Claims
- 1. A compound selected from the group consisting of:
(2-{4-[3-(1,4,5,6-Tetrahydropyrimidin-2-ylamino)propoxy]phenyl}-cyclopropyl)acetic acid; [2-(4-{3-[(5-Hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]propoxy}-phenyl)cyclopropyl]acetic acid; tert-Butyl 5-hydroxy-2-(methylthio)-5,6-dihydropyrimidine-1(4H)-carboxylate; 2-[4-(2-{6-[(2-methoxyethyl)amino]pyridin-2-yl}ethoxy)phenyl]cyclopropylacetic acid; (2-{3-Hydroxy-4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)acetic acid; (+) (2-{4-[3-(4,5-Dihydro-1H-imidazol-2-ylamino)propoxy]-3-fluorophenyl}cyclopropyl)acetic acid; (2-{3-Fluoro-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylamino)propoxy]phenyl}cyclopropyl)acetic acid; (+) (2-{3-Fluoro-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylamino)propoxy]phenyl}cyclopropyl)acetic acid; (−) (2-{3-Fluoro-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylamino)propoxy]phenyl}cyclopropyl)acetic acid; (2-{2,3-Difluoro-4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)acetic acid trifluoroacetate; (2,2-Dimethyl-3-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid trifluoroacetate; 2,2-Dimethyl-3-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropylacetic acid trifluoroacetate; (2,2-Dimethyl-3-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)acetic acid; (2,2-Dimethyl-3-{3-[3-(1,4,5,6-tetrahydropyrimidin-2-ylamino)propoxy]-phenyl}cyclopropyl)acetic acid; 1-phenyl-2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropylacetic acid; (1-(1,3-benzodioxol-5-yl)-2-{3-fluoro-4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)acetic acid; (1-(6-Methoxypyridin-3-yl)-2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)acetic acid; (2,2-Dichloro-3-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)acetic acid; (2,2-Dibromo-3-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)acetic acid; Ethyl {2-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethoxy)phenyl]-cyclopropyl}acetate; 3-{2-[4-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-ylmethoxy)phenyl]cyclopropyl}-propanoic acid; 3-(2-{4-[2-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)propanoic acid; 3-(2-{3-[2-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)propanoic acid; Preparation of (2-{4-[2-(1,2,3,5-tetrahydropyrido[2,3-e][1,4]oxazepin-8-yl)ethoxy]phenyl}cyclopropyl)acetic acid; (2-{3-bromo-4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)acetic acid trifluoroacetate; (2-Methyl-2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid trifluoroacetate; (1-methyl-2-{4-[2-(1-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl)ethoxy]phenyl}cyclopropyl)acetic acid trifluoroacetate; ((+)-2-{4-[2-(1-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl)ethoxy]phenyl}cyclopropyl)acetic acid; ((−)-2-{4-[2-(1-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl)ethoxy]phenyl}cyclopropyl)acetic acid; [(+)-2-(4-{2-[6-(methylamino)pyridin-2-yl]ethoxy}phenyl)cyclopropyl]acetic acid trifluoroacetate; (2,2-Dichloro-3-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)acetic acid hydrochloride; (2,2-dimethyl-3-{4-[2-(1-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl)ethoxy]phenyl}cyclopropyl)acetic acid trifluoroacetate; 2-(1-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl)ethanol; (2,2-dimethyl-3-{4-[3-(1,4,5,6-tetrahydropyrimidin-2-ylamino)propoxy]phenyl}cyclopropyl)acetic acid trifluoroacetate; (1-methyl-2-{4-[2-(1-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl)ethoxy]phenyl}cyclopropyl)acetic acid trifluoroacetate; (2E)-(2,2-dimethyl-3-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclobutylidene)ethanoic acid trifluoroacetate; (2,2-dimethyl-3-{4-[2-(1-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl)ethoxy]phenyl}cyclobutyl)acetic acid trifluoroacetate; and (3,3-dimethyl-2-oxo-4-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclobutyl)acetic acid trifluoroacetate.
- 2. A method of treating an alpha-v beta-3-mediated condition in a subject in need thereof comprising administering an amount of a compound of claim 1.
- 3. The method of claim 2 wherein the alpha-v beta-3-mediated condition treated is selected from the group consisting of tumor metastasis, solid tumor growth, angiogenesis, osteoporosis, humoral hypercalcemia of malignancy, smooth muscle cell migration, restenosis, atheroscelorosis, macular degeneration, retinopathy, and arthritis.
Parent Case Info
[0001] The present application is a Continuation-In-Part of U.S. patent application Ser. No. 09/882,186, filed Jun. 15, 2001, which claims priority of Provisional Application Serial No. 60/211,781 filed Jun. 15, 2000.
Provisional Applications (1)
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Number |
Date |
Country |
|
60211781 |
Jun 2000 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09882186 |
Jun 2001 |
US |
Child |
10326299 |
Dec 2002 |
US |