Derivatives of GLP-1 analogs

Abstract

The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.

Description

FIELD OF THE INVENTION

The present invention relates to novel derivatives of human glucagon-like peptide-1 (GLP-1) and fragments and/or analogues thereof which have a protracted profile of action and to methods of making and using them.

BACKGROUND OF THE INVENTION

Peptides are widely used in medical practice, and since they can be produced by recombinant DNA technology it can be expected that their importance will increase also in the years to come. When native peptides or analogues thereof are used in therapy it is generally found that they have a high clearance. A high clearance of a therapeutic agent is inconvenient in cases where it is desired to maintain a high blood level thereof over a prolonged period of time since repeated administrations will then be necessary. Examples of peptides which have a high clearance are: ACTH, corticotropin-releasing factor, angiotensin, calcitonin, insulin, glucagon, glucagon-like peptide-1, glucagon-like peptide-2, insulin-like growth factor-1, insulin-like growth factor-2, gastric inhibitory peptide, growth hormone-releasing factor, pituitary adenylate cyclase activating peptide, secretin, enterogastrin, somatostatin, somatotropin, somatomedin, parathyroid hormone, thrombopoietin, erythropoietin, hypothalamic releasing factors, prolactin, thyroid stimulating hormones, endorphins, enkephalins, vasopressin, oxytocin, opiods and analogues thereof, superoxide dismutase, interferon, asparaginase, arginase, arginine deaminase, adenosine deaminase and ribonuclease. In some cases it is possible to influence the release profile of peptides by applying suitable pharmaceutical compositions, but this approach has various shortcomings and is not generally applicable.

The hormones regulating insulin secretion belong to the so-called enteroinsular axis, designating a group of hormones, released from the gastrointestinal mucosa in response to the presence and absorption of nutrients in the gut, which promote an early and potentiated release of insulin. The enhancing effect on insulin secretion, the so-called incretin effect, is probably essential for a normal glucose tolerance. Many of the gastrointestinal hormones, including gastrin and secretin (cholecystokinin is not insulinotropic in man), are insulinotropic, but the only physiologically important ones, those that are responsible for the incretin effect, are the glucose-dependent insulinotropic polypeptide, GIP, and glucagon-like peptide-1(GLP-1). Because of its insulinotropic effect, GIP, isolated in 1973 (1) immediately attracted considerable interest among diabetologists. However, numerous investigations carried out during the following years clearly indicated that a defective secretion of GIP was not involved in the pathogenesis of insulin dependent diabetes mellitus (IDDM) or non insulin-dependent diabetes mellitus (NIDDM) (2). Furthermore, as an insulinotropic hormone, GIP was found to be almost ineffective in NIDDM (2). The other incretin hormone, GLP-1 is the most potent insulinotropic substance known (3). Unlike GIP, it is surprisingly effective in stimulating insulin secretion in NIDDM patients. In addition, and in contrast to the other insulinotropic hormones (perhaps with the exception of secretin) it also potently inhibits glucagon secretion. Because of these actions it has pronounced blood glucose lowering effects particularly in patients with NIDDM.

GLP-1, a product of the proglucagon (4), is one of the youngest members of the secretin-VIP family of peptides, but is already established as an important gut hormone with regulatory function in glucose metabolism and gastrointestinal secretion and metabolism (5). The glucagon gene is processed differently in the pancreas and in the intestine. In the pancreas (9), the processing leads to the formation and parallel secretion of 1) glucagon itself, occupying positions 33-61 of proglucagon (PG); 2) an N-terminal peptide of 30 amino acids (PG (1-30)) often called glicentin-related pancreatic peptide, GRPP (10, 11); 3) a hexapeptide corresponding to PG (64-69); 4) and, finally, the so-called major proglucagon fragment (PG (72-158)), in which the two glucagon-like sequences are buried (9). Glucagon seems to be the only biologically active product. In contrast, in the intestinal mucosa, it is glucagon that is buried in a larger molecule, while the two glucagon-like peptides are formed separately (8). The following products are formed and secreted in parallel: 1) glicentin, corresponding to PG (1-69), with the glucagon sequence occupying residues Nos. 33-61 (12); 2) GLP-1(7-36)amide (PG (78-107))amide (13), not as originally believed PG (72-107)amide or 108, which is inactive). Small amounts of C-terminally glycine-extended but equally bioactive GLP-1(7-37), (PG (78-108)) are also formed (14); 3) intervening peptide-2 (PG (111-122)amide) (15); and 4) GLP-2 (PG (126-158)) (15, 16). A fraction of glicentin is cleaved further into GRPP (PG (1-30)) and oxyntomodulin (PG (33-69)) (17, 18). Of these peptides, GLP-1, has the most conspicuous biological activities.

Being secreted in parallel with glicentin/enteroglucagon, it follows that the many studies of enteroglucagon secretion (6, 7) to some extent also apply to GLP-1 secretion, but GLP-1 is metabolised more quickly with a plasma half-life in humans of 2 min (19). Carbohydrate or fat-rich meals stimulate secretion (20), presumably as a result of direct interaction of yet unabsorbed nutrients with the microvilli of the open-type L-cells of the gut mucosa. Endocrine or neural mechanisms promoting GLP-1 secretion may exist but have not yet been demonstrated in humans.

The incretin function of GLP-1(29-31) has been clearly illustrated in experiments with the GLP-1 receptor antagonist, exendin 9-39, which dramatically reduces the incretin effect elicited by oral glucose in rats (21, 22). The hormone interacts directly with the βcells via the GLP-1 receptor (23) which belongs to the glucagon/VIP/calcitonin family of G-protein-coupled 7-transmembrane spanning receptors. The importance of the GLP-1 receptor in regulating insulin secretion was illustrated in recent experiments in which a targeted disruption of the GLP-1 receptor gene was carried out in mice. Animals homozygous for the disruption had greatly deteriorated glucose tolerance and fasting hyperglycaemia, and even heterozygous animals were glucose intolerant (24). The signal transduction mechanism (25) primarily involves activation of adenylate cyclase, but elevations of intracellular Ca 2+ are also essential (25, 26). The action of the hormone is best described as a potentiation of glucose stimulated insulin release (25), but the mechanism that couples glucose and GLP-1 stimulation is not known. It may involve a calcium-induced calcium release (26, 27). As already mentioned, the insulinotropic action of GLP-1 is preserved in diabetic β-cells. The relation of the latter to its ability to convey “glucose competence” to isolated insulin-secreting cells (26, 28), which respond poorly to glucose or GLP-1 alone, but fully to a combination of the two, is also not known. Equally importantly, however, the hormone also potently inhibits glucagon secretion (29). The mechanism is not known, but seems to be paracrine, via neighbouring insulin or somatostatin cells (25). Also the glucagonostatic action is glucose-dependent, so that the inhibitory effect decreases as blood glucose decreases. Because of this dual effect, if the plasma GLP-1 concentrations increase either by increased secretion or by exogenous infusion the molar ratio of insulin to glucagon in the blood that reaches the liver via the portal circulation is greatly increased, whereby hepatic glucose production decreases (30). As a result blood glucose concentrations decrease. Because of the glucose dependency of the insulinotropic and glucagonostatic actions, the glucose lowering effect is self-limiting, and the hormone, therefore, does not cause hypoglycaemia regardless of dose (31). The effects are preserved in patients with diabetes mellitus (32), in whom infusions of slightly supraphysiological doses of GLP-1 may completely normalise blood glucose values in spite of poor metabolic control and secondary failure to sulphonylurea (33). The importance of the glucagonostatic effect is illustrated by the finding that GLP-1 also lowers blood glucose in type-i diabetic patients without residual β-cell secretory capacity (34).

In addition to its effects on the pancreatic islets, GLP-1 has powerful actions on the gastrointestinal tract. Infused in physiological amounts, GLP-1 potently inhibits pentagastrin-induced as well as meal-induced gastric acid secretion (35, 36). It also inhibits gastric emptying rate and pancreatic enzyme secretion (36). Similar inhibitory effects on gastric and pancreatic secretion and motility may be elicited in humans upon perfusion of the ileum with carbohydrate- or lipid-containing solutions (37, 38). Concomitantly, GLP-1 secretion is greatly stimulated, and it has been speculated that GLP-1 may be at least partly responsible for this so-called “ileal-brake” effect (38). In fact, recent studies suggest that, physiologically, the ileal-brake effects of GLP-1 may be more important than its effects on the pancreatic islets. Thus, in dose response studies GLP-1 influences gastric emptying rate at infusion rates at least as low as those required to influence islet secretion (39).

GLP-1 seems to have an effect on food intake. Intraventricular administration of GLP-1 profoundly inhibits food intake in rats (40, 42). This effect seems to be highly specific. Thus, N-terminally extended GLP-1(PG 72-107)amide is inactive and appropriate doses of the GLP-1 antagonist, exendin 9-39, abolish the effects of GLP-1(41). Acute, peripheral administration of GLP-1 does not inhibit food intake acutely in rats (41, 42). However, it remains possible that GLP-1 secreted from the intestinal L-cells may also act as a satiety signal.

Not only the insulinotropic effects but also the effects of GLP-1 on the gastrointestinal tract are preserved in diabetic patients (43), and may help curtailing meal-induced glucose excursions, but, more importantly, may also influence food intake. Administered intravenously, continuously for one week, GLP-1 at 4 ng/kg/min has been demonstrated to dramatically improve glycaemic control in NIDDM patients without significant side effects (44). The peptide is fully active after subcutaneous administration (45), but is rapidly degraded mainly due to degradation by dipeptidyl peptidase IV-like enzymes (46, 47).

The amino acid sequence of GLP-1 is given i.a. by Schmidt et al. ( Diabetologia 28 704-707 (1985). Human GLP-1 is a 37 amino acid residue peptide originating from preproglucagon which is synthesised, i.a. in the L-cells in the distal ileum, in the pancreas and in the brain. Processing of preproglucagon to GLP-1(7-36)amide, GLP-1(7-37) and GLP-2 occurs mainly in the L-cells. Although the interesting pharmacological properties of GLP-1(7-37) and analogues thereof have attracted much attention in recent years only little is known about the structure of these molecules. The secondary structure of GLP-1 in micelles has been described by Thorton et al. ( Biochemistry 33 3532-3539 (1994)), but in normal solution, GLP-1 is considered a very flexible molecule. Surprisingly, we found that derivatisation of this relatively small and very flexible molecule resulted in compounds whose plasma profile were highly protracted and still had retained activity.

GLP-1 and analogues of GLP-1 and fragments thereof are useful i.a. in the treatment of Type 1 and Type 2 diabetes and obesity.

WO 87/06941 discloses GLP-1 fragments, including GLP-1(7-37), and functional derivatives thereof and to their use as an insulinotropic agent.

WO 90/11296 discloses GLP-1 fragments, including GLP-1(7-36), and functional derivatives thereof which have an insulinotropic activity which exceeds the insulinotropic activity of GLP-1(1-36) or GLP-1(1-37) and to their use as insulinotropic agents.

The amino acid sequence of GLP-1(7-36) and GLP-1(7-37) is (SEQ ID NO: 1):

7   8   9  10  11  12  13  14  15  16  17 (I)
His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-
18  19  20  21  22  23  24  25  26  27  28
Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-
29  30  31  32  33  34  35  36
Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-X

wherein X is NH 2 for GLP-1(7-36) and X is Gly for GLP-1(7-37).

WO 91/11457 discloses analogues of the active GLP-1 peptides 7-34, 7-35, 7-36, and 7-37 which can also be useful as GLP-1 moieties.

EP 0708179-A2 (Eli Lilly & Co.) discloses GLP-1 analogues and derivatives that include an N-terminal imidazole group and optionally an unbranched C 6 -C 10 acyl group in attached to the lysine residue in position 34.

EP 0699686-A2 (Eli Lilly & Co.) discloses certain N-terminal truncated fragments of GLP-1 that are reported to be biologically active.

Unfortunately, the high clearance limits the usefulness of these compounds. Thus there still is a need for improvements in this field.

Accordingly, it is an object of the present invention to provide derivatives of GLP-1 and analogues thereof which have a protracted profile of action relative to GLP-1(7-37).

It is a further object of the invention to provide derivatives of GLP-1 and analogues thereof which have a lower clearance than GLP-1(7-37).

It is a further object of the invention to provide a pharmaceutical composition with improved solubility and stability.

References

1. Pederson RA. Gastric Inhibitory Polypeptide. In Walsh JH, Dockray GJ (eds) Gut peptides: Biochemistry and Physiology. Raven Press, New York 1994, pp. 217259.

2. Krarup T. Immunoreactive gastric inhibitory polypeptide. Endocr Rev 1988; 9: 122-134.

3. Ørskov C. Glucagon-like peptide-1, a new hormone of the enteroinsular axis. Diabetologia 1992; 35:701-711.

