The present invention relates to ultrasonic imaging technical field, in particular to a delayed excitation ultrasonic imaging method and apparatus, and a delayed excitation system.
Medical imaging generally refers to a technology and a processing process of obtaining an image of interior tissues of a human body or a certain part of the human body in a non-invasive manner for the purpose of medical treatment or medical research, which is inference calculus of an inverse problem, i.e., causes (characteristics of living tissue) are inversely inferred from consequences (an observed image signal). Medical imaging is used very widely in clinic, provides a great scientific and intuitive basis for diagnosis of diseases, can better cooperate with clinical symptoms, laboratory tests and etc., and plays an irreplaceable role in the final accurate diagnosis of the diseases.
Medical imaging refers to in general the course of checking parts of a human body that cannot be examined by nonsurgical means by modern imaging technologies such as X-ray imaging, X-ray computed tomography (CT), magnetic resonance imaging (MRI), ultrasonic imaging (US), Optical coherence tomography (OCT), and the like. Compared with other imaging technologies, medical ultrasonic imaging has unique advantages such as good real-time, no damage, no pain, high imaging accuracy and a low system cost, etc., and currently has been widely used in clinical medical detection.
An ultrasonic transducer is an apparatus that can convert an electric signal and an acoustic signal. Due to the piezoelectric effect of a material, after having received the electric signal, the ultrasonic transducer can convert the electric signal into mechanical vibration and emit ultrasonic waves; or, after having received the ultrasonic wave, the ultrasonic transducer can convert the mechanical vibration into the electric signal, and in terms of use function, most of the ultrasonic transducers are capable of both receiving and transmitting. In an ultrasonic signal receiving link, an acoustic signal is converted into an electric signal. In an ultrasonic signal transmitting link, an electric signal is converted into an acoustic signal. For conventional ultrasonic imaging, generally, the working frequency of the ultrasonic transducer is below 5 MHz. For high-frequency ultrasonic imaging, generally, the working frequency of the ultrasonic transducer is above 10 MHz.
An analog-to-digital conversion chip is an integrated chip that converts an analog signal into a digital signal. Based on the need of satisfying Nyquist sampling theorem, a sampling rate of the analog-to-digital conversion chip should be at least twice or more the frequency of the measured signal, and should preferably be five times or higher if better sampling data is desired. For a 40 MHz ultrasonic transducer that is currently used more, it has been very difficult for a conventional analog-to-digital conversion chip to obtain better sampling data (the frequency numerical values involved in the present invention, such as 40 MHz, 80 MHz, and the like, are used only as examples to facilitate descriptions, and the solutions of the present invention are not merely limited to these frequency values).
In a conventional design solution, the 40 MHz ultrasonic transducers currently used more need to use high-speed analog-to-digital conversion chips of 200 MHz or higher to obtain better sampling data, but the high-speed analog-to-digital conversion chips of 200 MHz not only has a very high price but also is often limited to China, so the cost of the ultrasonic imaging system is very high.
For the problem of a high cost of the ultrasonic imaging system in the related art, an effective solution has not yet been proposed.
The present invention provides a delayed excitation ultrasonic imaging method and apparatus, and a delayed excitation system, to at least solve the problem of a high cost of the ultrasonic imaging system in the related art.
According to one aspect of the present invention, there is provided with a delayed excitation ultrasonic imaging method, comprising: generating a regulating clock, and performing, according to the regulating clock, delayed excitation on an ultrasonic transducer once or multiple times; performing data collection on an ultrasonic echo signal of the ultrasonic transducer and signals after each time of performing delayed excitation; synthesizing and superimposing data as collected to obtain high sampling rate data; and performing ultrasonic imaging according to the high sampling rate data.
Preferably, the step of performing delayed excitation on the ultrasonic transducer once according to the regulating clock includes: taking one period of the regulating clock as a delay period, and performing delayed excitation on the ultrasonic transducer once according to the delay period.
Preferably, the step of performing delayed excitation on the ultrasonic transducer multiple times according to the regulating clock includes: taking one period of the regulating clock as a delay period, and performing delayed excitation on the ultrasonic transducer once according to this delay period; taking two periods of the regulating clock as a delay period, and performing delayed excitation on the ultrasonic transducer once according to this delay period; in a similar fashion, taking multiple periods of the regulating clock as a delay period, and performing delayed excitation on the ultrasonic transducer once according to this delay period.
