pant et al. | Oct 2002 | B1 |
6464690 | Castaneda et al. | Oct 2002 | B1 |
6464691 | Castaneda et al. | Oct 2002 | B1 |
6464694 | Massengill | Oct 2002 | B1 |
6468238 | Hawkins et al. | Oct 2002 | B1 |
6488697 | Ariura et al. | Dec 2002 | B1 |
6491699 | Henderson et al. | Dec 2002 | B1 |
6501978 | Wagshul et al. | Dec 2002 | B2 |
6506154 | Ezion et al. | Jan 2003 | B1 |
6506171 | Vitek et al. | Jan 2003 | B1 |
6507747 | Gowda et al. | Jan 2003 | B1 |
6510241 | Vaillant et al. | Jan 2003 | B1 |
6522142 | Freundlich | Feb 2003 | B1 |
6522913 | Swanson et al. | Feb 2003 | B2 |
6529765 | Franck et al. | Mar 2003 | B1 |
6542767 | McNichols et al. | Apr 2003 | B1 |
6543272 | Vitek | Apr 2003 | B1 |
6544248 | Bass | Apr 2003 | B1 |
6544257 | Nagase et al. | Apr 2003 | B2 |
6549800 | Malar et al. | Apr 2003 | B1 |
6551274 | Heiner | Apr 2003 | B2 |
6554826 | Deardorff | Apr 2003 | B1 |
6558375 | Sinofsky et al. | May 2003 | B1 |
6559644 | Froundlich et al. | May 2003 | B2 |
6575969 | Rittman, III | Jun 2003 | B1 |
6577888 | Chan et al. | Jun 2003 | B1 |
6579281 | Palmer et al. | Jun 2003 | B2 |
6582381 | Yehezkeli et al. | Jun 2003 | B1 |
6582420 | Castaneda et al. | Jun 2003 | B2 |
6585665 | Chapman et al. | Jul 2003 | B1 |
6589174 | Chopra et al. | Jul 2003 | B1 |
6591128 | Wu et al. | Jul 2003 | B1 |
6603988 | Dowlatshahi | Aug 2003 | B2 |
6606091 | Liang et al. | Aug 2003 | B2 |
6606513 | Lardo et al. | Aug 2003 | B2 |
6612988 | Maor et al. | Sep 2003 | B2 |
6613004 | Vitek et al. | Sep 2003 | B1 |
6613005 | Friedman et al. | Sep 2003 | B1 |
6618608 | Watkins et al. | Sep 2003 | B1 |
6618620 | Freundlich et al. | Sep 2003 | B1 |
6623490 | Crane et al. | Sep 2003 | B1 |
6626854 | Friedman et al. | Sep 2003 | B2 |
6628980 | Atalar et al. | Sep 2003 | B2 |
6631499 | Tsujii | Oct 2003 | B1 |
6645162 | Friedman et al. | Nov 2003 | B2 |
6666833 | Friedman et al. | Dec 2003 | B1 |
6671535 | McNichols et al. | Dec 2003 | B1 |
6675033 | Lardo et al. | Jan 2004 | B1 |
6675037 | Tsekos | Jan 2004 | B1 |
6684097 | Panel et al. | Jan 2004 | B1 |
6695871 | Maki et al. | Feb 2004 | B1 |
6701176 | Halperin et al. | Mar 2004 | B1 |
6701181 | Tang et al. | Mar 2004 | B2 |
6705994 | Vortman et al. | Mar 2004 | B2 |
6716215 | David et al. | Apr 2004 | B1 |
6731966 | Spigelman et al. | May 2004 | B1 |
6735461 | Vitek et al. | May 2004 | B2 |
6741883 | Gildenberg | May 2004 | B2 |
6752812 | Truwit | Jun 2004 | B1 |
6755849 | Gowda et al. | Jun 2004 | B1 |
6770031 | Hynynen et al. | Aug 2004 | B2 |
6773408 | Acker et al. | Aug 2004 | B1 |
6782288 | Truwit et al. | Aug 2004 | B2 |
6790180 | Vitek | Sep 2004 | B2 |
6801643 | Pieper | Oct 2004 | B2 |
6823216 | Salomir et al. | Nov 2004 | B1 |
6825838 | Smith et al. | Nov 2004 | B2 |
6843793 | Brock et al. | Jan 2005 | B2 |
6845193 | Loeb et al. | Jan 2005 | B2 |
6893447 | Dominguez et al. | May 2005 | B2 |
6898454 | Atalar et al. | May 2005 | B2 |
6902569 | Parmer et al. | Jun 2005 | B2 |
6904307 | Karmarkar et al. | Jun 2005 | B2 |
6986764 | Davenport et al. | Jan 2006 | B2 |
7033367 | Ghahremani et al. | Apr 2006 | B2 |
7072704 | Bucholz | Jul 2006 | B2 |
7074233 | Gowda et al. | Jul 2006 | B1 |
7097641 | Arless et al. | Aug 2006 | B1 |
7123255 | Frousett et al. | Oct 2006 | B2 |
7128711 | Medan et al. | Oct 2006 | B2 |
7133714 | Karmarkar et al. | Nov 2006 | B2 |
7163542 | Ryan | Jan 2007 | B2 |
7164940 | Hareyama et al. | Jan 2007 | B2 |
7166458 | Ballerstadt et al. | Jan 2007 | B2 |
7167741 | Torchia et al. | Jan 2007 | B2 |
7167760 | Dawant et al. | Jan 2007 | B2 |
7175596 | Vitek et al. | Feb 2007 | B2 |
7226414 | Ballerstadt et al. | Jun 2007 | B2 |
7228165 | Sullivan | Jun 2007 | B1 |
7229451 | Day et al. | Jun 2007 | B2 |
7235084 | Skakoon et al. | Jun 2007 | B2 |
7235089 | McGuckin, Jr. | Jun 2007 | B1 |
7236812 | Ballerstadt et al. | Jun 2007 | B1 |
7236816 | Kumar et al. | Jun 2007 | B2 |
7270656 | Gowda et al. | Sep 2007 | B2 |
7274847 | Gowda et al. | Sep 2007 | B2 |
7280686 | Hornegger et al. | Oct 2007 | B2 |
7292719 | Amon | Nov 2007 | B2 |
7315167 | Bottcher | Jan 2008 | B2 |
7321374 | Naske | Jan 2008 | B2 |
7344529 | Torchia et al. | Mar 2008 | B2 |
RE40279 | Sluijter et al. | Apr 2008 | E |
7366561 | Mills et al. | Apr 2008 | B2 |
7371210 | Brock et al. | May 2008 | B2 |
7377900 | Vitek et al. | May 2008 | B2 |
7412141 | Gowda et al. | Aug 2008 | B2 |
7450985 | Meloy | Nov 2008 | B2 |
7463801 | Brekke et al. | Dec 2008 | B2 |
7479139 | Cytron et al. | Jan 2009 | B2 |
7489133 | Keidl et al. | Feb 2009 | B1 |
7494489 | Roh | Feb 2009 | B2 |
7507244 | Dinkler | Mar 2009 | B2 |
7519210 | Hirsch et al. | Apr 2009 | B2 |
7521930 | Li et al. | Apr 2009 | B2 |
7535794 | Prus et al. | May 2009 | B2 |
7551953 | Lardo et al. | Jun 2009 | B2 |
7561906 | Atalar et al. | Jul 2009 | B2 |
7599729 | Atalar et al. | Oct 2009 | B2 |
7602190 | Piferi et al. | Oct 2009 | B2 |
7609927 | Gowda et al. | Oct 2009 | B2 |
7611462 | Vortman et al. | Nov 2009 | B2 |
7631233 | Parris et al. | Dec 2009 | B2 |
7634119 | Tsougarakis et al. | Dec 2009 | B2 |
7652410 | Prus | Jan 2010 | B2 |
7659719 | Vaughan et al. | Feb 2010 | B2 |
7661162 | Soerensen et al. | Feb 2010 | B2 |
7699780 | Vitek et al. | Apr 2010 | B2 |
7702140 | Hirsch et al. | Apr 2010 | B2 |
7706858 | Green et al. | Apr 2010 | B1 |
7717853 | Nita | May 2010 | B2 |
7736371 | Schoepp | Jun 2010 | B2 |
7778682 | Kumar et al. | Aug 2010 | B2 |
7792566 | Roland et al. | Sep 2010 | B2 |
7794469 | Kao et al. | Sep 2010 | B2 |
7801587 | Webber et al. | Sep 2010 | B2 |
7848788 | Tulley et al. | Dec 2010 | B2 |
7876939 | Yankelevitz et al. | Jan 2011 | B2 |
7925328 | Urquhart et al. | Apr 2011 | B2 |
7957783 | Atalar et al. | Jun 2011 | B2 |
8002706 | Vortman et al. | Aug 2011 | B2 |
