Claims
- 1. A process for cyclizing a compound represented by the formula ##STR157## wherein R' represents a member selected from the group consisting of (1) hydrogen, (2) C.sub.1 to C.sub.4 alkyl, (3) phenyl, (4) .alpha.-chlorobenzyl, (5) ArCQQ, (6) Ar-G-CQQ wherein Q represents hydrogen or methyl, G represents oxygen or sulfur and Ar represents (a) phenyl, (b) dihydrophenyl, (c) monocyclic heterocyclic aromatic containing from 1 to 4 hereto atoms selected from the group of nitrogen, oxygen and sulfur or (d) one of said groups (a) to (c) substituted by an inert group selected from the group of alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, chlorine, bromine, iodine, fluorine, trifluoromethyl hydroxy, cyano, aminomethyl, amino and nitro, or ##STR158## represents phthalimido, COX represents carboxy or protected carboxy, and
- Hal represents a halogen atom, which comprises the step of treating the said compound with a member of the group consisting of acid, base, solvent and a solvent together with a catalyzer selected from the group of a neutral or basic silica gel, alumina, diatomaceous earth and fluorisil to give a compound represented by the formula ##STR159##
- 2. A process according to claim 1 wherein the acid is a mineral acid, sulfonic acid, phosphonic acid, or carboxylic acid, or their salts with a weak base, or their acidic salts.
- 3. A process according to claim 1 wherein the base is a weak base.
- 4. A process according to claim 1 wherein the solvent is an amide, alcohol, or water solvents as the cyclization reagent.
- 5. A process for preparing a compound of the following formula: ##STR160## wherein R' and COX are as defined in claim 1 which comprises the step of treating a compound of the following formula: ##STR161## wherein R' and COX are as defined above, Hal is halogen, and Y is morpholino-4-yl, C.sub.4-8 alkyleneamino, C.sub.2-6 dialkylamino or C.sub.14-20 diaralkylamino, to the action of an aqueous protonic acid in a solvent selected from alcoholic, etheric and halohydrocarbon solvent.
Priority Claims (4)
Number |
Date |
Country |
Kind |
50-19612 |
Feb 1975 |
JPX |
|
50-22229 |
Feb 1975 |
JPX |
|
50-28452 |
Mar 1975 |
JPX |
|
50-33808 |
Mar 1975 |
JPX |
|
Parent Case Info
This application is a division of application Ser. No. 658,665, filed Feb. 17, 1976, now U.S. Pat. No. 4,079,181.
US Referenced Citations (4)
Divisions (1)
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Number |
Date |
Country |
Parent |
658665 |
Feb 1976 |
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