4. Bell GI, Sanchez-Pescador R, Laybourn PJ, Najarian RC. Exon duplication and divergence in the human preproglucagon gene. Nature 1983; 304: 368-371.

5. Holst JJ. Glucagon-like peptide-1 (GLP-1)—a newly discovered GI hormone. Gastroenterology 1994; 107: 1848-1855.

6. Holst JJ. Gut glucagon, enteroglucagon, gut GLI, glicentin—current status. Gastroenterology 1983; 84:1602-1613.

7. Hoist JJ, Ørskov C. Glucagon and other proglucagon-derived peptides. In Walsh JH, Dockray GJ, eds. Gut peptides: Biochemistry and Physiology. Raven Press, New York, pp. 305-340, 1993.

8. Ørskov C, Hoist JJ, Knuhtsen S, Baldissera FGA, Poulsen SS, Nielsen OV. Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from the pig small intestine, but not pancreas. Endocrinology 1986; 119:1467-1475.

9. Hoist JJ, Bersani M, Johnsen AH, Kofod H, Hartmann B, Ørskov C. Proglucagon processing in porcine and human pancreas. J Biol Chem, 1994; 269: 18827-1883.

10. Moody AJ, Hoist JJ, Thim L, Jensen SL. Relationship of glicentin to proglucagon and glucagon in the porcine pancreas. Nature 1981; 289: 514-516.

11. Thim L, Moody AJ, Purification and chemical characterisation of a glicentin-related pancreatic peptide (proglucagon fragment) from porcine pancreas. Biochim Biophys Acta 1982; 703:134-141.

12. Thim L, Moody AJ. The primary structure of glicentin (proglucagon). Regul Pept 1981; 2:139-151.

13. Ørskov C, Bersani M, Johnsen AH, Højrup P, Holst JJ. Complete sequences of glucagon-like peptide-1 (GLP-1) from human and pig small intestine. J. Biol. Chem. 1989; 264:12826-12829.

14. Ørskov C, Rabenhøj L, Kofod H, Wettergren A, Holst JJ. Production and secretion of amidated and glycine-extended glucagon-like peptide-I (GLP-1) in man. Diabetes 1991; 43: 535-539.

15. Buhl T, Thim L, Kofod H, Ørskov C, Harling H, & Holst JJ: Naturally occurring products of proglucagon 111-160 in the porcine and human small intestine. J. Biol. Chem. 1988; 263:8621-8624.

16. Ørskov C, Buhl T, Rabenhøj L, Kofod H, Holst JJ: Carboxypeptidase-B-like processing of the C-terminus of glucagon-like peptide-2 in pig and human small intestine. FEBS letters, 1989; 247:193-106.

17. Holst JJ. Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residues 33-69) of glicentin. Biochem J. 1980; 187:337-343.

18. Bataille D, Tatemoto K, Gespach C, Jörnvall H, Rosselin G, Mutt V. Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Characterisation of the peptide. FEBS Lett 1982; 146:79-86.

19. Ørskov C, Wettergren A, Holst JJ. The metabolic rate and the biological effects of GLP-1 7-36amide and GLP-1 7-37 in healthy volunteers are identical. Diabetes 1993; 42:658-661.

20. Elliott RM, Morgan LM, Tredger JA, Deacon S, Wright J, Marks V. Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. J Endocrinol 1993; 138: 159-166.

21. Kolligs F, Fehmann HC, Göke R, Göke B. Reduction of the incretin effect in rats by the glucagon-like peptide-1 receptor antagonist exendin (9-39)amide. Diabetes 1995; 44: 16-19.

22. Wang Z, Wang RM, Owji AA, Smith DM, Ghatei M, Bloom SR. Glucagon-like peptide-1 is a physiological incretin in rat. J. Clin. Invest. 1995; 95: 417-421.

23. Thorens B. Expression cloning of the pancreatic b cell receptor for the gluco-incretin Is hormone glucagon-like peptide 1. Proc Natl Acad Sci 1992; 89:8641-4645.

24. Scrocchi L, Auerbach AB, Joyner AL, Drucker DJ. Diabetes in mice with targeted disruption of the GLP-1 receptor gene. Diabetes 1996; 45: 21A.

25. Fehmann HC, Göke R, Göke B. Cell and molecular biology of the incretin hormones glucagon-like peptide-I (GLP-1) and glucose-dependent insulin releasing polypeptide (GIP). Endocrine Reviews, 1995; 16: 390-410.

26. Gromada J, Dissing S, Bokvist K, Renström E, Frøjaer-Jensen J, Wulff BS, Rorsman P. Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting bTC3-cells by enhancement of intracellular calcium mobilisation. Diabetes 1995; 44: 767-774.

27. Holz GG, Leech CA, Habener JF. Activation of a cAMP-regulated Ca 2+ -signaling pathway in pancreatic β-cells by the insulinotropic hormone glucagon-like peptide-1. J Biol Chem, 1996; 270: 17749-17759.

28. Holz GG, Kühltreiber WM, Habener JF. Pancreatic beta-cells are rendered glucose competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature 1993; 361:362-365.

29. Ørskov C, Holst JJ, Nielsen OV: Effect of truncated glucagon-like peptide-1 (proglucagon 78-107 amide) on endocrine secretion from pig pancreas, antrum and stomach. Endocrinology 1988; 123:2009-2013.

30. Hvidberg A, Toft Nielsen M, Hilsted J, Ørskov C, Hoist JJ. Effect of glucagon-like peptide-1 (proglucagon 78-107 amide) on hepatic glucose production in healthy man. Metabolism 1994; 43:104-108.

31. Qualmann C, Nauck M, Hoist JJ, Ørskov C, Creutzfeldt W. Insulinotropic actions of intravenous glucagon-like peptide-1 [7-36 amide] in the fasting state in healthy subjects. Acta Diabetologica, 1995; 32: 13-16.

32. Nauck MA, Heimesaat MM, Ørskov C, Hoist JJ, Ebert R, Creutzfeldt W. Preserved incretin activity of GLP-1(7-36 amide) but not of synthetic human GIP in patients with type 2-diabetes mellitus. J Clin Invest 1993; 91:301-307.

33. Nauck MA, Kleine N, Ørskov C, Hoist JJ, Willms B, Creutzfeldt W. Normalisation of fasting hyperglycaemia by exogenous GLP-1(7-36 amide) in type 2-diabetic patients. Diabetologia 1993; 36:741-744.

34. Creutzfeldt W, Kleine N, Willms B, Ørskov C, Hoist JJ, Nauck MA. Glucagonostatic actions and reduction of fasting hyperglycaemia by exogenous glucagon-liem, peptide-1 (7-36 amide) in type I diabetic patients. Diabetes Care 1996; 19: 580-586.

35. Schjoldager BTG, Mortensen PE, Christiansen J, Ørskov C, Hoist JJ. GLP-1 (glucagon-like peptide-1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in man. Dig. Dis. Sci. 1989; 35:703-708.

36. Wettergren A, Schjoldager B, Mortensen PE, Myhre J, Christiansen J, Holst JJ. Truncated GLP-1(proglucagon 72-107 amide) inhibits gastric and pancreatic functions in man. Dig Dis Sci 1993; 38:665-673.

37. Layer P, Hoist JJ, Grandt D, Goebell H: Ileal release of glucagon-like peptide-1 (GLP-1): association with inhibition of gastric acid in humans. Dig Dis Sci 1995; 40: 1074-1082.

38. Layer P, Holst JJ. GLP-1: A humoral mediator of the ileal brake in humans? Digestion 1993; 54: 385-386.

39. Nauck M, Ettler R, Niedereichholz U, Ørskov C, Hoist JJ, Schmiegel W. Inhibition of gastric emptying by GLP-1(7-36 amide) or (7-37): effects on postprandial glycaemia and insulin secretion. Abstract. Gut 1995; 37 (suppl. 2): A124.

40. Schick RR, vorm Walde T, Zimmermann JP, Schusdziarra V, Classen M. Glucagon-like peptide 1—a novel brain peptide involved in feeding regulation. in Ditschuneit H, Gries FA, Hauner H, Schusdziarra V, Wechsler JG (eds.) Obesity in Europe. John Libbey & Company ltd, 1994; pp. 363-367.

41. Tang-Christensen M, Larsen PJ, Göke R, Fink-Jensen A, Jessop DS, Møller M, Sheikh S. Brain GLP-1(7-36) amide receptors play a major role in regulation of food and water intake. Am. J. Physiol., 1996, in press.

42. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CMB, Meeran K, et al. A role for glucagon-like peptide-1 in the regulation of feeding. Nature 1996; 379: 69-72.

43. Willms B, Werner J, Creutzfeldt W, Ørskov C, Holst JJ, Nauck M. Inhibition of gastric emptying by glucagon-like peptide-1 (7-36 amide) in patients with type-2-diabetes mellitus. Diabetologia 1994; 37, suppl.1: A118.

44. Larsen J, Jallad N, Damsbo P. One-week continuous infusion of GLP-1(7-37) improves glycaemic control in NIDDM. Diabetes 1996; 45, suppl. 2: 233A.

45. Ritzel R, Ørskov C, Hoist JJ, Nauck MA. Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 [7-36 amide] after subcutaneous injection in healthy volunteers. Dose-response relationships. Diabetologia 1995; 38: 720-725.

46. Deacon CF, Johnsen AH, Hoist JJ. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 1995; 80: 952-957.

47. Deacon CF, Nauck MA, Toft-Nielsen M, Pridal L, Willms B, Holst JJ. 1995. Both subcutaneous and intravenously administered glucagon-like peptide-1 are rapidly degraded from the amino terminus in type II diabetic patients and in healthy subjects. Diabetes 44: 1126-1131.

SUMMARY OF THE INVENTION

The present invention relates to a pharmaceutical composition with improved solubility and stability comprising derivatives of GLP-1(1-45) and analogs and/or fragments thereof. The GLP-1 derivatives of the present invention have interesting pharmacological properites, in particular they have a more protracted profile of action than the parent peptides. The GLP-1 derivatives of the present invention also have insulinotropic activity, ability to decrease glucagon, ability to suppress gastric motility, ability to restore glucose competency to beta-cells, and/or ability to suppress appetite/reduce weight.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 shows the results of Circular Dichroism (CD) at 222 nm as a function of peptide concentration for native GLP-1(7-37) and various GLP-1 derivatives of the present invention.

DETAILED DESCRIPTION OF THE INVENTION

A simple system is used to describe fragments and analogues of GLP-1. For example, Gly 8 GLP-1(7-37) designates a peptide which relates to GLP-1 by the deletion of the amino acid residues at positions. 1 to 6 and substituting the naturally occurring amino acid residue in position 8 (Ala) by Gly. Similarly, Lys 34 (N 68 -tetradecanoyl) GLP-1(7-37) designates GLP-1(7-37) wherein the ε-amino group of the Lys residue in position 34 has been tetradecanoylated. Where reference in this text is made to C-terminally extended GLP-1 analogues, the amino acid residue in position 38 is Arg unless otherwise indicated, the amino acid residue in position 39 is also Arg unless otherwise indicated and the optional amino acid residue in position 40 is Asp unless otherwise indicated. Also, if a C-terminally extended analogue extends to position 41, 42, 43, 44 or 45, the amino acid sequence of this extension is as in the corresponding sequence in human preproglucagon unless otherwise indicated.

GLP-1 Analogs

The term “an analogue” is defined herein as a peptide wherein one or more amino acid residues of the parent peptide have been substituted by another amino acid residue. In a preferred embodiment, the total number of different amino acids between the GLP-1 derivative and the corresponding native form of GLP-1 is up to fifteen, preferably up to ten amino acid residues, and most preferably up to six amino acid residues.

The total number of different amino acids between the derivative of the GLP-1 analog and the corresponding native form of GLP-1 preferably does not exceed six. Preferably, the number of different amino acids is five. More preferably, the number of different amino acids is four. Even more preferably, the number of different amino acids is three. Even more preferably, the number of different amino acids is two. Most preferably, the number of different amino acids is one. In order to determine the number of different amino acids, one should compare the amino acid sequence of the GLP-1 derivative of the present invention with the corresponding native GLP-1. For example, there are two different amino acids between the derivative Gly 8 Arg 26 Lys 34 (N 68 -(7-deoxycholoyl)) GLP-1(7-40) and the corresponding native GLP-1(i.e., GLP-1(7-40)). The differences are located at positions 8 and 26. Similarly, there is only one different amino acid between the derivative Lys 26 (N 68 -(7-deoxycholoyl))Arg 34 GLP-1(7-40) and the corresponding native GLP-1. The difference is located at position 34.

In a preferred embodiment, the present invention relates to a GLP-1 derivative wherein the parent peptide is GLP-1(1-45) or an analogue thereof. In a further preferred embodiment, the par ent peptide is GLP-1(1-35), GLP-1(1-36), GLP-1(1-36)amide, GLP-1(1-37), GLP-1(1-38), GLP-1(1-39), GLP-1(1-40), GLP-1(1-41) or an analogue thereof.

