1. Technical Field
The present invention relates to a cuvette, and more particularly, it relates to a cuvette employed for analysis of a specimen such as blood (including plasma or serum) or urine.
2. Background Information
Various shaped cuvettes are known in general. For example, Japanese Patent Laying-Open No. 8-101209 discloses a cuvette having a square cylindrical lower portion and a cylindrical upper portion and configured such that outer and inner surfaces of the lower portion each has a multangular shape in horizontal cross section, as shown in
Japanese Utility Model Laying-Open No. 6-40848 discloses a cuvette in which a central portion is formed in a square cylindrical shape, upper and lower portions arranged so as to hold the central portion therebetween are each formed in a cylindrical shape, and each of outer and inner surfaces of the central portion is configured to have a square shape in horizontal cross section, as shown in
Each of the aforementioned cuvettes is employed for analysis of a specimen including steps of dispensing, stirring, and optically measuring the specimen and a reagent by automatically transferring the same on an analyzer. For example, each of the aforementioned cuvettes is transferred by grasping the upper portion of the cuvette with a transfer apparatus having a hand member capable of grasping the upper portion of the cuvette. A sample stored in the cuvette is stirred by vibrating the cuvette through drive of a vibration motor in a state of grasping the cuvette by the transfer apparatus. In the optical measurement, the cuvette storing the sample is irradiated with a measuring beam in a state where the cuvette is received in a receiving hole.
However, the cuvette in Japanese Patent Laying-Open No. 8-101209 shown in
The cuvette in Japanese Utility Model Laying-Open No. 6-40848 shown in
In the cuvette in Japanese Patent Laying-Open No. 2002-196007 shown in
The present invention has been proposed in order to solve the aforementioned problem, and an object of the present invention is to provide a cuvette capable of stirring a sample in a short time while suppressing respective components of an analyzer from complication.
A cuvette according to a first aspect of the present invention, which is a cuvette for containing a measurement sample therein, irradiated with a measuring beam for measuring characteristics of the measurement sample from a side part in an upright state when the cuvette is used, and having an opening, comprises a first body part located on a side of a bottom part, having inner and outer surfaces each formed in a circular shape in horizontal cross section, and irradiated with the measuring beam; and a second body part located on a side of the opening, having an inner surface formed in a non-circular shape in horizontal cross section and an outer surface formed in a circular shape in horizontal cross section.
A cuvette according to a second aspect of the present invention, which is a cuvette for containing a measurement sample therein, irradiated with a measuring beam for measuring characteristics of the measurement sample from a side part in an upright state when the cuvette is used, and having an opening, comprises: a first body part located on a side of a bottom part, having inner and outer surfaces each formed in a circular shape in horizontal cross section, and irradiated with the measuring beam; a second body part located on a side of the opening, having an inner surface formed in a non-circular shape in horizontal cross section; and a third body part located between the first body part and the second body part, and having an inner surface connecting the inner surface of the first body part and the inner surface of the second body part in a tapered manner.
An embodiment of the present invention is hereinafter described with reference to the drawings.
The structure of a cuvette 1 according to an embodiment of the present invention is now described with reference to
The cuvette 1 according to the embodiment of the present invention is employed for storing a sample such as a specimen or a reagent when analyzing the specimen such as blood (including plasma or serum) or urine.
The cuvette 1 according to this embodiment is formed by resin molding, employing clear and colorless polystyrene, as shown in
As shown in
As shown in
The area of a circle constituting the inner surface 5a of the first body part 5 is smaller than the area of a region surrounded by the inner surface 6a of the second body part 6 (region surrounded by the four straight lines a and the four curved lines b) in horizontal cross section. The circle constituting the inner surface 5a of the first body part 5 has a size larger than that of a circle inscribed in the inner surface 6a of the second body part 6 formed by the four straight lines a and the four curved lines b in horizontal cross section.
As shown in
The flange 6d of the outer surface 6b of the second body part 6 and a portion in the vicinity of the flange 6d (shaded (hatched) portion in
As shown in
The structure of the specimen analyzer 20 employing the cuvette 1 is described with reference to
This specimen analyzer 20 has a function of analyzing a sample stored in the cuvette 1. The specimen analyzer 20 is constituted by a detection mechanism part 21 and a transport mechanism part 22 arranged on a front side of the detection mechanism part 21 as shown in
The detection mechanism part 21 has a function of optically measuring a measurement sample prepared by adding a reagent to a specimen. The detection mechanism part 21 includes a cuvette supply part 23, a rotary transport part 24, a specimen dispensing arm 25, two reagent dispensing arms 26, a cuvette transfer part 27 and a detection part 28.
