Claims
- 1. The sustained release delivery means comprising:
- (a) a functionally effective amount of a biologically active agent; and
- (b) a hydrophilic linear block polyoxyalkylene-polyurethane copolymer of the type ABABAB . . . having blocks A linked to blocks B, substantially devoid of cross-linking, wherein A represents a hydrophilic block comprising one or more polyoxyalkylene moieties of molecular weight 600 to 6000, and B represents a hydrophobic block comprising a polyurethane moiety obtainable by reacting an aromatic or aliphatic diisocyanate with a short chain oxyalkylated diphenol.
- 2. A sustained release delivery means as claimed in claim 1 wherein B represents a hydrophobic block comprising a polyurethane moiety obtainable by reacting an aromatic or aliphatic dissocyanate with a short chain oxyalkylated diphenol and at least one alkyleneglycol of not more than 6 carbon atoms.
- 3. A sustained release delivery means as claimed in claim 1 wherein A represents a hydrophilic block comprising polyoxyethylene of molecular weight 600 to 6000.
- 4. A sustained release delivery means as claimed in claim 1 wherein the short chain oxyalkylated diphenol is 1,1'-isopropylidene-bis-p-phenyleneoxy-dipropanol-2.
- 5. A sustained release delivery means as claimed in claim 1 which contains a biologically acceptable buffer.
- 6. A sustained release delivery means as claimed in claim 2 which contains a biologically acceptable buffer.
- 7. The sustained release delivery means comprising:
- (a) a functionally effective amount of a biologically active agent; and
- (b) a hydrophilic linear block polyoxyalkylene--polyurethane copolymer substantially devoid of cross-linking and comprising the reaction product of (1) an aromatic or aliphatic diisocyanate, (2) at least one polyoxyalkylene of molecular weight 600 to 6000, and (3) a short chain oxyalkylated diphenol.
- 8. A sustained release delivery means as claimed in claim 7 wherein said block copolymer (b) comprises the reaction product of (1) an aromatic or aliphatic diisocyanate, (2) at least one polyoxyalkylene of molecular weight 600 to 6000, (3) a short chain oxyalkylated diphenol, and (4) at least one alkyleneglycol of not more than 6 carbon atoms.
- 9. A sustained release delivery means as claimed in claim 7 which contains a biologically acceptable buffer.
- 10. A sustained release delivery means as claimed in claim 8 which contains a biologically acceptable buffer.
Priority Claims (3)
Number |
Date |
Country |
Kind |
51917/76 |
Dec 1976 |
GBX |
|
31065/77 |
Nov 1977 |
AUX |
|
436/77 |
Nov 1977 |
PKX |
|
Parent Case Info
This application is a continuation-in-part of Ser. No. 855,332, filed Nov. 28, 1977, now U.S. Pat. No. 4,202,880, HSC Apr. 11, 1980.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3164565 |
Calamari et al. |
Jan 1965 |
|
3857932 |
Shepherd et al. |
Dec 1974 |
|
3975350 |
Hudgin et al. |
Aug 1976 |
|
3978266 |
Lock |
Aug 1976 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
2528068 |
Jan 1976 |
DEX |
1135966 |
Dec 1968 |
GBX |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
855332 |
Nov 1977 |
|