Claims
- 1. A compound of the formula ##STR152## R.sub.1 is --H or methyl; each of R.sub.2 and R.sub.3 is, independently, --H, alkyl, alkenyl or cycloalkyl;
- each of m, n and P is a positive whole number of at most 2; and
- ring B is optionally substituted by up to three methyl substituents; each alkyl having from 1 to 4 carbon atoms, each alkoxy having from 1 to 4 carbon atoms, each alkenyl having 3 or 4 carbon atoms and cycloalkyl having from 5 to 7 carbon atoms;
- or a pharmaceutically-acceptable acid-addition salt thereof.
- 2. A compound according to claim 1 wherein A is --CH.sub.2 -alkoxy, --O-alkoxyalkyl or -O-hydroxyalkyl.
- 3. A pharmaceutically-acceptable .beta.-adrenergic-blocking composition comprising diluent or excipient and an effective concentration of a compound according to claim 1.
- 4. A pharmaceutically-acceptable composition comprising diluent or excipient and a .beta.-adrenergic-blocking-effective concentration of a compound according to claim 2.
- 5. A compound according to claim 1 which is 1-(p-methoxybutoxyphenoxy)-3-(1-hydroxy-1-[pyridyl-3]-butyl-3-amino)propan-2-ol or a pharmaceutically-acceptable acid-addition salt thereof.
- 6. A compound according to claim 1 which is 1-(p-[2-propoxyethoxy]phenoxy)-3-(1-[2-methylpyridyl-5]-1-hydroxybutyl-3-amino)propan-2-ol or a pharmaceutically-acceptable acid-addition salt thereof.
- 7. A compound according to claim 1 which is 1-(p-2-hydroxyethoxy]phenoxy)-3(1-[2-methylpyridyl-5]-1-hydroxybutyl-3-amino)propan-2-ol or a pharmaceutically-acceptable acid-addition salt thereof.
- 8. A compound according to claim 1 which is 1-(p-cyclohexylureidophenoxy)-3-[pyridyl-3]-1-hydroxybutyl-3-amino)propan-2-ol or a pharmaceutically-acceptable acid-addition salt thereof.
- 9. A compound according to claim 1 which is 1-(p-cyclohexylureidophenoxy)-3-(1-[2-methylpyridyl-5]-1-hydroxybutyl-3-amino)propan-2-ol or a pharmaceutically-acceptable acid-addition salt thereof.
- 10. A compound according to claim 1 which is 1-(p-ethoxymethylenephenoxy)-3-(1-[pyridyl-3]-1-hydroxybutyl-3-amino)propan-2-ol or a pharmaceutically-acceptable acid-addition salt thereof.
- 11. A compound according to claim 1 which is 1-(p-ethylureidophenoxy)-3-(1-[pyridyl-3]-1-hydroxybutyl-3-amino)propan-2-ol or a pharmaceutically-acceptable acid-addition salt thereof.
- 12. A compound according to claim 1 which is 1-(p-ethoxyethoxyphenoxy)-3-(1-[pyridyl-3]-1-hydroxybutyl-3-amino)propan-2-ol or a pharmaceutically-acceptable acid-addition salt thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
34590 |
Dec 1973 |
LU |
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Parent Case Info
This is a continuation-in-part application of U.S. Pat. application Ser. No. 531,344, filed Dec. 10, 1974.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3830806 |
Raabe et al. |
Aug 1974 |
|
3852291 |
Augstein et al. |
Dec 1974 |
|
3940406 |
Raabe et al. |
Feb 1976 |
|
3969363 |
Raabe et al. |
Jul 1976 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
531344 |
Dec 1974 |
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