Patent Grant
9713665
The invention relates to a degassing vessel and related systems and methods that can remove certain gases such as carbon dioxide from a dialysis system. The invention further relates to mechanical systems and methods for degassing a dialysate or any fluid used for, during or resulting from dialysis.
In dialysis systems including sorbent based systems, certain amounts of gas such as carbon dioxide can be created by the breakdown of urea into ammonia and carbon dioxide by urease. The resulting gas can go into solution in a fluid such as a dialysate and/or form gas bubbles. The bicarbonate buffer system can also contribute to the creation of excess carbon dioxide in dialysis fluid. Removal of carbon dioxide and other dissolved and undissolved gases in a dialysis system can be important in order to maintain a required pH, certain fluid conditions such as bicarbonate or ion concentration, and avoid the creation of gas bubbles. For example, a desired partial pressure of carbon dioxide may be required for safe operation of dialysis. Additionally, gas bubbles can interfere with the smooth pumping of the dialysate in the dialysate loop, interfere with sensors in the dialysate flow loop, reduce diffusive clearance across the dialysis membrane, and can present a dangerous condition for a patient if the gas crosses the dialyzer membrane into the extracorporeal circuit and causes gas bubbles in the blood returning to the patient.
However, the water used to initially prepare a dialysate may contain a significant amount of dissolved gases, such as nitrogen and oxygen. Further, carbon dioxide may be formed as part of the breakdown of urea as spent dialysate flows through the sorbent cartridge. Dissolved gases may come out of solution in the dialysate flow loop, creating bubbles and interfering with sensors and the ability of the pumps of the dialysis system to smoothly pump fluid. In addition to carbon dioxide from the breakdown of urea, dialysate can also contain dissolved oxygen and nitrogen gas that crosses the dialysis membrane from the patient's blood.
The degassers known in the art do not necessarily efficiently remove dissolved gases, such as carbon dioxide, from fluid, or do not provide control over the amount of carbon dioxide removed. Hence, there is a need for a degasser that can remove large amounts of dissolved carbon dioxide from solution, while providing control over the amount of dissolved and undissolved gases removed from fluid before, during and after dialysis therapy. There is also a need for a degasser having the small size and weight necessary for a portable device.
The first aspect of the invention is drawn to a degassing vessel. In any embodiment of the first aspect of the invention, the degassing vessel can comprise a fluid inlet in the degassing vessel fluidly connected to a flow restriction; a fluid outlet in the degassing vessel for fluid connection to a fluid pump downstream of the degassing vessel; and a gas outlet for fluid connection to a vacuum pump.
In any embodiment of the first aspect of the invention, the degassing vessel can further comprise a carbon dioxide sensor positioned to detect carbon dioxide at the outlet of the degassing vessel.
In any embodiment of the first aspect of the invention, the degassing vessel can further comprise one or more selected from the group consisting of a degas sprayer, a nucleation chamber, and combinations thereof; wherein fluid entering the degassing vessel through the fluid inlet passes through any of the degas sprayer, the nucleation chamber, or the combinations thereof.
In any embodiment of the first aspect of the invention, the flow restriction can be comprised of a degas sprayer, a nucleation chamber, or both the degas sprayer and the nucleation chamber.
In any embodiment of the first aspect of the invention, the flow restriction can be selected from the group consisting of orifices, venturis, spray nozzles, a narrowing, pinch valves, gate valves, variable orifice valves, a pressure regulator, and combinations thereof.
In any embodiment of the first aspect of the invention, the degassing vessel can comprise a pressure sensor configured to determine a fluid pressure in the degassing vessel.
In any embodiment of the first aspect of the invention, the degassing vessel can further comprise one or more sensors in the degassing vessel; the one or more sensors are configured to determine the fluid level in the degassing vessel.
In any embodiment of the first aspect of the invention, the one or more sensors can comprise an upper level sensor and a lower level sensor in the degassing vessel; wherein the upper level sensor detects whether the fluid level in the degassing vessel is above a first pre-set point; and wherein the lower level sensor detects whether the fluid level in the degassing vessel is below a second pre-set point.
In any embodiment of the first aspect of the invention, the degassing vessel can further comprise an overflow float in the degassing vessel, the overflow float being of a lower density than water; and a mechanical vent valve placed on the degassing vessel at the gas outlet, such that if the fluid level in the degassing vessel is above a pre-set point, the overflow float will cover the mechanical vent valve or the float can move an actuator that leads to blocking fluid from passing through the mechanical vent valve.
Any of the features disclosed as being part of the first aspect of the invention can be included in the first aspect of the invention, either alone or in combination.
The second aspect of the invention is drawn to a degassing system. In any embodiment of the second aspect of the invention, the degassing system can have a degassing vessel having a fluid inlet, and a fluid outlet, a degas flow restrictor fluidly connected to the inlet of the degassing vessel, a fluid pump fluidly connected to the degassing vessel, and located downstream of the degassing vessel, for pulling fluid into the degassing vessel through the fluid inlet and out of the degassing vessel through the fluid outlet; and a vacuum pump attached to the degassing vessel for removing gas from the degassing vessel.
In any embodiment of the second aspect of the invention, the degassing system can further comprise one or more of a degas sprayer located inside the degassing vessel at the fluid inlet of the degassing vessel such that fluid entering the degassing vessel through the fluid inlet passes through the degas sprayer, a nucleation chamber located either between the degas flow restrictor and the degassing vessel or inside the degassing vessel, and combinations thereof.
