Claims
- 1. A compound represented by general formula (II) or a salt thereof:
- 2. A compound according to claim 1 represented by general formula (II) or a salt thereof, wherein the compound is selected from the group consisting of trans-4-(2,5-dimethylpiperazin-1-yl)-2-trifluoromethylbenzonitrile; 4-piperazin-1-yl-2-trifluoromethylbenzonitrile; trans-4-(2,5-dimethylpiperazin-1-yl)benzonitrile; trans-4-(2,5-dimethylpiperazin-1-yl)-2-fluorobenzonitrile; trans-2-chloro-4-(2,5-dimethylpiperazin-1-yl)benzonitrile; trans-2-bromo-4-(2,5-dimethylpiperazin-1-yl)benzonitrile; trans-4-(2,5-dimethylpiperazin-1-yl)-2-methylbenzonitrile; trans-4-(2,5-dimethylpiperazin-1-yl)-3-fluorobenzonitrile; trans-4-(2,5-dimethylpiperazin-1-yl)-3-trifluoromethylbenzonitrile; 4-(3-methylpiperazin-1-yl)-2-trifluoromethylbenzonitrile; trans-6-(2,5-dimethylpiperazin-1-yl)nicotinonitrile; 4-(hexahydro-1H-1,4-diazepin-1-yl)-2-trifluromethylbenzonitrile; cis-4-(3,5-dimethylpiperazin-1-yl)-2-trifluoromethylbenzonitrile; and trans-2,5-dimethyl-1-[4-nitro-3-(trifluoromethyl)phenyl]piperazine.
- 3. A compound according to claim 1 represented by general formula (II) or a salt thereof, wherein the compound is 4-(2-methylpiperazin-1-yl)-2-trifluoromethylbenzonitrile.
- 4. A compound according to claim 1 represented by general formula (II) or a salt thereof, wherein the compound is selected from the group consisting of 4-(2-ethylpiperazin-1-yl)-2-trifluoromethylbenzonitrile; 4-[2-(1-methylethyl)piperazin-1-yl]-2-trifluoromethylbenzonitrile; and 4-(2 ,2-dimethylpiperazin-1-yl)-2-trifluoromethylbenzonitrile.
- 5. A compound according to claim 1 represented by general formula (II) or a salt thereof, wherein the compound is trans-4-(2,5-dimethylpiperazin-1-yl)phthalonitrile.
- 6. A compound according to claim 1 represented by general formula (II) or a salt thereof, wherein the compound is selected from the group consisting of 4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2-trifluoromethylbenzonitrile; and 4-[(2R,5S)-2,5-dimethylpiperazin-1-yl]-2-trifluoromethylbenzonitrile.
- 7. A compound according to claim 1 represented by general formula (II) or a salt thereof, wherein the compound is selected from the group consisting of trans-4-(2,5-dimethylpiperazin-1-yl)-2-methoxybenzonitrile; trans-4-(2,5-dimethylpiperazin-1-yl)-2-(2-methoxyethoxy)benzonitrile; and trans-4-(2,5-dimethylpiperazin-1-yl)-2-(2-morpholin-4-yl-ethoxy)benzonitrile.
Priority Claims (2)
Number |
Date |
Country |
Kind |
P. HEI. 10-267508 |
Sep 1998 |
JP |
|
P. HEI. 11-155398 |
Jun 1999 |
JP |
|
Parent Case Info
[0001] This is a divisional of application Ser. No. 09/787,672 filed Mar. 21, 2001, which is a Continuation Application of PCT Application No. PCT/JP99/05149 filed Sep. 21, 1999; the above noted prior applications are all hereby incorporated by reference.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09787672 |
Mar 2001 |
US |
Child |
10608341 |
Jun 2003 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
PCT/JP99/05149 |
Sep 1999 |
US |
Child |
09787672 |
Mar 2001 |
US |