Claims
- 1. A pharmaceutical composition having enhanced antibacterial activity comprising a synergistically effective amount of a compound of formula (II): ##STR12## or a pharmaceutically acceptable salt or pharmaceutically acceptable ester thereof wherein A is a hydrogen atom or an esterifying radical; X is an alkylene group of 1-12 carbon atoms optionally substituted by a hydroxy, amino, formyl, C.sub.1-6 alkanoyl, halo (C.sub.1-6) alkanyl, acetyl or trifluoracetyl or C.sub.1-6 alkoxy group, which substituents are not on the carbon atom adjacent the nitrogen atom; or a C.sub.5-7 cycloalkyl group; or a phenylalkyl group wherein the carbon atom content of the alkyl part is 1-6 and the phenyl part is optionally substituted with a fluorine, bromine, chlorine, C.sub.1-6 alkyl, or C.sub.1-6 alkoxy; with the proviso that when X represents an optionally substituted phenylalkyl group and A represents C.sub.1-3 alkyl, then the --CO.sub.2 A group is attached to the alkyl part of the phenylalkyl group, together with an antibacterially effective amount of a penicillin and a pharmaceutically acceptable carrier.
- 2. A composition according to claim 1 wherein the penicillin is selected from benzylpenicillin, phenoxymethylpenicillin, carbenicillin, azidocillin, propicillin, ampicillin, amoxycillin, epicillin, ticarcillin, cyclacillin, pirbenicillin, azlocillin, mezlocillin, celbinicillin, or pharmaceutically acceptable in vivo hydrolysable esters thereof.
- 3. A composition according to claim 2 wherein the pharmaceutically acceptable penicillin esters are selected from acetoxymethyl, pivaloyloxymethyl, .alpha.-ethoxycarbonyloxyethyl or phthalidyl esters.
- 4. A composition according to claim 1 wherein the penicillins are aldehyde or ketone adducts containing a 6-.alpha.-aminoacetamide side chain.
- 5. A composition according to claim 4 wherein the aldehyde or ketone adduct is hetacillin or metampicillin.
- 6. A composition according to claim 2 wherein the pharmaceutically acceptable esters are the phenyl or indanyl .alpha.-esters of carbenicillin or ticarcillin.
- 7. A composition according to claim 1 wherein the penicillin is ampicillin or amoxycillin.
- 8. A composition according to claim 1 wherein the penicillin is in the form of a pharmaceutically acceptable salt or a hydrate.
- 9. A composition according to claim 1 which is in form suitable for oral or parenteral administration.
- 10. A composition according to claim 1 wherein the penicillin is present, with relation to the compound of formula (II), in the ratio of 10:1 to 1:10.
- 11. A pharmaceutical composition having enhanced antibacterial activity comprising a synergistically effective amount of 9-N-(2'-carboxyethyl) aminodeoxyclavulanic acid as synergist and an antibacterially effective amount of amoxycillin as the active antibiotic.
- 12. A method for the treatment of bacterial infections in humans or domestic mammals which comprises administering to such humans or domestic mammals an anti-infective amount of a composition according to claim 1.
Parent Case Info
This application is a division of application Ser. No. 176,161 filed Aug. 7, 1980 and now abandoned.
Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts 90:168574x, (1978). |
Divisions (1)
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Number |
Date |
Country |
Parent |
176161 |
Aug 1980 |
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