Claims
- 1. A delivery system for delivering a beneficial agent to a fluid biological environment of use, wherein the delivery system comprises:
- (1) a housing member comprising;
- (2) a lead end and a rear end;
- (3) an exit in the lead end;
- (4) a wall closed and continuous the length of the housing member; the wall comprising:
- (5) a first section impermeable to the passage for fluid and joined in a fluid tight arrangement with;
- (6) a second section permeable to the passage for fluid;
- (7) in the first section: (a) a beneficial agent that is sensitive to fluid; and (b) a carrier for the beneficial agent, wherein said first section protects the beneficial agent from fluid in the environment of use;
- (8) an osmopolymer as push means in the second section for delivering the beneficial agent through the exit from the delivery system; and
- (9) a layer interposed between the first and second sections, said layer being sufficiently impermeable to restrict passage for fluid from the second section into the first, beneficial agent, section, said layer acting to slide into the first section, aiding in the delivery of beneficial agent, when the push means expands.
- 2. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is a somatotropin.
- 3. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is porcine somatotropin.
- 4. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is a hormone.
- 5. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is a somatotropin analogue.
- 6. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is a bovine somatotropin.
- 7. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the carrier comprises glycerol.
- 8. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the carrier comprises a surfactant.
- 9. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the carrier comprises a buffer.
- 10. A method for delivering a somatotropin to an animal wherein the method comprises admitting into the animal a delivery system according to claim 2.
- 11. The delivery system according to claim 1, wherein said first section is manufactured from a composition comprising a different polymer than the polymer from which said second section is manufactured, and wherein said first and second sections are joined to define a closed continuous wall.
Parent Case Info
This application is a continuation of application Ser. No. 07/513,361, filed Apr. 20, 1990 ABD and benefit of the filing date of said earlier filed application is claimed under 35 U.S.C. @120. Ser. No. 07/513,361 is a division of U.S. Ser. No. 07/283,359 filed on Dec. 13, 1988 now U.S. Pat. No. 5,034,229, which application is incorporated herein by reference, and benefit is claimed of its filing date. These applications are assigned to the ALZA Corporation of Palo Alto, Calif.
US Referenced Citations (35)
Divisions (1)
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Number |
Date |
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Parent |
283359 |
Dec 1988 |
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Continuations (1)
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Number |
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513361 |
Apr 1990 |
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