In a preferred embodiment, the present invention relates to derivatives of GLP-1 analogues of formula I (SEQ ID NO:2):

7   8   9  10  11  12  13  14  15  16  17 (I)
Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-
18  19  20  21  22  23  24  25  26  27  28
Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Phe-
29  30  31  32  33  34  35  36  37  38
Ile-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa
39  40  41  42  43  44  45
Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa

wherein

Xaa at position 7 is His, a modified amino acid or is deleted,

Xaa at position 8 is Ala, Gly, Ser, Thr, Leu, Ile, Val, Glu, Asp, or Lys, or is deleted,

Xaa at position 9 is Glu, Asp, or Lys, or is deleted,

Xaa at position 10 is Gly or is deleted,

Xaa at position 11 is Thr, Ala, Gly, Ser, Leu, Ile, Val, Glu, Asp, or Lys, or is deleted,

Xaa at position 12 is Phe or is deleted,

Xaa at position 13 is Thr or is deleted,

Xaa at position 14 is Ser, Ala, Gly, Thr, Leu, Ile, Val, Glu, Asp, or Lys, or is deleted,

Xaa at position 15 is Asp or is deleted,

Xaa at position 16 is Val, Ala, Gly, Ser, Thr, Leu, Ile, Tyr, Glu, Asp, or Lys, or is deleted,

Xaa at position 17 is Ser, Ala, Gly, Thr, Leu, Ile, Val, Giu, Asp, or Lys, or is deleted,

Xaa at position 18 is Ser, Ala, Gly, Thr, Leu, Ile, Val, Glu, Asp, or Lys,

Xaa at position 19 is Tyr, Phe, Trp, Glu, Asp, or Lys,

Xaa at position 20 is Leu, Ala, Gly, Ser, Thr, Leu, Ile, Val, Glu, Asp, or Lys,

Xaa at position 21 is Glu, Asp, or Lys,

Xaa at position 22 is Gly, Ala, Ser, Thr, Leu, Ile, Val, Glu, Asp, or Lys,

Xaa at position 23 is Gln, Asn, Arg, Glu, Asp, or Lys,

Xaa at position 24 is Ala, Gly, Ser, Thr, Leu, Ile, Val, Arg, Glu, Asp, or Lys,

Xaa at position 25 is Ala, Gly, Ser, Thr, Leu, Ile, Val, Glu, Asp, or Lys,

Xaa at position 26 is Lys, Arg, Gln, Glu, Asp, or His,

Xaa at position 27 is Glu, Asp, or Lys,

Xaa at position 30 is Ala, Gly, Ser, Thr, Leu, Ile, Val, Glu, Asp, or Lys,

Xaa at position 31 is Trp, Phe, Tyr, Glu, Asp, or Lys,

Xaa at position 32 is Leu, Gly, Ala, Ser, Thr, Ile, Val, Glu, Asp, or Lys,

Xaa at position 33 is Val, Gly, Ala, Ser, Thr, Leu, Ile, Glu, Asp, or Lys,

Xaa at position 34 is Lys, Arg, Glu, Asp, or His,

Xaa at position 35 is Gly, Ala, Ser, Thr, Leu, Ile, Val, Glu, Asp, or Lys,

Xaa at position 36 is Arg, Lys, Glu, Asp, or His,

Xaa at position 37 is Gly, Ala, Ser, Thr, Leu, Ile, Val, Glu, Asp, or Lys, or is deleted,

Xaa at position 38 is Arg, Lys, Glu, Asp, or His, or is deleted,

Xaa at position 39 is Arg, Lys, Glu, Asp, or His, or is deleted,

Xaa at position 40 is Asp, Glu, or Lys, or is deleted,

Xaa at position 41 is Phe, Trp, Tyr, Glu, Asp, or Lys, or is deleted,

Xaa at position 42 is Pro, Lys, Glu, or Asp, or is deleted,

Xaa at position 43 is Giu, Asp, or Lys, or is deleted,

Xaa at position 44 is Glu, Asp, or Lys, or is deleted, and

Xaa at position 45 is Val, Glu, Asp, or Lys, or is deleted, or

(a) a C-1-6-ester thereof, (b) amide, C-1-6-alkylamide, or C-1-6-dialkylamide thereof and/or (c) a pharmaceutically acceptable salt thereof, provided that when the amino acid at position 37, 38, 39, 40, 41, 42, 43 or 44 is deleted, then each amino acid downstream of the amino acid is also deleted and when the amino acid at position 8, 9, 10, 11, 12, 13, 14, 15, 16 or 17 is deleted then each amino acid upstream of the amino acid is also deleted.

The term “modified amino acid” is defined herein as A is:

wherein R 1 , R 2 and R 3 are independently H, lower alkyl, optionally substituted phenyl, NH 2 , NH—CO-(lower alkyl), —OH, lower alkoxy, halogen, SO 2 -(lower alkyl) or CF 3 , wherein said phenyl is optionally substituted with at least one group selected from NH 2 , —OH, lower alkyl or lower alkoxy having 1-6 carbon atoms, halogen, SO 2 -(lower alkyl), NH—CO-(lower alkyl) or CF 3 , or R 1 and R 2 may together form a bond; and Y is a five or six membered ring system selected from the group consisting of:

wherein Z is N, O or S, and said ring system is optionally substituted with one or more functional groups selected from the group consisting of NH 2 , NO 2 , OH, lower alkyl, lower alkoxy, halogen, CF 3 and aryl (i.e., optionally substituted phenyl, as define above), provided that A is not histidine;

The terms “lower alkyl” and “lower alkoxy” refer to an alkyl or alkoxy group, respectively, having 1-6 carbon atoms.

In a preferred embodiment, A is:

In another preferred embodiment, A is:

In another preferred embodiment, A is:

In another preferred embodiment, A is:

In another preferred embodiment, A is:

In another preferred embodiment, A is 4-imidazopropionyl.

In another preferred embodiment, A is 4-imidazoacetyl.

In another preferred embodiment, A is 4-imidazo-α,α-dimethyl-acetyl.

The GLP-1 derivatives of the present invention preferably have only one or two Lys wherein the ε-amino group of one or both Lys is substituted with a lipophilic substituent. Preferably, the GLP-1 derivatives of the present invention have only one Lys. In a more preferred embodiment, there is only one Lys which is located at the carboxy terminus of the derivative of the GLP-1 analogs. In an even more preferred embodiment, the GLP-1 derivatives of the present invention have only one Lys and Glu or Asp is adjacent to Lys.

In a preferred embodiment, the amino acids at positions 37-45 are absent.

In another preferred embodiment, the amino acids at positions 38-45 are absent.

In another preferred embodiment, the amino acids at positions 39-45 are absent.

In another preferred embodiment, the amino acid at position 7 is deleted.

In another preferred embodiment, the amino acids at positions 7 and 8 are deleted.

In another preferred embodiment, the amino acids at positions 7-9 are deleted.

In another preferred embodiment, the amino acids at positions 7-10 are deleted.

In another preferred embodiment, the amino acids at positions 7-11 are deleted.

In another preferred embodiment, the amino acids at positions 7-12 are deleted.

In another preferred embodiment, the amino acids at positions 7-13 are deleted.

In another preferred embodiment, the amino acids at positions 7-14 are deleted.

In another preferred embodiment, the amino acids at positions 7-15 are deleted.

In another preferred embodiment, the amino acids at positions 7-16 are deleted.

In another preferred embodiment, the amino acids at positions 7-17 are deleted.

In another preferred embodiment, Xaa at position 7 is His.

In another preferred embodiment, Xaa at position 8 is Ala, Gly, Ser, Thr, or Val.

In another preferred embodiment, Xaa at position 9 is Glu.

In another preferred embodiment, Xaa at position 10 is Gly.

In another preferred embodiment, Xaa at position 11 is Thr.

In another preferred embodiment, Xaa at position 12 is Phe.

In another preferred embodiment, Xaa at position 13 is Thr.

In another preferred embodiment, Xaa at position 14 is Ser.

In another preferred embodiment, Xaa at position 15 is Asp.

In another preferred embodiment, Xaa at position 16 is Val.

In another preferred embodiment, Xaa at position 17 is Ser.

In another preferred embodiment, Xaa at position 18 is Ser, Lys, Glu, or Asp.

In another preferred embodiment, Xaa at position 19 is Tyr, Lys, Glu, or Asp.

In another preferred embodiment, Xaa at position 20 is Leu, Lys, Glu, or Asp.

In another preferred embodiment, Xaa at position 21 is Glu, Lys, or Asp.

In another preferred embodiment, Xaa at position 22 is Gly, Glu, Asp, or Lys.

In another preferred embodiment, Xaa at position 23 is Gln, Glu, Asp, or Lys.

In another preferred embodiment, Xaa at position 24 is Ala, Glu, Asp, or Lys.

In another preferred embodiment, Xaa at position 25 is Ala, Glu, Asp, or Lys.

In another preferred embodiment, Xaa at position 26 is Lys, Glu, Asp, or Arg.

In another preferred embodiment, Xaa at position 27 is Glu, Asp, or Lys.

In another preferred embodiment, Xaa at position 30 is Ala, Glu, Asp, or Lys.

In another preferred embodiment, Xaa at position 31 is Trp, Glu, Asp, or Lys.

In another preferred embodiment, Xaa at position 32 is Leu, Glu, Asp, or Lys.

In another preferred embodiment, Xaa at position 33 is Val, Glu, Asp, or Lys.

In another preferred embodiment, Xaa at position 34 is Lys, Arg, Glu, or Asp.

In another preferred embodiment, Xaa at position 35 is Gly, Glu, Asp, or Lys.

In another preferred embodiment, Xaa at position 36 is Arg, Lys, Glu, or Asp.

In another preferred embodiment, Xaa at position 37 is Gly, Glu, Asp, or Lys.

In another preferred embodiment, Xaa at position 38 is Arg or Lys, or is deleted.

In another preferred embodiment, Xaa at position 39 is deleted.

In another preferred embodiment, Xaa at position 40 is deleted.

In another preferred embodiment, Xaa at position 41 is deleted.

In another preferred embodiment, Xaa at position 42 is deleted.

In another preferred embodiment, Xaa at position 43 is deleted.

In another preferred embodiment, Xaa at position 44 is deleted.

In another preferred embodiment, Xaa at position 45 is deleted.

In another preferred embodiment, Xaa at position 26 is Arg, each of Xaa at positions 37-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-36).

In another preferred embodiment, Xaa at position 26 is Arg, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-37).

In another preferred embodiment, Xaa at position 26 is Arg, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-38).

In another preferred embodiment, Xaa at position 34 is Arg, each of Xaa at positions 37-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-36).

In another preferred embodiment, Xaa at position 34 is Arg, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-37).

In another preferred embodiment, Xaa at position 34 is Arg, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-38).

In another preferred embodiment, Xaa at positions 26 and 34 is Arg, Xaa at position 36 is Lys, each of Xaa at positions 37-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-36).

In another preferred embodiment, Xaa at positions 26 and 34 is Arg, Xaa at position 36 is Lys, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-37).

In another preferred embodiment, Xaa at positions 26 and 34 is Arg, Xaa at position 36 is Lys, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-38).

In another preferred embodiment, Xaa at positions 26 and 34 is Arg, Xaa at position 38 is Lys, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-38).

In another preferred embodiment, Xaa at position 8 is Thr, Ser, Gly or Val, Xaa at position 37 is Asp or Glu, Xaa at position 36 is Lys, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-37).

In another preferred embodiment, Xaa at position 8 is Thr, Ser, Gly or Val, Xaa at position 37 is Asp or Glu, Xaa at position 36 is Lys, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-38).

In another preferred embodiment, Xaa at position 8 is Thr, Ser, Gly or Val, Xaa at position 36 is Lys, each of Xaa at positions 37-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-36).

In another preferred embodiment, Xaa at position 8 is Thr, Ser, Gly or Val, Xaa at position 36 is Lys, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-37).

In another preferred embodiment, Xaa at position 8 is Thr, Ser, Gly or Val, Xaa at position 36 is Lys, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-38).

In another preferred embodiment, Xaa at position 8 is Thr, Ser, Gly or Val, Xaa at position 37 is Glu or Asp, Xaa at position 38 is Lys, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-38).

In another preferred embodiment, Xaa at position 8 is Thr, Ser, Gly or Val, Xaa at position 38 is Lys, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-38).

In another preferred embodiment, Xaa at position 18, 23 or 27 is Lys, and Xaa at positions 26 and 34 is Arg, each of Xaa at positions 37-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-36).

In another preferred embodiment, Xaa at position 18, 23 or 27 is Lys, and Xaa at positions 26 and 34 is Arg, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-37).

