Patent Application
20100144753
The present invention relates to the use of specific transmission dyes for protecting human hair and skin against UV radiation and skin aging and preventing tanning and cosmetic or dermatological compositions comprising these dyes.
It is known that certain photostable organic UV filters, for example bis-ethylhexyloxyphenol methoxyphenyl triazine, methylene bis-benzotriazolyl tetramethylbutylphenol disodium phenyl dibenzimidazole tetrasulfonate, terephthalylidene dicamphor sulfonic acid or butyl methoxy dibenzoyl methane which is photo-stabilized with octocrylene exhibit pronounced UV filtering properties in the UV-A range up to 380 nm.
However, in the range from 380 nm to 420 nm no satisfactory UV protection can be achieved.
On the other hand it is known that in the region>380 nm the sun light significantly contributes to skin aging and enhanced skin cancer risk.
Surprisingly it was found that specific UV absorbers which have absorption maxima above 380 nm show no significant color when applied to the skin.
Therefore the present invention relates to the use of an aqueous dispersion comprising
(a) a micronized sparingly soluble organic benzophenone derivative of formula
selected from the crystal modifications (B) and (C),
The crystal modification (B) is preferably characterized by peaks in the X-ray diffraction pattern with d-spacings of about 4.29, 5.36 und 7.70 Å, more preferably with d-spacings of about 3.81, 4.29, 4.84, 5.36, 5.58, 7.28, 7.70 und 8.54 Å, and most preferably with d-spacings of about 3.76, 3.81, 4.02, 4.07, 4.29, 4.54, 4.70, 4.84, 4.98, 5.01, 5.25, 5.36, 5.58, 5.73, 5.77, 5.92, 6.19, 6.40, 6.54, 6.87, 7.28, 7.70, 8.02, 8.54 und 14.54 Å.
Table 1 shows the characteristic spacing between the lattice planes of modification (B) designated by d and expressed in Ångström units [Å] and their corresponding characteristic relative intensity (weak, medium or strong).
The X-ray diffraction pattern of crystal modification (B) exhibits diffraction angles (2Θ) as seen below:
In addition X-ray diffraction data of a single-crystal of the new modification (B) are recorded on a Nonius-Kappa-CCD using Mo X-rays [λ(MoKα)=0.71073 Å] at 200K. The unit cell and the crystal structure are determined with these data.
The crystal used has the following dimensions: 0.15×0.09×0.04 mm.
The basic crystallographic data (diffraction on single crystal) for the new crystal modification (B) of compound of formula (1) are shown in Table 2:
The crystal modification (C) of the compound of formula (1) is preferably characterized by peaks in the an X-ray diffraction pattern with d-spacings of about 4.17, 4.37 and 7.06 Å, more preferably by peaks with d-spacings of about 4.17, 4.33, 4.37, 4.67 and 7.06 Å, and most preferably by peaks with d-spacings of about 3.26, 3.31, 3.52, 3.70, 3.92, 4.04, 4.11, 4.17, 4.33, 4.37, 4.54, 4.67, 4.89, 5.38, 5.56, 5.98, 6.09, 6.27, 6.64, 6.88, 7.06, 7.32, 7.81, 8.63 Å.
Table 3 shows the characteristic spacing between the lattice planes of modification (C) designated by d and expressed in Ångström units [Å] and their corresponding characteristic relative intensity (weak, medium or strong).
The X-ray diffraction pattern of crystal modification (C) exhibits diffraction angles (2θ) as seen in FIG. 2.
The compounds of formula (1) may be prepared according to known methods as described for example in EP-1,046,391 or WO 04/052837.
The crystal modification (B) of formula (1) is obtained by dissolving the compound of formula (1), prepared according to known methods, in acetonitrile by heating to the boiling point and cooling down to 25° C. with a exponential descending temperature profile.
The crystal modification (C) of formula (1) is obtained by elutriation of the compound of formula (1) in N-methylpyrrolidone at 25° C. and stirring the suspension for about three days at 25° C.
Alternatively, the crystal modifications (C) of formula (1) is obtained by elutriation of the crystal modifications (B) of formula (1) in N-methylpyrrolidone or in other solvents or in mixtures of these at temperatures between 0 and 50° C. and stirring the suspension for about three days.