Preferably, the step of performing data collection on the ultrasonic echo signal of the ultrasonic transducer and the signals after each time of performing delayed excitation includes: performing data collection on the ultrasonic echo signal at a rising edge of a sampling clock; and performing data collection on the signals after each time of performing delayed excitation at a rising edge of the sampling clock.
Preferably, the step of synthesizing and superimposing the data as collected to obtain the high sampling rate data includes: synthesizing and superimposing the data as collected in accordance with a time-sequential relationship of delayed excitation to obtain the high sampling rate data.
Preferably, the ultrasonic transducer is a single ultrasonic transducer, or an ultrasonic array transducer consisting of a plurality of ultrasonic transducer elements.
According to another aspect of the present invention, there is provided with a delayed excitation ultrasonic imaging apparatus, wherein the delayed excitation ultrasonic imaging apparatus includes: a delayed excitation module configured to generate a regulating clock, and perform, according to the regulating clock, delayed excitation on an ultrasonic transducer once or multiple times; a data collection module configured to perform data collection on an ultrasonic echo signal of the ultrasonic transducer and signals after each time of performing delayed excitation; a data synthesis module configured to synthesize and superimpose data as collected to obtain high sampling rate data; and an ultrasonic imaging module configured to perform ultrasonic imaging according to the high sampling rate data.
Preferably, the delayed excitation module is further configured to take one period of the regulating clock as a delay period, and perform delayed excitation on the ultrasonic transducer once according to the delay period.
Preferably, the delayed excitation module is further configured to take one period of the regulating clock as a delay period, and perform delayed excitation on the ultrasonic transducer once according to this delay period; take two periods of the regulating clock as a delay period, and perform delayed excitation on the ultrasonic transducer once according to this delay period; in a similar fashion, take multiple periods of the regulating clock as a delay period, and perform delayed excitation on the ultrasonic transducer once according to this delay period.
Preferably, a first collection unit is configured to perform data collection on the ultrasonic echo signal at a rising edge of a sampling clock; and a second collection unit is configured to perform data collection on signals after each time of performing delayed excitation at a rising edge of the sampling clock.
Preferably, the data synthesis module is further configured to synthesize and superimpose the data as collected in accordance with a time-sequential relationship of delayed excitation to obtain the high sampling rate data.
Preferably, the ultrasonic transducer is a single ultrasonic transducer, or an ultrasonic array transducer consisting of a plurality of ultrasonic transducer elements.
According to a further aspect of the invention, there is provided with a delayed excitation system, wherein the delayed excitation system includes: a signal receiving module configured to receive an ultrasonic signal and convert the ultrasonic signal as received into an ultrasonic echo signal; a programmable logic control module configured to generate a regulating clock and transmit a control signal of a delayed excitation to a signal transmitting module, and further configured to collect data of a delayed excitation, and synthesize and superimpose the data as collected to obtain high sampling rate data; a signal transmitting module configured to perform a delayed excitation on the ultrasonic echo signal according to the regulating clock after receiving the control signal transmitted by the programmable logic control module.
Preferably, the signal receiving module includes: a switch configured to be turned off when the ultrasonic signal is transmitted and turned on when the ultrasonic signal is received; a low noise signal amplification unit (LNA) configured to perform a first level of amplification on the ultrasonic signal as received; a programmable gain amplification unit (PGA) configured to amplify the ultrasonic signal after the first level of amplification once more, wherein an amplification factor is adjusted by the programmable logic control module; a low pass filter (LPF) configurable analog filtering unit configured to adjust a cut-off frequency of low-pass filtering, and filter out high-frequency noise having a frequency higher than a cut-off frequency in the ultrasonic signal that are amplified by the programmable gain amplification circuit (PGA); a high precision A/D conversion unit (ADC) configured to convert the ultrasonic signal filtered out by the LPF configurable analog filtering unit into the ultrasonic echo signal.