8022705 | Bogdanov | Sep 2011 | B2 |
RE42856 | Karmarkar et al. | Oct 2011 | E |
8029471 | Khan-Sahibzada et al. | Oct 2011 | B1 |
8034569 | Jackson et al. | Oct 2011 | B2 |
8055351 | Atalar et al. | Nov 2011 | B2 |
8060182 | He et al. | Nov 2011 | B2 |
8068893 | Guttman et al. | Nov 2011 | B2 |
8088067 | Vortman et al. | Jan 2012 | B2 |
8094900 | Steines et al. | Jan 2012 | B2 |
8099150 | Piferi et al. | Jan 2012 | B2 |
8100132 | Markstroem | Jan 2012 | B2 |
8108028 | Karmarkar | Jan 2012 | B2 |
8114068 | Rheinwald et al. | Feb 2012 | B2 |
8116843 | Dai et al. | Feb 2012 | B2 |
8157828 | Piferi | Apr 2012 | B2 |
8165658 | Waynik et al. | Apr 2012 | B2 |
8175677 | Sayler et al. | May 2012 | B2 |
8190237 | Driemel | May 2012 | B2 |
8195272 | Piferi et al. | Jun 2012 | B2 |
8208993 | Piferi et al. | Jun 2012 | B2 |
8211095 | Gowda et al. | Jul 2012 | B2 |
8216854 | Ballerstadt et al. | Jul 2012 | B2 |
8221427 | Roh | Jul 2012 | B2 |
8224420 | Mu et al. | Jul 2012 | B2 |
8233701 | Frakes et al. | Jul 2012 | B2 |
8235901 | Schmidt et al. | Aug 2012 | B2 |
8251908 | Vortman et al. | Aug 2012 | B2 |
8267938 | Murphy | Sep 2012 | B2 |
8270698 | Geiger | Sep 2012 | B2 |
8285097 | Griffin | Oct 2012 | B2 |
8287537 | Dinkler, II | Oct 2012 | B2 |
8298245 | Li et al. | Oct 2012 | B2 |
8314052 | Jackson | Nov 2012 | B2 |
8315689 | Jenkins et al. | Nov 2012 | B2 |
8320990 | Vij | Nov 2012 | B2 |
8340743 | Jenkins et al. | Dec 2012 | B2 |
RE43901 | Freundlich et al. | Jan 2013 | E |
8343138 | Asfora | Jan 2013 | B2 |
8364217 | Ballerstadt et al. | Jan 2013 | B2 |
8368401 | Levy et al. | Feb 2013 | B2 |
8369930 | Jenkins et al. | Feb 2013 | B2 |
8374677 | Piferi et al. | Feb 2013 | B2 |
8380277 | Atalar et al. | Feb 2013 | B2 |
8387220 | Ishikura et al. | Mar 2013 | B2 |
8396532 | Jenkins et al. | Mar 2013 | B2 |
8404495 | Ballerstadt et al. | Mar 2013 | B2 |
8409099 | Vitek et al. | Apr 2013 | B2 |
8414597 | Kao et al. | Apr 2013 | B2 |
8425424 | Zadicario et al. | Apr 2013 | B2 |
8433421 | Atalar et al. | Apr 2013 | B2 |
8482285 | Grissom et al. | Jul 2013 | B2 |
8520932 | Cool et al. | Aug 2013 | B2 |
8548561 | Vortman et al. | Oct 2013 | B2 |
8548569 | Piferi et al. | Oct 2013 | B2 |
8608672 | Vortman et al. | Dec 2013 | B2 |
8617073 | Prus et al. | Dec 2013 | B2 |
RE44726 | Parris et al. | Jan 2014 | E |
RE44736 | Karmarkar et al. | Jan 2014 | E |
8644906 | Piferi et al. | Feb 2014 | B2 |
8649842 | Atalar et al. | Feb 2014 | B2 |
8661873 | Medan et al. | Mar 2014 | B2 |
8688226 | Atalar et al. | Apr 2014 | B2 |
8728092 | Qureshi et al. | May 2014 | B2 |
8737712 | Geiger | May 2014 | B2 |
8979871 | Tyc et al. | Mar 2015 | B2 |
9333038 | Torchia et al. | May 2016 | B2 |
9387042 | Torchia et al. | Jul 2016 | B2 |
20010003798 | McGovern et al. | Jun 2001 | A1 |
20020019641 | Truwit | Feb 2002 | A1 |
20020042605 | Castaneda et al. | Apr 2002 | A1 |
20020052610 | Skakoon et al. | May 2002 | A1 |
20020087148 | Brock et al. | Jul 2002 | A1 |
20020103459 | Sparks et al. | Aug 2002 | A1 |
20020169460 | Foster et al. | Nov 2002 | A1 |
20020177843 | Anderson et al. | Nov 2002 | A1 |
20030023236 | Gowda et al. | Jan 2003 | A1 |
20030060813 | Loeb et al. | Mar 2003 | A1 |
20030171741 | Ziebol et al. | Sep 2003 | A1 |
20030187371 | Vortman et al. | Oct 2003 | A1 |
20040059265 | Candy | Mar 2004 | A1 |
20040073100 | Ballerstadt et al. | Apr 2004 | A1 |
20040075031 | Crain et al. | Apr 2004 | A1 |
20040082984 | Osorio et al. | Apr 2004 | A1 |
20040122446 | Solar | Jun 2004 | A1 |
20040123870 | Stamper et al. | Jul 2004 | A1 |
20040133190 | Hobart et al. | Jul 2004 | A1 |
20040134884 | Wei et al. | Jul 2004 | A1 |
20040158237 | Abboud | Aug 2004 | A1 |
20040167542 | Solar et al. | Aug 2004 | A1 |
20040167543 | Mazzocchi et al. | Aug 2004 | A1 |
20040249261 | Torchia et al. | Dec 2004 | A1 |
20040267284 | Parmer et al. | Dec 2004 | A1 |
20050070920 | Solar et al. | Mar 2005 | A1 |
20050154378 | Teague et al. | Jul 2005 | A1 |
20060009749 | Weckwerth et al. | Jan 2006 | A1 |
20060089626 | Vlegele et al. | Apr 2006 | A1 |
20060122590 | Bliweis et al. | Jun 2006 | A1 |
20060122629 | Skakoon | Jun 2006 | A1 |
20060175484 | Wood et al. | Aug 2006 | A1 |
20060192319 | Solar | Aug 2006 | A1 |
20060195119 | Mazzocchi et al. | Aug 2006 | A1 |
20060206105 | Chopra et al. | Sep 2006 | A1 |
20060212044 | Bova et al. | Sep 2006 | A1 |
20060229641 | Gupta et al. | Oct 2006 | A1 |
20060241393 | Liu et al. | Oct 2006 | A1 |
20060265022 | John et al. | Nov 2006 | A1 |
20060287647 | Torchia et al. | Dec 2006 | A1 |
20070016039 | Vortman et al. | Jan 2007 | A1 |
20070043342 | Kleinberger | Feb 2007 | A1 |
20070088416 | Atalar et al. | Apr 2007 | A1 |
20070100346 | Wyss et al. | May 2007 | A1 |
20070106305 | Kao et al. | May 2007 | A1 |
20070149977 | Heavener | Jun 2007 | A1 |
20070191867 | Mazzocchi et al. | Aug 2007 | A1 |
20070197918 | Vitek et al. | Aug 2007 | A1 |
20070208352 | Henderson et al. | Sep 2007 | A1 |
20070225562 | Spivey et al. | Sep 2007 | A1 |
20070238978 | Kumar et al. | Oct 2007 | A1 |
20070239062 | Chopra et al. | Oct 2007 | A1 |
20070250077 | Skakoon et al. | Oct 2007 | A1 |
20070270717 | Tang et al. | Nov 2007 | A1 |
20070282404 | Cottrell et al. | Dec 2007 | A1 |
20080002927 | Furnish | Jan 2008 | A1 |
20080027463 | Labadie et al. | Jan 2008 | A1 |
20080033278 | Assif | Feb 2008 | A1 |
20080033292 | Shafran | Feb 2008 | A1 |
20080046122 | Manzo et al. | Feb 2008 | A1 |
20080077159 | Madhani et al. | Mar 2008 | A1 |
20080097187 | Gielen et al. | Apr 2008 | A1 |
20080114340 | Fox et al. | May 2008 | A1 |
20080123921 | Gielen et al. | May 2008 | A1 |
20080123922 | Gielen et al. | May 2008 | A1 |
20080195085 | Loeb | Aug 2008 | A1 |