The crystal modifications (B) and (C) of the compound of formula (1) according to the present invention are sparingly soluble organic compounds which are preferably used in the present invention in the micronized state. The preparation of micronized particles may be carried out by any known processes, for example wet-milling, wet-kneading, spray-drying from a suitable solvent, by expansion according to the RESS process (Rapid Expansion of Supercritical Solutions) of supercritical fluids (e.g. CO2, by reprecipitation from suitable solvents, including supercritical fluids (GASR process=Gas Anti-Solvent Recrystallisation/PCA process=Precipitation with Compressed Anti-solvents)).
As milling apparatus for the preparation of the sparingly soluble micronized organic compounds there may be used, for example, a jet mill, ball mill, vibratory mill or hammer mill, preferably a high-speed mixing mill. Even more preferable mills are modern ball mills; manufacturers of these types of mill are, for example, Netzsch (LMZ mill), Drais (DCP-Viscoflow or Cosmo), Bühler AG (centrifugal mills) or Bachhofen.
Examples of kneading apparatus for the preparation of the micronised organic UV absorbers are typical sigma-blade batch kneaders but also serial batch kneaders (IKA-Werke) or continuous kneaders (Continua from Werner and Pfleiderer).
The grinding of the sparingly soluble organic compounds used in the present invention is preferably carried out with a grinding aid.
The dispersing agent (b) is used as a low molecular weight grinding aid for all the above micronisation processes.
Useful anionic, non-ionic or amphoteric surfactants are disclosed below in the sections entitled “specific dispersing agents”.
Preferred useful grinding aids for an aqueous dispersion are anionic surfactants with a HLB (Hydrophile-Lipophile Balance) value higher than 8, more preferably higher than 10.
Any conventionally usable anionic, non-ionic or amphoteric surfactants can be used as dispersing agents (component (b)). Such surfactant systems may comprise for example: carboxylic acids and their salts: alkaline soap of sodium, potassium and ammonium, metallic soap of calcium or magnesium, organic basis soap such as Lauric, myristic, palmitic, stearic and oleic acid etc. . . . . Alkyl phosphates or phosphoric acid esters, acid phosphate, diethanolamine phosphate, potassium cetyl phosphate. Ethoxylated carboxylic acids or polyethylene-glycol esters, PEG-n acylates. Fatty alcohol polyglycolether such as laureth-n, myreth-n, ceteareth-n, steareth-n, oleth-n. Fatty acid polyglycolether such as PEG-n stearate, PEG-n oleate, PEG-n cocoate. Monoglycerides and polyol esters. C12-C22 fatty acid mono- and di-esters of addition products of from 1 to 100 mol of ethylene oxide with polyols. Fatty acid and polyglycerol ester such as monostearate glycerol, diisostearoyl polyglyceryl-3-diisostearates, polyglyceryl-3-diisostearates, triglyceryl diisostearates, polyglyceryl-2-sesquiisostearates or polyglyceryl dimerates. Mixtures of compounds from a plurality of those substance classes are also suitable. Fatty acid polyglycolesters such as monostearate diethylene glycol, fatty acid and polyethylene glycol esters, fatty acid and saccharose esters such as sucro esters, glycerol and saccharose esters such as sucro glycerides. Sorbitol and sorbitan, sorbitan mono- and di-esters of saturated and unsaturated fatty acids having from 6 to 22 carbon atoms and ethylene oxide addition products. Polysorbate-n series, sorbitan esters such as sesquiisostearate, sorbitan, PEG-(6)-isostearate sorbitan, PEG-(10)-sorbitan laurate, PEG-17-dioleate sorbitan. Glucose derivatives, C8-C22 alkyl-mono and oligo-glycosides and ethoxylated analogues with glucose being preferred as the sugar component. O/W emulsifiers such as methyl gluceth-20 sesquistearate, sorbitan stearate/sucrose cocoate, methyl glucose sesquistearate, cetearyl alcohol/cetearyl glucoside. W/O emulsifiers such as methyl glucose dioleate/methyl glucose isostearate. Sulfates and sulfonated derivatives, dialkylsulfosuccinates, dioctyl succinate, alkyl lauryl sulfonate, linear sulfonated parafins, sulfonated tetrapropylene sulfonate, sodium lauryl sulfates, ammonium and ethanolamine lauryl sulfates, lauryl ether sulfates, sodium laureth sulfates [Texapon N70] or sodium myreth sulfates [Texapon K14S], sulfosuccinates, acetyl isothionates, alkanolamide sulfates, taurines, methyl taurines, imidazole sulfates. Zwitterionic or amphoteric surfactants that carry at least one quaternary ammonium group and at least one carboxylate and/or sulfonate group in the molecule. Zwitterionic surfactants that are especially suitable are betaines, such as N-alkyl-N,N-dimethylammonium glycinates, cocoalkyldimethylammonium glycinate, N-acylaminopropyl-N,N-dimethylammonium glycinates, cocoacylaminopropyldimethylammonium glycinate and 2-alkyl-3-carboxymethyl-3-hydroxyethylimidazolines each having from 8 to 18 carbon atoms in the alkyl or acyl group and also cocoacylaminoethylhydroxyethylcarboxymethylglycinate, N-alkylbetaine, N-alkylaminobetaines.
