Claims
- 1. Prostaglandin analogues of the general formula: ##STR62## wherein X represents ethylene, Z represents ##STR63## R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents a hydrogen atom or a methyl group, R.sup.3 and R.sup.4 together represent a straight- or branched-chain alkyl group containing from 1 to 10 carbon atoms, and the double bond between C.sub.3 -C.sub.4 is trans or cis, or trans and cis, and the double bond between C.sub.13 -C.sub.14 is trans and cyclodextrin clathrates of such acids and esters, and when R.sup.1 represents a hydrogen atom, non-toxic salts thereof.
- 2. Prostaglandin analogues according to claim 1 wherein R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms.
- 3. Prostaglandin analogues according to claim 2 wherein R.sup.1 represents a hydrogen atom or a methyl group.
- 4. Prostaglandin analogues according to claim 1 wherein R.sup.2 represents a hydrogen atom.
- 5. Prostaglandin analgoues according to claim 1 wherein R.sup.3 and R.sup.4 together represent a pentyl group or a 1,1-dimethylpentyl group.
- 6. Prostaglandin analogues according to claim 1 wherein the hydroxy groups depicted in formula VI in claim 1 .alpha.- or .beta.-configuration are attached to the carbon atom in .alpha.-configuration.
- 7. A compound according to claim 1 which is methyl 9-oxo-11.alpha.-dihydroxy-16,16-dimethylprosta-trans and cis-3, trans-13-dienoate.
Priority Claims (2)
Number |
Date |
Country |
Kind |
10118/76 |
Mar 1976 |
GBX |
|
33154/76 |
Aug 1976 |
GBX |
|
Parent Case Info
This is a division of application Ser. No. 774,828 filed Mar. 7, 1977.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3931296 |
Hayashi et al. |
Jan 1976 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
774828 |
Mar 1977 |
|