In any embodiment of the second aspect of the invention, the degassing system can further comprise a nucleation chamber, wherein the nucleation chamber is located between the degas flow restrictor and the degassing vessel or the nucleation chamber is located inside the degassing vessel.
In any embodiment of the second aspect of the invention, the selected nucleation chamber can comprise one or more of glass beads, fiber mesh and a filter.
In any embodiment of the second aspect of the invention, the degassing system can further comprise a carbon dioxide sensor located downstream of the degassing vessel.
In any embodiment of the second aspect of the invention, the degassing system can further comprise a control unit in electronic communication with the carbon dioxide sensor, the vacuum pump and the fluid pump.
In any embodiment of the second aspect of the invention, the control unit can automatically adjust the pump rates of the fluid pump and the vacuum pump in response to the information received from the carbon dioxide sensor.
In any embodiment of the second aspect of the invention, the degassing system can further comprise a vent valve positioned on a connector, wherein the connector is attached to the degassing vessel, and wherein gas can flow out of the degassing vessel through the vent valve.
In any embodiment of the second aspect of the invention, the degassing system can be positioned in a degassing flow loop wherein the degassing flow loop is fluidly connected to a dialysate flow loop and is parallel to the dialysate flow loop; and wherein the flow rate of the fluid in the degassing flow loop can be operated independently of the flow rate of the fluid in the dialysate flow loop.
In any embodiment of the second aspect of the invention, the degassing flow loop can be parallel to the dialysate flow loop.
In any embodiment of the second aspect of the invention, air can be drawn into the degassing vessel through the vent valve and out through a fluid port of the degassing vessel.
In any embodiment of the second aspect of the invention, the degassing system can comprise a particle filter in fluid communication with the vent valve such that air that is forced into the system through the vent valve first passes through the particle filter.
In any embodiment of the second aspect of the invention, the degassing system can comprise a pressure sensor located between the degas flow restrictor and the fluid pump. In any embodiment of the second aspect of the invention, the pressure sensor can be used to measure the operating pressure in the degassing system.
In any embodiment of the second aspect of the invention, the vacuum pump can pump gas removed from the degassing vessel to a fluid drain line of the dialysate flow path.
In any embodiment of the second aspect of the invention, the vent port can be in fluid communication through a control valve to the dialysate flow path.
In any embodiment of the second aspect of the invention, the flow restrictor can comprise a pressure regulator. In any embodiment of the second aspect of the invention, the flow restrictor can cause the restriction to vary such that a predetermined pressure is maintained in the degasser.
In any embodiment of the second aspect of the invention, the fluid pump and vacuum pump can be any one of a gear pump, a peristaltic pump, a diaphragm pump or an impeller pump, or combinations thereof.
In any embodiment of the second aspect of the invention, the degassing system can comprise a sensor positioned on the fluid pump to monitor the wear of the fluid pump.
In any embodiment of the second aspect of the invention, the degassing system can comprise one or more sensors in the degassing vessel; wherein the one or more sensors detect or measure the fluid level in the degassing vessel; wherein if the one or more sensors detect that the fluid level in the degassing vessel is above a first pre-set point, either the pump rate of the fluid pump is increased, the pump rate of the vacuum pump is decreased, or a combination thereof; and if the one or more sensors detect that the fluid level in the degassing vessel is below a second pre-set point, either the pump rate of the fluid pump is decreased, the pump rate of the vacuum pump is increased, or a combination thereof.
In any embodiment of the second aspect of the invention, the fluid pump and vacuum pump can be capable of creating an absolute pressure in the degassing vessel of between any of 60 mmHg and 200 mmHg, 60 mmHg and 100 mmHg, 80 mmHg and 150 mmHg, and 100 mmHg and 200 mmHg. In any embodiment of the second aspect of the invention, the fluid pump and vacuum pump can be capable of creating an absolute pressure in the degassing vessel of between any of 60 mmHg and 200 mmHg, 60 mmHg and 100 mmHg, 80 mmHg and 150 mmHg, and 100 mmHg and 200 mmHg.
In any embodiment of the second aspect of the invention, if the one or more sensors detect that the fluid level in the degassing vessel is above a first pre-set point, either the pump rate of the fluid pump can be automatically increased, the pump rate of vacuum pump can be automatically reduced, or a combinations thereof, and if the one or more sensors detect that the fluid level in the degassing vessel is below a second pre-set point, either the pump rate of the fluid pump can be automatically decreased, the pump rate of vacuum pump can be automatically increased, or a combination thereof.
In any embodiment of the second aspect of the invention, the degassing system can comprise an overflow float in the degassing vessel, the overflow float being of a lower density than water.
In any embodiment of the second aspect of the invention, the degassing system can comprise a mechanical vent valve placed on the degassing vessel before the connector with the vent valve, such that if the fluid level in the degassing vessel is above a pre-set point, the overflow float will cover the mechanical vent valve or the float can move an actuator and that leads to blocking fluid from passing into the connector, while still allowing air to enter and exit the degassing vessel through the mechanical vent valve.
In any embodiment of the second aspect of the invention, the liquid pump can cause the flow through the degassing flow loop to be faster than the flow through the dialysate flow loop.
In any embodiment of the second aspect of the invention, the degassing system can be fluidly connected to a controlled compliant dialysis system.
In any embodiment of the second aspect of the invention, the degassing system can be part of the dialysate flow path of a recirculating regenerative sorbent-based hemodialysis system.
In any embodiment of the second aspect of the invention, the fluid pump and vacuum pump can be capable of creating a pressure differential of between any of −1500 and 700 mmHg, −1500 and 0 mmHg, 0 and 500 mmHg, 400 and 700 mmHg, 400 and 500 mmHg, 450 and 600 mmHg, or 550 and 700 mmHg.