Examples of suitable mild surfactants as dispersing agents, that is to say surfactants especially well tolerated by the skin, include fatty alcohol polyglycol ether sulfates, monoglyceride sulfates, mono- and/or di-alkyl sulfosuccinates, fatty acid isethionates, fatty acid sarcosinates, fatty acid taurides, fatty acid glutamates, α-olefin sulfonates, ethercarboxylic acids, alkyl oligoglucosides, fatty acid glucamides, alkylamidobetaines and/or protein fatty acid condensation products, the latter preferably being based on wheat proteins.
Non ionic surfactants such as PEG-6 beeswax (and) PEG-6 stearate (and) polyglyceryl-2-isostearate [Apifac], glyceryl stearate (and) PEG-100 stearate. [Arlacel 165], PEG-5 glyceryl stearate [arlatone 983 S], sorbitan oleate (and) polyglyceryl-3 ricinoleate. [Arlacel 1689], sorbitan stearate and sucrose cocoate [arlatone 2121], glyceryl stearate and laureth-23 [Cerasynth 945], cetearyl alcohol and ceteth-20 [Cetomacrogol Wax], cetearyl alcohol and colysorbate 60 and PEG-150 and stearate-20 [Polawax GP 200, Polawax NF], cetearyl alcohol and cetearyl polyglucoside [Emulgade PL 1618], cetearyl alcohol and ceteareth-20 [Emulgade 1000NI, Cosmowax], cetearyl alcohol and PEG-40 castor oil [Emulgade F Special], cetearyl alcohol and PEG-40 castor oil and sodium cetearyl sulfate [Emulgade F], stearyl alcohol and steareth-7 and steareth-10 [Emulgator E 2155], cetearyl alcohol and szeareth-7 and steareth-10 [Emulsifying wax U.S.N.F], glyceryl stearate and PEG-75 stearate [Gelot 64], propylene glycol ceteth-3 acetate. [Hetester PCS], propylene glycol isoceth-3 acetate [Hetester PHA], cetearyl alcohol and ceteth-12 and oleth-12 [Lanbritol Wax N 21], PEG-6 stearate and PEG-32 stearate [Tefose 1500], PEG-6 stearate and ceteth-20 and steareth-20 [Tefose 2000], PEG-6 stearate and ceteth-20 and glyceryl stearate and steareth-20 [Tefose 2561], glyceryl stearate and ceteareth-20 [Teginacid H, C, X].
Anionic emulsifiers such as PEG-2 stearate SE, glyceryl stearate SE [Monelgine, Cutina KD], propylene glycol stearate [Tegin P], cetearyl Alcohol and Sodium cetearyl sulfate [Lanette N, Cutina LE, Crodacol GP], cetearyl alcohol and sodium lauryl sulfate [Lanette W], trilaneth-4 phosphate and glycol stearate and PEG-2 stearate [Sedefos 75], glyceryl stearate and sodium lauryl Sulfate [Teginacid Special]. Cationic acid bases such as cetearyl alcohol and cetrimonium bromide.
