Crystallization Tools for Structural Genomics

Information

  • Research Project
  • 6471445
  • ApplicationId
    6471445
  • Core Project Number
    R44GM060178
  • Full Project Number
    3R44GM060178-02A1S1
  • Serial Number
    60178
  • FOA Number
  • Sub Project Id
  • Project Start Date
    5/1/1999 - 26 years ago
  • Project End Date
    5/31/2003 - 22 years ago
  • Program Officer Name
    EDMONDS, CHARLES G.
  • Budget Start Date
    6/1/2001 - 24 years ago
  • Budget End Date
    5/31/2002 - 23 years ago
  • Fiscal Year
    2001
  • Support Year
    2
  • Suffix
    A1S1
  • Award Notice Date
    7/13/2001 - 24 years ago

Crystallization Tools for Structural Genomics

DESCCRIPTION: Applicant?s abstract) An integrated, automated protein crystallization system,RoboHTC (Robotic High-Throughput Crystallization), will be developed, consisting of software and hardware tools suitable for large-scale protein crystallography projects, such as structural genomics. These tools will also be highly modular, allowing individual home laboratories to use one or more components of the system as their needs demand. These tools will address current problems in crystallization, the rate-limiting step in protein crystallography, following isolation and purification of the target protein. We will also be integrating these tools with a Web-based Java applet to allow researchers to order custom crystallization solutions. This will alleviate researchers from having to make their own crystallization screens, which is presently one of the most tedious tasks in protein crystallization. The entire crystallographic community stands to benefit from the proposed research. As part of the further development of our crystallization database software, we will implement features to allow researchers to easily transfer crystallization data to and from the Protein Data Bank. These publicly accessible crystallization data can then guide other researchers in their crystallization efforts. As protein crystallography becomes an increasingly important aspect of biological research, the proposed tools will make protein crystal structure determination a more routine part of any biological research program. PROPOSED COMMERCIAL APPLICATION: Not Available

IC Name
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
  • Activity
    R44
  • Administering IC
    GM
  • Application Type
    3
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    60000
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    821
  • Ed Inst. Type
  • Funding ICs
    NIGMS:60000\
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    DECODE BIOSTRUCTURES
  • Organization Department
  • Organization DUNS
    781613492
  • Organization City
    BAINBRIDGE ISLAND
  • Organization State
    WA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    98110
  • Organization District
    UNITED STATES