In another preferred embodiment, Xaa at position 18, 23 or 27 is Lys, and Xaa at positions 26 and 34 is Arg, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-38).

In another preferred embodiment, Xaa at position 8 is Thr, Ser, Gly, or Val, Xaa at position 18, 23 or 27 is Lys, and Xaa at position 26 and 34 is Arg, each of Xaa at positions 37-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-36).

In another preferred embodiment, Xaa at position 8 is Thr, Ser, Gly, or Val, Xaa at position 18, 23 or 27 is Lys, and Xaa at position 26 and 34 is Arg, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-37).

In another preferred embodiment, Xaa at position 8 is Thr, Ser, Gly, or Val, Xaa at position 18, 23 or 27 is Lys, and Xaa at position 26 and 34 is Arg, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(7-38).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 26 is Arg, each of Xaa at positions 37-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-36).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 26 is Arg, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-37).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 26 is Arg, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-38).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 34 is Arg, each of Xaa at positions 37-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-36).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 34 is Arg, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-37).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 34 is Arg, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-38).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at positions 26 and 34 is Arg, Xaa at position 36 is Lys, each of Xaa at positions 37-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-36).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at positions 26 and 34 is Arg, Xaa at position 36 is Lys, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-37).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at positions 26 and 34 is Arg, Xaa at position 36 is Lys, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-38).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at positions 26 and 34 is Arg, Xaa at position 38 is Lys, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-38).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 8 is Thr, Ser, Gly or Val, Xaa at position 37 is Glu, Xaa at position 36 is Lys, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-37).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 8 is Thr, Ser, Gly or Val, Xaa at position 37 is Glu, Xaa at position 36 is Lys, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-38).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 8 is Thr, Ser, Gly or Val, Xaa at position 37 is Glu, Xaa at position 38 is Lys, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-38).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 18, 23 or 27 is Lys, and Xaa at positions 26 and 34 is Arg, each of Xaa at positions 37-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-36).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 18, 23 or 27 is Lys, and Xaa at positions 26 and 34 is Arg, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-37).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 18, 23 or 27 is Lys, and Xaa at positions 26 and 34 is Arg, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-38).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 8 is Thr, Ser, Gly, or Val, Xaa at position 18, 23 or 27 is Lys, and Xaa at position 26 and 34 is Arg, each of Xaa at positions 37-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-36).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 8 is Thr, Ser, Gly, or Val, Xaa at position 18, 23 or 27 is Lys, and Xaa at position 26 and 34 is Arg, each of Xaa at positions 38-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-37).

In another preferred embodiment, Xaa at position 7 is a modified amino acid or is deleted, Xaa at position 8 is Thr, Ser, Gly, or Val, Xaa at position 18, 23 or 27 is Lys, and Xaa at position 26 and 34 is Arg, each of Xaa at positions 39-45 is deleted, and each of the other Xaa is the amino acid in native GLP-1(8-38).

Derivatives

The term “derivative” is defined as a modification of one or more amino acid residues of a peptide by chemical means, either with or without an enzyme, e.g., by alkylation, acylation, ester formation, or amide formation.

Lipophilic Substituents

To obtain a satisfactory protracted profile of action of the GLP-1 derivative, one or more lipophilic substituents are attached to a GLP-1 moiety. The lipophilic substituents preferably comprises 4-40 carbon atoms, in particular 8-25 carbon atoms. The lipophilic substituent may be attached to an amino group of the GLP-1 moiety by means of a carboxyl group of the lipophilic substituent which forms an amide bond with an amino group of the amino acid residue to which it is attached. Preferably, the GLP-1 derivatives have three, more preferably two, and most preferably one lipophilic substituent.

In a preferred embodiment, the present invention relates to a GLP-1 derivative wherein at least one amino acid residue of the parent peptide has a lipophilic substituent attached with the proviso that if only one lipophilic substituent is present and this substituent is attached to the N-terminal or to the C-terminal amino acid residue of the parent peptide then this substituent is an alkyl group or a group which has an ω-carboxylic acid group.

In another preferred embodiment, the present invention relates to a GLP-1 derivative having only one lipophilic substituent which substituent is an alkyl group or a group which has an ω-carboxylic acid group and is attached to the N-terminal amino acid residue of the parent peptide.

In another preferred embodiment, the present invention relates to a GLP-1 derivative having only one lipophilic substituent which substituent is an alkyl group or a group which has an ω-carboxylic acid group and is attached to the C-terminal amino acid residue of the parent peptide.

In another preferred embodiment, the present invention relates to a GLP-1 derivative having only one lipophilic substituent which substituent can be attached to any one amino acid residue which is not the N-terminal or C-terminal amino acid residue of the parent peptide.

In another preferred embodiment, the present invention relates to a GLP-1 derivative wherein two lipophilic substituents are present, one being attached to the N-terminal amino acid residue while the other is attached to the C-terminal amino acid residue.

In another preferred embodiment, the present invention relates to a GLP-1 derivative wherein two lipophilic substituents are present, one being attached to the N-terminal amino acid residue while the other is attached to an amino acid residue which is not N-terminal or the C-terminal amino acid residue.

In another preferred embodiment, the present invention relates to a GLP-1 derivative wherein two lipophilic substituents are present, one being attached to the C-terminal amino acid residue while the other is attached to an amino acid residue which is not the N-terminal or the C-terminal amino acid residue.

A lipophilic substituent may be attached to an amino acid residue in such a way that a carboxyl group of the lipophilic substituent forms an amide bond with an amino group of the amino acid residue. Alternatively, a lipophilic substituent may be attached to an amino acid residue in such a way that an amino group of the lipophilic substituent forms an amide bond with a carboxyl group of the amino acid residue.

In a further preferred embodiment, the present invention relates to a GLP-1 derivative wherein a lipophilic substituent is attached to the parent peptide by means of a spacer. For example, the lipophilic substituent may be attached to the GLP-1 moiety by means of a spacer in such a way that a carboxyl group of the spacer forms an amide bond with an amino group of the GLP-1 moiety.

In a most preferred embodiment, the lipophilic substituent is attached—optionally via a spacer—to the ε-amino group of a Lys residue contained in the parent peptide.

In a preferred embodiment, the spacer is an α,ω-amino acid. Examples of suitable spacers are succinic acid, Lys, Glu or Asp, or a dipeptide such as Gly-Lys. When the spacer is succinic acid, one carboxyl group thereof may form an amide bond with an amino group of the amino acid residue, and the other carboxyl group thereof may form an amide bond with an amino group of the lipophilic substituent. When the spacer is Lys, Glu or Asp, the carboxyl group thereof may form an amide bond with an amino group of the amino acid residue, and the amino group thereof may form an amide bond with a carboxyl group of the lipophilic substituent. When Lys is used as the spacer, a further spacer may in some instances be inserted between the ε-amino group of Lys and the lipophilic substituent. In one preferred embodiment, such a further spacer is succinic acid which forms an amide bond with the ε-amino group of Lys and with an amino group present in the lipophilic substituent. In another preferred embodiment such a further spacer is Glu or Asp which forms an amide bond with the ε-amino group of Lys and another amide bond with a carboxyl group present in the lipophilic substituent, that is, the lipophilic substituent is a N 68 -acylated lysine residue. Other preferred spacers are N ε -(γ-L-glutamyl), N ε -(β-L-asparagyl), N ε -glycyl, and N ε -(α-(γ-aminobutanoyl).

In another preferred embodiment of the present invention, the lipophilic substituent has a group which can be negatively charged. One preferred such group is a carboxylic acid group.

In a further preferred embodiment, the lipophilic substituent comprises from 4 to 40 carbon atoms, more preferred from 8 to 25 carbon atoms.

In a further preferred embodiment, the lipophilic substituent is attached to the parent peptide by means of a spacer which is an unbranched alkane α,ω-dicarboxylic acid group having from 1 to 7 methylene groups, preferably two methylene groups which spacer forms a bridge between an amino group of the parent peptide and an amino group of the lipophilic substituent.

In a further preferred embodiment, the lipophilic substituent is attached to the parent peptide by means of a spacer which is an amino acid residue except Cys, or a dipeptide such as Gly-Lys. The expression “a dipeptide such as Gly-Lys” is defined herein as a dipeptide wherein the C-terminal amino acid residue is Lys, His or Trp, preferably Lys, and wherein the N-terminal amino acid residue is selected from the group comprising Ala, Arg, Asp, Asn, Gly, Glu, Gln, Ile, Leu, Val, Phe and Pro.

In a further preferred embodiment, the lipophilic substituent is attached to the parent peptide by means of a spacer which is an amino acid residue except Cys, or is a dipeptide such as Gly-Lys and wherein a carboxyl group of the parent peptide forms an amide bond with an amino group of a Lys residue or a dipeptide containing a Lys residue, and the other amino group of the Lys residue or a dipeptide containing a Lys residue forms an amide bond with a carboxyl group of the lipophilic substituent.

In a further preferred embodiment, the lipophilic substituent is attached to the parent peptide by means of a spacer which is an amino acid residue except Cys, or is a dipeptide such as Gly-Lys and wherein an amino group of the parent peptide forms an amide bond with a carboxylic group of the amino acid residue or dipeptide spacer, and an amino group of the amino acid residue or dipeptide spacer forms an amide bond with a carboxyl group of the lipophilic substituent.

In a further preferred embodiment, the lipophilic substituent is attached to the parent peptide by means of a spacer which is an amino acid residue except Cys, or is a dipeptide such as Gly-Lys and wherein a carboxyl group of the parent peptide forms an amide bond with an amino group of the amino acid residue spacer or dipeptide spacer, and the carboxyl group of the amino acid residue spacer or dipeptide spacer forms an amide bond with an amino group of the lipophilic substituent.

In a further preferred embodiment, the lipophilic substituent is attached to the parent peptide by means of a spacer which is an amino acid residue except Cys, or is a dipeptide such as Gly-Lys, and wherein a carboxyl group of the parent peptide forms an amide bond with an amino group of a spacer which is Asp or Glu, or a dipeptide spacer containing an Asp or Glu residue, and a carboxyl group of the spacer forms an amide bond with an amino group of the lipophilic substituent.

In a further preferred embodiment, the lipophilic substituent is a partially or completely hydrogenated cyclopentanophenathrene skeleton.

In a further preferred embodiment, the lipophilic substituent is a straight-chain or branched alkyl group.

In a further preferred embodiment, the lipophilic substituent is the acyl group of a straight-chain or branched fatty acid.

In a further preferred embodiment, the lipophilic substituent is an acyl group of the formula CH 3 (CH 2 ) n CO—, wherein n is an integer from 4 to 38, preferably an integer from 4 to 24, more preferrably CH 3 (CH 2 ) 6 CO—, CH 3 (CH 2 ) 8 CO—, CH 3 (CH 2 ) 10 CO—, CH 3 (CH 2 ) 12 CO—, CH 3 (CH 2 ) 14 CO—, CH 3 (CH 2 ) 16 CO—, CH 3 (CH 2 ) 18 CO—, CH 3 (CH 2 ) 20 CO— or CH 3 (CH 2 ) 22 CO—.

In a further preferred embodiment, the lipophilic substituent is an acyl group of a straight-chain or branched alkane α,ω-dicarboxylic acid.

In a further preferred embodiment, the lipophilic substituent is an acyl group of the formula HOOC(CH 2 ) m CO—, wherein m is an integer from 4 to 38, preferably an integer from 4 to 24, more preferably HOOC(CH 2 ) 14 CO—, HOOC(CH 2 ) 16 CO—, HOOC(CH 2 ) 18 CO—, HOOC(CH 2 ) 20 CO— or HOOC(CH 2 ) 22 CO—.

In a further preferred embodiment, the lipophilic substituent is a group of the formula CH 3 (CH 2 ) p ((CH 2 ) q COOH)CHNH—CO(CH 2 ) 2 CO—, wherein p and q are integers and p+q is an integer of from 8 to 33, preferably from 12 to 28.

In a further preferred embodiment, the lipophilic substituent is a group of the formula CH 3 (CH 2 ) r CO—NHCH(COOH)(CH 2 ) 2 CO—, wherein r is an integer of from 10 to 24.

In a further preferred embodiment, the lipophilic substituent is a group of the formula CH 3 (CH 2 ) s CO—NHCH((CH 2 ) 2 COOH)CO—, wherein s is an integer of from 8 to 24.

In a further preferred embodiment, the lipophilic substituent is a group of the formula COOH(CH 2 ) t CO— wherein t is an integer of from 8 to 24.

In a further preferred embodiment, the lipophilic substituent is a group of the formula —NHCH(COOH)(CH 2 ) 4 NH—CO(CH 2 ) u CH 3 , wherein u is an integer of from 8 to 18.

In a further preferred embodiment, the lipophilic substituent is a group of the formula CH 3 (CH 2 ) v CO—NH—(CH 2 ) z —CO, wherein n is an integer of from 8 to 24 and z is an integer of from 1 to 6.

