Claims
- 1. A composition useful for the prolonged release of a biologically-active substance comprising a sphere or particle comprising a non-covalently cross-linked crystalline polymeric carbohydrate matrix, said matrix incorporating 0.001-50% by weight of an absorbed or covalently bonded biologically-active substance.
- 2. The composition of claim 1 wherein said sphere or particle has an average diameter within the range of 0.01-1,000 .mu.m.
- 3. The composition of claim 1 wherein said sphere or particle has an average diameter within the range of 0.01-1.0 .mu.m.
- 4. The composition of claim 1 wherein said carbohydrate is selected from the group consisting of dextran, starch and the derivatives thereof.
- 5. The composition of claim 1 wherein the carbohydrate is selected from the group consisting of alginate, chitosan, agarose, carrageenan, cellulose, glycogen, pullullan and the derivatives thereof.
- 6. The composition of claim 1 wherein said biologically-active substance is an antigen.
- 7. The composition of claim 1 wherein the biologically-active substance is insulin.
- 8. The composition of claim 1 wherein the biologically-active substance is an allergen.
- 9. The composition of claim 1 wherein the biologically-active substance is a growth hormone.
- 10. A process for producing a composition useful for the prolonged release of a biologically-active substance, comprising,
- (a) forming a solution of a polymeric carbohydrate and a biologically-active substance in one or more hydrophillic solvents;
- (b) emulsifying the mixture of the carbohydrate and the biologically active substance in a liquid hydrophobic medium to form spherical droplets; and
- (c) introducing the emulsion into a crystallizing medium to form spheres having a non-covalently cross-linked crystalline polymeric carbohydrate matrix, said matrix incorporating 0.001-50% by weight of the biologically-active substance.
- 11. The process of claim 10 wherein the droplets are crystallized by introducing them into a crystallizing medium comprising acetone, ethanol or methanol.
- 12. The process of claim 10 wherein the emulsification is conducted at 4.degree.-40.degree. C. so that the activity of the biologically-active substance is preserved.
Priority Claims (2)
Number |
Date |
Country |
Kind |
8106723 |
Nov 1981 |
SEX |
|
8204244 |
Jul 1982 |
SEX |
|
Parent Case Info
This application is a continuation of Ser. No. 588,099, filed Feb. 22, 1984 and now abandoned. This application also contains subject matter common to Ser. No. 522,159, filed July 8, 1983, now U.S. Pat. No. 4,501,726, based on PCT application Ser. No. SE 82/00381, filed Nov. 12, 1982 and claiming priority from Swedish application Ser. No. 8106723-3, filed Nov. 21, 1981.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/SE83/00268 |
7/4/1983 |
|
|
2/22/1984 |
2/22/1984 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO84/00293 |
2/2/1984 |
|
|
US Referenced Citations (9)
Foreign Referenced Citations (3)
Number |
Date |
Country |
6904024 |
Dec 1974 |
SEX |
7800005 |
Dec 1978 |
SEX |
795977 |
Jun 1958 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Radley, J. A.; Starch and Its Derivatives, 4th Ed., Chapter 6, pp. 194-202, Chapman and Hall Ltd., London (1968). |
Continuations (1)
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Number |
Date |
Country |
Parent |
588099 |
Feb 1984 |
|