Most preferred dispersing agents (b) are sodium alkyl sulfates or sodium alkyl ether sulfates, such as sodium laureth sulfate [Texapon N70 from Cognis] or sodium myreth sulfate [Texapon K14 S from Cognis].
The specific dispersing agents may be used in an amount of, for example, from 1 to 30% by weight, especially from 2 to 20% by weight and preferably from 3 to 10% by weight, based on the total weight of the composition.
Useful solvents are water, brine, (poly-)ethylene glycol, glycerol or cosmetically acceptable oils. Other useful solvents are disclosed below in the sections entitled “Esters of fatty acids”, “Natural and synthetic triglycerides, including glyceryl esters and derivatives”, “Pearlescent waxes”, “Hydrocarbon oils” and “Silicones or siloxanes”.
The micronised sparingly soluble organic compounds so obtained usually have an average particle size from 0.02 to 2 micrometres, preferably from 0.03 to 1.5 micrometres and more especially from 0.05 to 1.0 micrometres.
The aqueous dispersion used in the present invention generally comprises
The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C.
This modification is therefore suitable in dispersions comprising micro-fine particles.
Advantageously, dispersions comprising this specific crystal modification are not subjected to phase transformations resulting in a crystal growth.
The aqueous dispersion according to the present invention is preferably used in cosmetic formulations.
The cosmetic formulations or pharmaceutical compositions according to the present invention can also comprise one or more than one further UV filter as listed in Table 4:
The cosmetic or pharmaceutical preparations can be prepared by physically mixing the UV absorber(s) with the adjuvant using customary methods, for example by simply stirring together the individual components, especially by making use of the dissolution properties of already known cosmetic UV absorbers, like octyl methoxy cinnamate, salicylic acid isooctyl ester, etc. The UV absorber can be used, for example, without further treatment, or in the micronised state, or in the form of a powder.
Cosmetic or pharmaceutical preparations contain from 0.05-40% by weight, based on the total weight of the composition, of one UV absorber or UV absorber mixtures.
Preference is given to the use of mixing ratios of the compound of formula (1) according to the present invention and optionally further light-protective agents from 1:99 to 99:1, preferably from 5:95 to 95:5 and most preferably from 10:90 to 90:10, based on weight. Of special interest are mixing ratios of from 20:80 to 80:20, preferably from 40:60 to 60:40 and most preferably approximately 50:50. Such mixtures can be used, inter alia, to improve the solubility or to increase UV absorption.
The compounds of formula (1) may also be used as an anti-wrinkle perception modifier.
This is a further object of the present invention.
The cosmetic or pharmaceutical preparations may be, for example, creams, gels, lotions, alcoholic and aqueous/alcoholic solutions, emulsions, wax/fat compositions, stick preparations, powders or ointments. In addition to the above mentioned UV filters, the cosmetic or pharmaceutical preparations may contain further adjuvants as described below.
As water- and oil-containing emulsions (e.g. W/O, O/W, O/W/O and W/O/W emulsions or microemulsions) the preparations contain, for example, from 0.1 to 30% by weight, preferably from 0.1 to 15% by weight and especially from 0.5 to 10% by weight, based on the total weight of the composition, of one or more UV absorbers, from 1 to 60% by weight, especially from 5 to 50% by weight and preferably from 10 to 35% by weight, based on the total weight of the composition, of at least one oil component, from 0 to 30% by weight, especially from 1 to 30% by weight and preferably from 4 to 20% by weight, based on the total weight of the composition, of at least one emulsifier, from 10 to 90% by weight, especially from 30 to 90% by weight, based on the total weight of the composition, of water, and from 0 to 88.9% by weight, especially from 1 to 50% by weight, of further cosmetically acceptable adjuvants.
The cosmetic or pharmaceutical compositions/preparations according to the invention may also contain one or one more additional compounds as like fatty alcohols, esters of fatty acids, natural or synthetic triglycerides including glyceryl esters and derivatives, pearlescent waxes, hydrocarbon oils, silicones or siloxanes (organosubstituted polysiloxanes), fluorinated or perfluorinated oils, emulsifiers, djuvants and additives, super-fatting agents, surfactants, consistency regulators/thickeners and rheology modifiers, polymers, biogenic active ingredients, deodorising active ingredients, anti-dandruff agents, antioxidants, hydrotropic agents, preservatives, bacteria-inhibiting agents, perfume oils, colourants, polymeric beads or hollow spheres as SPF enhancers.