In a further preferred embodiment, the lipophilic substituent is a group of the formula —NHCH(COOH)(CH 2 ) 4 NH—COCH((CH 2 ) 2 COOH)NH—CO(CH 2 ) w CH 3 , wherein w is an integer of from 10 to 16.

In a further preferred embodiment, the lipophilic substituent is a group of the formula —NHCH(COOH)(CH 2 ) 4 NH—CO(CH 2 ) 2 CH(COOH)NH—CO(CH 2 ) x CH 3 , wherein x is an integer of from 10 to 16.

In a further preferred embodiment, the lipophilic substituent is a group of the formula —NHCH(COOH)(CH 2 ) 4 NH—CO(CH 2 ) 2 CH(COOH)NHCO(CH 2 ) y CH 3 , wherein y is zero or an integer of from 1 to 22.

In a further preferred embodiment, the lipophilic substituent contains a group that can be negatively charged. Such a lipophilic substituent can for example be a substituent which has a carboxyl group.

Other Derivatives

The derivatives of GLP-1 analogues of the present invention may be in the form of one or more of (a) a C-1-6-ester, (b) an amide, C-1-6-alkylamide, or C-1-6-dialkylamide, and (c) a pharmaceutical salt. In a preferred embodiment, the derivatives of GLP-1 analogues are in the form of an acid addition salt or a carboxylate salt, most preferably in the form of an acid addition salt.

Preferred Derivatives of GLP-1 Analogues of the Present Invention

In a preferred embodiment, a parent peptide for a derivative of the invention is Arg 26 GLP-1(7-37); Arg 34 GLP-1(7-37); Lys 36 GLP-1(7-37); Arg 26, 34 Lys 36 GLP-1(7-37); Arg 26, 34 Lys 38 GLP-1(7-38); Arg 26, 34 Lys 39 GLP-1(7-39); Arg 26, 34 Lys 40 GLP-1(7-40); Arg 26 Lys 36 GLP-1(7-37); Arg 34 Lys 36 GLP-1(7-37); Arg 26 Lys 39 GLP-1(7-39); Arg 34 Lys 40 GLP-1(7-40); Arg 26, 34 Lys 36,39 GLP-1(7-39); Arg 26, 34 Lys 36,40 GLP-1(7-40); Gly 8 Arg 26 GLP-1(7-37); Gly 8 Arg 34 GLP-1(7-37); Gly 8 Lys 36 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 39 GLP-1(7-39); Gly 8 Arg 26, 34 Lys 40 GLP-1(7-40); Gly 8 Arg 26 Lys 36 GLP-1(7-37); Gly 8 Arg 34 Lys 36 GLP-1(7-37); Gly 8 Arg 26 Lys 39 GLP-1(7-39); Gly 8 Arg 34 Lys 40 GLP-1(7-40); Gly 8 Arg 26, 34 Lys 36,39 GLP-1(7-39); or Gly 8 Arg 26, 34 Lys 36,40 GLP-1(7-40).

In a further preferred embodiment, the parent peptide is Arg 26, 34 Lys 38 GLP-1(7-38); Arg 26, 34 Lys 39 GLP-1(7-39); Arg 26, 34 Lys 40 GLP-1(7-40); Arg 26, 34 Lys 41 GLP-1(7-41); Arg 26, 34 Lys 42 GLP-1(7-42); Arg 26, 34 Lys 43 GLP-1(7-43); Arg 26, 34 Lys 44 GLP-1(7-44); Arg 26, 34 Lys 45 GLP-1(7-45); Arg 26, 34 Lys 38 GLP-1(1-38); Arg 26, 34 Lys 39 GLP-1(1-39); Arg 26, 34 Lys 40 GLP-1(1-40); Arg 26, 34 Lys 41 GLP-1(1-41); Arg 26, 34 Lys 42 GLP-1(1-42); Arg 26, 34 Lys 43 GLP-1(1-43); Arg 26, 34 Lys 44 GLP-1(1-44); Arg 26, 34 Lys 45 GLP-1(1-45); Arg 26, 34 Lys 38 GLP-1(2-38); Arg 26, 34 Lys 39 GLP-1(2-39); Arg 26, 34 Lys 40 GLP-1(2-40); Arg 26, 34 Lys 41 GLP-1(2-41); Arg 26, 34 Lys 42 GLP-1(2-42); Arg 26, 34 Lys 43 GLP-1(2-43); Arg 26, 34 Lys 44 GLP-1(2-44); Arg 26, 34 Lys 45 GLP-1(2-45); Arg 26, 34 Lys 38 GLP-1(3-38); Arg 26, 34 Lys 39 GLP-1(3-39); Arg 26, 34 Lys 40 GLP-1(3-40); Arg 26, 34 Lys 41 GLP-1(3-41); Arg 26, 34 Lys 42 GLP-1(3-42); Arg 26, 34 Lys 43 GLP-1(3-43); Arg 26, 34 Lys 44 GLP-1(3-44); Arg 26, 34 Lys 45 GLP-1(3-45); Arg 26, 34 Lys 38 GLP-1(4-38); Arg 26, 34 Lys 39 GLP-1(4-39); Arg 26, 34 Lys 40 GLP-1(4-40); Arg 26, 34 Lys 41 GLP-1(4-41); Arg 26, 34 Lys 42 GLP-1(4-42); Arg 26, 34 Lys 43 GLP-1(4-43); Arg 26, 34 Lys 44 GLP-1(4-44); Arg 26, 34 Lys 45 GLP-1(4-45); Arg 26, 34 Lys 38 GLP-1(5-38); Arg 26, 34 Lys 39 GLP-1(5-39); Arg 26, 34 Lys 40 GLP-1(5-40); Arg 26, 34 Lys 41 GLP-1(5-41); Arg 26, 34 Lys 42 GLP-1(5-42); Arg 26, 34 Lys 43 GLP-1(5-43); Arg 26, 34 Lys 44 GLP-1(5-44); Arg 26, 34 Lys 45 GLP-1(5-45); Arg 26, 34 Lys 38 GLP-1(6-38); Arg 26, 34 Lys 39 GLP-1(6-39); Arg 26, 34 Lys 40 GLP-1(6-40); Arg 26, 34 Lys 41 GLP-1(6-41); Arg 26, 34 Lys 42 GLP-1(6-42); Arg 26, 34 Lys 43 GLP-1(6-43); Arg 26, 34 Lys 44 GLP-1(6-44); Arg 26, 34 Lys 45 GLP-1(6-45); Arg 26 Lys 38 GLP-1(1-38); Arg 34 Lys 38 GLP-1(1-38); Arg 26, 34 Lys 36,38 GLP-1(1-38); Arg 26 Lys 38 GLP-1(7-38); Arg 34 Lys 38 GLP-1(7-38); Arg 26, 34 Lys 36,38 GLP-1(7-38); Arg 26, 34 Lys 38 GLP-1(7-38); Arg 26 Lys 39 GLP-1(1-39); Arg 34 Lys 39 GLP-1(1-39); Arg 26, 34 Lys 36,39 GLP-1(1-39); Arg 26 Lys 39 GLP-1(7-39); Arg 34 Lys 39 GLP-1(7-39) or Arg 26, 34 Lys 36,39 GLP-1(7-39).

In a further preferred embodiment, the present invention relates to a GLP-1 derivative wherein the parent peptide is Arg 26 GLP-1(7-37), Arg 34 GLP-1(7-37), Lys 36 GLP-1(7-37), Arg 26, 34 Lys 36 GLP-1(7-37), Arg 26 Lys 36 GLP-1(7-37), Arg 34 Lys 36 GLP-1(7-37), Gly 8 Arg 26 GLP-1(7-37), Gly 8 Arg 34 GLP-1(7-37), Gly 8 Lys 36 GLP-1(7-37), Gly 8 Arg 26, 34 Lys 36 GLP-1(7-37), Gly 8 Arg 26 Lys 36 GLP-1(7-37) or Gly 8 Arg 34 Lys 36 GLP-1(7-37).

In a further preferred embodiment, the present invention relates to a GLP-1 derivative wherein the parent peptide is Arg 26 Lys 38 GLP-1(7-38), Arg 26, 34 Lys 38 GLP-1(7-38), Arg 26, 34 Lys 36,38 GLP-1(7-38), Gly 8 Arg 26 Lys 38 GLP-1(7-38) or Gly 8 Arg 26, 34 Lys 36,38 GLP-1(7-38).

In a further preferred embodiment, the present invention relates to a GLP-1 derivative wherein the parent peptide is Arg 26 Lys 39 GLP-1(7-39), Arg 26, 34 Lys 36,39 GLP-1(7-39), Gly 8 Arg 26 Lys 39 GLP-1(7-39) or Gly 8 Arg 26, 34 Lys 36,39 GLP-1(7-39).

In a further preferred embodiment, the present invention relates to a GLP-1 derivative wherein the parent peptide is Arg 34 Lys 40 GLP-1(7-40), Arg 26, 34 Lys 36,40 GLP-1(7-40), Gly 8 Arg 34 Lys 40 GLP-1(7-40) or Gly 8 Arg 26, 34 Lys 36,40 GLP-1(7-40).

In a further preferred embodiment, the present invention relates to a GLP-1 derivative wherein the parent peptide is:

Arg 26 GLP-1(7-36); Arg 34 GLP-1(7-36); Arg 26, 34 Lys 36 GLP-1(7-36); Arg 26 GLP-1(7-36)amide; Arg 34 GLP-1(7-36)amide; Arg 26, 34 Lys 36 GLP-1(7-36)amide; Arg 26 GLP-1(7-37); Arg 34 GLP-1(7-37); Arg 26, 34 Lys 36 GLP-1(7-37); Arg 26 GLP-1(7-38); Arg 34 GLP-1(7-38); Arg 26, 34 Lys 38 GLP-1(7-38); Arg 26 GLP-1(7-39); Arg 34 GLP-1(7-39); Arg 26, 34 Lys 39 GLP-1(7-39);

Gly 8 Arg 26 GLP-1(7-36); Gly 8 Arg 34 GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 GLP-1(7-36); Gly 8 Arg 26 GLP-1(7-36)amide; Gly 8 Arg 34 GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Gly 8 Arg 26 GLP-1(7-37); Gly 8 Arg 34 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 GLP-1(7-37); Gly 8 Arg 26 GLP-1(7-38); Gly 8 Arg 34 GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 GLP-1(7-38); Gly 8 Arg 26 GLP-1(7-39); Gly 8 Arg 34 GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 GLP-1(7-39);

Val 8 Arg 26 GLP-1(7-36); Val 8 Arg 34 GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 GLP-1(7-36); Val 8 Arg 26 GLP-1(7-36)amide; Val 8 Arg 34 GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Val 8 Arg 26 GLP-1(7-37); Val 8 Arg 34 GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 GLP-1(7-37); Val 8 Arg 26 GLP-1(7-38); Val 8 Arg 34 GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 GLP-1(7-38); Val 8 Arg 26 GLP-1(7-39); Val 8 Arg 34 GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 GLP-1(7-39);

Ser 8 Arg 26 GLP-1(7-36); Ser 8 Arg 34 GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 GLP-1(7-36); Ser 8 Arg 26 GLP-1(7-36)amide; Ser 8 Arg 34 GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Ser 8 Arg 26 GLP-1(7-37); Ser 8 Arg 34 GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 GLP-1(7-37); Ser 8 Arg 26 GLP-i (7-38); Ser 8 Arg 34 GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 GLP-1(7-38); Ser 8 Arg 26 GLP-1(7-39); Ser 8 Arg 34 GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 GLP-1(7-39);

Thr 8 Arg 26 GLP-1(7-36); Thr 8 Arg 34 GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 GLP-1(7-36); Thr 8 Arg 26 GLP-1(7-36)amide; Thr 8 Arg 34 GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Thr 8 Arg 26 GLP-1(7-37); Thr 8 Arg 34 GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 GLP-1(7-37); Thr 8 Arg 26 GLP-1(7-38); Thr 8 Arg 34 GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 GLP-1(7-38); Thr 8 Arg 26 GLP-1(7-39); Thr 8 Arg 34 GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39);

Val8Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 GLP1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -:--15GLP-1(7-39);

Arg 26, 34 Lys 18 GLP-1(7-36); Arg 26, 34 Lys 18 GLP-1(7-36)amide; Arg 26, 34 Lys 18 GLP-1(7-37); Arg 26, 34 Lys 18 GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-38);

Arg 26, 34 Lys 23 GLP-1(7-36); Arg 26, 34 Lys 23 GLP-1l(7-36)amide; Arg 26, 34 Lys 23 GLP-1(7-37); Arg 26, 34 Lys 23 GLP-1(7-38); Gly 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36); Gly 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36); Gly 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Gly 8 Asp 22 Arg 26 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Gly 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-37); Gly 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-38); Gly 8 Asp 22 Arg 26, 34 Lys 23 GLP61(7-38);