20080208034 | Yang et al. | Aug 2008 | A1 |
20080242978 | Simon et al. | Oct 2008 | A1 |
20080243142 | Gildenberg | Oct 2008 | A1 |
20080243218 | Bottomley et al. | Oct 2008 | A1 |
20080255583 | Gielen et al. | Oct 2008 | A1 |
20080262584 | Bottomley et al. | Oct 2008 | A1 |
20080269588 | Csavoy et al. | Oct 2008 | A1 |
20080269602 | Csavoy et al. | Oct 2008 | A1 |
20080287917 | Cunningham | Nov 2008 | A1 |
20080306375 | Sayler et al. | Dec 2008 | A1 |
20090012509 | Csavoy et al. | Jan 2009 | A1 |
20090018446 | Medan et al. | Jan 2009 | A1 |
20090048588 | Peng et al. | Feb 2009 | A1 |
20090048606 | Tipirneni et al. | Feb 2009 | A1 |
20090082783 | Piferi | Mar 2009 | A1 |
20090088623 | Vortman et al. | Apr 2009 | A1 |
20090099045 | Jackson et al. | Apr 2009 | A1 |
20090112082 | Piferi et al. | Apr 2009 | A1 |
20090118610 | Karmarkar et al. | May 2009 | A1 |
20090124398 | Thompson | May 2009 | A1 |
20090131783 | Jenkins et al. | May 2009 | A1 |
20090148493 | Ballerstadt et al. | Jun 2009 | A1 |
20090171184 | Jenkins et al. | Jul 2009 | A1 |
20090192487 | Broaddus et al. | Jul 2009 | A1 |
20090198309 | Gowda et al. | Aug 2009 | A1 |
20090204111 | Bissig et al. | Aug 2009 | A1 |
20090234368 | Gore | Sep 2009 | A1 |
20090240242 | Neuberger | Sep 2009 | A1 |
20090264876 | Roy et al. | Oct 2009 | A1 |
20090266760 | Jackson et al. | Oct 2009 | A1 |
20090275130 | Navran et al. | Nov 2009 | A1 |
20090287199 | Hanley et al. | Nov 2009 | A1 |
20090308400 | Wilson et al. | Dec 2009 | A1 |
20090326525 | Hixon et al. | Dec 2009 | A1 |
20100016930 | Gowda et al. | Jan 2010 | A1 |
20100022951 | Ferrera et al. | Jan 2010 | A1 |
20100030076 | Vortman et al. | Feb 2010 | A1 |
20100041938 | Stoianovici et al. | Feb 2010 | A1 |
20100042112 | Qureshi et al. | Feb 2010 | A1 |
20100079580 | Waring, IV | Apr 2010 | A1 |
20100082035 | Keefer | Apr 2010 | A1 |
20100087336 | Jackson et al. | Apr 2010 | A1 |
20100146713 | Medan et al. | Jun 2010 | A1 |
20100179425 | Zadicario | Jul 2010 | A1 |
20100198052 | Jenkins et al. | Aug 2010 | A1 |
20100241036 | Vortman et al. | Sep 2010 | A1 |
20100305580 | Henderson et al. | Dec 2010 | A1 |
20100312094 | Guttman et al. | Dec 2010 | A1 |
20100312095 | Jenkins et al. | Dec 2010 | A1 |
20100312096 | Guttman et al. | Dec 2010 | A1 |
20100318002 | Prus et al. | Dec 2010 | A1 |
20110009734 | Foley et al. | Jan 2011 | A1 |
20110009828 | Prechtel et al. | Jan 2011 | A1 |
20110034800 | Vitek et al. | Feb 2011 | A1 |
20110040172 | Carpentier et al. | Feb 2011 | A1 |
20110046472 | Schmidt et al. | Feb 2011 | A1 |
20110046475 | Assif et al. | Feb 2011 | A1 |
20110066032 | Vitek et al. | Mar 2011 | A1 |
20110092848 | Hibner et al. | Apr 2011 | A1 |
20110118715 | Zerfas | May 2011 | A1 |
20110137147 | Skliar et al. | Jun 2011 | A1 |
20110141759 | Smith | Jun 2011 | A1 |
20110166447 | Windolf et al. | Jul 2011 | A1 |
20110175615 | Grissom et al. | Jul 2011 | A1 |
20110190787 | Sahni | Aug 2011 | A1 |
20110217665 | Walsh et al. | Sep 2011 | A1 |
20110224576 | Jackson et al. | Sep 2011 | A1 |
20110226260 | Eder et al. | Sep 2011 | A1 |
20110230753 | Mahon et al. | Sep 2011 | A1 |
20110237930 | Donaldson et al. | Sep 2011 | A1 |
20110238139 | Gowda et al. | Sep 2011 | A1 |
20110251528 | Canney et al. | Oct 2011 | A1 |
20110260728 | Biber et al. | Oct 2011 | A1 |
20110267059 | Shvartsberg et al. | Nov 2011 | A1 |
20110270075 | Vitek et al. | Nov 2011 | A1 |
20110270136 | Vitek et al. | Nov 2011 | A1 |
20110270366 | Mahon et al. | Nov 2011 | A1 |
20110295161 | Chopra et al. | Dec 2011 | A1 |
20110301450 | Hue et al. | Dec 2011 | A1 |
20110306054 | Jackson et al. | Dec 2011 | A1 |
20110319747 | Schmidt et al. | Dec 2011 | A1 |
20110319748 | Bronskill et al. | Dec 2011 | A1 |
20110319910 | Roelle et al. | Dec 2011 | A1 |
20120015359 | Jackson et al. | Jan 2012 | A1 |
20120029396 | Vortman et al. | Feb 2012 | A1 |
20120053573 | Alksnis | Mar 2012 | A1 |
20120059243 | Vortman et al. | Mar 2012 | A1 |
20120059335 | Bobo Sr. | Mar 2012 | A1 |
20120065629 | Elkins et al. | Mar 2012 | A1 |
20120070058 | Raju et al. | Mar 2012 | A1 |
20120071746 | Vortman et al. | Mar 2012 | A1 |
20120095364 | Bobo Sr. | Apr 2012 | A1 |
20120101412 | Vortman et al. | Apr 2012 | A1 |
20120108459 | Jackson et al. | May 2012 | A1 |
20120121533 | Jackson | May 2012 | A1 |
20120165225 | Stepanov et al. | Jun 2012 | A1 |
20120191020 | Vitek et al. | Jul 2012 | A1 |
20120197112 | McNichols | Aug 2012 | A1 |
20120245573 | Gowda et al. | Sep 2012 | A1 |
20130006095 | Jenkins et al. | Jan 2013 | A1 |
20130018430 | Murphy | Jan 2013 | A1 |
20130030408 | Piferi et al. | Jan 2013 | A1 |
20130034915 | Ballerstadt et al. | Feb 2013 | A1 |
20130035582 | Radulescu et al. | Feb 2013 | A1 |
20130041356 | Smith et al. | Feb 2013 | A1 |
20130053678 | Vitek et al. | Feb 2013 | A1 |
20130053867 | Gowda et al. | Feb 2013 | A1 |
20130060253 | Couture et al. | Mar 2013 | A1 |
20130085342 | Stefanchik et al. | Apr 2013 | A1 |
20130090639 | Atias et al. | Apr 2013 | A1 |
20130102883 | Piferi et al. | Apr 2013 | A1 |
20130116543 | Jenkins et al. | May 2013 | A1 |
20130119984 | Levy et al. | May 2013 | A1 |
20130123598 | Jenkins et al. | May 2013 | A1 |
20130131496 | Jenkins et al. | May 2013 | A1 |
20130150704 | Vitek et al. | Jun 2013 | A1 |
20130150756 | Vitek et al. | Jun 2013 | A1 |
20130157871 | Jackson | Jun 2013 | A1 |
20130158577 | Mahon et al. | Jun 2013 | A1 |
20130163841 | Geiger | Jun 2013 | A1 |
20130184563 | Driemel | Jul 2013 | A1 |
20130190607 | Biber et al. | Jul 2013 | A1 |
20130217950 | Partanen et al. | Aug 2013 | A1 |
20130245243 | Jackson | Sep 2013 | A1 |
20130245741 | Atalar et al. | Sep 2013 | A1 |
20130274778 | Mercier et al. | Oct 2013 | A1 |
20130325012 | Piferi et al. | Dec 2013 | A1 |