Preferably, the programmable logic control module includes: a serial peripheral interface (SPI) logic control unit configured to control the signal transmitting module; a delayed excitation regulating clock unit configured to generate a regulating clock; a sampling data synthesis unit configured to collect the data of delayed excitation, and synthesize and superimpose the data as collected to obtain the high sampling rate data.
Preferably, the signal transmitting module includes: a metal-oxide-semiconductor field effect transistor (MOSFET) driver configured to receive the control signal of the programmable logic control module, amplify the control signal and then transmit it to a MOSFET high voltage conduction unit; the MOSFET high voltage conduction unit configured to perform a delayed excitation on the ultrasonic echo signal according to the control signal as received; and an impedance matching high voltage excitation unit configured to match different types of ultrasonic transducers.
The invention provides a delayed excitation ultrasonic imaging method and apparatus, and a delayed excitation system. By performing delayed excitation on the ultrasonic transducer, a conventional analog-to-digital conversion chip can also perform high-frequency ultrasonic imaging, and a solution of performing ultrasonic imaging by low-cost sampling and delayed excitation can be implemented. The present invention can be used not only in a traditional low-frequency ultrasonic imaging system, but also in a high-frequency ultrasonic imaging system, which can greatly reduce the system cost.
The drawings described herein are used for providing further understanding to the present invention and constitute a part of the present application, and schematic embodiments of the present invention and the description thereof are used for explaining the present invention and are not intended to limit the present invention. In the drawings:
Hereinafter the technical solution in the embodiments of the present invention will be described clearly and completely in combination with the accompanying drawings in the embodiments of the present invention, and obviously, the described embodiments are merely part of the embodiments, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments that are obtained by persons skilled in the art without paying creative efforts fall within the protection scope of the present invention.
An embodiment of the present invention provides a delayed excitation ultrasonic imaging method,
step S102: generating a regulating clock, and performing, according to the regulating clock, delayed excitation on an ultrasonic transducer once or multiple times;
step S104: performing data collection on an ultrasonic echo signal of the ultrasonic transducer and signals after each time of performing delayed excitation;
step S106: synthesizing and superimposing data as collected to obtain high sampling rate data; and
step S108: performing ultrasonic imaging according to the high sampling rate data.
By performing delayed excitation on the ultrasonic transducer, the embodiment of the present invention enables a conventional analog-to-digital conversion chip also to perform high-frequency ultrasonic imaging, and a solution of performing ultrasonic imaging by low-cost sampling and delayed excitation can be implemented. The technical solution provided by the embodiment can be used not only in a traditional low-frequency ultrasonic imaging system but also in a high-frequency ultrasonic imaging system, which can greatly reduce the system cost.
In the present embodiment, the number of times of performing delayed excitation on the ultrasonic transducer can be one or multiple, which can be set according to specific demands. After delayed excitation, it needs to perform data collection on the ultrasonic echo signal at a rising edge of the sampling clock; and to perform data collection on signals after each time of performing delayed excitation at a rising edge of the sampling clock. Then, the data as collected are synthesized and superimposed in accordance with a time-sequential relationship of delayed excitation to obtain high sampling rate data. The more the number of times of performing delayed excitation is, the higher the precision of the obtained high sampling rate data will be.
If it is set that delayed excitation is performed on the ultrasonic transducer once, then one period of the regulating clock is taken as a delay period, and delayed excitation is performed on the ultrasonic transducer once according to the delay period.
The data collection after delayed excitation is performed twice: the first collection is to obtain two sampling points at the rising edge of the sampling clock; at the time of the second collection, because the ultrasonic excitation is performed for the time delayed by one regulating clock, the ultrasonic echo signal also arrives late by one period of the regulating clock and is collected at the time staggered by one phase, thus two sampling points are obtained at the rising edge of the sampling clock.
Of course,
If it is set that delayed excitation is performed on the ultrasonic transducer multiple times, then: one period of the regulating clock is taken as a delay period, and delayed excitation is performed once on the ultrasonic transducer according to this delay period; two periods of the regulating clock are taken as a delay period, and delayed excitation is performed once on the ultrasonic transducer according to this delay period; in a similar fashion, multiple periods of the regulating clock are taken as a delay period, and delayed excitation is performed once on the ultrasonic transducer according to this delay period.