As shown in
As shown in
The interval D1 (see
As shown in
As shown in
The specimen dispensing arm 25 is configured such that the specimens in the test tubes 150 transported to the suctional/dispensing position 22a with the transport mechanism part 22 are sucked with a pipette part 25a (see
The reagent dispensing arms 26 each has a function of sucking the reagents from the reagent containers (not shown) with the pipette part 26a (see
The cuvette transfer part 27 has a function of transferring the cuvettes 1 between the rotary transport part 24 and the detection part 28. As shown in
The detection part 28 has a function of warming the specimens up to about 37° C. and a function of optically measuring the measurement samples prepared by mixing the specimens and the reagents. As shown in
As shown in
A method of using the cuvette 1 in the specimen analyzer 20 is now described with reference to
As shown in
The specimen dispensing arm 25 first dispenses a prescribed quantity of the specimen in the test tube 150 of the transport mechanism part 22 into the cuvette 1 supplied to the rotary transport part 24. The cuvette transfer part 27 carries the cuvette 1 dispensed with the specimen thereinto to the detection part 28 after the rotary transport part 24 transports the same to a prescribed position. The cuvette transfer part 27 takes out the cuvette 1 from the warming receiving hole 28a after the cuvette 1 is inserted into the warming receiving hole 28a having a warming function and warmed for a prescribed time. The reagent dispensing arm 26 adds the reagent to the specimen in the cuvette 1.
After the specimen and the reagent are added in the cuvette 1, the driving mechanism part 27b of the cuvette transfer part 27 vibrates the hand portion 27a so that the specimen and the reagent in the cuvette 1 are stirred. An operation of stirring the specimen and the reagent by the cuvette transfer part 27 is hereinafter described in detail.
When the reagent is dispensed into the cuvette 1, the specimen and the reagent are accumulated in the first body part 5 positioned on the side of the bottom part 4 due to its own weight. The driving mechanism part 27b vibrates the hand member 27a in a state where the hand member 27a grasps the cuvette 1 storing the specimen and the reagent. This vibration generates a horizontal rotational flow along the inner surface 5a of the first body part 5 in the sample in the cuvette 1. The sample rotationally flowing moves toward the inner surface 5a of the first body part 5 with centrifugal force. The sample having collided with the inner surface 5a of the first body part 5 moves upward along the inner surface 5a of the first body part 5. The sample having moved upward while rotating as described above reaches the second body part 6 through the third body part 7 and rotates along the inner surface 6a of the second body part 6.
According to this embodiment, the bent parts 6c is provided on the inner surface 6a of the second body part 6, whereby the flow of the sample along the inner surface 6a of the second body part 6 is disturbed by the bent parts 6c. The sample, the flow of which is disturbed by the bent parts 6c, flows down to the first body part 5 due to its own weight. Thus, the specimen and the reagent are stirred to prepare the measurement sample.
The cuvette 1 storing the measurement sample is transferred to the detection part 28 with the cuvette transfer part 27 again and inserted into the measurement receiving hole 28c of the part 28b. As shown in
In some measurement items, optical measurement is performed while stirring the measurement sample. In such cases, a magnetic agitator (not shown) is put into the cuvette 1, and measurement is performed while stirring the sample in the cuvette 1 by rotating the magnetic agitator with magnetic force from the outside.
According to this embodiment, as hereinabove described, the bent parts 6c is provided on the inner surface 6a of the second body part 6 located on the side of the opening 3, whereby the bent parts 6c disturbs the flow of the specimen and the reagent at the time of stirring the specimen and the reagent by the cuvette transfer part 27. Thus, stirring of the specimen and the reagent can be facilitated and hence time required for stirring the sample can be reduced. The outer surface 6b of the second body part 6 is formed in the circular shape in horizontal cross section, whereby resin molding can easily be performed as compared with a case where the outer surface 6b of the second body part 6 is formed in a non-circular shape in horizontal cross section.
