Claims
- 1. A 1-methylcarbapenem derivative of formula (I-1) in crystalline form:
- 2. A 1-methylcarbapenem derivative of formula (I-2) in crystalline form:
- 3. A 1-methylcarbapenem derivative of formula (I-3) in crystalline form:
- 4. A 1-methylcarbapenem derivative of formula (I) or a pharmaceutically acceptable salt thereof in crystalline form, wherein the crystalline form shows main peaks at interplanar spacings d=6.65, 5.68, 4.86, 4.57 and 4.03 Å in the X-ray powder diffraction pattern obtained with a Cu Kα irradiation of λ=1.54 Å, the main peaks having relative intensities not less than 74, relative to the intensity of the peak at 4.57 Å which is evaluated as 100 wherein formula (I) is
- 5. A solid pharmaceutical composition for the prevention or treatment of bacterial infections comprising a therapeutically effective amount of a 1-methylcarbapenem derivative of formula (I-1) in crystalline form as claimed in claim 1 as an active ingredient together with a diluent or carrier therefor.
- 6. A solid pharmaceutical composition for the prevention or treatment of bacterial infections comprising a therapeutically effective amount of a 1-methylcarbapenem derivative of formula (I-2) in crystalline form as claimed in claim 2 as an active ingredient together with a diluent or carrier therefor.
- 7. A solid pharmaceutical composition for the prevention or treatment of bacterial infections comprising a therapeutically effective amount of a 1-methylcarbapenem derivative of formula (I-3) in crystalline form as claimed in claim 3 as an active ingredient together with a diluent or carrier therefor.
- 8. A solid pharmaceutical composition for the prevention or treatment of bacterial infections comprising a therapeutically effective amount of a 1-methylcarbapenem derivative in crystalline form as claimed in claim 4 as an active ingredient together with a diluent or carrier therefor.
- 9. A method for preventing or treating bacterial infections which comprises administering to a warm-blooded animal in need of such prevention or treatment a pharmacologically effective amount of a 1-methylcarbapenem derivative of formula (I-1) in crystalline form as claimed in claim 1.
- 10. A method for preventing or treating bacterial infections which comprises administering to a warm-blooded animal in need of such prevention or treatment a pharmacologically effective amount of a 1-methylcarbapenem derivative of formula (I-2) in crystalline form as claimed in claim 2.
- 11. A method for preventing or treating bacterial infections which comprises administering to a warm-blooded animal in need of such prevention or treatment a pharmacologically effective amount of a 1-methylcarbapenem derivative of formula (I-3) in crystalline form as claimed in claim 3.
- 12. A method for preventing or treating bacterial infections which comprises administering to a warm-blooded animal in need of such prevention or treatment a pharmacologically effective amount of a 1-methylcarbapenem derivative in crystalline form as claimed in claim 4.
Priority Claims (1)
Number |
Date |
Country |
Kind |
HEI-11-191368 |
Jul 1999 |
JP |
|
Parent Case Info
[0001] This is a Continuation-in-Part Application of Ser. No. 10/407,546 filed Apr. 3, 2003 which is a continuation application of Ser. No. 10/034,548 filed Dec. 28, 2001, which is a continuation application of PCT/JP00/04496 filed Jul. 6, 2000 (not published in English).
Continuations (2)
|
Number |
Date |
Country |
Parent |
10034548 |
Dec 2001 |
US |
Child |
10407546 |
Apr 2003 |
US |
Parent |
PCT/JP00/04496 |
Jul 2000 |
US |
Child |
10034548 |
Dec 2001 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
10407546 |
Apr 2003 |
US |
Child |
10625317 |
Jul 2003 |
US |