Claims
- 1. A dispenser for delivering a beneficial agent to an animal, the dispenser comprising: a wall surrounding an internal lumen comprising a pair of ends in mated contact to form a closed dispenser, said wall comprising a section that substantially limits the passage of fluid into the lumen and a section that permits the passage of fluid into the lumen; a beneficial agent in the lumen comprising the section that limits the passage of fluid; an expandable hydrophilic hydrogel selected from the groups consisting of cross-linked and non-crosslinked hydrogels which exhibit a 2 to 50 fold volume increase in the lumen in the section that permits the passage of fluid; and, an exit passageway in the dispenser for delivering the beneficial agent to the animal.
- 2. A method for delivering a somatotropin to a hog, wherein the method comprises:
- (a) implanting in the hog a dispenser comprising:
- (1) a wall that surrounds an internal lumen, said wall (i) comprising at least in part a section that restricts the passage of fluid into the lumen, and (ii) comprising at least in part a section that permits the passageway of fluid into the lumen;
- (2) a porcine somatotropin in the lumen in section (i);
- (3) an osmotically effective solute in the lumen in section (ii);
- (4) an inert partition between the porcine somatotropin and the osmotically effective solute in the lumen;
- (5) at least one exit passageway in the dispenser for delivering the porcine somatotropin from the dispenser; and,
- (b) delivering the porcine somatotropin by the osmotically effective solute mixing with the fluid and increasing in volume, thereby pushing the porcine somatotropin through a passageway to the hog.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a division of U.S. Ser. No. 07/283,359 filed on Dec. 13, 1988 and now U.S. Pat. No. 5,034,229, which application is incorporated herein by reference, and benefit is claimed of its filing date. These applications are assigned to the ALZA Corporation of Palo Alto, CA.
US Referenced Citations (31)
Divisions (1)
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Number |
Date |
Country |
Parent |
283359 |
Dec 1988 |
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