R. Evans, “The Steroid and Thyroid Hormone Receptor Superfamily”, Science, 240:889 (May 13, 1988). |
A. Ulmann et al, “Clinical Uses of Mifepristone (MFP)”, Ann. N.Y. Acad. Sci., 261:248 (Jun. 12, 1995). |
R. Kekkonen et al, “Sequential Regiment of the Antiprogesterone RU486 and Synthetic Progestin for Contraception”, Fertility and Sterility, 60(4):610 (Oct., 1993). |
K. Horwitz et al, “Progestin, Progesterone Receptors, and Breast Cancer”, Horm. Cancer, publisher: Birkhaeuser, Boston, Mass., ed. Vedeckis, pp. 283-306 (1996) (absatract only). |
A. Murphy et al, “Regression of Uterine Leiomyomata in Response to the Antiprogesterone RU486”, J. Clin. Endo. Metab., 76(2):513 (Feb., 1993). |
L. Kettel et al, “Endocrine Responses to Long-Term Administration of the Antiprogesterone RU486 in Patients with Pelvic Endometriosis”, Fertility and Sterility, 56(3):402 (Sep., 1991). |
H. Michna et al, “Differentiation Therapy with Progesterone Antagonists”, Ann. N.Y. Acad. Sci., 761:224 (Jun., 1995). |
L. Zhi et al, “5-Aryl-1,2-Dihydrochromeno[3,4-f]quinolines: A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists”, J. Med. Chem., 41(3):291 (Oct. 22, 1998). |
D. Combs et al, “Nonsteroidal Progesterone Receptor Ligands. 2. High-Affinity Ligands with Selectivity for Bone Cell Progesterone Receptors”, J. Med. Chem., 38:4880 (Dec. 8, 1995). |
K. Perlman et al, “20-Oxopregnacalciferols: Vitamin D Compounds that Bind the Progesterone Receptor”, Tet. Letters, 35(15)2295 (1994). |
L. Hamann et al, “Synthesis and Biological Activity of Novel Nonsteroidal Progesterone Receptor Antagonists”, Ann. N.Y. Acad. Sci., 761:383 (Jun. 12, 1995). |
R. Chen et al, “Synthesis and SAR of a Novel Series of Spirobenzothlzaepine Derivatives with Antiprogestin Activity”, POI-37, 16th Int. Cong. Het. Chem., Montana (1997). |
B. Narr et al, “Preparation, Testing, and Formulation of Imidazobenzoxazines as Cardiotonics”, Chemical Abstracts, 109:22973 (1988). |
R. Hartmann et al, “Effects of Brofoxine, A New Anxiolytic on Experimentally Induced Conflict in Rats”, Proc. West. Pharmacol. Soc., 21:51-55 (1978). |
B. Singh et al, “Novel cAMP PDE III Inhibitor” Imidazo[4,5-b]pyridin-2(3H)-ones and Thiazolo[4,5-b]pyridin-2(3H)-ones and their Analogs, J. Med. Chem., 37:248 (Jan. 21, 1994). |
A. Andreani et al, “Potential Antitumor Agents XVII (1). Cytotoxic Agents from Indole Derivatives and their Intermediates”, Acta. Pharm. Nord., 2(6):407 (1990). |
Sakata et al, “Silver Halide Photographic Materials Useful for Platemaking”, Chemical Abstracts, 123:301431 (1993). |
P. Pflegel et al, “Polarografie con 7-Chlor-5-phenyl-2-thioxo-1H-2,3-dihydro-1,3,4-benzotriazepinen”, Pharmazie, 37(10):714-717 (1982). |
E. Barengolts et al, “Progesterone Antagonist RU486 has Bone-Sparing Effects in Ovariectomized Rats”, Bone, 17(1):21 (Jul., 1995). |
E. Gromachevskaya et al, “Studies of 4H-3, 1-Benzoxazines”, Chem. Heterocycl. Cmpds., 33(10):1209-1214 (1997). |
D. Chiarino et al, “2,1-Benzisothiazoline 2,2-Dioxide and Derivatives”, J. Heterocycl. Chem., 23(6):1645-1649 (Nov.-Dec., 1986). |
A. Turck et al, “On the Metabolism of 3-Substituted and 3,6-Disubstituted Pyridazines”, Tetrahedron, 49(3):599-606 (1993). |
V. Kumar et al, “Synthesis of 7-Azaindole and 7-Azaoxindole Derivatives through a Palladium Catalyzed Cross-Coupling Reaction”, J. Org. Chem., 57(25):6995-6998 (1992). |
P. Canonne et al, “Spirocyclization of 1-(o-Aminophenyl)cycloalkanols and 1-(2′-Amino-3′-pyridinyl)Cycloalkanols”, J Heterocyclic Chem., 26:113 Jan.-Feb., 1989). |