In any embodiment of the second aspect of the invention, the degassing system can comprise a semi-permeable membrane between the vacuum pump and the degassing vessel, wherein the semi-permeable membrane allows gas to pass through the membrane but does not allow liquid to pass through the membrane.
In any embodiment of the second aspect of the invention, the degassing system can comprise a control unit in electronic communication with the pressure sensor and at least one of the fluid pump, vacuum pump or flow restrictor.
In any embodiment of the second aspect of the invention, the control unit can automatically adjust the pump rates of the fluid pump or the vacuum pump in response to the information received from the pressure sensor.
In any embodiment of the second aspect of the invention, the control unit can automatically adjust the amount of flow restriction caused by the flow restrictor.
In any embodiment of the second aspect of the invention, in response to a signal from the carbon dioxide sensor showing that the carbon dioxide concentration is above a pre-set point, the control unit can be configured to automatically do one or more of increase the pump rate of the fluid pump, increase the pump rate of the vacuum pump, or a combination thereof.
In any embodiment of the second aspect of the invention, in response to a signal from the carbon dioxide sensor showing that the carbon dioxide concentration is below a pre-set point, the control unit can be configured to automatically do one or more of: shut off the fluid pump, shut off the vacuum pump, decrease the pump rate of the fluid pump, decrease the pump rate of the vacuum pump, or a combination thereof.
In any embodiment of the second aspect of the invention, the degassing system can comprise a vent line, wherein the vent line is in fluid communication with a recirculating dialysate flow path.
In any embodiment of the second aspect of the invention, fluid can be recirculated through the vent line and vent valve to a recirculating dialysate flow path.
In any embodiment of the second aspect of the invention, the fluid recirculated through the vent line and vent valve can be a fluid for cleaning or disinfection.
Any of the features disclosed as being part of the second aspect of the invention can be included in the second aspect of the invention, either alone or in combination.
The third aspect of the invention is drawn to a method for controlling the amount of carbon dioxide in a fluid. In any embodiment of the third aspect of the invention, the method can include lowering the pressure of a fluid, inducing bubbles to come out of solution, and collecting the gas from the bubbles at a pressure below atmospheric pressure.
In any embodiment of the third aspect of the invention, the step of inducing bubbles to come out of solution can comprise passing the fluid through a sprayer. In any embodiment of the third aspect of the invention, the step of inducing bubbles to come out of solution can comprise passing the fluid through a nucleation chamber.
In any embodiment of the third aspect of the invention, the method can include directing the fluid into a degasser, wherein the degasser comprises a degassing vessel having a fluid inlet, and a fluid outlet; a degas flow restrictor disposed upstream of the degassing vessel; a liquid pump fluidly connected to the degassing vessel and located downstream of the degassing vessel, for pulling fluid into the degassing vessel through the fluid inlet and out of the degassing vessel through the fluid outlet; a vacuum pump attached to the degassing vessel for removing gas from the degassing vessel; and a carbon dioxide sensor located downstream of the degassing vessel; and adjusting the pump rates of the vacuum pump and the fluid pump in response to the data received from the carbon dioxide sensor.
In any embodiment of the third aspect of the invention, the degasser can further comprise a control unit in electronic communication with the carbon dioxide sensor, the fluid pump and the vacuum pump; and the control unit automatically makes the adjustments to the pump rates of the vacuum pump and the fluid pump in response to the data received from the carbon dioxide sensor.
In any embodiment of the third aspect of the invention, in response to a signal from the carbon dioxide sensor showing that the carbon dioxide level is above a pre-set point the method can comprise one or more of increasing the pump rate of the fluid pump or increasing the pump rate of the vacuum pump.
In any embodiment of the third aspect of the invention, in response to a signal from the carbon dioxide sensor showing that the carbon dioxide level is below a pre-set point the method can comprise one or more of: shut off the fluid pump, shut off the vacuum pump, and decrease the pump rate of the fluid pump, or decrease the pump rate of the vacuum pump.
In any embodiment of the third aspect of the invention, the rate of the fluid pump can be controlled in proportion to the rate of the dialysate pump.
In any embodiment of the third aspect of the invention, the rate of the fluid pump can be controlled at varying flow rates and a variable degas restrictor can coordinately change the amount of flow restriction in the degassing loop to maintain a predetermined pressure in the degasser.
In any embodiment of the third aspect of the invention, the rate of the vacuum pump can be increased to raise the level of liquid in the degassing vessel or decreased to reduce the level of fluid in the degassing vessel.
In any embodiment of the third aspect of the invention, a sensor can be used to measure the level of liquid in the degassing vessel and the controller can adjust the rate of the vacuum pump the achieve the desired liquid level in the degassing vessel.
Any of the features disclosed as being part of the third aspect of the invention can be included in the third aspect of the invention, either alone or in combination.
Unless defined otherwise, all technical and scientific terms used herein generally have the same meaning as commonly understood by one of ordinary skill in the relevant art.
The articles “a” and “an” are used herein to refer to one or to more than one (i.e., to at least one) of the grammatical object of the article. By way of example, “an element” means one element or more than one element.
The term “cartridge” refers to any container designed to contain a powder, fluid, or gas made for ready connection to a device or mechanism. The container can have one or more compartments. Instead of compartments, the container can also be comprised of a system of two or more modules connected together to form the cartridge wherein the two or more modules once formed can be connected to a device or mechanism.
The term “carbon dioxide sensor” refers to devices that can detect or measure the concentration of carbon dioxide in a liquid or gas.