20140024909 | Vij et al. | Jan 2014 | A1 |
20140024925 | Piferi | Jan 2014 | A1 |
20140024927 | Piferi | Jan 2014 | A1 |
20140034377 | Vij | Feb 2014 | A1 |
20140046167 | Vij et al. | Feb 2014 | A1 |
20140046343 | Okazaki et al. | Feb 2014 | A1 |
20140066750 | Piferi et al. | Mar 2014 | A1 |
20140066953 | Keating et al. | Mar 2014 | A1 |
20140112095 | Medan et al. | Apr 2014 | A1 |
20140128881 | Tyc et al. | May 2014 | A1 |
20150148659 | Vahala | May 2015 | A1 |
20150265306 | Andrews et al. | Sep 2015 | A1 |
20150265353 | Andrews et al. | Sep 2015 | A1 |
20150265365 | Andrews et al. | Sep 2015 | A1 |
20150265366 | Andrews et al. | Sep 2015 | A1 |
Number | Date | Country |
---|---|---|
1317641 | May 1993 | CA |
2348867 | May 2000 | CA |
2370222 | Oct 2000 | CA |
2398967 | Aug 2001 | CA |
2.404352 | Oct 2001 | CA |
2403822 | Oct 2001 | CA |
2404352 | Oct 2001 | CA |
2482291 | Oct 2002 | CA |
2.587691 | May 2006 | CA |
2587691 | May 2006 | CA |
2606824 | Nov 2006 | CA |
2623453 | Apr 2007 | CA |
2679498 | Sep 2008 | CA |
2681367 | Sep 2008 | CA |
2695494 | Dec 2008 | CA |
2700523 | Apr 2009 | CA |
2700529 | Apr 2009 | CA |
2700531 | Apr 2009 | CA |
2700577 | Apr 2009 | CA |
2700607 | Apr 2009 | CA |
2704739 | Apr 2009 | CA |
2.648973 | Jul 2009 | CA |
2252431 | Jul 2009 | CA |
2648973 | Jul 2009 | CA |
2715015 | Sep 2009 | CA |
2748053 | Apr 2010 | CA |
2753397 | Sep 2010 | CA |
2372.001 | Oct 2010 | CA |
2372001 | Oct 2010 | CA |
2764677 | Dec 2010 | CA |
1317641 | May 2011 | CA |
2487140 | Sep 2011 | CA |
2800238 | Sep 2011 | CA |
2482202 | Jul 2012 | CA |
2849106 | Apr 2013 | CA |
2575313 | Jul 2013 | CA |
2548.226 | Jan 2014 | CA |
2548226 | Jan 2014 | CA |
2620289 | Jun 2004 | CN |
2748071 | Dec 2005 | CN |
101040772 | Sep 2007 | CN |
101194853 | Jun 2008 | CN |
26 21 909 | Dec 1977 | DE |
2621909 | Dec 1977 | DE |
0 610 991 | Aug 1994 | EP |
0610991 | Aug 1994 | EP |
0 614 651 | Sep 1994 | EP |
0614651 | Sep 1994 | EP |
0 755 697 | Jan 1997 | EP |
0755697 | Jan 1997 | EP |
0844581 | May 1998 | EP |
1 046 377 | Oct 2000 | EP |
1046377 | Oct 2000 | EP |
0 844 581 | Jul 2007 | EP |
1 829 764 | Sep 2007 | EP |
1 829 764 | Sep 2007 | EP |
1 455 672 81 | May 2008 | EP |
1455672 | May 2008 | EP |
1 985 330 | Oct 2008 | EP |
54-88120 | Jul 1979 | JP |
59-42165 | Mar 1984 | JP |
60-154698 | Aug 1985 | JP |
7-308393 | Nov 1995 | JP |
7-328028 | Dec 1995 | JP |
9-038220 | Feb 1997 | JP |
10-155805 | Jun 1998 | JP |
10-258066 | Sep 1998 | JP |
11-253562 | Sep 1999 | JP |
2000-000319 | Jan 2000 | JP |
2000-000319 | Jan 2000 | JP |
2000-126316 | May 2000 | JP |
2000-126316 | May 2000 | JP |
2002-543865 | Dec 2002 | JP |
2002-543865 | Dec 2002 | JP |
54-88120 | May 2014 | JP |
59-42165 | Jun 2016 | JP |
9005494 | May 1990 | WO |
WO 9005494 | May 1990 | WO |
1992010142 | Jun 1992 | WO |
WO 1992010142 | Jun 1992 | WO |
9320769 | Oct 1993 | WO |
WO 9320769 | Oct 1993 | WO |
9404220 | Mar 1994 | WO |
WO 9404220 | Mar 1994 | WO |
1994023308 | Oct 1994 | WO |
WO 1994023308 | Oct 1994 | WO |
9529737 | Nov 1995 | WO |
WO 9529737 | Nov 1995 | WO |
1997040396 | Oct 1997 | WO |
WO 1997040396 | Oct 1997 | WO |
9823214 | Jun 1998 | WO |
WO 9823214 | Jun 1998 | WO |
9851229 | Nov 1998 | WO |
9852465 | Nov 1998 | WO |
WO 9851229 | Nov 1998 | WO |
WO 9852465 | Nov 1998 | WO |
9951156 | Oct 1999 | WO |
WO 9951156 | Oct 1999 | WO |
0023000 | Apr 2000 | WO |
WO 0023000 | Apr 2000 | WO |
2000028895 | May 2000 | WO |
WO 2000028895 | May 2000 | WO |
2000032102 | Jun 2000 | WO |
WO 2000032102 | Jun 2000 | WO |
2000062672 | Oct 2000 | WO |
2000064003 | Oct 2000 | WO |
WO 2000062672 | Oct 2000 | WO |
WO 2000064003 | Oct 2000 | WO |
0067640 | Nov 2000 | WO |
WO 0067640 | Nov 2000 | WO |
2001006925 | Feb 2001 | WO |
WO 2001006925 | Feb 2001 | WO |
2001025810 | Apr 2001 | WO |
WO 2001025810 | Apr 2001 | WO |
2001035825 | May 2001 | WO |
WO 2001035825 | May 2001 | WO |
2001040819 | Jun 2001 | WO |
WO 2001040819 | Jun 2001 | WO |
2001056469 | Aug 2001 | WO |
WO 2001056469 | Aug 2001 | WO |
2001065490 | Sep 2001 | WO |
WO 2001065490 | Sep 2001 | WO |
01076498 | Oct 2001 | WO |
2001073461 | Oct 2001 | WO |
2001074241 | Oct 2001 | WO |
WO 01076498 | Oct 2001 | WO |
WO 2001073461 | Oct 2001 | WO |
WO 2001074241 | Oct 2001 | WO |
2001080708 | Nov 2001 | WO |
2001080709 | Nov 2001 | WO |
2001082806 | Nov 2001 | WO |
WO 2001080708 | Nov 2001 | WO |
WO 2001080709 | Nov 2001 | WO |
WO 2001082806 | Nov 2001 | WO |
2002000093 | Jan 2002 | WO |
2002000298 | Jan 2002 | WO |
WO 2002000093 | Jan 2002 | WO |
WO 2002000298 | Jan 2002 | WO |
2002009812 | Feb 2002 | WO |
WO 2002009812 | Feb 2002 | WO |
2002024075 | Mar 2002 | WO |
2002024094 | Mar 2002 | WO |
WO 2002024075 | Mar 2002 | WO |
WO 2002024094 | Mar 2002 | WO |
2002043804 | Jun 2002 | WO |
2002043805 | Jun 2002 | WO |
2002044753 | Jun 2002 | WO |
2002045073 | Jun 2002 | WO |
WO 2002043804 | Jun 2002 | WO |
WO 2002043805 | Jun 2002 | WO |
WO 2002044753 | Jun 2002 | WO |
WO 2002045073 | Jun 2002 | WO |
2002051501 | Jul 2002 | WO |
WO 2002051501 | Jul 2002 | WO |
2002058791 | Aug 2002 | WO |
WO 2002058791 | Aug 2002 | WO |
2002083016 | Oct 2002 | WO |
2002084316 | Oct 2002 | WO |
2002085216 | Oct 2002 | WO |
WO 2002083016 | Oct 2002 | WO |
WO 2002084316 | Oct 2002 | WO |
WO 2002085216 | Oct 2002 | WO |
2002097466 | Dec 2002 | WO |
2002103380 | Dec 2002 | WO |
WO 2002097466 | Dec 2002 | WO |
WO 2002103380 | Dec 2002 | WO |
2003011160 | Feb 2003 | WO |
WO 2003011160 | Feb 2003 | WO |
2003017843 | Mar 2003 | WO |
WO 2003017843 | Mar 2003 | WO |
2003042707 | May 2003 | WO |
WO 2003042707 | May 2003 | WO |
2003048702 | Jun 2003 | WO |
2003052444 | Jun 2003 | WO |
WO 2003048702 | Jun 2003 | WO |
WO 2003052444 | Jun 2003 | WO |
03094759 | Nov 2003 | WO |