In this embodiment, the ultrasonic transducer can be a single ultrasonic transducer, or can be an ultrasonic array transducer consisting of a plurality of ultrasonic transducer elements. It is not limited in the present invention.
Based on the same inventive concept, an embodiment of the present invention further provides a delayed excitation ultrasonic imaging apparatus which can be used for implementing the method described in the above embodiment, as described in the embodiment below. Since the principle based on which the delayed excitation ultrasonic imaging apparatus solves the problem is similar to that of the delayed excitation ultrasonic imaging method, therefore, the implementation of the delayed excitation ultrasonic imaging apparatus can refer to the implementation of the delayed excitation ultrasonic imaging method, and is not repeated here. As used below, the term “unit” or “module” is a combination of software and/or hardware that can implement a predetermined function. Although preferably the system described in the following embodiment is implemented by software, implementation by hardware, or a combination of software and hardware is also possible and is conceivable.
The delayed excitation module 10 is configured to generate a regulating clock, and perform, according to the regulating clock, delayed excitation on an ultrasonic transducer once or multiple times.
The data collection module 20 is configured to perform data collection on an ultrasonic echo signal of the ultrasonic transducer and signals after each time of performing delayed excitation.
The data synthesis module 30 is configured to synthesize and superimpose the data as collected to obtain high sampling rate data.
The ultrasonic imaging module 40 is configured to perform ultrasonic imaging according to the high sampling rate data.
By performing delayed excitation on the ultrasonic transducer, the embodiment of the present invention enables a conventional analog-to-digital conversion chip to perform high-frequency ultrasonic imaging, and a solution of performing ultrasonic imaging by low-cost sampling and delayed excitation can be implemented. The technical solution provided by the present embodiment can be used not only in a traditional low-frequency ultrasonic imaging system, but also in a high-frequency ultrasonic imaging system, which can greatly reduce the system cost.
The number of times that the ultrasonic transducer performs delayed excitation can be one or multiple, which can be set according to specific demands. In the present embodiment, the delayed excitation module 10 is configured to take one period of the regulating clock as a delay period, and perform delayed excitation on the ultrasonic transducer once according to the delay period. The delayed excitation module 10 is further configured to take one period of the regulating clock as a delay period, and perform delayed excitation on the ultrasonic transducer once according to this delay period; take two periods of the regulating clock as a delay period, and perform delayed excitation on the ultrasonic transducer once according to this delay period; in a similar fashion, take multiple periods of the regulating clock as a delay period, and perform delayed excitation on the ultrasonic transducer once according to this delay period. The more the number of times of performing delayed excitation is, the higher the precision of the obtained high sampling rate data will be.
In one embodiment, the data synthesis module 30 is configured to synthesize and superimpose the data as collected in accordance with a time-sequential relationship of delayed excitation to obtain high sampling rate data. Thus, the high sampling rate data with high accuracy and high precision can be obtained.
In this embodiment, the ultrasonic transducer can be a single ultrasonic transducer, or can be an ultrasonic array transducer consisting of a plurality of ultrasonic transducer elements. It is not limited in the present invention.
Of course, the above-described module division is merely a schematic division, and the present invention is not limited to this. The apparatus can also only include: a delayed excitation module, a data processing module and an ultrasonic imaging module, wherein the delayed excitation module performs functions related to delayed excitation, the data processing module performs functions related to data collection and data synthesis, and the ultrasonic imaging module performs a function related to ultrasonic imaging. Any module division should fall within the protection scope of the present invention as long as it can realize the purpose of the present invention.
Based on the same inventive concept, an embodiment of the present invention further provides a delayed excitation system which can be used for implementing the method described in the above embodiment.
The signal receiving module is configured to receive an ultrasonic signal and then convert the ultrasonic signal into an ultrasonic echo signal.
The programmable logic control module is configured to generate a regulating clock to transmit a control signal of delayed excitation to the signal transmitting module, and is further configured to collect data of delayed excitation, and synthesize and superimpose the data as collected to obtain high sampling rate data.
The signal transmitting module is configured to perform delayed excitation on the ultrasonic echo signal according to the regulating clock after receiving the control signal transmitted by the programmable logic control module.
