Claims
- 1. A cyclic compound of formula ##STR14## wherein: the bond between C.sub.2 and C.sub.3 is a single or a double bond;
- R.sub.1 is OR.sub.5, wherein R.sub.5 is H, an alkyl or acyl group having one to six carbon atoms or CO.sub.2 R.sub.6 wherein R.sub.6 is H or an alkyl group having one to six carbon atoms;
- R.sub.2 is an alkenyl group having one to six carbon atoms;
- each of R.sub.3 and R.sub.4 is independently H, an alkyl or alkenyl group having one to six carbon atoms, or a phenyl group which may be attached via an alkyl or alkenyl group having one to six carbon atoms or a halogen atom, or R.sub.3 and R.sub.4 may be taken together to form a methylidene, an alkylidene having one to six carbon atoms or an arylidene group; and
- Y is H or an O-acyl substituted group.
- 2. The cyclic compound of claim 1, wherein R.sub.3 and R.sub.4 are not simultaneously H.
- 3. The cyclic compound of claim 1, wherein R.sub.3 and R.sub.4 taken together form a group selected from: ##STR15##
- 4. The cyclic compound of claim 1, wherein each of R.sub.3 and R.sub.4 is independently H, an alkyl or alkenyl group having one to six carbon atoms, or a phenyl group which may be attached via an alkyl or alkenyl group having one to six carbon atoms or a halogen atom.
- 5. The cyclic compound of claim 1, wherein the bond between C.sub.2 and C.sub.3 is a single bond and R.sub.2 is a group selected from: ##STR16##
- 6. The cyclic compound of claim 1, wherein R.sub.1 is CO.sub.2 R.sub.6 wherein R.sub.6 is H or an alkyl group having one to six carbon atoms.
- 7. The cyclic compound of claim 1, wherein R.sub.1 is OR.sub.5, wherein R.sub.5 is H, an alkyl or acyl group having one to six carbon atoms.
- 8. The cyclic compound of claim 1, wherein the bond between C.sub.2 and C.sub.3 is a double bond.
- 9. The cyclic compound of claim 1, wherein the bond between C.sub.2 and C.sub.3 is a single bond.
- 10. A cyclic compound of the formula selected from the group consisting of ##STR17##
- 11. A cyclic compound of formula ##STR18## wherein: the bond between C.sub.2 and C.sub.3 is a single or a double bond;
- R.sub.1 is OR.sub.5, wherein R.sub.5 is H, an alkyl or acyl group having one to six carbon atoms or CO.sub.2 R.sub.6 wherein R.sub.6 is H or an alkyl group having one to six carbon atoms;
- R.sub.2 is an alkyl group having one to six carbon atoms;
- each of R.sub.3 and R.sub.4 is independently an alkyl or alkenyl group having one to six carbon atoms, or a phenyl group which may be attached via an alkyl or alkenyl group having one to six carbon atoms or a halogen atom, or R.sub.3 and R.sub.4 may be taken together to form a methylidene, an alkylidene having one to six carbon atoms or an arylidene group; and
- Y is H or an O-acyl substituted group.
- 12. The cyclic compound of claim 11, wherein R.sub.3 and R.sub.4 taken together form a group selected from: ##STR19##
- 13. The cyclic compound of claim 11, wherein each of R.sub.3 and R.sub.4 is independently an alkyl or alkenyl group having one to six carbon atoms, or a phenyl group which may be attached via an alkyl or alkenyl group having one to six carbon atoms or a halogen atom.
- 14. The cyclic compound of claim 11, wherein R.sub.2 is a group selected from CH.sub.3, CH.sub.2 CH.sub.3, and i-pr.
- 15. The cyclic compound of claim 11, wherein R.sub.1 is CO.sub.2 R.sub.6 wherein R.sub.6 is H or an alkyl group having one to six carbon atoms.
- 16. The cyclic compound of claim 11, wherein R.sub.1 is OR.sub.5, wherein R.sub.5 is H, an alkyl or acyl group having one to six carbon atoms.
- 17. The cyclic compound of claim 11, wherein the bond between C.sub.2 and C.sub.3 is a double bond.
- 18. The cyclic compound of claim 11, wherein the bond between C.sub.2 and C.sub.3 is a single bond.
- 19. A cyclic compound of formula ##STR20## wherein: X is ##STR21## when specified in the C.sub.4 to C.sub.n direction; R.sub.1 is OR.sub.5, wherein R.sub.5 is H, an alkyl or acyl group having one to six carbon atoms or CO.sub.2 R.sub.6 wherein R.sub.6 is H or an alkyl group having one to six carbon atoms;
- R.sub.2 is H, an alkyl or alkenyl group having one to six carbon atoms;
- each of R.sub.3 and R.sub.4 is independently H, an alkyl or alkenyl group having one to six carbon atoms, or a phenyl group which may be attached via an alkyl or alkenyl group having one to six carbon atoms or a halogen atom, or R.sub.3 and R.sub.4 may be taken together to form a methylidene, an alkylidene having one to six carbon atoms or an arylidene group; and
- Y is H, OH, or an O-acyl substituted group.
- 20. A composition useful as an anti-tumor promoter agent comprising a therapeutically effective amount of at least one cyclic compound of claim 1.
- 21. A composition useful as an anti-tumor promoter agent comprising a therapeutically effective amount of at least one cyclic compound of claim 11.
- 22. A composition useful as an anti-tumor promoter agent comprising a therapeutically effective amount of at least one cyclic compound of claim 19.
- 23. A method for preventing or treating tumors in a mammalian host, which comprises administering to said host a pharmaceutically effective amount of a cyclic compound according to claim 1.
- 24. A method for preventing or treating tumors in a mammalian host, which comprises administering to said host a pharmaceutically effective amount of a cyclic compound according to claim 11.
- 25. A method for preventing or treating tumors in a mammalian host, which comprises administering to said host a pharmaceutically effective amount of a cyclic compound according to claim 19.
Parent Case Info
This is a continuation division, of application Ser. No. 07/854,414, filed on Mar. 19, 1992 now Pat. No. 5,276,217.
LICENSE RIGHTS
Certain embodiments of this invention were made with Government support under Grant No. 5R01CA45288, awarded by the National institutes of Health, National Cancer Institute. The Government has certain rights in this invention.
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JPX |
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JPX |
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Continuations (1)
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