Cosmetic or pharmaceutical formulations are contained in a wide variety of cosmetic preparations. There come into consideration, for example, especially the following preparations: skin-care preparations, bath preparations, cosmetic personal care preparations, foot-care preparations, light-protective preparations, skin-tanning preparations, depigmenting preparations, insect-repellents, deodorants, antiperspirants, preparations for cleansing and caring for blemished skin, hair-removal preparations in chemical form (depilation), shaving preparations, fragrance preparations, cosmetic hair-treatment preparations,
The final formulations listed may exist in a wide variety of presentation forms, for example:
Of special importance as cosmetic preparations for the skin are light-protective preparations, such as sun milks, lotions, creams, oils, sunblocks or tropicals, pretanning preparations or after-sun preparations, also skin-tanning preparations, for example self-tanning creams. Of particular interest are sun protection creams, sun protection lotions, sun protection milk and sun protection preparations in the form of a spray.
Of special importance as cosmetic preparations for the hair are the above-mentioned preparations for hair treatment, especially hair-washing preparations in the form of shampoos, hair conditioners, hair-care preparations, e.g. pretreatment preparations, hair tonics, styling creams, styling gels, pomades, hair rinses, treatment packs, intensive hair treatments, hair-straightening preparations, liquid hair-setting preparations, hair foams and hairsprays. Of special interest are hair-washing preparations in the form of shampoos.
Other typical ingredients in such formulations are preservatives, bactericides and bacteriostatic agents, perfumes, dyes, pigments, thickening agents, moisturizing agents, humectants, fats, oils, waxes or other typical ingredients of cosmetic and personal care formulations such as alcohols, poly-alcohols, polymers, electrolytes, organic solvents, silicon derivatives, emollients, emulsifiers or emulsifying surfactants, surfactants, dispersing agents, antioxidants, anti-irritants and anti-inflammatory agents etc.
The cosmetic preparation according to the invention is distinguished by excellent protection of human skin against the damaging effect of sunlight.
59.0 g 3 diethylamino-dibenzo-oxepin of formula
(prepared according to Example 1 of WO 2004/052837) are dissolved in 250 ml acetic acid ethyl ester at room temperature.
8.6 g piperazine are added to this solution with stirring whereas the temperature rises to 40° C.
The product precipitates during adding of the reaction mass.
Then the suspension is stirred for about 3 h under reflux, filtered off and the residue is recrystallized from 2-methoxy-ethanol.
After drying of the citric yellow crystals 67 g of the end product are obtained.
Fp=256-258° C.
Table 5 shows the characteristic spacing between the lattice planes of modification (A) designated by d and expressed in Ångström units [Å] and their corresponding characteristic relative intensity (weak, medium or strong).
Table 6 lists the basic crystallographic data obtained by X-ray diffraction of a single-crystal of modification (A) using Mo X-rays [λ(MoKα)=0.71073 Å] at 200K
The crystal used has had the following dimensions: 0.32×0.19×0.14 mm.
5 g of the compound of formula (101) are dissolved in acetonitrile by heating to the boiling point.
The solution is cooled down to 25° C. with an exponential descending temperature profile of 80 C.°.
The obtained crystals are filtered off, washed twice with 10 g water each and dried in a vacuum drying cabinet.
FIG. 1 shows the powder X-ray diffraction pattern of modification (B), obtained from example A2; the values are given in 2θ. The characteristic d-spacings of modification (B) are listed in Table 1.
5 g of the compound obtained in Example A2 (modification (B)) are elutriated in 50 g N-methylpyrrolidone at 25 C.
The suspension is stirred for 3 days at 25 C.
The crystals are filtered off, washed twice with water and dried in a vacuum drying cabinet at 50 C.
5 g of the compound of formula (1) obtained in Example A1 are elutriated in 50 g 2-butanone at 25 C.
The suspension is stirred for 3 days at 25 C.
The crystals are filtered off, washed twice with water and dried in a vacuum drying cabinet at 50 C.
FIG. 2 shows the powder X-ray diffraction pattern of modification (C), obtained from example A3.2; the values are given in 2θ.