2003097162 | Nov 2003 | WO |
WO 03094759 | Nov 2003 | WO |
WO 2003097162 | Nov 2003 | WO |
2003102614 | Dec 2003 | WO |
WO 2003102614 | Dec 2003 | WO |
2004056421 | Jul 2004 | WO |
WO 2004056421 | Jul 2004 | WO |
2004075722 | Sep 2004 | WO |
WO 2004075722 | Sep 2004 | WO |
20041 05624 | Dec 2004 | WO |
2004103472 | Dec 2004 | WO |
WO 2004103472 | Dec 2004 | WO |
WO 2004105624 | Dec 2004 | WO |
2005046451 | May 2005 | WO |
2005046753 | May 2005 | WO |
WO 2005046451 | May 2005 | WO |
WO 2005046753 | May 2005 | WO |
2006014966 | Feb 2006 | WO |
2006018686 | Feb 2006 | WO |
WO 2006014966 | Feb 2006 | WO |
WO 2006018686 | Feb 2006 | WO |
2006021851 | Mar 2006 | WO |
WO 2006021851 | Mar 2006 | WO |
2006055554 | May 2006 | WO |
WO 2006055554 | May 2006 | WO |
2006119492 | Nov 2006 | WO |
WO 2006119492 | Nov 2006 | WO |
2006136912 | Dec 2006 | WO |
WO 2006136912 | Dec 2006 | WO |
2007047966 | Apr 2007 | WO |
WO 2007047966 | Apr 2007 | WO |
2007056458 | May 2007 | WO |
2007060474 | May 2007 | WO |
WO 2007056458 | May 2007 | WO |
WO 2007060474 | May 2007 | WO |
2007064937 | Jun 2007 | WO |
WO 2007064937 | Jun 2007 | WO |
2007085892 | Aug 2007 | WO |
WO 2007085892 | Aug 2007 | WO |
2007129166 | Nov 2007 | WO |
WO 2007129166 | Nov 2007 | WO |
2008015520 | Feb 2008 | WO |
2008015521 | Feb 2008 | WO |
2008015522 | Feb 2008 | WO |
2008015523 | Feb 2008 | WO |
WO 2008015520 | Feb 2008 | WO |
WO 2008015521 | Feb 2008 | WO |
WO 2008015522 | Feb 2008 | WO |
WO 2008015523 | Feb 2008 | WO |
2008070685 | Jun 2008 | WO |
WO 2008070685 | Jun 2008 | WO |
2008109864 | Sep 2008 | WO |
2008115383 | Sep 2008 | WO |
2008115426 | Sep 2008 | WO |
WO 2008109864 | Sep 2008 | WO |
WO 2008115383 | Sep 2008 | WO |
WO 2008115426 | Sep 2008 | WO |
WO-2008134509 | Nov 2008 | WO |
WO-2008142686 | Nov 2008 | WO |
2008153975 | Dec 2008 | WO |
WO 2008153975 | Dec 2008 | WO |
2009007847 | Jan 2009 | WO |
WO 2009007847 | Jan 2009 | WO |
2009042130 | Apr 2009 | WO |
2009042131 | Apr 2009 | WO |
2009042135 | Apr 2009 | WO |
2009042136 | Apr 2009 | WO |
2009042152 | Apr 2009 | WO |
2009042155 | Apr 2009 | WO |
2009042160 | Apr 2009 | WO |
2009044276 | Apr 2009 | WO |
WO 2009042130 | Apr 2009 | WO |
WO 2009042131 | Apr 2009 | WO |
WO 2009042135 | Apr 2009 | WO |
WO 2009042136 | Apr 2009 | WO |
WO 2009042152 | Apr 2009 | WO |
WO 2009042155 | Apr 2009 | WO |
WO 2009042160 | Apr 2009 | WO |
WO 2009044276 | Apr 2009 | WO |
2009067205 | May 2009 | WO |
WO 2009067205 | May 2009 | WO |
2009117069 | Sep 2009 | WO |
WO 2009117069 | Sep 2009 | WO |
2009124301 | Oct 2009 | WO |
WO 2009124301 | Oct 2009 | WO |
2009135198 | Nov 2009 | WO |
WO 2009135198 | Nov 2009 | WO |
WO-2010017641 | Feb 2010 | WO |
2010030373 | Mar 2010 | WO |
WO 2010030373 | Mar 2010 | WO |
2010034099 | Apr 2010 | WO |
WO 2010034099 | Apr 2010 | WO |
2010058292 | May 2010 | WO |
2010058293 | May 2010 | WO |
WO 2010058292 | May 2010 | WO |
WO 2010058293 | May 2010 | WO |
2010082135 | Jul 2010 | WO |
WO 2010082135 | Jul 2010 | WO |
2010087961 | Aug 2010 | WO |
WO 2010087961 | Aug 2010 | WO |
2010110929 | Sep 2010 | WO |
WO 2010110929 | Sep 2010 | WO |
2010119340 | Oct 2010 | WO |
WO 2010119340 | Oct 2010 | WO |
2010141102 | Dec 2010 | WO |
2010143072 | Dec 2010 | WO |
2010144402 | Dec 2010 | WO |
2010144405 | Dec 2010 | WO |
2010144419 | Dec 2010 | WO |
2010148083 | Dec 2010 | WO |
2010148088 | Dec 2010 | WO |
WO 2010141102 | Dec 2010 | WO |
WO 2010143072 | Dec 2010 | WO |
WO 2010144402 | Dec 2010 | WO |
WO 2010144405 | Dec 2010 | WO |
WO 2010144419 | Dec 2010 | WO |
WO 2010148083 | Dec 2010 | WO |
WO 2010148088 | Dec 2010 | WO |
2011013001 | Feb 2011 | WO |
2011015949 | Feb 2011 | WO |
2011021106 | Feb 2011 | WO |
WO 2011013001 | Feb 2011 | WO |
WO 2011015949 | Feb 2011 | WO |
WO 2011021106 | Feb 2011 | WO |
2011024074 | Mar 2011 | WO |
2011028505 | Mar 2011 | WO |
WO 2011024074 | Mar 2011 | WO |
WO 2011028505 | Mar 2011 | WO |
2011045669 | Apr 2011 | WO |
WO 2011045669 | Apr 2011 | WO |
2011058437 | May 2011 | WO |
WO 2011058437 | May 2011 | WO |
2011087495 | Jul 2011 | WO |
2011090990 | Jul 2011 | WO |
WO 2011087495 | Jul 2011 | WO |
WO 2011090990 | Jul 2011 | WO |
2011112249 | Sep 2011 | WO |
2011112251 | Sep 2011 | WO |
2011115664 | Sep 2011 | WO |
WO 2011112249 | Sep 2011 | WO |
WO 2011112251 | Sep 2011 | WO |
WO 2011115664 | Sep 2011 | WO |
2011130107 | Oct 2011 | WO |
WO 2011130107 | Oct 2011 | WO |
2011135455 | Nov 2011 | WO |
2011135458 | Nov 2011 | WO |
WO 2011135455 | Nov 2011 | WO |
WO 2011135458 | Nov 2011 | WO |
2012014074 | Feb 2012 | WO |
WO 2012014074 | Feb 2012 | WO |
2012038826 | Mar 2012 | WO |
WO 2012038826 | Mar 2012 | WO |
2012052847 | Apr 2012 | WO |
WO 2012052847 | Apr 2012 | WO |
WO-2012057915 | May 2012 | WO |
2012112829 | Aug 2012 | WO |
2012116265 | Aug 2012 | WO |
WO 2012112829 | Aug 2012 | WO |
WO 2012116265 | Aug 2012 | WO |
WO2013063027 | Oct 2012 | WO |
2012154961 | Nov 2012 | WO |
2012147614 | Nov 2012 | WO |
WO 2012147614 | Nov 2012 | WO |
WO 2012154961 | Nov 2012 | WO |
2013028811 | Feb 2013 | WO |
WO 2013028811 | Feb 2013 | WO |
2013030671 | Mar 2013 | WO |
WO 2013030671 | Mar 2013 | WO |
2013049108 | Apr 2013 | WO |
WO 2013049108 | Apr 2013 | WO |
2013117991 | Aug 2013 | WO |
2013117992 | Aug 2013 | WO |
WO 2013117991 | Aug 2013 | WO |
WO 2013117992 | Aug 2013 | WO |
2013181008 | Dec 2013 | WO |
WO 2013181008 | Dec 2013 | WO |
2014014585 | Jan 2014 | WO |
WO 2014003855 | Jan 2014 | WO |
WO-2014003855 | Jan 2014 | WO |
WO 2014014585 | Jan 2014 | WO |
WO 2014003855 | Jan 2014 | WO |
2014039481 | Mar 2014 | WO |
WO 2014039481 | Mar 2014 | WO |
WO-2016149125 | Sep 2016 | WO |
Entry |
---|
