Claims
- 1. Cathepsin inhibitors of the formula: whereinB is H or an amino acid blocking group for an N-terminal amino acid nitrogen; R1 is the amino acid side chain of the P1 amino acid residue; R2 is the amino acid residue of the P2 amino acid; R3 is the amino acid residue of the P3 amino acid; n is 0 or 1; m is 0 or 1; and Het is a pyridine or a substituted pyridine.
- 2. A cathepsin inhibitor according to claim 1 wherein n is 0 and m is 1.
- 3. A cathepsin inhibitor according to claim 2 wherein R2 is the residue of phenylalanyl (Phe).
- 4. A cathepsin inhibitor according to claim 3 wherein R1 is a side chain such that the P1 amino acid residue is the residue of homophenylalanyl (HPhe).
- 5. A cathepsin inhibitor according to claim 4 wherein B is Mu.
- 6. A cathepsin dipeptidyl peptidase inhibitor according to claim 1 wherein B═H.
- 7. A cathepsin inhibitor according to claim 1 wherein Het is a benzo-fused pyridine.
- 8. A cathepsin inhibitor according to claim 1 wherein Het is a hydroxypyridine.
- 9. A cathespin H inhibitor according to claim 6 wherein Het is a pyridine.
- 10. A cathespin H inhibitor according to claim 7 wherein B═H, n=0 and m=0.
- 11. A cathepsin inhibitor according to claim 1, wherein said inhibitor is in a pharmaceutically acceptable carrier.
- 12. Cathepsin inhibitors of the formula: whereinB is H or an amino acid blocking group for an N-terminal amino acid nitrogen; R1 is the amino acid side chain of the P1 amino acid residue; R2 is the amino acid residue of the P2 amino acid; R3 is the amino acid residue of the P3 amino acid; n is 0 or 1; m is 0 or 1; and Het is a pyridine or a substituted pyridine.
Parent Case Info
This application is a divisional application of applicant's application Ser. No. 08/921,683, filed Sep. 2, 1997, now U.S. Pat. No. 5,925,772, which is a divisional application of Ser. No. 08/599,459, filed Jan. 22, 1996, now issued U.S. Pat. No. 5,663,380, which is a divisional of Ser. No. 08/164,031, filed Dec. 8, 1993, now issued U.S. Pat. No. 5,486,623.
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