M-C. Forest et al, “A Novel Class of Cardiotonic Agents: Synthesis and Biological Evaluation of 5-Substituted 3,6-Dihydrothiadiazin-2-ones with Cyclic AMP Phosphodiesterase Inhibiting and Myofibrillar Calcium Sensitizing Properties”, J. Med. Chem., 35:163-172 (Jan., 1992). |
D. Combs et al, “Heteroatom Analogues of Bemoradan: Chemistry and Cardiotonic Activity of 1,4-Benzothiazinylpyridazinones”, J. Med. Chem., 35:172-176 (Jan., 1992). |
Kurihari et al., “Synthesis of (±)-PD1092A, B, and C; New Nonsteroidal Progesterone Receptor Ligands”, J. Antibiotics 50(4):360 (Apr., 1997). |
A. Kende et al., “Regioselective C-3 Alkylation of Oxindole Dianion”, Synth. Commun. 12(1):1 (1982). |
T. Tucker et al., “Synthesis of a Series of 4-(Arylethylnyl)-6-Chloro-4-Cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors”, J. Med. Chem., 37:2347-2444 (Jul. 22, 1994). |
J. Edwards et al., “5-Aryl-1,2-Dihydro-5H-Chromeno[3,4-f]Quinolines as Potent, Orally Active, Nonsteroidal Progesterone Receptor Agonists: The Effect of D-Ring Substituents” J. Med. Chem., 41:303-310 (Jan. 29, 1998). |
Derwent WPI abstract, “New Imidazo-Pyridine Derivatives—Useful as Platelet Agglutination Inhibitor, Antiallergic, Antiinflammatory Sedative, Cardiac, and Cardiovascular Vasodilators”, JP 63112584 (May 1988). |
Derwent WPI abstract, N. Brumagniez et al., “Benzimidazole and Azabenzimidazole(s)—Having Cardiotonic, Vasodilating, Anti-Hypertensive, Anti-Aggregation, and Anti-Ulcer Activity”, EP 385850 (Feb. 1990). |
Derwent WPI abstract, F. Arndt et al., “New Heterocycle substituted Benzo-Fused Azine and Azole Derivatives—Useful as Selective Herbicides for Pre or Post-Emergence Application”, AP 311135 (Oct. 1988). |
K. Horwitz et al., “Progestin, Progesterone Receptors, and Breast Cancer”, “Hormones and Cancer”, Publisher: Birkhaeuser, Boston, Mass., ed. Vedeckis, pp. 283-306 (1996). |
V. Mamaev et al., “Synthesis of 4H-Thieno [3,2-B] Pyrrol-5(6H)-One” Bulletin of the Acadmey of Sciences on the USSR. Division of Chemical Science, US, Consultants Bureau. New York. vol. 9, pp. 1549-1553, (1966). |
Derwent WPI Abstract, K. Chwalisz et al. “Female Contraceptive Method Comprises Gestation Treatment with Intermittent Progesterone Antagonist Administration.” DE 4,330,234 (Mar. 1995). |
Derwent WPI Abstract, K. Chwalisz et al. “Contraceptive Pack for Implantation Inhibition—Contains Competitive Progesterone Antagonist and Gestagen for Sequential Oral Administration.” DE 4,344,463 (Jun. 1995). |
K. Kolasa et al., “Preliminary Pharmacological Studies of the Central Action of Phenyl and Piperidinomethyl Derivatives of 2-Benzoxazolone”, Chemical Abstracts, vol. 99, No. 1, Abst. No. 157a (Jul. 4, 1983). |
N. Meanwell et al., “Regiospecific Funtionalization of 1,3-dihydro-2H-Benzimidazol-2-One and Structurally Related Cyclic Urea Derivatives”, J. Organic Chem., 60(6):1565-82 (Mar. 24, 1995). |
B. Katzung, “Basic & Clinical Pharmacology”, a Lange Medical Book, 6th ed., p. 620 (1995). |
B. Singh et al., “An Efficient and Novel Synthesis of Fused Thiazol-2(3H)-ones” Heterocycles, 36(1):133-134, p. 136, compounds 16a, 18a (Jan. 1993). |
G. Vernin et al., “Etude Dans la Serie des Radiacaux Heterocycliques. Partie XV. Decomposition aprotique de l'amino-6-ethyl-2-benzothiazole dans des substrats aromatiques et heteroaromatiques: preparation des mesityl-6- et furyl-6-ethyl-2-benzothiazoles, des sels quaternaires et des piropyrannes correspondants”, Helvetica Chimica Acta, 62(1/3):21-30 (Jan. 24, 1979). |