The terms “communicate” and “communication” include, but are not limited to, the connection of system electrical elements, either directly or remotely, for data transmission among and between said elements. The terms also include, but are not limited to, the connection of system fluid elements enabling fluid interface among and between said elements.
The term “comprising” includes, but is not limited to, whatever follows the word “comprising.” Thus, use of the term indicates that the listed elements are required or mandatory but that other elements are optional and may or may not be present.
The term “connectable” refers to being able to be joined together for purposes including but not limited to maintaining a position, allowing a flow of fluid, performing a measurement, transmitting power, and transmitting electrical signals. The term “connectable” can refer to being able to be joined together temporarily or permanently.
A “connector” and “for connection” as used herein describes the concept of forming a fluid connection between two components wherein fluid or gas can flow from one component, through a connector or a component for connection, to another component. The connector provides for a fluid connection in its broadest sense and can include any type of tubing, fluid or gas passageway, or conduit between any one or more components of the invention.
The term “consisting of” includes and is limited to whatever follows the phrase “consisting of.” Thus, the phrase indicates that the limited elements are required or mandatory and that no other elements may be present. The term “consisting essentially of” includes whatever follows the term “consisting essentially of” and additional elements, structures, acts or features that do not affect the basic operation of the apparatus, structure or method described.
A “control system” consists of combinations of components that act together to maintain a system to a desired set of performance specifications. The control system can use processors, memory and computer components configured to interoperate to maintain the desired performance specifications. The control system can also include fluid or gas control components, and solute control components as known within the art to maintain the performance specifications.
A “control valve” is a valve for controlling the movement of a liquid or a gas. When the control valve directs the movement of gas, the control valve can open or close to regulate the movement of gas from a high pressure gas source to a lower pressure.
A “controller,” “control unit,” “processor,” or “microprocessor” is a device which monitors and affects the operational conditions of a given system. The operational conditions are typically referred to as output variables of the system wherein the output variables can be affected by adjusting certain input variables.
A “degas restrictor” is a flow restriction through which a pump pulls fluid, thereby generating a reduced pressure within the fluid flowing between the flow restriction and the pump.
A “degasser” is a component that is capable of removing dissolved and undissolved gasses from fluids. The term “degasser” can encompass a degassing vessel, and a fluid pump and a vacuum pump connected to the degassing vessel and working in concert to create a vacuum in the fluid flowing through the degassing vessel and to evacuate gas from the degassing vessel.
A “degassing flow loop” is a portion of a fluid pathway that conveys a dialysate from a dialysate flow loop to a degasser and back to the dialysate flow loop.
A “degassing membrane” is a semi-permeable membrane having a permeability coefficient selective to a particular gas such that specific gases may be removed from dialysate with particularity. The membrane may be constructed materials known in the art having the desired permeability coefficient for the targeted gas to be removed from the dialysate.
A “degassing vessel” or a “degas vessel” is a component of a degasser, and can be any structure having an inlet through which dialysate enters the vessel, a first outlet through which gas removed from the dialysate may pass, and a second outlet through which dialysate can exit the vessel once gas has been removed from the dialysate.
The term “detachable” or “detached” relates to any component of the present invention that can be separated from a system, module, cartridge or any component of the invention. “Detachable” can also refer to a component that can be taken out of a larger system with minimal time or effort. In certain instances, the components can be detached with minimal time or effort, but in other instances can require additional effort. The detached component can be optionally reattached to the system, module, cartridge or other component. A detachable module can often be part of a reusable module.
“Dialysate” is the fluid that passes through the dialyzer on the side of the dialysis membrane that is opposite to the fluid (e.g. blood) that is being dialyzed.
The term “dialysate flow loop,” “dialysate flow path” or “dialysate conduit flow path” refers to any portion of a fluid pathway that conveys a dialysate and is configured to form at least part of a fluid circuit for hemodialysis, hemofiltration, ultrafiltration, hemodiafiltration or ultrafiltration. Optionally, the fluid pathway can contain priming fluid during a priming step or cleaning fluid during a cleaning step.
“Dialysis” is a type of filtration, or a process of selective diffusion through a membrane. Dialysis removes solutes of a specific range of molecular weights via diffusion through a membrane from a fluid to be dialyzed into a dialysate. During dialysis, a fluid to be dialyzed is passed over a filter membrane, while dialysate is passed over the other side of that membrane. Dissolved solutes are transported across the filter membrane by diffusion between the fluids. The dialysate is used to remove solutes from the fluid to be dialyzed. The dialysate can also provide enrichment to the other fluid.
The terms “dialysis membrane,” “hemodialysis membrane,” “hemofiltration membrane,” “hemodiafiltration membrane,” “ultrafiltration membrane,” can generally be referred to as a “membrane,” or can refer to a semi-permeable barrier selective to allow diffusion and/or convection of solutes between blood and dialysate, or blood and filtrate, of a specific range of molecular weights in either direction through the barrier that separates blood and dialysate, or blood and filtrate, while allowing diffusive and/or convective transfer between the blood on one side of the membrane and the dialysate or filtrate circuit on the other side of the membrane.
The term “dialyzer” refers to a cartridge or container with two flow paths separated by semi-permeable membranes. One flow path is for blood and one flow path is for dialysate. The membranes can be in the form of hollow fibers, flat sheets, or spiral wound or other conventional forms known to those of skill in the art. Membranes can be selected from the following materials of polysulfone, polyethersulfone, poly(methyl methacrylate), modified cellulose, or other materials known to those skilled in the art.
