Claims
- 1. A composition having cytostatic or cytotoxic effects on lymphoma cells, comprising:
- a therapeutically acceptable carrier and, in quantities having in combination of two active substances a synergistic therapeutic effect at the lymphoma cells,
- vincristin as one of said two active substances and
- at least one histone selected from the group consisting of H1, H2A, H2B, and a dimer H2A:H2B.
- 2. The composition of claim 1, wherein said histones and vincristine are 100 .mu.g/ml of H2A:H2B and 5 .mu.g/ml of vincristine, respectively.
- 3. A composition having cytostatic or cytotoxic effects on melanoma cells, comprising:
- a therapeutically acceptable carrier and, in quantities having in combination of two active substances a synergistic therapeutic effect at the melanoma cells,
- a cytostatic agent selected from the group consisting of methotrexate and cisplantin as one of said two active substances and
- at least one histone selected from the group consisting of H1, H2A, H2B, and dimer H2A:H2B.
- 4. The composition of claim 3, wherein said histones and cytostatic agent are 100 .mu.g/ml of H2A:H2B and 5 .mu.g/ml of methotrexate, respectively.
- 5. The composition of claim 3, wherein said histones and cytostatic agent are 100 .mu.g/ml of H2A:H2B and one .mu.g/ml of cisplatin.
Priority Claims (1)
Number |
Date |
Country |
Kind |
40 00 154.7 |
Jan 1990 |
DEX |
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Parent Case Info
This application is a continuation of U.S. application Ser. No. 07/635,709 filed Dec. 28, 1990 and now abandoned, which is incorporated herein by reference.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4902505 |
Pardridge et al. |
Feb 1990 |
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Non-Patent Literature Citations (2)
Entry |
Buxman, J. Invest. Derm., vol. 73, No. 3, pp. 250-255, 1979. |
Ginsburg et al., Biological Abstracts, vol. 78, 8, 1984, Abst No. :59767. |
Continuations (1)
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Number |
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Parent |
635709 |
Dec 1990 |
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