According to this embodiment, as hereinabove described, each of the inner and outer surfaces 5a and 5b of the first body part 5 irradiated with the measuring beam is formed in the circular shape in horizontal cross section. Therefore, there does not occur a problem that the angle of the light entering from the light source with respect to a wall surface of the square cylindrical portion is not constant depending on a direction which the cuvette faces as in a cuvette shown in
According to this embodiment, as hereinabove described, the measuring beam is applied to the first body part 5 located on the side of the bottom part 4, whereby the necessary quantity of the sample to be stored in the cuvette 1 for applying the measuring beam to the sample can be reduced. Thus, the measurement can be performed for a small quantity of the sample.
According to this embodiment, as hereinabove described, the inner surface 6a of the second body part 6 is formed in the square shape with the chamfered corners in horizontal cross section, whereby the eight bent parts 6c can be provided. Such a shape is a relatively simple shape, and hence resin molding can easily be performed. The corners of the square are chamfered, whereby the shape constituted by the inner surface 6a of the second body part 6 can be close to the circular shape of the outer surface 6b of the second body part 6. Thus, the area of the region surrounded by the inner surface 6a of the second body part 6 can be increased and hence the volume in the cuvette 1 can sufficiently be ensured while improving stirring function.
According to this embodiment, as hereinabove described, the inner surface 7a of the third body part 7 is so inclined as to broaden upward and narrow downward, whereby the sample stored in the first body part 5 can easily be moved to the upper second body part 6 along the inner surface 7a of the third body part 7 at the time of stirring. The sample reaching the second body part 6 at the time of stirring can be smoothly flown down to the first body part 5 without staying in the second body part 6 after completing stirring.
According to this embodiment, as hereinabove described, the area of the region surrounded by the inner surface 5a of the first body part 5 is smaller than the area of the region surrounded by the inner surface 6a of the second body part 6 in horizontal cross section. Thus, the height of the sample required for optical measurement can be ensured by a small quantity of the sample. The area of the region surrounded by the inner surface 6a of the second body part 6 is larger than the area of the region surrounded by the inner surface 5a of the first body part 5 in horizontal cross section. Therefore, the pipette part 25a of the specimen dispensing arm 25 or the pipette part 26a of the reagent dispensing arm 26 can easily be inserted into the cuvette 1.
According to this embodiment, as hereinabove described, the size of the circle constituting the inner surface 5a of the first body part 5 is identical with or smaller than the circle inscribed in the inner surface 6a of the second body part 6 in horizontal cross section. Therefore, centrifugal force applied to the sample in the first body part 5 is larger than centrifugal force applied to the sample in the second body part 6 when the sample is stirred. Thus, the flow of the sample in the second body part 6, to which the larger centrifugal force is applied, is disturbed by the bent parts 6c of the second body part 6, and hence stirring can further be facilitated.
According to this embodiment, as hereinabove described, the outer surface 6a of the second body part 6 is formed in a circular shape in horizontal cross section on the region in the vicinity of a lower side of the flange 6d. Thus, the cuvette 1 can smoothly slide down without getting stuck on the way, when the cuvette 1 slides down while engaging with the upper surface of the induction plates 23b. The outer surface 6b of the second body part 6 has the circular shape in horizontal cross section and hence can easily be clipped with the clip members 23g of the supply catcher part 23d irrespective of the direction which the cuvette 1 faces.
According to this embodiment, as hereinabove described, the light absorption part 6e is provided on the upper portion of the second body part 6, whereby the light absorption part 6e can absorb the light from the outside. Thus, the light from the outside can be inhibited from entering the photoreceptive parts 28e during measurement, and hence the light from the outside can be inhibited from influencing results of the measurement.
According to this embodiment, as hereinabove described, the upper surface 4a of the bottom part 4 of the cuvette 1 is formed in a flat surface shape. Thus, the magnetic agitator does not get stuck on the upper surface 4a of the bottom part 4 when the sample is stirred by rotating the magnetic agitator on the upper surface 4a of the bottom part 4, and hence the magnetic agitator can easily be rotated on the upper surface 4a of the bottom part 4 of the cuvette 1.
The embodiment disclosed this time must be considered as illustrative in all points and not restrictive. The range of the present invention is shown not by the above description of the embodiment but by the scope of claim for patent, and all modifications within the meaning and range equivalent to the scope of claim for patent are included.
