Claims
- 1. Crystals of N-(2-(4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride trihydrate.
- 2. The crystals of claim 1, wherein peaks are present at diffraction angles (20θ±0.1) of 14.6, 19.6, 21.8, 22.3, 22.9, 24.1, 26.6 and 28.3° in powder X-ray diffraction.
- 3. Crystals of N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride anhydride, wherein peaks are present at diffraction angles (20θ±0.1) of 12.8, 15.0, 19.4, 22.4, 23.8, 27.2 and 27.9° in powder X-ray diffraction.
- 4. A process for producing the crystals of N-(2-(4(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino)ethyl)1-formyl-4-piperidinecarboxamide hydrochloride trihydrate, which comprises crystallization of the anhydride of claim 3 in a temperature and humidity controlled chamber.
- 5. The process of claim 4, wherein the temperature is maintained at from 20 to 90° C.
- 6. The process of claim 5, wherein the temperature is maintained at from about 25° C. and 90° C.
- 7. The process of claim 4, wherein the relative humidity is maintained at from 50 to 100%.
- 8. The process of claim 7, wherein the relative humidity is maintained at from about 50 to 90%.
Priority Claims (2)
Number |
Date |
Country |
Kind |
7-274175 |
Oct 1995 |
JP |
|
8-263010 |
Oct 1996 |
JP |
|
Parent Case Info
This application is a continuation of application Ser. No. 08/735,696, filed Oct. 23, 1996.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5932593 |
Makino et al. |
Aug 1999 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
08/735696 |
Oct 1996 |
US |
Child |
09/672080 |
|
US |