Arg 26, 34 Lys 27 GLP-1(7-36); Arg 26, 34 Lys 27 GLP-1(7-36)amide; Arg 26, 34 Lys 27 GLP-1(7-37); Arg 26, 34 Lys 27 GLP-1(7-38); Gly 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36); Gly 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36); Gly 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Gly 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Gly 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-37); Gly 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-38); Gly 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-38);

Arg 26, 34 Lys 18 GLP-1(7-36); Arg 26, 34 Lys 18 GLP-1(7-36)amide; Arg 26, 34 Lys 18 GLP-1(7-37); Arg 26, 34 Lys 18 GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-38);

Arg 26, 34 Lys 23 GLP-1(7-36); Arg 26, 34 Lys 23 GLP-1(7-36)amide; Arg 26, 34 Lys 23 GLP-1(7-37); Arg 26, 34 Lys 23 GLP-1(7-38); Val 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36); Val 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36); Val 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Val 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Val 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-37); Val 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-38); Val 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-38);

Arg 26, 34 Lys 27 GLP-1(7-36); Arg 26, 34 Lys 27 GLP-1(7-36)amide; Arg 26, 34 Lys 27 GLP-1(7-37); Arg 26, 34 Lys 27 GLP-1(7-38); Val 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36); Val 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36); Val 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Val 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Val 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-37); Val 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-38); Val 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-38);

Arg 26, 34 Lys 18 GLP-1(7-36); Arg 26, 34 Lys 18 GLP-1(7-36)amide; Arg 26, 34 Lys 18 GLP-1(7-37); Arg 26, 34 Lys 18 GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 GLP-y(7-38);

Arg 26, 34 Lys 23 GLP-1(7-36); Arg 26, 34 Lys 23 GLP-1(7-36)amide; Arg 26, 34 Lys 23 GLP-1(7-37); Arg 26, 34 Lys 23 GLP-1(7-38); Ser 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36); Ser 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36); Ser 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Ser 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Ser 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-37); Ser 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-38); Ser 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-38);

Arg 26, 34 Lys 27 GLP-1(7-36); Arg 26, 34 Lys 27 GLP-1(7-36)amide; Arg 26, 34 Lys 27 GLP-1(7-37); Arg 26, 34 Lys 27 GLP-1(7-38); Ser 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36); Ser 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36); Ser 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Ser 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Ser 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-37); Ser 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-38); Ser 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-38);

Arg 26, 34 Lys 18 GLP-1(7-36); Arg 26, 34 Lys 18 GLP-1(7-36)amide; Arg 26, 34 Lys 18 GLP-1(7-37); Arg 26, 34 Lys 18 GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36); Thr 8 Asp 2 7 Arg 26, 34 Lys 18 GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-38);

Arg 26, 34 Lys 23 GLP-1(7-36); Arg 26, 34 Lys 23 GLP-1(7-36)amide; Arg 26, 34 Lys 23 GLP-1(7-37); Arg 26, 34 Lys 23 GLP-1(7-38); Thr 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36); Thr 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36); Thr 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Thr 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Thr 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-37); Thr 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-38); Thr 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-38);

Arg 26, 34 Lys 27 GLP-1(7-36); Arg 26, 34 Lys 27 GLP-1(7-36)amide; Arg 26, 34 Lys 27 GLP-1(7-37); Arg 26, 34 Lys 27 GLP-1(7-38); Thr 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36); Thr 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36); Thr 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Thr 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Thr 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-37); Thr 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-38); or Thr 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-38).

In a further preferred embodiment, the present invention relates to a GLP-1 derivative wherein the parent peptide is:

Arg 26 Lys 36 GLP-1(7-36); Arg 34 Lys 36 GLP-1(7-36); Arg 26 Lys 36 GLP-1(7-37); Arg 34 Lys 36 GLP-1(7-37); Arg 26 Lys 37 GLP-1(7-37); Arg 34 Lys 37 GLP-1(7-37); Arg 26 Lys 39 GLP-1(7-39); Arg 34 Lys 39 GLP-1(7-39); Arg 26, 34 Lys 36,39 GLP-1(7-39);

Arg 26 Lys 18 GLP-1(7-36); Arg 34 Lys 18 GLP-1(7-36); Arg 26 Lys 18 GLP-1(7-37); Arg 34 Lys 18 GLP-1(7-37); Arg 26 Lys 18 GLP-1(7-38); Arg 34 Lys 18 GLP-1(7-38); Arg 26 Lys 18 GLP-1(7-39); Arg 34 Lys 18 GLP-1(7-39);

Arg 26 Lys 23 GLP-1(7-36); Arg 34 Lys 23 GLP-1(7-36); Arg 26 Lys 23 GLP-1(7-37); Arg 34 Lys 23 GLP-1(7-37); Arg 26 Lys 23 GLP-1(7-38); Arg 34 Lys 23 GLP-1(7-38); Arg 26 Lys 23 GLP-1(7-39); Arg 34 Lys 23 GLP-1(7-39);

Arg 26 Lys 27 GLP-1(7-36); Arg 34 Lys 27 GLP-1(7-36); Arg 26 Lys 27 GLP-1(7-37); Arg 34 Lys 27 GLP-1(7-37); Arg 26 Lys 27 GLP-1(7-38); Arg 34 Lys 27 GLP-1(7-38); Arg 26 Lys 27 GLP-1(7-39); Arg 34 Lys 27 GLP-1(7-39);

Arg 26, 34 Lys 18,36 GLP-1(7-36); Arg 26, 34 Lys 18 GLP-1(7-37); Arg 26, 34 Lys 18,37 GLP-1(7-37); Arg 26, 34 Lys 18,38 GLP-1(7-38); Arg 26, 34 Lys 18,39 GLP-1(7-39); Arg 26, 34 Lys 23,36 GLP-1(7-36); Arg 26, 34 Lys 23 GLP-1(7-37); Arg 26, 34 Lys 23,37 GLP-1(7-37); Arg 26, 34 Lys 23,38 GLP-1(7-38); Arg 26, 34 Lys 23,39 GLP-1(7-39); Arg 26, 34 Lys 27,36 GLP-1(7-36); Arg 26, 34 Lys 27 GLP-1(7-37); Arg 26, 34 Lys 27,37 GLP-1(7-37); Arg 26, 34 Lys 27,38 GLP-1(7-38); Arg 26, 34 Lys 27,39 GLP-1(7-39); Gly 8 GLP-1(7-36); Gly 8 GLP-1(7-37); Gly 8 GLP-1(7-38); Gly 8 GLP-1(7-39);

Gly 8 Arg 26 Lys 36 GLP-1(7-36); Gly 8 Arg 34 Lys 36 GLP-1(7-36); Gly 8 Arg 26 Lys 36 GLP-1(7-37); Gly 8 Arg 34 Lys 36 GLP-1(7-37); Gly 8 Arg 26 Lys 37 GLP-1(7-37); Gly 8 Arg 34 Lys 37 GLP-1(7-37); Gly 8 Arg 26 Lys 39 GLP-1(7-39); Gly 8 Arg 34 Lys 39 GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 GLP-1(7-39); Gly 8 Arg 26 Lys 18 GLP-1(7-36); Gly 8 Arg 34 Lys 18 GLP-1(7-36); Gly 8 Arg 26 Lys 18 GLP-1(7-37); Gly 8 Arg 34 Lys 18 GLP-1(7-37); Gly 8 Arg 26 Lys 18 GLP-1(7-38); Gly 8 Arg 34 Lys 18 GLP-1(7-38); Gly 8 Arg 26 Lys 18 GLP-1(7-39); Gly 8 Arg 34 Lys 18 GLP-1(7-39);

Gly 8 Arg 26 Lys 23 GLP-1(7-36); Gly 8 Arg 34 Lys 23 GLP-1(7-36); Gly 8 Arg 26 Lys 23 GLP-1(7-37); Gly 8 Arg 34 Lys 23 GLP-1(7-37); Gly 8 Arg 26 Lys 23 GLP-1(7-38); Gly 8 Arg 34 Lys 23 GLP-1(7-38); Gly 8 Arg 26 Lys 23 GLP-1(7-39); Gly 8 Arg 34 Lys 23 GLP-1(7-39);

Gly 8 Arg 26 Lys 27 GLP-1(7-36); Gly 8 Arg 34 Lys 27 GLP-1(7-36); Gly 8 Arg 26 Lys 27 GLP-1(7-37); Gly 8 Arg 34 Lys 27 GLP-1(7-37); Gly 8 Arg 26 Lys 27 GLP-1(7-38); Gly 8 Arg 34 Lys 27 GLP-1(7-38); Gly 8 Arg 26 Lys 27 GLP-1(7-39); Gly 8 Arg 34 Lys 27 GLP-1(7-39);

Gly 8 Arg 26, 34 Lys 18,36 GLP-1(7-36); Gly 8 Arg 26, 34 Lys 18 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 18,37 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 18,38 GLP-1(7-38); Gly 8 Arg 26, 34 Lys 18,39 GLP-1(7-39); Gly 8 Arg 26, 34 Lys 23,36 GLP-1(7-36); Gly 8 Arg 26, 34 Lys 23 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 23,37 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 23,38 GLP-1(7-38); Gly 8 Arg 26, 34 Lys 23,39 GLP-1(7-39); Gly 8 Arg 26, 34 Lys 27,36 GLP-1(7-36); Gly 8 Arg 26, 34 Lys 27 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 27,37 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 27,38 GLP-1(7-38); Gly 8 Arg 26, 34 Lys 27,39 GLP-1(7-39);

Val 8 GLP-1(7-36); Val 8 GLP-1(7-37); Val 8 GLP-1(7-38); Val 8 GLP-1(7-39);

Val 8 Arg 26 Lys 36 GLP-1(7-36); Val 8 Arg 34 Lys 36 GLP-1(7-36); Val 8 Arg 26 Lys 36 GLP-1(7-37); Val 8 Arg 34 Lys 36 GLP-1(7-37); Val 8 Arg 26 Lys 37 GLP-1(7-37); Val 8 Arg 34 Lys 37 GLP-1(7-37); Val 8 Arg 26 Lys 39 GLP-1(7-39); Val 8 Arg 34 Lys 39 GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 GLP-1(7-39);

Val 8 Arg 26 Lys 18 GLP-1(7-36); Val 8 Arg 34 Lys 18 GLP-1(7-36); Val 8 Arg 6 Lys 18 GLP-1(7-37); Val 8 Arg 34 Lys 18 GLP-1(7-37); Val 8 Arg 26 Lys 18 GLP-1(7-38); Val 8 Arg 34 Lys 18 GLP-1(7-38); Val 8 Arg 26 Lys 18 GLP-1(7-39); Val 8 Arg 34 Lys 18 GLP-1(7-39);

Val 8 Arg 26 Lys 23 GLP-1(7-36); Val 8 Arg 34 Lys 23 GLP-1(7-36); Val 8 Arg 26 Lys 23 GLP-1(7-37); Val 8 Arg 34 Lys 23 GLP-1(7-37); Val 8 Arg 26 Lys 23 GLP-1(7-38); Val 8 Arg 34 Lys 23 GLP-1(7-38); Val 8 Arg 26 Lys 23 GLP-1(7-39); Val 8 Arg 34 Lys 23 GLP-1(7-39);

Val 8 Arg 26 Lys 27 GLP-1(7-36); Val 8 Arg 34 Lys 27 GLP-1(7-36); Val 8 Arg 26 Lys 27 GLP-1(7-37); Val 8 Arg 34 Lys 27 GLP-1(7-37); Val 8 Arg 26 Lys 27 GLP-1(7-38); Val 8 Arg 34 Lys 27 GLP-1(7-38); Val 8 Arg 26 Lys 27 GLP-1(7-39); Val 8 Arg 34 Lys 27 GLP-1(7-39); Val 8 Arg 26, 34 Lys 18,36 GLP-1(7-36); Val 8 Arg 26, 34 Lys 18 GLP-1(7-37); Val 8 Arg 26, 34 Lys 18,37 GLP-1(7-37); Val 8 Arg 26, 34 Lys 18,38 GLP-1(7-38); Val 8 Arg 26, 34 Lys 18,39 GLP-1(7-39); Val 8 Arg 26, 34 Lys 23,36 GLP-1(7-36); Val 8 Arg 26, 34 Lys 23 GLP-1(7-37); Val 8 Arg 26, 34 Lys 23,37 GLP-1(7-37); Val 8 Arg 26, 34 Lys 23,38 GLP-1(7-38); Val 8 Arg 26, 34 Lys 23,39 GLP-1(7-39); Val 8 Arg 26, 34 Lys 27,36 GLP-1(7-36); Val 8 Arg 26, 34 Lys 27 GLP-1(7-37); Val 8 Arg 26, 34 Lys 27,37 GLP-1(7-37); Val 8 Arg 26, 34 Lys 27,38 GLP-1(7-38); or Val 8 Arg 26, 34 Lys 27,39 GLP-1(7-39).