By performing delayed excitation on the ultrasonic transducer, this embodiment enables a conventional analog-to-digital conversion chip also to perform high-frequency ultrasonic imaging, and a solution of performing ultrasonic imaging by low-cost sampling and delayed excitation can be implemented. The technical solution provided by this embodiment can be used not only in a traditional low-frequency ultrasonic imaging system, but also in a high-frequency ultrasonic imaging system, which can greatly reduce the system cost.
The technical solution of the present application can be applied to a single ultrasonic transducer, or can also be applied to an array transducer consisting of a plurality of ultrasonic transducer elements, the ultrasonic transducer/the array transducer plays the role of receiving or transmitting an ultrasonic signal.
(I) An Ultrasonic Signal Receiving Link
After receiving an ultrasonic signal, the ultrasonic transducer or the array transducer converts the acoustic signal into an electric signal, the electric signal passes through a switch to enter a data collection channel, at this time the electric signal is very weak, and a low noise signal amplification needs to be performed on the electric signal by a low noise amplifier (LNA), and then the electric signal is amplified again by a programmable gain amplifier (PGA), passes through a Low Pass Filter (LPF) configurable analog filtering module and then enters an analog-to-digital converter (ADC) to convert an analog signal into a digital signal.
The signal receiving module can adopt an integrated dedicated chip, and can also set up separate analog circuits.
a switch that is turned off when an ultrasonic signal is transmitted and is turned on when an ultrasonic signal is received, the transmitting/receiving switch mainly playing a role of protecting a receiving circuit, and can prevent high voltage excitations of the transmitting circuit from flowing to the receiving circuit, thereby damaging the electronic devices;
a low noise signal amplification unit (LNA) for configured to perform a first level of amplification on the ultrasonic signal as received. It is possible to introduce less other noise signals on the basis of maximizing the amplification of the ultrasonic signals;
a programmable gain amplification unit (PGA) configured to amplify the ultrasonic signal after the first level of amplification once more; wherein the amplification factor is adjusted by the programmable logic control module. The gain (an amplified value) of the programmable gain amplification unit (PGA) amplified by the previous level LNA is often insufficient and it needs to be amplified once more to obtain a satisfactory amplification effect. In the present invention, a flexible design is made, that is, the programmable gain amplification unit (PGA) can be controlled by a core logic device field programmable gate array (FPGA) by an SPI serial communication bus to realize that the gain is adjustable, i.e., the amplification factor can be adjusted by programming;
an LPF configurable analog filtering unit configured to adjust the cut-off frequency of low-pass filtering, to filter out high-frequency noise having a frequency higher than the cut-off frequency in the ultrasonic signals that are amplified by the programmable gain amplification unit (PGA). The LPF configurable analog filtering unit can be a configurable analog low pass filter, can be controlled by the core logic device FPGA by the SPI serial communication bus, can adjust the cut-off frequency of low-pass filtering according to a change of signals, to filter out the high-frequency noise having a frequency higher than the cut-off frequency;
a high precision A/D conversion unit (ADC) configured to convert the ultrasonic signal filtered out by the LPF configurable analog filtering unit into an ultrasonic echo signal. The analog signal that has subjected to a previous level of amplification and low-pass filtering can enter the high precision A/D conversion unit (ADC) to perform data collection. The setting of the working parameters of the high precision A/D conversion unit (ADC) can also be controlled by the core logic device FPGA by the SPI serial communication bus, and the sampling frequency and the sampling precision can be adjusted according to the change of signals.
(II) A Programmable Logic Control Link
This link works in the programmable logic device FPGA, is responsible for global logic control, includes: working time sequence of the ultrasonic signal receiving link, working time sequence of the ultrasonic signal transmitting link, and generation of a high-frequency regulating clock within the programmable logic device FPGA to perform control of delayed excitation, and synthesizing of sampling results of delayed excitation to improve an effective sampling rate.
The programmable logic control module is designed and completed on FPGA by programming, or can also be replaced with a solution of building a digital circuit or a complex programmable logic device (CPLD) to a certain extent.
an SPI logic control unit configured to control a signal transmitting module. In the present invention, a circuit design and function matching are performed based on its actual needs, the FPGA is programmed by hardware description language, an SPI logic control module within the FPGA is designed, thereby functional reconstruction of a conventional chip being completed.
