Claims
- 1. Crystalline (−)-3R,4R-trans-7-methoxy-2,2-dimethyl-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}chromane, hydrogen maleate.
- 2. A process for the preparation of crystalline(−)-3R,4R-trans-7-methoxy-2,2-dimethyl-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}chromane, hydrogen maleate of claim 1, which process comprises dissolving maleic acid and (−)-3R,4R-trans-7-methoxy-2,2-dimethyl-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}chromane in a common solvent, and crystallizing the resulting salt from the solution.
- 3. A pharmaceutical composition comprising the crystalline (−)-3R,4R-trans-7-methoxy-2,2-dimethyl-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}chromane, hydrogen maleate of claim 1 together with a pharmaceutically acceptable carrier or diluent.
- 4. The pharmaceutical composition of claim 3 in the form of a dosage unit containing about 0.1-280 mg per day.
- 5. A method for reducing or preventing bones loss comprising administering to a patient in need of such treatment or prevention an effective amount of a compound of claim 1.
- 6. The method of claim 5 wherein the bone loss is due to osteoporosis.
Priority Claims (1)
Number |
Date |
Country |
Kind |
0692/97 |
Jun 1997 |
DK |
|
CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims the benefit of U.S. provisional application No. 60/050,192 filed on Jun. 19, 1997 the contents of which are fully incorporated herein by reference.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4093631 |
Gardner |
Jun 1978 |
A |
4447622 |
Salman et al. |
May 1984 |
A |
5453442 |
Bryant et al. |
Sep 1995 |
A |
5464862 |
Labroo et al. |
Nov 1995 |
A |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/050192 |
Jun 1997 |
US |