The characteristic d-spacings of modification (C) are listed in Table 3.
5 g of the compound obtained in Example A2 (modification (B)) and 5 g of the compound of formula (1) obtained in Example A1 are elutriated in 50 g N-methylpyrrolidone at 25° C.
The suspension is stirred for 3 days at 25° C.
The crystals are filtered off, washed twice with water and dried in a vacuum drying cabinet at 50 C.
With this method a micropigment dispersion of a UV absorber is obtained.
Definition of components (UV absorbers used in Examples B1-B4:
Part A by is prepared by incorporating all ingredients, then stirred under moderate speed and heated to 75° C. Part B is prepared and heated to 75° C. At this temperature part B is poured into part A under progressive stirring speed. Then the mixture is homogenized (30 sec., 15000 rpm). At a temperature <55° C. the ingredients of part C are incorporated. The mixture is cooled down under moderate stirring, then the pH is checked and adjusted with triethanolamine.
Part A is prepared by incorporating all ingredients, then stirred under moderate speed and heated to 75° C. Part B is prepared and heated to 75° C. At this temperature, part B is poured into part A under progressive stirring speed. Below 65° C. the ingredients of part D are added separately. After cooling down under moderate stirring to 55° C. part C is added. The pH is then checked and adjusted with sodium hydroxide. The mixture is homogenized for 30 sec at 16000 rpm.
Part A is prepared by incorporating all ingredients, then stirred under moderate speed and heated to 75° C. Part C is prepared and heated to 75° C. Part C is poured into the part A under moderate stirring. Immediately after the emulsification part B is added, then neutralized with a part of the triethanolamine. The mixture is homogenized for 30 sec. After cooling down under moderate stirring Cyclopentasiloxane (and) Dimethiconol are added. Below 35° C. the pH is checked and adjusted with triethanolamine.
Part A and part B are heated up to 80° C. Part A is blended into part B under stirring and homogenized with an UltraTurrax at 11 000 rpm for 30 sec. Part C is heated to 60° C. and added slowly to the emulsion. After cooling down to 40° C. part D is incorporated at room temperature and part E is added.
Part A and B are heated to 75° C. Part A is added into part B under continuous stirring and homogenized with 11000 rpm for 1 minute. After cooling down to 50° C. part C is added under continuous stirring. After cooling further down to 30° C. part D is added. Afterwards the pH is adjusted between 6.00-6.50.
Part A and B are heated separately to 75° C. After adding part B into part A the mixture is homogenized with Ultra Turrax for one minute at 11000 rpm. After cooling down to 50° C. part C is added. Afterwards the mixture is homogenized for one minute at 16000 rpm. At a temperature <40° C. part D is added. At room temperature the pH-value is adjusted with part E between 6.00 and 6.50.
Part A and B are heated separately up to 75° C., part C is heated to 60° C. Afterwards part B is poured into part A under stirring. The mixture is homogenized with an Ultra Turrax for 30 sec. at 11 000 rpm and part C is incorporated. After cooling down to 40° C. part D is added. At room temperature the pH-value is adjusted with Sodium Hydroxide between 6.30 and 6.70 and part F is added.
Part A and B are heated separately up to 75° C., part C is heated to 60° C. Afterwards part B is poured into part A under stirring. The mixture is homogenized with an Ultra Turrax for 30 sec. at 11 000 rpm and part C is incorporated. After cooling down to 40° C. part D is added. At room temperature the pH-value is adjusted with Sodium Hydroxide between 6.30 and 6.70 and part F is added.
Part A and part B are heated separately to 75° C. Part B is added into part A under continuous stirring and afterwards homogenized with Ultra Turrax for 30 sec at 11000 rpm. After cooling down to 60° C. part C is added. At 40° C. part C is added and homogenized for 15 sec at 11000 rpm. At room temperature the pH-value is adjusted with part E.
Part A and B are heated separately to 75° C.; part C to 60° C. Part B is poured into part A under stirring. After one-minute of homogenization at 11000 rpm part C is added to the mixture of A/B. After cooling down to 40° C. part D is incorporated. At room temperature the pH value is adjusted with part E between 6.3 and 7.0. Finally part F is added.