A delayed excitation regulating clock unit is configured to generate a regulating clock. It is assumed that the working frequency of the ultrasonic transducer adopted in the present invention is 40 MHz, the sampling frequency of the analog-to-digital conversion chip as adopted is 80 MHz, and there is a key design point here, i.e., a higher speed regulating clock of 160 Mz is generated within the programmable logic device. Because the higher speed regulating clock has a finer phase adjustment capability, which provides a necessary condition for the delayed excitation phase adjustment of a latter level. The sampling clock is a work clock of the analog-to-digital conversion chip (ADC), and the data collection and conversion are performed at the time of a rising edge of the sampling clock. In
A sampling data synthesis unit is configured to collect the data of delayed excitation, and synthesize and superimpose the data as collected to obtain the high sampling rate data.
(III) An Ultrasonic Signal Transmitting Link
In this link, after having received the control signal transmitted from a front-end programmable logic device, a high voltage excitation is performed on the ultrasonic transducer or the array transducer by a MOSFET driver and a MOSFET high voltage conduction unit.
The signal transmitting module can adopt an integrated dedicated chip, and may also build a discrete analog circuit.
a MOSFET driver configured to receive a control signal of the programmable logic control module, amplify the control signal and then transmit it to a MOSFET high voltage conduction unit. The MOSFET driver is controlled by the front-end programmable logic device, and its function is that because the programmable logic device cannot directly drive a metal-oxide-semiconductor field effect transistor (MOSFET), there is a need to provide a MOSFET driving circuit to receive the control signal of the programmable logic device, amplify the control signal here and then drive a subsequent level of MOSFET high voltage conduction unit. The change of the control signal lies only in amplification of voltage and current, the phase relationship and shape of the control signal are not changed.
A MOSFET high voltage conduction unit is configured to perform delayed excitation on the ultrasonic echo signal according to the received control signal. The MOSFET high voltage conduction unit is controlled by a previous level of MOSFET driver to conduct positive high voltage and negative high voltage according to a change of the control signal, to form high voltage excitation on the ultrasonic transducer.
An impedance matching high voltage excitation unit mainly consists of a transformer and other discrete elements and is used for matching different types of ultrasonic transducers.
It can be seen from
High frequency ultrasonic imaging technology is getting more and more attention and expectation from the medical community because it can obtain clearer medical diagnostic images on special diagnostic occasions to help doctors analyze a patient's condition. The high frequency ultrasonic imaging technology also becomes increasingly important at the forefront of science because the scientific research of many small animals and humans can be made, and it is an indispensable scientific research tool. In the present invention, by generating a high-frequency regulating clock, the delayed excitation is performed on the ultrasonic transducer, to realize ultrasonic imaging by multiple collections and data synthesis. The invention can be applied in traditional low-frequency ultrasonic imaging field, which can greatly reduce the system cost.
In the description, the descriptions with reference to the terms “one embodiment”, “some embodiments”, “example”, “specific example” or “some examples” and the like mean that the specific features, structures, materials or characteristics described in combination with the embodiment or example are included in at least one embodiment or example of the present invention. In the description, exemplary expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the described specific features, structures, materials or characteristics may be combined in a suitable manner in any one or more of the embodiments or examples.
The objects, technical solutions and beneficial effects of the present invention have been further described in detail in the above specific embodiments, it should be understood that the above contents are merely specific embodiments of the present invention and are not for limiting the protection scope of the present invention, and any modification, equivalent replacement, improvement and the like within the spirit and principle of the present invention shall fall within the protection scope of the present invention.
Number | Date | Country | Kind |
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201610257356.2 | Apr 2016 | CN | national |
This application is a continuation of International Application No. PCT/CN2016/083132, filed on May 24, 2016, which claims priority to Chinese Patent Application No. 201610257356.2, and filed on Apr. 22, 2016, both of which are hereby incorporated by reference in their entireties.
Number | Date | Country | |
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Parent | PCT/CN2016/083132 | May 2016 | US |
Child | 16167060 | US |