Claims
- 1. A compound of Formula I
- 2. The compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein Z is HO2C.
- 3. The compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein Z is selected from:
- 4. The compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein Z is selected from:
- 5. The compound according to any one of claims 1 to 4, or a pharmaceutically acceptable salt thereof, wherein Q is N(R6)C(O).
- 6. The compound according to any one of claims 1 to 4, or a pharmaceutically acceptable salt thereof, wherein Q is selected from:
C≡C; CH2C≡C; C≡CCH2; CF2C≡C; and C≡CCF2.
- 7. The compound according to claim 1, selected from:
4-(3-{3-[3-(3,4-Difluoro-benzyl)-4-oxo-3,4-dihydro-quinazolin-6-yl-]-prop-2-ynyl}-phenyl)-butyric acid; and 5-(3,4-Difluoro-benzyl)-7-methyl-4,6-dioxo-3a,4,5,6-tetrahydro-thieno[3,2-c]pyridine-2-carboxylic acid [2-(3-mercapto-propoxy)-pyridin-4-ylmethyl]-amide; or a pharmaceutically acceptable salt thereof.
- 8. A pharmaceutical composition, comprising a compound according to claim 1, or a pharmaceutically acceptable salt thereof, admixed with a pharmaceutically acceptable carrier, excipient, or diluent.
- 9. The pharmaceutical composition according to claim 8, comprising a compound according to claim 7, or a pharmaceutically acceptable salt thereof, admixed with a pharmaceutically acceptable carrier, excipient, or diluent.
- 10. A method for treating osteoarthritis, comprising administering to a patient suffering from osteoarthritis or rheumatoid arthritis a nontoxic effective amount of a compound according to claim 1, or a pharmaceutically acceptable salt thereof.
- 11. The method according to claim 10, wherein the compound administered is a compound according to claim 7, or a pharmaceutically acceptable salt thereof.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims benefit of priority from U.S. Provisional Patent Application No. 60/403,255, filed Aug. 13, 2002.
Provisional Applications (1)
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Number |
Date |
Country |
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60403255 |
Aug 2002 |
US |