European Examination Communication pursuant to Article 94(3) EPC, issued by the European Patent Office, regarding corresponding patent application Serial No. EP 16773825.1; dated Mar. 5, 2019; 8 pages. |
Supplementary European Search Report, issued by the European Patent Office, regarding corresponding patent application Serial No. EP 16773825.1; dated Feb. 11, 2019; 8 pages. |
Partial Supplementary European Search Report, issued by the European Patent Office, regarding corresponding patent application Serial No. EP16773825.1, dated Sep. 12, 2018. 14 pages. |
Office Action dated Jul. 5, 2016 in Chinese Patent Application No. 201380043974.1. |
U.S. Office Action dated Jun. 27, 2016 in U.S. Appl. No. 14/661,310, filed Mar. 18, 2015. |
Lubowitz, “Thermal chondroplasty using the Smith & Nephew Dyonics Glider Articular Cartilage Probe,” https://www.smith-nephew.com/global/surgicaltechniques/sports%20med/dyonics˜lider_pre-shapedprobe_tg_10600072a.pdf, Jul. 2006, pp. 1-8. |
International Search Report and Written Opinion dated Jun. 17, 2016 in PCT/US2016/024168 filed Mar. 25, 2016. |
International Search Report and Written Opinion dated Jun. 10, 2013, in PCT/US13/32273. |
Office Action dated Dec. 27, 2013, in Israeli Patent Application No. 210878. |
International Preliminary Report on Patentability dated Feb. 15, 2011, in PCT/CA2009/01137, 8 pages. |
International Preliminary Report on Patentability dated Feb. 15, 2011, in PCT/CA2009/01138, 5 pages. |
Office Action dated Oct. 25, 2011, in Brazilian Patent Application No. PI-0214951-6 (English translation). |
Office Action dated May 28, 2013, in Brazilian Patent Application No. PI-0214951-6 (English translation). |
Office Action dated Nov. 1, 2012, in Japanese Patent Application No. 2011-522361 (with English-language translation). |
Combined Chinese OA and Search Report dated Mar. 13, 2013, in Chinese Patent Application No. 200980131609.X. |
Kahn et al., “MRI-Guided Laser-Induced Interstitial Thermotherapy of Cerebral Neoplasms,” Journal of Computer Assisted Tomography, vol. 18, No. 4, pp. 519-532, Jul./Aug. 1994, Raven Press, Ltd., New York, NY. |
Kahn et al., “In Vivo MRI Thermometry Using a Phase-Sensitive Sequence: Preliminary Experience During MRI-Guided Laser-Induced Interstitial Thermotherapy of Brain Tumors,” Journal of Magnetic Resonance Imaging, vol. 8, No. 1, pp. 160-164, Williams & Wilkins, 1998, Baltimore, MD. |
McNichols et al., “MR Thermometry-Based Feedback Control of Laser Interstitial Thermal Therapy at 980 nm,” Lasers in Surgery and Medicine, 2004, 34: 48-55, Wiley-Liss, Inc. |
Schwarzmaier et al., “MR-guided laser-induced interstitial thermotherapy of recurrent glioblastoma multiforme: Preliminary results in 16 patients,” European Journal of Radiology, vol. 59, Issue 2, pp. 208-215, Aug. 2006. |
Office Action dated Oct. 8, 2012, in Chinese Patent Application No. 200980131600.9 (with English-language translation). |
Office Action dated Jul. 17, 2013, in Japanese Patent Application No. 2011-522361 (with English-language translation). |
Office Action dated Jul. 29, 2013, in Japanese Patent Application No. 2011-522360 (with English-language translation). |
Jerome Shaunnessey, Petition for General Supervisory Review by the Director under 37 CFR 1.181, Jul. 2014, 6 pages. |
International Search Report dated Aug. 3, 2012 in PCT/IB2012/051716. |
Office Action dated Nov. 1, 2012, in Japanese Patent Application No. 2011-522360 (with English Translation). |
Castro et al. “Interstitial laaser phototherapy assisted by magnetic resonance imaging: A new technique for monitoring laser-tissue interaction” The Laryngoscope, vol. 100, Issue , pp. 541-547, May 1990 (abstract only). |
Nabavi et al. “Neurosurgical procedures in a 0.5 tesla, open-configuration intraoperative MRI: planning, visualization, and navigation” Automedica, vol. 00, pp. 1-35, 2001. |
T. Menovsky, et al., “Interstitial Laser Thermotherapy in Neurosurgery: A Review”, Acta Neurochir (Wien) (1996) 138:1019-1026, 8 pages. |
Ferenc A. Jolesz M.D., et al., “MRI-Guided Laser-Induced Interstitial Thermotherapy: Basic Principles”, Harvard Medical School and Brigham and Women's Hospital, Department of Radiology, appears in: SPIE Institute on Laser-Induced Interstitial Thermotherapy (LITT), Jun. 22-23, 1995, 17 pages. |
Thorsten Harth, et al., “Determination of Laser-Induced Temperature Distributions Using Echo-Shifted TurboFLASH”, MRM 38:238-245 (1997), 8 pages. |
Lawrence P. Panych, et al., “Effects Related to Temperature Changes during MR Imaging”, JMRI, vol. 2, No. 1, Jan./Feb. 1992, pp. 69-74. |
John De Poorter, “Noninvasive MRI Thermometry with the Proton Resonance Frequency Method: Study of Susceptibility Effects”, MRM 34:359-367 (1995), 9 pages. |
Ron Corbett, et al., “Noninvasive Measurements of Human Brain Temperature Using Volume-Localized Proton Magnetic Resonance Spectroscopy”, Journal of Cerebral Blood Flow and Metabolism, vol. 17, No. 4, 1997, pp. 363-369. |
Waldemar Wlodarczyk, et al., “Comparison of four magnetic resonance methods for mapping small temperature changes”, Phys. Med. Biol. 44, 1999, pp. 607-624. |
Carpentier, et al. “Real-Time Magnetic Resonance-Guided Laser Thermal Therapy For Focal Metastatic Brain Tumors”, Operative Neurogurgery 1, vol. 63, 2008, pp. 21-39. |
Carpentier, et al. “MR-Guided Laser Induced Thermal Therapy (LITT) for Recurrent Glioblastomas”, Lasers in Surgery and Medicine, vol. 44, pp. 361-368, 2012. |
Carpentier, et al. “Laser Thermal Therapy: Real-time MRI-guided and Computer-controlled Procedures for Metastatic Brain Tumors”, Lasers in Surgery and Medicine, vol. 43, pp. 943-950, 2011. |
Gewiese, et al. “Magenetic Resonance Imaging-Controlled Laser-Induced Interstitial Thermotherapy”, Investigative Radiology, vol. 29, No. 3, pp. 345-351, 1994. |