A “fiber mesh” is a component made of strands of fibers with spaces between the fibers to allow fluid or gas to flow through the mesh.
“Flow” refers to the movement of a fluid or gas.
The term “flow loop” refers to a grouping of components that may guide the movement of a fluid, convey the fluid, exchange energy with the fluid, modify the composition of the fluid, measure a characteristic of the fluid and/or detect the fluid. A flow loop comprises a route or a collection of routes for a fluid to move within. Within a flow loop there may be more than one route that a volume of fluid can follow to move from one position to another position. A fluid volume may move through a flow loop such that the fluid volume recirculates, or passes the same position more than once as the fluid volume moves through a flow loop. A flow loop may operate to cause fluid volume ingress to and fluid volume egress from the flow loop. The term “flow loop” and “flow path” often may be used interchangeably.
The terms “flow restriction,” “flow restriction device,” “flow restrictor” and “restrictor” refer to an element or grouping of elements that resist the flow of fluid through the element or grouping of elements such that the fluid pressure within a flow stream that passes through the element or grouping of elements is greater upstream of the element or grouping of elements than downstream of the element or grouping of elements. A flow restrictor may be an active or passive device. Non-limiting examples of passive flow restriction devices are orifices, venturis, spray nozzles, a narrowing, or a simple length of tubing with flow cross section that produces the desired pressure drop when the fluid flows through the flow restrictor, such tubing being essentially rigid or compliant. Non-limiting examples of active flow restrictors are pinch valves, gate valves and variable orifice valves.
A “flow sensing apparatus” or “flow measuring apparatus” is an apparatus capable of measuring the flow of fluid or gas within a specific area.
A “fluid” is a liquid substance, optionally having a combination of gas and liquid phases in the fluid. Notably, a liquid, as used herein, can therefore also have a mixture of gas and liquid phases of matter.
The term “fluid communication” refers to the ability of fluid or gas to move from one component or compartment to another within a system or the state of being connected, such that fluid or gas can move by pressure differences from one portion that is connected to another portion.
The terms “fluidly connectable” and “fluid connection” refer to the ability of providing for the passage of fluid or gas from one point to another point. The two points can be within or between any one or more of compartments, modules, systems, components, and rechargers, all of any type.
A “fluid pump” is a pump used to move fluid throughout a system. In any embodiment, the fluid pump can create low pressure in a degassing vessel such that fluid is drawn into the degassing vessel. In any embodiment, the fluid pump can be used together with a degas restrictor. The fluid pump can work in concert with a vacuum pump to create a low pressure environment within the degassing vessel such that gas is separated from the fluid.
A “gas” is a state of matter, as opposed to liquid, solid or plasma. A gas may be comprised of elemental molecules made from one type of atom (e.g., oxygen, nitrogen), and may comprise compound molecules made from a variety of atoms (e.g., carbon dioxide). Gas may be dissolved or undissolved in a fluid, such as dialysate. At higher pressures, a greater amount of gas will remain dissolved in fluid; however, as the fluid is subjected to lower pressures, the gas will precipitate out of the fluid. In the present invention, the phrase “any other gas” refers to any gas that is not carbon dioxide that may be found in dialysate or any other fluid used in dialysis, such as nitrogen and oxygen.
A “gear pump” is a pump that uses the meshing of gears to create a pressure to displace fluid, gas or both.
The term “hydrophobic membrane” refers to a semipermeable porous material that may allow gas phases of matter to pass through the membrane, but which substantially resists the flow of liquid water through the membrane due to the surface interaction between the liquid water and the hydrophobic material of the membrane.
A “level sensor” is a component capable of determining the level of a fluid in a container. The terms “upper level sensor” and “lower level sensor” refer to the respective positions of level sensors.
The term “particle filter” refers to a device configured to inhibit the passage particulate matter conveyed by a fluid or solution while allowing the passage of the fluid or solution.
A “narrowing” is a portion of a fluid flow path having a smaller interior diameter than a portion of a fluid flow path immediately adjacent to the narrowing in any direction of fluid flow. The portions adjacent to the narrowing having a larger diameter can occur either before or after, and in some cases before and after the narrowing. All rates at which the diameter of the narrowing can be reduced relative to adjacent portions or to the degree to which a flow path can be narrowed, are contemplated by the present definition.
A “nucleation chamber” is a device containing a high surface area medium, such as a filter, fiber mesh, or beads onto which gases can nucleate to form bubbles.
An “operational line” or “line” is a passageway, conduit or connector that directs fluid or gas in a path used while the system is in operation.
An “overflow float” is a component in a degassing vessel that serves to keep liquid from moving through the gas vent port in the degassing vessel. The overflow float has a density less than that of water. As the liquid level in the degassing vessel rises, the overflow float will float on top of the liquid, eventually coming into contact with, and blocking the vent.
The terms “pathway,” “conveyance pathway,” “fluid flow path,” and “flow path” refer to the route through which a fluid or gas, such as dialysate or blood travels.
A “patient” or “subject” is a member of any animal species, preferably a mammalian species, optionally a human. The subject can be an apparently healthy individual, an individual suffering from a disease, or an individual being treated for a disease.
The term “peristaltic pump” refers to a pump that operates by compression of a flexible conduit or tube through which the fluid to be pumped passes.
The term “physiologically compatible fluid” or “physiologically compatible solution” refers to a fluid that can be safely introduced into the bloodstream of a living subject.
The terms “pressure meter” and “pressure sensor” refer to a device for measuring the pressure of a gas or fluid in a vessel or container.
