Claims
- 1. A compound having the formula ##STR121## in which (1) R' is phenyl, furyl or substituted phenyl, in which said substituted phenyl is substituted with from 1 to 5 substituents which are the same or different and are selected from the group consisting of alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, hydroxy, halogen, halogenated alkyl having 1 to 6 carbon atoms, amino, mono- or di-alkyl amino in which the alkyl has 1 to 6 carbon atoms and --O--(CH.sub.2).sub.a --O-- bonded to any two adjacent carbon atoms of the phenyl nucleus and in which "a" is 1 or 2;
- (2) M is --CH.sub.2 --.sub.m, wherein "m" is zero or an integer from 1 to 4;
- (3) X, Y and Z, which can be the same or different, are hydrogen, lower alkyl, lower alkoxy, lower alkyl carbonyloxy, hydroxy, lower alkyl sulfonyl, nitro, cyano or halogen; and pharmacologically acceptable salts thereof.
- 2. A compound according to claim 1 having the formula: ##STR122## and pharmacologically acceptable salts thereof.
- 3. A compound according to claim 1 having the formula: ##STR123## and pharmacologically acceptable salts thereof.
- 4. A compound according to claim 1 having the formula: ##STR124## and pharmacologically acceptable salts thereof.
- 5. A compound according to claim 1 having the formula: ##STR125## and pharmacologically acceptable salts thereof.
- 6. A compound according to claim 1 having the formula: ##STR126## and pharmacologically acceptable salts thereof.
- 7. A compound according to claim 1 having the formula: ##STR127## and pharmacologically acceptable salts thereof.
- 8. A compound according to claim 1 having the formula: ##STR128## and pharmacologically acceptable salts thereof.
- 9. A compound according to claim 1 having the formula: ##STR129## and pharmacologically acceptable salts thereof.
- 10. A composition for treating hypertension comprising an effective amount of a compound as defined in claim 1 mixed with a pharmaceutical carrier.
- 11. A method treating a subject suffering from hypertension which comprises administering to that subject an effective antihypertensive amount of a compound having the formula ##STR130## in which (1) R' is phenyl, furyl or substituted phenyl, in which said substituted phenyl is substituted with from 1 to 5 substituents which are the same or different and are selected from the group consisting of alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, hydroxy, halogen, halogenated alkyl having 1 to 6 carbon atoms, amino, mono-or di-alkyl amino in which the alkyl has 1 to 6 carbon atoms and --O--(CH.sub.2).sub.a --O-- bonded to any two adjacent carbon atoms of the phenyl nucleus and in which "a" is 1 or 2;
- (2) M is --CH.sub.2 --.sub.m or --NH--, wherein "m" is zero or an integer from 1 to 4;
- (3) X, Y and Z, which can be the same or different, are hydrogen, lower alkyl, lower alkoxy, lower alkyl carbonyloxy, hydroxy, lower alkyl sulfonyl, nitro, cyano or halogen;
- and pharmacologically acceptable salts thereof.
Priority Claims (2)
Number |
Date |
Country |
Kind |
54-37696 |
Mar 1979 |
JPX |
|
54-115240 |
Sep 1979 |
JPX |
|
Parent Case Info
This is a division, of application Ser. No. 133 694, filed Mar. 25, 1980 now U.S. Pat. No. 4,350,705.
Foreign Referenced Citations (3)
Number |
Date |
Country |
48-32850 |
May 1973 |
JPX |
49-30343 |
Mar 1974 |
JPX |
558318 |
Jan 1975 |
CHX |
Divisions (1)
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Number |
Date |
Country |
Parent |
133694 |
Mar 1980 |
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