In a further preferred embodiment, the parent peptide is:

Arg 26 GLP-1(7-37); Arg 34 GLP-1(7-37); Lys 36 GLP-1(7-37); Arg 26, 34 Lys 36 GLP-1(7-37); Arg 26, 34 Lys 38 GLP-1(7-38); Arg 26, 34 Lys 39 GLP-1(7-39); Arg 26, 34 Lys 40 GLP-l (7-40); Arg 26 Lys 36 GLP-1(7-37); Arg 34 Lys 36 GLP-1(7-37); Arg 26 Lys 39 GLP-1(7-39); Arg 34 Lys 40 GLP-1(7-40); Arg 26, 34 Lys 36,39 GLP-1(7-39); Arg 26, 34 Lys 36,40 GLP-1(7-40);

Gly 8 Arg 26 GLP-1(7-37); Gly 8 Arg 34 GLP-1(7-37); Gly 8 Lys 36 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 39 GLP-1(7-39); Gly 8 Arg 26, 34 Lys 40 GLP-1(7-40); Gly 8 Arg 26 Lys 36 GLP-1(7-37); Gly 8 Arg 34 Lys 36 GLP-1(7-37); Gly 8 Arg 26 Lys 39 GLP-1(7-39); Gly 8 Arg 34 Lys 40 GLP-1(7-40); Gly 8 Arg 26, 34 Lys 36,39 GLP-1(7-39); or Gly 8 Arg 26, 34 Lys 36,40 GLP-1(7-40).

In a further preferred embodiment, the parent peptide is:

Arg 26, 34 Lys 38 GLP-1(7-38); Arg 26, 34 Lys 39 GLP-1(7-39); Arg 26, 34 Lys 40 GLP-1(7-40); Arg 26, 34 Lys 41 GLP-1(7-41); Arg 26, 34 Lys 42 GLP-1(7-42); Arg 26, 34 Lys 43 GLP-1(7-43); Arg 26, 34 Lys 44 GLP-1(7-44); Arg 26, 34 Lys 45 GLP-1(7-45); Arg 26 Lys 38 GLP-1(7-38); Arg 34 Lys 38 GLP-1(7-38); Arg 26, 34 Lys 36,38 GLP-1(7-38); Arg 26, 34 Lys 38 GLP-1(7-38); Arg 26 Lys 39 GLP-1(7-39); Arg 34 Lys 39 GLP-1(7-39); or Arg 26, 34 Lys 36,39 GLP-1(7-39).

In a further preferred embodiment, the parent peptide is Arg 26 GLP-1(7-37), Arg 34 GLP-1(7-37), Lys 36 GLP-1(7-37), Arg 26, 34 Lys 36 GLP-1(7-37), Arg 26 Lys 36 GLP-1(7-37), Arg 34 Lys 36 GLP-1(7-37), Gly 8 Arg 26 GLP-1(7-37), Gly 8 Arg 34 GLP-1(7-37), Gly 8 Lys 36 GLP-1(7-37), Gly 8 Arg 26, 34 Lys 36 GLP-1(7-37), Gly 8 Arg 26 Lys 36 GLP-1(7-37) or Gly 8 Arg 34 Lys 36 GLP-1(7-37).

In a further preferred embodiment, the parent peptide is Arg 26 Lys 38 GLP-1(7-38), Arg 26, 34 Lys 38 GLP-1(7-38), Arg 26, 34 Lys 36,38 GLP-1(7-38), Gly 8 Arg 26 Lys 38 GLP-1(7-38) or Gly 8 Arg 26, 34 Lys 36,38 GLP-1(7-38).

In a further preferred embodiment, the parent peptide is Arg 26 Lys 39 GLP-1(7-39), Arg 26, 34 Lys 36,39 GLP-1(7-39), Gly 8 Arg 26 Lys 39 GLP-1(7-39) or Gly 8 Arg 26, 34 Lys 36,39 GLP-1(7-39).

In a further preferred embodiment, the parent peptide is Arg 34 Lys 40 GLP-1(7-40), Arg 26, 34 Lys 36,40 GLP-1(7-40), Gly 8 Arg 34 Lys 40 GLP-1(7-40) or Gly 8 Arg 26, 34 Lys 36,40 GLP-1(7-40).

In a further preferred embodiment, the parent peptide is:

Arg 26 GLP-1(7-36); Arg 34 GLP-1(7-36); Arg 26, 34 Lys 36 GLP-1(7-36); Arg 26 GLP-1(7-36)amide; Arg 34 GLP-1(7-36)amide; Arg 26, 34 Lys 36 GLP-1(7-36)amide; Arg 26 GLP-1(7-37); Arg 34 GLP-1(7-37); Arg 26, 34 Lys 36 GLP-1(7-37); Arg 26 GLP-1(7-38); Arg 34 GLP-1(7-38); Arg 26, 34 Lys 38 GLP-1(7-38); Arg 26 GLP-1(7-39); Arg 34 GLP-1(7-39); Arg 26, 34 Lys 39 GLP-1(7-39); Gly 8 Arg 26 GLP-1(7-36); Gly 8 Arg 34 GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 GLP-1(7-36); Gly 8 Arg 26 GLP-1(7-36)amide; Gly 8 Arg 34 GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Gly 8 Arg 26 GLP-1(7-37); Gly 8 Arg 34 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 GLP-1(7-37); Gly 8 Arg 26 GLP-1(7-38); Gly 8 Arg 34 GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 GLP-1(7-38); Gly 8 Arg 26 GLP-1(7-39);

Gly 8 Arg 34 GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 GLP-1(7-39); Val 8 Arg 26 GLP-1(7-36); Val 8 Arg 34 GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 GLP-1(7-36); Val 8 Arg 26 GLP-1(7-36)amide; Val 8 Arg 34 GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Val 8 Arg 26 GLP-1(7-37); Val 8 Arg 34 GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 GLP-1(7-37); Val 8 Arg 26 GLP-1(7-38); Val 8 Arg 34 GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 GLP-1(7-38); Val 8 Arg 26 GLP-1(7-39); Val 8 Arg 34 GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 GLP-1(7-39); Ser 8 Arg 26 GLP-1(7-36); Ser 8 Arg 34 GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 GLP-1(7-36); Ser 8 Arg 26 GLP-1(7-36)amide; Ser 8 Arg 34 GLP-1(7-36)amide;

Ser 8 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Ser 8 Arg 26 GLP-1(7-37); Ser 8 Arg 34 GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 GLP-1(7-37); Ser 8 Arg 26 GLP-1(7-38); Ser 8 Arg 34 GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 GLP-1(7-38); Ser 8 Arg 26 GLP-1(7-39); Ser 8 Arg 34 GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 GLP-1(7-39); Thr 8 Arg 26 GLP-1(7-36); Thr 8 Arg 34 GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 GLP-1(7-36); Thr 8 Arg 26 GLP-1(7-36)amide; Thr 8 Arg 34 GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Thr 8 Arg 26 GLP-1(7-37); Thr 8 Arg 34 GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 GLP-1(7-37); Thr 8 Arg 26 GLP-1(7-38); Thr 8 Arg 34 GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 GLP-1(7-38); Thr 8 Arg 26 GLP-1(7-39); Thr 8 Arg 34 GLP-1-(7-39); Thr 8 Arg 26, 34 Lys 39 GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 l GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(7-39); Arg 26, 34 Lys 18 GLP-l (7-36); Arg 26, 34 Lys 18 GLP-1(7-36)amide; Arg 26, 34 Lys 18 GLP-1(7-37); Arg 26, 34 Lys 18 GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-38); Arg 26, 34 Lys 23 GLP-1(7-36); Arg 26, 34 Lys 23 GLP-1(7-36)amide; Arg 26, 34 Lys 23 GLP-1(7-37); Arg 26, 34 Lys 23 GLP-1(7-38); Gly 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36); Gly 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36); Gly 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-37)amide; Gly 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Gly 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-37); Gly 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-38); Gly 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-38); Arg 26, 34 Lys 27 GLP-1(7-36); Arg 26, 34 Lys 27 GLP-1(7-36)amide; Arg 26, 34 Lys 27 GLP-1(7-37); Arg 26, 34 Lys 27 GLP-1(7-38); Gly 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36); Gly 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36); Gly 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Gly 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Gly 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-37); Gly 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-38); Gly 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-38); Arg 26, 34 Lys 18 GLP-1(7-36); Arg 26, 34 Lys 18 GLP-1(7-36)amide; Arg 26, 34 Lys 18 GLP-1(7-37); Arg 26, 34 Lys 18 GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 GLP-l (7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-38); Arg 26, 34 Lys 23 GLP-1(7-36); Arg 26, 34 Lys 23 GLP-1(7-36)amide; Arg 26, 34 Lys 23 GLP-1(7-37); Arg 26, 34 Lys 23 GLP-1(7-38); Val 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36); Val 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36); Val 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Val 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Val 8 Asp 24 Arg 26, 34 Lys 23 GLP-1-(7-37); Val 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-38); Val 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-38); Arg 26, 34 Lys 27 GLP-1(7-36); Arg 26, 34 Lys 27 GLP-1(7-36)amide; Arg 26, 34 Lys 27 GLP-1(7-37); Arg 26, 34 Lys 27 GLP-1(7-38); Val 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36); Val 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36); Val 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Val 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Val 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-37); Val 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-38); Val 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-38); Arg 26, 34 Lys 18 GLP-1(7-36); Arg 26, 34 Lys 18 GLP-1(7-36)amide; Arg 26, 34 Lys 18 GLP-1(7-37); Arg 26, 34 Lys 18 GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-38); Arg 26, 34 Lys 23 GLP-1(7-36); Arg 26, 34 Lys 23 GLP-1(7-36)amide; Arg 26, 34 Lys 23 GLP-1(7-37); Arg 26, 34 Lys 23 GLP-1(7-38); Ser 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36); Ser 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36); Ser 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Ser 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Ser 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-37); Ser 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-38); Ser 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-38); Arg 26, 34 Lys 27 GLP-1(7-36); Arg 26, 34 Lys 27 GLP-1(7-36)amide; Arg 26, 34 Lys 27 GLP-1(7-37); Arg 26, 34 Lys 27 GLP-1(7-38); Ser 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36); Ser 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36); Ser 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Ser 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Ser 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-37); Ser 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-38); Ser 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-38); Arg 26, 34 Lys 18 GLP-1(7-36); Arg 26, 34 Lys 18 GLP-1(7-36)amide; Arg 26, 34 Lys 18 GLP-1(7-37); Arg 26, 34 Lys 18 GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 GLP-l (7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(7-38); Arg 26, 34 Lys 23 GLP-1(7-36); Arg 26, 34 Lys 23 GLP-1(7-36)amide; Arg 26, 34 Lys 23 GLP-1(7-37); Arg 26, 34 Lys 23 GLP-1(7-38); Thr 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36); Thr 8 Asp 2 Arg 26, 34 Lys 23 GLP-1(7-36); Thr 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Thr 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-36)amide; Thr 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-37); Thr 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(7-38); Thr 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(7-38); Arg 26, 34 Lys 27 GLP-1(7-36); Arg 26, 34 Lys 27 GLP-1(7-36)amide; Arg 26, 34 Lys 27 GLP-1(7-37); Arg 26, 34 Lys 27 GLP-1(7-38); Thr 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36); Thr 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36); Thr 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Thr 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-36)amide; Thr 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-37); Thr 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(7-38); or Thr 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(7-38).