The term “pulsatile pump” refers to a pump wherein the pumped fluid undergoes periodic variation in velocity and/or pressure.
The term “pump” refers to any device that causes the movement of fluids or gases by the application of suction or pressure.
The terms “pump rate” and “volumetric pumping rate” refer to the volume of fluid that a pump conveys per unit of time.
A “recirculating flow path” is a flow path configured such that fluid or gas within the flow path can pass by the same point in the flow path more than one time.
A “sensor” is a component capable of determining the states of one or more variables in a system.
The term “ultrafiltrate” refers to fluid that is removed from a subject by convection through a permeable membrane during hemodialysis, hemofiltration, hemodiafiltration, or peritoneal dialysis. The term “ultrafiltrate,” as used herein, can also refer to the fluid in a reservoir that collects fluid volume removed from the patient, but such a reservoir may also include fluids or collections of fluids that do not originate from the subject.
The term “undissolved gases” refers to gases that are not part of a solution, including free gases or bubbles. By contrast, “dissolved gases” include gases dissolved in a liquid such as water or dialysate.
A “vacuum pump” is a pump used to create negative pressure in a degassing vessel and remove gas from the vessel.
A “valve” is a device capable of directing the flow of fluid or gas by opening, closing or obstructing one or more pathways to allow the fluid or gas to travel in a particular path. One or more valves configured to accomplish a desired flow can be configured into a “valve assembly.”
A “vent valve” is a valve that controls the movement of a gas into and out of a vent. A “mechanical vent valve” is a vent valve that is opened or closed based on an external component, such as an overflow float, blocking or not blocking the mechanical vent valve.
The term “vent” as referred to in relationship to a gas, refers to a means for permitting the escape of a gas from a defined portion of the system, such as, for example, would be found in the degassing module.
A “vent line” is a passage for fluid, gas, or mixtures thereof, wherein the passage can be fluidly connectable to a vent.
Degassing Module
The first, second and third aspects of the invention relate to a degasser and related systems and methods for removing gas, and specifically carbon dioxide, generated from the breakdown of urea in the sorbent cartridge. A degassing module in accordance with the first, second and third aspects of the invention is shown in
As the dialysate enters the degassing module, the dialysate can pass a degas restrictor 13 of
The degassing vessel 11 of the first, second and third aspects of the invention can be operated at a pressure lower than atmospheric pressure due to the presence of vacuum pump 14. By maintaining the degassing vessel 11 at a pressure less than atmospheric pressure, carbon dioxide present in the fluid can be more easily removed than in the absence of the described system of pumps of the first, second and third aspects of the invention. In any embodiment of the first, second and third aspects of the invention, the vent valve 10 can allow gas to leave directly into the atmosphere through vent valve filter 29, as represented by arrow 30. The vent valve filter 29 is a particle filter that serves to remove particulate matter from air flowing through filter 29. In any embodiment of the first, second and third aspects of the invention, the gases may travel through degas line 23, to the gas removal pump assembly 15 and into the atmosphere as represented by arrow 24.
Vent valve 10 can be a three way valve, as shown in
Lower level sensor 17 and upper level sensor 16 can sense the fluid level in the degassing vessel 11. The fluid level in the degassing vessel 11 can be a function of the vacuum created by fluid pump 12 and vacuum pump 14 working independently or in concert. The pump rate of the fluid pump 12 and vacuum pump 14 can be adjusted as necessary to maintain the correct fluid level in the degassing vessel 11. In any embodiment of the first, second and third aspects of the invention, the lower level sensor 17 and upper level sensor 16 can be in electronic communication with a control system (not shown). The pump rates of the fluid pump 12 and vacuum pump 14 can be automatically adjusted by the control system to maintain the proper level of fluid in the degas vessel 11. If the fluid level in the degas vessel 11 is near or above the maximum fluid level 26, the pump rates of the fluid pump 12 can be increased, and/or vacuum pump 14 can be reduced. If the fluid level in the degas vessel 11 is near or below the minimum fluid level 22, the pump rates of the fluid pump 12 can be reduced and/or vacuum pump 14 can be increased.
In any embodiment of the first, second and third aspects of the invention, only one sensor is necessary to detect the fluid level in the degassing vessel 11. For example, an ultrasonic sensor or mechanical float can be used to determine the fluid level in the degassing vessel 11. Any other type of fluid level sensor known in the art is contemplated by the first, second and third aspects of the invention.
Carbon dioxide sensor 28 can determine the amount of carbon dioxide present in the dialysate flow loop after dialysate has passed through the degasser. The pump rates of fluid pump 12 and vacuum pump 14 can be adjusted as discussed below in response to signals received from the carbon dioxide sensor 28 in order to remove more or less carbon dioxide from the dialysate, and therefore deliver more or less carbon dioxide to the main dialysate flow path. In any embodiment of the first, second and third aspects of the invention, the pumps can be adjusted automatically if the level of carbon dioxide detected in the dialysate by carbon dioxide sensor 28 is higher or lower than a pre-set value. In any embodiment of the first, second and third aspects of the invention, the pumps can be adjusted manually in response to output from the carbon dioxide sensor 28. In any embodiment of the first, second and third aspects of the invention, the optimum carbon dioxide concentration in the fluid after passing through the degasser can be between any of 50 and 200 mmHg partial pressure, 50 and 120 mmHg partial pressure, 50 and 80 mmHg partial pressure, 70 and 100 mmHg partial pressure, 80 and 120 mmHg partial pressure, 50 and 200 mmHg partial pressure, or 100 and 200 mmHg partial pressure. The carbon dioxide sensor 28 can be placed anywhere in the dialysate flow loop, but preferably between the outlet of the degassing flow path and the inlet of the dialyzer (not shown).