Ferenc A. Jolesz, MD, et al., “MR Imaging of Laser-Tissue Interactions”, Magnetic Resonance Imaging, Radiology 1988; 168, pp. 249-253. |
Yoshimi Anzai, MD, et al., “Nd:YAG Interstitial Laser Phototherapy Guided by Magnetic Resonance Imaging in an Ex Vivo Model: Dosimetry of Laser-MR-Tissue Interaction”, Laryngoscope 101: Jul. 1991, pp. 755-760. |
Harvey E. Cline, et al., “MR-Guided Focused Ultrasound Surgery”, Journal of Computer Assisted Tomography, Nov./Dec. 1992, vol. 16, No. 6, pp. 956-965. |
Harvey E. Cline, PhD, et al., “Focused US System for MR Imaging-guided Tumor Ablation” Magnetic Resonance Imaging, Radiology 1995; Mar. 1995, vol. 194, No. 3, pp. 731-737. |
Kullervo Hynynen, PhD, et al., “A Clinical, Noninvasive, MR Imaging-monitored Ultrasound Surgery Method”, Imaging & Therapeutic Technology, RadioGraphics 1996; Jan. 1996, vol. 16, No. 1, pp. 185-195. |
Nobuhiko Hata, et al., “Computer-Assisted Intra-Operative Magnetic Resonance Imaging Monitoring of Interstitial Laser Therapy in the Brain: A Case Report”, Journal of Biomedical Optics, Jul. 1998, vol. 3, No. 3, pp. 304-311. |
Joachim Kettenbach, MD, et al., “Monitoring and Visualization Techniques for MR-Guided Laser Ablations in an Open MR System” Journal of Magnetic Resonance Imaging, Jul./Aug. 1998, vol. 8, No. 4, pp. 933-943. |
Ferenc A. Jolesz, MD, et al., “Integration of Interventional MRI with Computer-Assisted Surgery”, Journal of Magnetic Resonance Imaging, Jan. 2001;13(1), pp. 69-77. |
Frederic C. Vimeux, et al., “Real-Time Control of Focused Ultrasound Heating Based on Rapid MR Thermometry”, Investigative Radiology, Mar. 1999, vol. 34(3), pp. 190-193. |
J. Delannoy, et al., “Hyperthermia system combined with a magnetic resonance imaging unit”, Medical Physics, vol. 17, No. 5, Sep./Oct. 1990, pp. 855-860. |
Zientara, Gary P., et al. “MRI monitoring of laser ablation using optical flow.” Journal of Magnetic Resonance Imaging 8.6 (1998): 1306-1318. |
Alan R. Bleier, et al., “Real-Time Magnetic Resonance Imaging of Laser Heat Deposition in Tissue”, Magnetic Resonance in Medicine 21, 1991, pp. 132-137. |
Kullervo Hynynen, et al., “Focused Ultrasound Thermal Surgery Guided and Monitored by Magnetic Resonance Imaging”, Interventional Radiology, 1997, vol. 2, Third Edition, pp. 1811-1816 (with cover pages). |
Ferenc A. Jolesz, “MR-guided thermal ablation of brain tumors”, Interventional MR: Techniques and Clinical Experience, 1998, pp. 123-129 (with cover pages). |
F.A. Jolesz, et al., “Image-Guided Neurosurgery with Intraoperative MRI”, Interventional Magnetic Resonance Imaging, 1998, pp. 253-260 (with cover pages). |
Kullervo Hynynen, et al., “Principles of MR-Guided Focused Ultrasound”, Chapter 25, Interventional MRI, 1999, pp. 237-243 (with cover pages). |
Masoud Panjehpour, PhD et al., “Nd:YAG Laser-Induced Interstitial Hyperthermia Using a Long Frosted Contact Probe”, Lasers in Surgery and Medicine 10, 1990, pp. 16-24. |
S. Bosman, et al., “Effect of percutaneous interstitial thermal laser on normal liver of pigs: sonographic and histopathological correlations”, Br. J. Surg., May 1991, vol. 78, No. 5, pp. 572-575. |
M. Fan, M.D., et al., “Interstitial 1.06 Nd:YAG Laser Thermotherapy for Brain Tumors Under Real-Time Monitoring of MRI: Experimental Study and Phase I Clinical Trial”, Journal of Clinical Laser Medicine & Surgery, vol. 10, No. 5, 1992, pp. 355-361. |
Office Action issued in Chinese Patent Application No. 200980131609.X dated Jan. 10, 2014. |
Office Action dated Aug. 22, 2013, in Chinese Patent Application No. 200980131600.9 (with English-language translation). |
Vogl et al. “Internally Cooled Power Laser for MR-guided Interstitial Laser-induced Thermotherapy of Liver Lesions: Initial Clinical Results,” Radiology, vol. 209, No. 2. 1998, 381-385. |
International Search Report dated Jul. 27, 2015 in PCT/US2015/021228 filed Mar. 18, 2015. |
Written Opinion dated Jul. 27, 2015 in PCT/US2015/021228 filed Mar. 18, 2015. |
Chinese Office Action dated Apr. 23, 2020 for Corresponding Appln No. CN201680020426.0, 15 pages. |
Information about Related Patents and Patent Applications, see section 4 of the accompanying Information Disclosure Statement Letter, which concerns Related Patents and Patent Applications. |
Lubowiiz, “Thermal chondroplasty using the Smith & Nephew Dyonics Glider Articular Carttilage Probe”, Smith & Nephew (Jul. 2006), pp. 1-8. |
International Search Reprot and Written Opinion dated Jun. 10, 2013, in Application No. PCT/US13/32273. |
International Preliminary Reporton Patentability dated Feb. 15, 2011, in Application No. PCT/CA2009/001138 (5 pages). |
Kahn et al., “MRI-Guided Laser-Induced Interstitial Thermotherapy of Cerebral Neoplasms,” Journal of Computer Assisted Tomography (Jul./Aug. 1994), 18(4):519-532. |
Kahn et al., “MRI-Guided Laser-Induced Interstitial Thermotherapy of Cerebral Neoplasms,” J of Comp Assisted Tomography (Jul./Aug. 1994), 18(4):519-532. |
Vogl et al., “Internally Cooled Power Laser for MR-guided Interstitial Laser-induced Thermotherapy of Liver Lesions Initial Clinical Results”, in Radiology, 1998, 209: pp. 381-385. |
Mcnichols et al., “MR Thermometry-Based Feedback Control of Laser Interstitial Thermal Therapy at 980 nm,” Lasers in Surgery and Medicine (2004), 34:48-55. |
Schwarzmaier et al., “MR-guided laser-induced interstitial thermotherapy of recurrent glioblastoma multiforme Preliminary results in 16 patients,” European Journal of Radiology (Aug. 2006), 59(2):208-215. |
International Search Report, dated Aug. 3, 2012 in Application No. PCT/IB2012/051716. |
Supplementary European Search Report dated Oct. 18, 2013, in European Patent Application No. 09806277.1. |