For example, while the inner surface 6a of the second body part 6 is formed in the square shape with the corners chamfered in horizontal cross section in the aforementioned embodiment, the present invention is not restricted to this but the inner surface 6a of the second body part 6 may alternatively be formed in the multangular shape other than the square shape in horizontal cross section. The inner surface 6a of the second body part 6 may alternatively be formed to have at least one projecting portion in horizontal cross section. For example, as in a second body part 60 of a cuvette according to a first modification shown in
While the inner surface 7a of the third body part 7 is tapered such that the opposed surfaces are inclined symmetrical with respect to the central axis of the cuvette 1 in the aforementioned embodiment, the present invention is not restricted to this. For example, the third body part may alternatively be formed such that only a part of the inner surface is inclined while the inner surface other than this part is not inclined, and also formed so as to connect the inner surfaces of the first body part and the second body part.
While the two alternate long and short dash lines m gradually narrow toward a lower part in the third body part 7 as shown in
While the light absorption part 6e is colored with a black color in the aforementioned embodiment, the present invention is not restricted to this but the light absorption part 6e may alternatively be coated with other color paint similar to black paint such as dark brown paint or deep indigo paint. These colors can also absorb lights having a large number of wavelengths. A specimen analyzer 20 may be provided with an optical filter on the photoreceptive part 28e of the detection part 28 so that only light having a specific wavelength is detected. In such a case, the color of the light absorption part 6e is not restricted to black or the color similar to black, but the color absorbing at least the light having the specific wavelength may be applicable.
While the outer side of the light absorption part 6e of the cuvette 1 is coated with the black paint in the aforementioned embodiment, the present invention is not restricted to this but the inner side of the cuvette 1 may alternatively be coated with the black paint.
While the light absorption part 6e is coated with the black paint in the aforementioned embodiment, the present invention is not restricted to this but the light absorption part may alternatively be formed by resin molding employing a material previously colored with black.
While the portion of the cuvette 1 other than the light absorption part 6e is clear and colorless in the aforementioned embodiment, the present invention is not restricted to this. For example, the portion other than the first body part 5, which is the portion other than light absorption part 6e may not be clear and colorless, so far as at least the first body part 5 has sufficiently translucency in order to perform optical measurement.
While the measurement sample prepared by adding the specimen to the reagent is employed in the aforementioned embodiment, the present invention is not restricted to this but a specimen with no reagent added thereto may be alternatively employed as the measurement sample.
Number | Date | Country | Kind |
---|---|---|---|
2005-218097 | Jul 2005 | JP | national |
This application is a continuation of PCT/JP2006/312784, filed Jun. 27, 2006, which claims priority to Japanese Application No. JP2005-218097 filed Jul. 27, 2005. The entire contents of these applications are incorporated herein by reference.
Number | Name | Date | Kind |
---|---|---|---|
3977794 | Liedholz | Aug 1976 | A |
4115011 | Brunsting | Sep 1978 | A |
4229104 | Lahme et al. | Oct 1980 | A |
4549809 | Minekane et al. | Oct 1985 | A |
4560269 | Baldszun et al. | Dec 1985 | A |
4634576 | Galle et al. | Jan 1987 | A |
5284624 | Behnk | Feb 1994 | A |
5582796 | Carey et al. | Dec 1996 | A |
5587129 | Kurosaki et al. | Dec 1996 | A |
5651941 | Stark et al. | Jul 1997 | A |
5653940 | Carey et al. | Aug 1997 | A |
5658532 | Kurosaki et al. | Aug 1997 | A |
20020009397 | Hirono et al. | Jan 2002 | A1 |
20020155035 | Kansy et al. | Oct 2002 | A1 |
20050282283 | Vozza-Brown et al. | Dec 2005 | A1 |
Number | Date | Country |
---|---|---|
661532 | Jul 1995 | EP |
51-36177 | Mar 1976 | JP |
57-144463 | Sep 1982 | JP |
60-166843 | Aug 1985 | JP |
61-202073 | Dec 1986 | JP |
6-40848 | May 1994 | JP |
7-43523 | Aug 1995 | JP |
8-101209 | Apr 1996 | JP |
8-299775 | Nov 1996 | JP |
2002-196007 | Jul 2002 | JP |
Number | Date | Country | |
---|---|---|---|
20080123091 A1 | May 2008 | US |
Number | Date | Country | |
---|---|---|---|
Parent | PCT/JP2006/312784 | Jun 2006 | US |
Child | 12020375 | US |