Carbon dioxide sensors and sensors are known in the art. Examples include non-dispersive infrared (NDIR) detectors that detect carbon dioxide concentration in a gas and which are commercially available from a number of manufacturers, for example Gas Sensing Solutions, Glasgow Scotland; colormetric optical detectors that detect carbon dioxide in a liquid by means of a substrate that produce color change when the concentration of carbon dioxide in the liquid changes (PreSens Precision Sensing GmbH, Regensburg Germany); and sensors that utilize Severinghaus electrodes, such as the InPro CO2 sensor from Mettler Toledo, Leicester England.
The pumps of the degassing module can be of any type known in the art. In any embodiment of the first, second and third aspects of the invention, fluid pump 12 and vacuum pump 14 can be the same type of pump. In any embodiment of the first, second and third aspects of the invention, fluid pump 12 and vacuum pump 14 may be different types of pumps. In any embodiment of the first, second and third aspects of the invention, the fluid pump 12 and vacuum pump 14 can be a gear pump. In any embodiment of the first, second and third aspects of the invention, fluid pump 12 and vacuum pump 14 can be a peristaltic pump, a diaphragm pump or an impeller pump. In any embodiment of the first, second and third aspects of the invention, fluid pump 12 can also have a sensor 31 attached to the pump 12 to monitor performance of the pump 12 and detect wear. In any embodiment of the first, second and third aspects of the invention, the fluid pump 12 must be selected for operating with the pump inlet at a low absolute pressure necessary to efficiently remove carbon dioxide.
Flow of fluid through the degassing module can be variable. Control over the flow can be provided by fluid pump 12. Under certain operating conditions the flow rate provided by fluid pump 12 can be less than the flow rate through the main dialysate loop. In any embodiment of the first, second and third aspects of the invention, fluid pump 12 can be operated so that flow through the degassing module is significantly greater than flow through the main dialysate loop. In any embodiment of the first, second and third aspects of the invention, the fluid pump 12 can be operated to move fluid through the degassing flow loop at a rate of 2-3 times that of the dialysate flow loop. In any embodiment of the first, second and third aspects of the invention, the fluid pump 12 can be operated to move fluid through the degassing flow loop at a rate between 1-6 times that of the dialysate flow loop, 1-2 times that of the dialysate flow loop, 3-4 times that of the dialysate flow loop, 4-5 times that of the dialysate flow loop or 5-6 times that of the dialysate flow loop. In any embodiment of the first, second and third aspects of the invention, the flow through the degassing module can be controlled automatically depending on the amount of carbon dioxide that is to be removed.
The first, second and third aspects of the invention can utilize the vacuum pump 14 to remove gas from the degassing vessel 11 to the atmosphere when the degassing vessel is operated under vacuum. Known degassing systems pump fluid into a vessel at ambient pressure where bubbles are allowed to escape. However, providing a second pump or any one of the specific pump configurations described in the first, second and third aspects of the invention to keep a degassing vessel under vacuum can unexpectedly result in higher amount of gases such as carbon dioxide being removed.
In any embodiment of the first, second and third aspects of the invention, the passage from the degassing vessel 11 to valve 10 can be covered by a hydrophobic membrane (not shown). A hydrophobic membrane will prevent fluid from escaping the degassing vessel 11 through vent opening 20. This, in turn, protects the vacuum pump 14 from being damaged by liquid and prevents undesired loss of liquid from the system while still enabling gas to be removed. In any embodiment of the first, second and third aspects of the invention, the hydrophobic membrane can be positioned in any appropriate location to guard against inadvertent fluid flow to the vacuum pump 14, and thereby prevent fluid damage. One example of a hydrophobic membrane is Polytetrafluoroethylene, or PTFE. However, the hydrophobic membrane can be made of any material.
During draining of the dialysis system of the first, second and third aspects of the invention, air can be drawn into the system in order to drain out the fluid in the fluid pathways of the system. Air can be added to the system through valve 10 as shown in
In any embodiment of the first, second and third aspects of the invention, as shown in
In any embodiment of the first, second and third aspects of the invention, both a nucleation chamber and a degas sprayer can be used. Such an arrangement can further help gas to be released from solution to collect at the top of the degas vessel 11. In any embodiment of the first, second and third aspects of the invention, only one of a degas sprayer or nucleation chamber can be used.
As shown in
As can be seen in
The outlet CO2 concentration can be dependent on the inlet CO2 concentration, the fluid pressures within the degassing flow loop, and the rates of flow through dialysate flow loop and the degassing flow loop. In any embodiment of the first, second and third aspects of the invention, the dialysate flow loop and the degassing flow loop can operate in parallel or in series.
In any embodiment of the first, second and third aspects of the invention, the control system can set initial pump rates for both the vacuum pump and fluid pump based on the initial carbon dioxide concentration in the dialysate. For example, if the initial carbon dioxide concentration in the dialysate is 415 mmHg partial pressure, the fluid pump and vacuum pump may be set to maintain an absolute pressure in the degas vessel of 100 mmHg. As shown in
In any embodiment of the first, second and third aspects of the invention, the degasser can be located in a fluid flow path in a position directly after the sorbent cartridge. The position of the degasser, however, is not limited to any one position. In any embodiment of the first, second and third aspects of the invention, the degassing module may be located in other positions between the sorbent cartridge and the dialyzer.
