D-homosteroids

Abstract

Novel D-homosteroids of the formula ##STR1## are disclosed. The novel D-homosteroids exhibit anti-inflammatory activity and are useful intermediates for the synthesis of anti-inflammatory D-homosteroids.

Description

Claims

1. A compound of the formula ##STR11## wherein R.sub.2 is hydrogen or methyl, R.sub.3 is hydroxy or C.sub.1-8 alkanoic acid acyloxy, and, R.sub.4 is methyl, hydroxy or C.sub.1-8 alkanoic acid acyloxy; R.sub.1 is hydrogen, fluoro, chloro, hydroxy, C.sub.1-16 hydrocarbon carboxylic acid acyloxy, sulfato or phosphato; X is hydrogen, fluoro or methyl; Y is hydrogen and Z is alpha-hydroxy, or alpha-lower alkanoyloxy, or Z is alpha-hydroxy, alpha-lower alkanoyloxy or hydrogen when both R.sub.1 and R.sub.2 are substituents other than hydrogen; or Y and Z taken together is a carbon to carbon bond; and the dotted line in the 1,2-position together with the corresponding solid line denotes a single or double bond provided that there is a double bond in the 1,2-position when X and R.sub.2 or X and R.sub.4 each independently are hydrogen or methyl.

2. The compound of claim 1 which is 21-acetoxy-17.alpha.-methyl-D-homo-1,4,9(11)-pregnatriene-3,20-dione.

3. The compound of claim 1 which is 6.alpha.-fluoro-21-acetoxy-17.alpha.-methyl-D-homo-4-pregnene-3,20-dione.

4. The compound of claim 1 which is 6.alpha.-fluoro-21-trimethylacetoxy-17.alpha.-methyl-D-homo-1,4,9(11)-pregnatriene-3,20-dione.

5. The compound of claim 1 which is 6.alpha.-fluoro-21-acetoxy-17.alpha.-methyl-D-homo-1,4,9(11)-pregnatriene-3,20-dione.

6. The compound of claim 1 which is 17.alpha.,17a.alpha.-dihydroxy-21-acetoxy-D-homo-4-pregnene-3,20-dione.

7. The compound of claim 1 which is 17.alpha.,17a.alpha.-dihydroxy-11.alpha.-acetoxy-D-homo-4-pregnene-3,20-dione.

8. The compound of claim 1 which is 21-acetoxy-D-homo-1,4,9(11)-pregnatriene-3,20-dione.