Part A and part B are heated separately to 75° C. Part A is poured into part B under stirring. Immediately after the emulsification, part C is added to the mixture and homogenized with an Ultra Turrax at 11000 rpm for 30 sec. After cooling down to 65° C. Sodium Acrylates Copolymer (and) Mineral Oil (and) PPG-1 Trideceth-6 At 50° C. is added slowly to the UV absorber dispersion. At about 35-30° C. part F is incorporated. The pH is adjusted with part G between 5.5 and 6.5.
Part A and part B are heated separately up to 80° C. Part A is poured into part B while stirring and homogenized with an Ultra Turrax by 11000 rpm for 30 sec. After cooling down to 60° C. part C is incorporated. At 40° C. part D is added slowly under continuous stirring. The pH is adjusted with part E between 6.50-7.00.
Part A and part B are heated separately up to 80° C., part C is heated to 50° C. Part B is poured into part A and homogenized with an Ultra Turrax for 1 minute at 11000 rpm. After cooling down to 50° C. part C is added under continuous stirring. At 40° C. part D is incorporated and homogenized again for 10 sec. at 11000 rpm. The pH is adjusted with part E.
Part A and part B are heated separately up to 75° C., part C is heated to 60° C. Afterwards part B is poured into part A under stirring. The mixture is homogenized with an Ultra Turrax for 30 sec. at 11 000 rpm and part C is incorporated. After cooling down to 40° C. part D is added. At room temperature the pH-value is adjusted with Sodium Hydroxide between 6.30 and 6.70 and part F is added.
Part A and part B are heated separately to 80° C. Part A is poured into part B under continuous stirring. Afterwards the mixture is homogenized with an Ultra Turrax at 11 000 rpm for 1 min. After cooling down to 60° C. part C is incorporated. At 40° C. part D is added and the mixture homogenized for a short time again. At 35° C. part E is added and at room temperature Fragrance is added. Finally the pH is adjusted with Sodium Hydroxide.
Part A and part B are heated separately up to 80° C. Part B is poured into part A under moderate stirring. The mixture is homogenized with an Ultra Turrax at 11000 rpm for 1 minute. After cooling down to 70° C. part C is added under stirring. After cooling further down to 50° C. part D is incorporated very slowly. At 40° C. part E is added. At room temperature the pH adjusted with part F to 7.00 and part G is added.
Part A and part B are heated separately up to 80° C. Part B is poured into part A under moderate stirring. The mixture is homogenized with an Ultra Turrax at 11000 rpm for 1 minute. After cooling down to 70° C. add part C is added under stirring. After cooling further down to 50° C. part D is incorporated very slowly. At 40° C. part E is added. At room temperature the pH is adjusted with part F to 7.00 and part G is added.
Part A and part B are heated separately up to 75° C. Part B is poured into part A under progressive stirring speed. At a temperature <65° C. the ingredients of part D are added separately. After cooling down to 55° C. under moderate stirring part C is added. At a temperature <35° C. the pH is checked and adjusted with Sodium Hydroxide and homogenized with an Ultra Turrax for 30 sec. at 11 000 rpm. At room temperature part F is added.
Part A is heated to 80° C. whilst stirring. Part B is added into part A and homogenized with an Ultra Turrax at 11 000 rpm for one minute. After cooling down to 30° C. part C is incorporated.
Part A is heated separately to 80° C. under gentle stirring. Part B is added to part A and homogenized for one minute at 11000 rpm. After cooling down to 30° C. part C is added under continuous stirring.
This Sunscreen may also be used as an anti-wrinkle perception modifier.
Mix part A and heat up from 60 to 65° C. and add Disp. Slowly under fast stirring
Add part B under moderate stirring at 60° C.
Add part B into part A under stirring at 60° C. to 75° C.
Add part C under stirring until homogenization (emulsification at fast stirring, may be with ultra turrax)
Add part D under moderate stirring (60° C.)
Finally add part E under stirring (60° C.) and cool down under moderate stirring
| Number | Date | Country | Kind |
|---|---|---|---|
| 07107681.4 | May 2007 | EP | regional |
| Filing Document | Filing Date | Country | Kind | 371c Date |
|---|---|---|---|---|
| PCT/EP08/55139 | 4/28/2008 | WO | 00 | 2/5/2010 |