Castro et al. “Interstitial laaser phototherapy assisted by magnetic resonance imaging: A new technique for monitoring laser-tissue interaction” The Larvnaoscooe (May 1990), vol. 100(DD):541-547 (abstract only). |
Nabavi et al. “Neurosurgical procedures in a 0.5 tesla, open-configuration intraoperative MRI: planning, visualization, and navigation” Automedica, vol. oo; pp. 1-35, 2001. |
Menovsky et al., “Interstitial Laser Thermotherapy in Neurosurgery: A Review”, Acta Neurochir (Wien) (1996) 138:1019-1026. |
Jolesz M.D., et al., “MRI-Guided Laser-Induced Interstitial Thermotherapy: Basic Principles”, Harvard Medical School and Brigham and Women's Hospital, Department of Radiology, appears in: SPIE Institute on Laser-Induced nterstitial Thermotherapy (LITT), Jun. 22-23, 1995 (17 pages). |
Harth, et al., “Determination of Laser-Induced Temperature Distributions Using Echo-Shifted TurboFLASH”, MRM (1997), 38:238-245. |
Panych, et al., “Effects Related to Temperature Changes during MR Imaging”, JMRI, (Jan./Feb. 1992,) 2(1):69-74. |
De Poorter, “Noninvasive MRI Thermometry with the Proton Resonance Frequency Method: Study of Susceptibility Effects”, MRM (1995), 34:359-367. |
Corbett, et al., “Noninvasive Measurements of Human Brain Temperature Using Volume-Localized Proton Magnetic Resonance Spectroscopy”, Journal of Cerebral Blood Flow and Metabolism (1997), 17(4):363-369. |
Wlodarczyk, et al., “Comparison of four magnetic resonance methods for mapping small temperature changes”, Phys. Med. Biol. (1999), 44:607-624. |
Carpentier et al. “Real-Time Magnetic Resonance-Guided Laser Thermal Therapy For Focal Metastatic Brain Tumors”, Operative Neurogurgery 1 (2008), 63:21-39. |
Canney, et al. “A Multi-element Interstitial Ultrasound Applicator for the Thermal Therapy of Brain Tumors”, Acoustical Society of America, Pt. 2, Aug. 2013, pp. 1647-1655. |
Carpentier, et al. “MR-Guided Laser Induced Thermal Therapy (LITT) for Recurrent Glioblastomas”, Lasers in Surgery and Medicine (2012), 44:361 368. |
Carpentier, et al. “Laser Thermal Therapy: Real-time MRI-guided and Computer-controlled Procedures for Metastatic Brain Tumors”, Lasers in Surgery and Medicine(2011), 43:943-950. |
Gewiese, et al. “Magenetic Resonance Imaging-Controlled Laser-Induced Interstitial Thermotherapy”, Investigative Radiology (1994), 29(3):345-351. |
Jolesz, MD, et al., “MR Imaging of Laser-Tissue Interactions”, Magnetic Resonance Imaging, Radiology (1988) 168:249-253. |
Anzai, MD, et al., “Nd:YAG Interstitial Laser Phototherapy Guided by Magnetic Resonance Imaging in an Ex Vivo Model: Dosimetry of Laser-MR-Tissue Interaction”, Laryngoscope 101: Jul. 1991, pp. 755-760. |
Cline, et al., “MR-Guided Focused Ultrasound Surgery”, Journal of Computer Assisted Tomography, (Nov./Dec. 1992), 16(6):956-965. |
Cline, PhD, et al.. “Focused US System for MR Imaging-guided Tumor Ablation” Magnetic Resonance Imaging, Radiology 1995; 194(3):731-737. |
Hynynen, PhD, et al, “A Clinical, Noninvasive, MR Imaging-monitored Ultrasound Surgery Method”. Imaging & Therapeutic Technology, RadioGraphics 1996, 16(1):185-195. |
Hata, et al., “Computer-Assisted Intra-Operative Magnetic Resonance Imaging Monitoring of Interstitial Laser Therapy in the Brain: A Case Report”, Journal of Biomedical Optics. (Jul. 1998), 3(3):304-311. |
Kettenbach, MD, et al., “Monitoring and Visualization Techniques for MR-Guided Laser Ablations in an Open MR System” Journal of Magnetic Resonance Imaging (Jul./Aug. 1998), 8(4):933-943. |
Jolesz, MD, et al., “Integration of Interventional MRI with Computer-Assisted Surgery”, Journal of Magnetic Resonance Imaging (Jan. 2001), 13(1):69-77. |
Vimeux, et al., “Real-Time Control of Focused Ultrasound Heating Based on Rapid MR Thermometry”, Investigative Radiology (Mar. 1999), 34(3):190-193. |
Delannoy, et al., “Hyperthermia system combined with a magnetic resonance imaging unit”, Medical Physics (Sep./Oct. 1990), 17(5):855-860. |
Zientara et al. “MRI monitoring of laser ablation using optical flow.” Journal of Magnetic Resonance Imaging 8.6 (1998), pp. 1306-1318. |
Bleier, et al., “Real-Time Magnetic Resonance Imaging of Laser Heat Deposition in Tissue”, Magnetic Resonance in Medicine (1991), 21:132-137. |
Hynynen et al., “Focused Ultrasound Thermal Surgery Guided and Monitored by Magnetic Resonance Imaging”, Interventional Radiology, Third Edition (1997), 2:1811-1816 (with cover pages). |
Jolesz, “MR-guided thermal ablation of brain tumors”, Interventional MR: Techniques and Clinical Experience (1998), pp. 123-129 (with cover pages). |
Jolesz et al., “Image-Guided Neurosurgery with Intraoperative MRI”, Interventional Magnetic Resonance Imaging (1998), pp. 253-260 (with cover pages). |
Hynynen et al., “Principles of MR-Guided Focused Ultrasound”, Interventional MRI (1999), Chapter 25, pp. 237-243 (with cover pages). |
Panjehpour, PhD et al., “Nd:YAG Laser-Induced Interstitial Hyperthermia Using a Long Frosted Contact Probe”, Lasers in Surgery and Medicine (1990), 10:16-24. |
Bosman et al., “Effect of percutaneous interstitial thermal laser on normal liver of pigs: sonographic and histopathological correlations”, Br. J. Surg. (May 1991), 78(5):572-575. |
Fan, M.D., et al., “Interstitial 1.06 Nd:YAG Laser Thermotherapy for. Brain Tumors Under Real-Time Monitoring of MRI: Experimental Study and Phase I Clinical Trial”, Journal of Clinical Laser Medicine & Surgery (1992), 10(5):355-361. |
International Search Report and Written Opinion dated Jul. 27, 2015 in Application No. PCT/US2015/021228. |
Number | Date | Country | |
---|---|---|---|
20190262057 A1 | Aug 2019 | US |
Number | Date | Country | |
---|---|---|---|
62141612 | Apr 2015 | US |
Number | Date | Country | |
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Parent | 14841109 | Aug 2015 | US |
Child | 16397015 | US |