To make use of the dialysis system of the first, second and third aspects of the invention easier, the valves and pumps may be operated by a programmable controller or computer system that can be programmed to regulate flow through the pumps and valves and into and out of the reservoirs. A rotometer or turbine with optical sensor, photocell, magnetic sensor, or other flow sensing apparatus may detect the flow of fluid through any two points in the degassing system. For example, an optical fluid flow device can be provided for measuring flow wherein the device includes an optical fluid pressure measuring device having sensors positioned in any one of the flow paths between the reservoirs, in the connectors, or in the valves or valve assemblies. In any embodiment of the first, second and third aspects of the invention, the optical fluid sensors described above can be connected to an interferometer associated with an opto-electronic demodulator which has an output signal representing the differential pressure between the two sensed areas. In any embodiment of the first, second and third aspects of the invention, a flow sensing apparatus can have a flow-responsive element projecting into a fluid flow path, and a position sensor associated with the element which detects a change in position of the flow-responsive element in response to the fluid flow. The flow-responsive element can be made of a wide variety of materials having the desired properties known to those of ordinary skill in the art.
The reader is directed to
Referring to
The released gas can exit the degassing vessel 68 at outlet connector 33 and pass through vent line 63 to vent valve 40 through outflow line 42 to outflow valve 41. During degassing, outflow valve 41 directs the flow path to gas removal apparatus 15 through gas removal line 64. Vacuum pump 14 pulls the gas from the low pressure environment of degassing vessel 68 and pumps the gas out through degassing outlet line 43. Degassing outlet line 43 can optionally be connected to drain line 46. Connecting degassing outlet line 43 to drain line 46 muffles the noise of the gas removal pump 14 and directs any condensed water vapor to reservoir 60 through drain line 46 and connector 59. The removed gas flows out of reservoir 60 through vent 58.
Level sensor 61 can measure the liquid level 26 in degassing vessel 68. Level sensor 61 can be an ultrasonic sensor. Level sensor 61 can be an array of reed switches that detect the height of a magnetic float. Level sensor 61 can be an array of hall-effect sensors. The rate of gas removal pump 14 can be increased to increase the liquid level 26 when level sensor 61 detects that the liquid level 26 is below a predetermined level. The rate of gas removal pump 14 can be reduced when the level sensor 61 detects that the liquid level 26 is above a predetermined level. In any embodiment of the first, second and third aspects of the invention, the gas removal pump 14 can act as a check valve preventing air or liquid from returning to the degasser through degassing outlet line 43, but can allow gas outflow from the degasser through degassing outlet line 43 including when the gas removal pump is de-energized or turned off. Air can be rapidly evacuated from the dialysate flow path 55 through outlet connector 33, vent line 63, vent control valve 40, degassing outflow valve 41 and gas removal apparatus 15 and degassing outlet line 43 during priming operations when the liquid entering the dialysate flow path 55 causes the pressure to increase, forcing the air in the gas space 21 of degassing vessel 68 through outlet connector 33 when the pressure in gas space 21 is greater than atmospheric pressure.
Vent valve 40 can be switched to filter 29 and air can be drawn into the degassing vessel 68 as depicted by arrow 45 when liquid is being drained from the recirculating dialysate flow path 55 through drain valve 47 through drain line 46 and connector 59 to reservoir 60. Filter 29 can have a pore size that excludes microbes and particulate to prevent contamination of the system when air is drawn in.
During flushing, cleaning and disinfection of the dialysis system, degassing vessel 68 can be completely filled with liquid and liquid can be passed out through outlet connector 33 through vent line 63, vent control valve 40, and degassing outflow valve 41 to recirculation line 44. This flow path enables cleaning and disinfection solutions, including the non-limiting examples of hot water, heated citric acid solution, and bleach to be recirculate through the outlet connector 33, vent line 63, and vent control valve 40. In this manner microbiological contamination and biofilms can be minimize in the degassing vessel 68 and also in the flow path used to bring air into the system when liquid is being drained from the system.
In any embodiment of the first, second and third aspects of the invention, the flow restrictor 67 can have a fixed restriction, or can comprise a pressure regulator that changes the amount of flow restriction as the pumping rate of fluid pump 12 changes, such that a predetermined pressure is maintained in the dialysate exiting the restrictor across a range of operating rates of fluid pump 12. In any embodiment of the first, second and third aspects of the invention, the amount of restriction caused by flow restrictor 67 can be controlled to achieve a predetermined pressure in the fluid passing through the degas ser.
Pressure sensor 62 can measure the fluid pressure in the degassing system. Pressure sensor 62 can be located on the degassing vessel and can measure the pressure in the liquid or the gas. Pressure sensor 62 can be located at any point in the degasser between the flow restrictor 67 and fluid pump 12. In any embodiment of the first, second and third aspects of the invention, the pressure measurement obtained from pressure sensor 62 can be used to adjust the restriction of flow restrictor 67 to obtain a predetermined pressure in the degassing system. In any embodiment of the first, second and third aspects of the invention, the rate of fluid pump 12 can be controlled to achieve a predetermined fluid pressure in the degassing system. The rate of fluid pump 12 can be increased to reduce the fluid pressure in the degasser if the fluid pressure measured by pressure sensor is above the predetermined pressure. The rate of fluid pump 12 can be decreased to increase the fluid pressure in the degasser if the fluid pressure measured by pressure sensor 62 is below the predetermined fluid pressure.
In
It will be apparent to one skilled in the art that various combinations and/or modifications and variations can be made in the dialysis system depending upon the specific needs for operation. Moreover features illustrated or described as being part of an aspect of the invention can be included in the aspect of the invention, either alone or in combination.
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