Claims
- 1. A process for the preparation of .gamma.-form crystalline bestatin which comprises heating hygroscopic bestatin, or a hydrate thereof, at a temperature of from 148.degree. C. to the melting point of bestatin for a period of at least one hour.
- 2. The process of claim 1 wherein the bestatin is heated at a temperature of from 150.degree. C. to about 200.degree. C.
- 3. A process for the preparation of .gamma.-form crystalline bestatin which comprises suspending or kneading hygroscopic bestatin, or a hydrate thereof in acetone, methyl ethyl ketone, diethyl ketone, tetrahydrofuran, ethyl acetate, dioxane, isopropanol, aqueous methanol or a mixture thereof for more than ten minutes.
- 4. The process of claim 3 wherein the bestatin is suspended or kneaded in acetone for about twenty minutes to about three hours.
Priority Claims (1)
Number |
Date |
Country |
Kind |
56-208144 |
Dec 1981 |
JPX |
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a division of our co-pending application Ser. No. 877,066 filed June 23, 1986 now abandoned which is a continuation of Ser. No. 692,682 filed 1/16/85, now abandoned, which was a continuation of Ser. No. 450,620 filed 1/17/82, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4052449 |
Umezawa et al. |
Oct 1977 |
|
4189604 |
Umezawa et al. |
Feb 1980 |
|
4281180 |
Umezawa et al. |
Jul 1981 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
877066 |
Jun 1986 |
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Continuations (2)
|
Number |
Date |
Country |
Parent |
692682 |
Jan 1985 |
|
Parent |
450620 |
Jan 1982 |
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