In a further preferred embodiment, the present invention relates to a GLP-1 derivative wherein the parent peptide is:

Arg 26 Lys 36 GLP-1(7-36); Arg 34 Lys 36 GLP-1(7-36); Arg 26 Lys 36 GLP-1(7-37); Arg 34 Lys 36 GLP-1(7-37); Arg 26 Lys 37 GLP-1(7-37); Arg 34 Lys 37 GLP-1(7-37); Arg 26 Lys 39 GLP-1(7-39); Arg 26 Lys 39 GLP-1(7-39); Arg 26, 34 Lys 36,39 GLP-1(7-39); Arg 26 Lys 18 GLP-1(7-36); Arg 34 Lys 18 GLP-1(7-36); Arg 26 Lys 18 GLP-1(7-37); Arg 34 Lys 18 GLP-1(7-37); Arg 26 Lys 18 GLP-1(7-38); Arg 34 Lys 18 GLP-1(7-38); Arg 26 Lys 18 GLP-1(7-39); Arg 34 Lys 18 GLP-1(7-39); Arg 26 Lys 23 GLP-1(7-36); Arg 34 Lys 23 GLP-1(7-36); Arg 26 Lys 23 GLP-1(7-37); Arg 34 Lys 23 GLP-1(7-37); Arg 26 Lys 23 GLP-1(7-38); Arg 34 Lys 23 GLP-1(7-38); Arg 26 Lys 23 GLP-1(7-39); Arg 34 Lys 23 GLP-1(7-39); Arg 26 Lys 27 GLP-1(7-36); Arg 34 Lys 27 GLP-1(7-36); Arg 26 Lys 27 GLP-1(7-37); Arg 34 Lys 27 GLP-1(7-37); Arg 26 Lys 27 GLP-1(7-38); Arg 34 Lys 27 GLP-1(7-38); Arg 26 Lys 27 GLP-1(7-39); Arg 34 Lys 27 GLP-1(7-39); Arg 26, 34 Lys 18,36 GLP-1(7-36); Arg 26, 34 Lys 18 GLP-1(7-37); Arg 26, 34 Lys 18,37 GLP-1(7-37); Arg 26, 34 Lys 18,38 GLP-1(7-38); Arg 26, 34 Lys 18,39 GLP-1(7-39); Arg 26, 34 Lys 23,36 GLP-1(7-36); Arg 26, 34 Lys 23 GLP-1(7-37); Arg 26, 34 Lys 23,37 GLP-1(7-37); Arg 26, 34 Lys 23,38 GLP-1(7-38); Arg 26, 34 Lys 23,39 GLP-1(7-39); Arg 26, 34 Lys 27,36 GLP-1(7-36); Arg 26, 34 Lys 27 GLP-1(7-37); Arg 26, 34 Lys 27,37 GLP-1(7-37); Arg 26, 34 Lys 27,38 GLP-1(7-38); Arg 26, 34 Lys 27,39 GLP-1(7-39); Gly 8 GLP-1(7-36); Gly 8 GLP-1(7-37); Gly 8 GLP-1(7-38); Gly 8 GLP-1(7-39); Gly 8 Arg 26 Lys 36 GLP-1(7-36); Gly 8 Arg 34 Lys 36 GLP-1(7-36); Gly 8 Arg 26 Lys 36 GLP-1(7-37); Gly 8 Arg 34 Lys 36 GLP-1(7-37); Gly 8 Arg 26 Lys 37 GLP-1(7-37); Gly 8 Arg 34 Lys 37 GLP-1(7-37); Gly 8 Arg 26 Lys 39 GLP-1(7-39); Gly 8 Arg 34 Lys 39 3GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 GLP-1(7-39); Gly 8 Arg 26 Lys 18 GLP-1(7-36); Gly 8 Arg 34 Lys 18 GLP-1(7-36); Gly 8 Arg 26 Lys 18 GLP-1(7-37); Gly 8 Arg 34 Lys 18 GLP-1(7-37); Gly 8 Arg 26 Lys 18 GLP-1(7-38); Gly 8 Arg 34 Lys 18 GLP-1(7-38); Gly 8 Arg 26 Lys 18 GLP-1(7-39); Gly 8 Arg 34 Lys 18 GLP-1(7-39); Gly 8 Arg 26 Lys 23 GLP-1(7-36); Gly 8 Arg 34 Lys 23 GLP-1(7-36); Gly 8 Arg 26 Lys 23 GLP-1(7-37); Gly 8 Arg 34 Lys 23 GLP-1(7-37); Gly 8 Arg 26 Lys 23 GLP-1(7-38); Gly 8 Arg 34 Lys 23 GLP-1(7-38); Gly 8 Arg 26 Lys 23 GLP-1(7-39); Gly 8 Arg 34 Lys 23 GLP-l1(7-39); Gly 8 Arg 26 Lys 27 GLP-1(7-36); Gly 8 Arg 34 Lys 27 GLP-1(7-36); Gly 8 Arg 26 Lys 27 GLP-1(7-37); Gly 8 Arg 34 Lys 27 GLP-1(7-37); Gly 8 Arg 26 Lys 27 GLP-1(7-38); Gly 8 Arg 34 Lys 27 GLP-1(7-38); Gly 8 Arg 26 Lys 27 GLP-1(7-39); Gly 8 Arg 34 Lys 27 GLP-1(7-39); Gly 8 Arg 26, 34 Lys 18,36 GLP-1(7-36); Gly 8 Arg 26, 34 Lys 18 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 18,37 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 18,38 GLP-1(7-38); Gly 8 Arg 26, 34 Lys 18,39 GLP-1(7-39); Gly 8 Arg 26, 34 Lys 23,36 GLP-1(7-36); Gly 8 Arg 26, 34 Lys 23 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 23,37 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 23,38 GLP-1(7-38); Gly 8 Arg 26, 34 Lys 23,39 GLP-1(7-39); Gly 8 Arg 26, 34 Lys 27,36 GLP-1(7-36); Gly 8 Arg 26, 34 Lys 27 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 27,37 GLP-1(7-37); Gly 8 Arg 26, 34 Lys 27,38 GLP-1(7-38); Gly 8 Arg 26, 34 Lys 27,39 GLP-1(7-39); Val 8 GLP-1(7-36); Val 8 GLP-1(7-37); Val 8 GLP-1(7-38); Val 8 GLP-1(7-39); Val 8 Arg 26 Lys 36 GLP-1(7-36); Val 8 Arg 34 Lys 36 GLP-1(7-36); Val 8 Arg 26 Lys 36 GLP-1(7-37); Val 8 Arg 34 Lys 36 GLP-1(7-37); Val 8 Arg 26 Lys 37 GLP-1(7-37); Val 8 Arg 34 Lys 37 GLP-1(7-37); Val 8 Arg 26 Lys 39 GLP-1(7-39); Val 8 Arg 34 Lys 39 GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 GLP-1(7-39); Val 8 Arg 26 Lys 18 GLP-1(7-36); Val 8 Arg 34 Lys 18 GLP-1(7-36); Val 8 Arg 26 Lys 18 GLP-1(7-37); Val 8 Arg 34 Lys 18 GLP-1(7-37); Val 8 Arg 26 Lys 18 GLP-1(7-38); Val 8 Arg 34 Lys 18 GLP-1(7-38); Val 8 Arg 26 Lys 18 GLP-1(7-39); Val 8 Arg 34 Lys 18 GLP-1(7-39); Val 8 Arg 26 Lys 23 GLP-1(7-36); Val 8 Arg 34 Lys 23 GLP-1(7-36); Val 8 Arg 26 Lys 23 GLP-1(7-37); Val 8 Arg 34 Lys 23 GLP-1 1(7-37); Val 8 Arg 26 Lys 23 GLP-1(7-38); Val 8 Arg 34 Lys 23 GLP-1(7-38); Val 8 Arg 26 Lys 23 GLP-1(7-39); Val 8 Arg 34 Lys 23 GLP-1(7-39); Val 8 Arg 26 Lys 27 GLP-1(7-36); Val 8 Arg 34 Lys 27 GLP-1(7-36); Val 8 Arg 26 Lys 27 GLP-1(7-37); Val 8 Arg 34 Lys 27 GLP-1(7-37); Val 8 Arg 26 Lys 27 GLP-1(7-38); Val 8 Arg 34 Lys 27 GLP-1(7-38); Val 8 Arg 26 Lys 27 GLP-1-(7-39); Val 8 Arg 34 Lys 27 GLP-1(7-39); Val 8 Arg 26, 34 Lys 18,36 GLP-1(7-36); Val 8 Arg 26, 34 Lys 18 GLP-1(7-37); Val 8 Arg 26, 34 Lys 18,37 GLP-1(7-37); Val 8 Arg 26, 34 Lys 18,38 GLP-1(7-38); Val 8 Arg 26, 34 Lys 18,39 GLP-1(7-39); Val 8 Arg 26, 34 Lys 23,36 GLP-1(7-36); Val 8 Arg 26, 34 Lys 23 GLP-1(7-37); Val 8 Arg 26, 34 Lys 23,37 GLP-1(7-37); Val 8 Arg 26, 34 Lys 23,38 GLP-1(7-38); Val 8 Arg 26, 34 Lys 23,39 GLP-1(7-39); Val 8 Arg 26, 34 Lys 27,36 -GLP -1(7-36); Val 8 Arg 26, 34 Lys 27 GLP-1(7-37); Val 8 Arg 26, 34 Lys 27,37 GLP-1(7-37); Val 8 Arg 26, 34 Lys 27,38 GLP-l (7-38); or Val 8 Arg 26, 34 Lys 27,39 GLP-1(7-39).

In a further preferred embodiment, the present invention relates to a GLP-1 derivative wherein the parent peptide is:

Arg 26 GLP-1(8-37); Arg 34 GLP-1(8-37); Lys 36 GLP-1(8-37); Arg 26, 34 Lys 36 GLP-1(8-37); Arg 26, 34 Lys 38 GLP-1(8-38); Arg 26, 34 Lys 39 GLP-1(8-39); Arg 26, 34 Lys 40 GLP-1(8-40); Arg 26 Lys 36 GLP-1(8-37); Arg 34 Lys 36 GLP-1(8-37); Arg 26 Lys 39 GLP-1(8-39); Arg 34 Lys 40 GLP-1(8-40); Arg 26, 34 Lys 36,39 GLP-1(8-39); Arg 26, 34 Lys 36,40 GLP-1(8-40); Gly 8 Arg 26 GLP-1(8-37); Gly 8 Arg 34 GLP-1(8-37); Gly 8 Lys 36 GLP-1(8-37); Gly 8 Arg 26, 34 Lys 36 GLP-1(8-37); Gly 8 Arg 26, 34 Lys 39 GLP-1(8-39); Gly 8 Arg 26, 34 Lys 40 GLP-1(8-40); Gly 8 Arg 26 Lys 36 GLP-1(8-37); Gly 8 Arg 34 Lys 36 GLP-1(8-37); Gly 8 Arg 26 Lys 39 GLP-1(8-39); Gly 8 Arg 34 Lys 40 GLP-1(8-40); Gly 8 Arg 26, 34 Lys 36,39 GLP-1(8-39); or Gly 8 Arg 26, 34 Lys 36,40 GLP-1(8-40).

In a further preferred embodiment, the parent peptide is:

Arg 26, 34 Lys 38 GLP-1(8-38); Arg 26, 34 Lys 39 GLP-1(8-39); Arg 26, 34 Lys 40 GLP-1(8-40); Arg 26, 34 Lys 41 GLP-1(8-41); Arg 26, 34 Lys 42 GLP-1(8-42); Arg 26, 34 Lys 43 GLP-1(8-43); Arg 26, 34 Lys 44 GLP-1(8-44); Arg 26, 34 Lys 45 GLP-1(8-45); Arg 26 Lys 38 GLP-1(8-38); Arg 34 Lys 38 GLP-1(8-38); Arg 26, 34 Lys 36,38 GLP-1(8-38); Arg 26, 34 Lys 38 GLP-1(8-38); Arg 26 Lys 39 GLP-1(8-39); Arg 34 Lys 39 GLP-1(8-39); or Arg 26, 34 Lys 36,39 GLP-1(8-39).

In a further preferred embodiment, the parent peptide is Arg 26 GLP-1(8-37), Arg 34 GLP-1(8-37) Lys 36 GLP-1(8-37), Arg 26, 34 Lys 36 GLP-1(8-37), Arg 26 Lys 36 GLP-1(8-37), Arg 34 Lys 36 GLP-1(8-37), Gly 8 Arg 26 GLP-1(8-37), Gly 8 Arg 34 GLP-1(8-37), Gly 8 Lys 36 GLP-1(8-37), Gly 8 Arg 26, 34 Lys 36 GLP-1(8-37), Gly 8 Arg 26 Lys 36 GLP-1(8-37), or Gly 8 Arg 34 Lys 36 GLP-1(8-37).

In a further preferred embodiment, the parent peptide is Arg 26 Lys 38 GLP-1(8-38), Arg 26, 34 Lys 38 GLP-1(8-38), Arg 26, 34 Lys 36,38 GLP-1(8-38), Gly 8 Arg 26 Lys 38 GLP-1(8-38) or Gly 8 Arg 26, 34 Lys 36,38 GLP-1(8-38).

In a further preferred embodiment, the parent peptide is Arg 26 Lys 39 GLP-1(8-39), Arg 26, 34 Lys 36,39 GLP-1(8-39), Gly 8 Arg 26 Lys 39 GLP-1(8-39) or Gly 8 Arg 26, 34 Lys 36,39 GLP-1(8-39).

In a further preferred embodiment, the present invention relates to a GLP-1 derivative wherein the parent peptide is Arg 34 Lys 40 GLP-1(8-40), Arg 26, 34 Lys 36,40 GLP-1(8-40), Gly 8 Arg 34 Lys 40 GLP-1(8-40) or Gly 8 Arg 26, 34 Lys 36,40 GLP-1(8-40).

In a further preferred embodiment, the present invention relates to a GLP-1 derivative wherein the parent peptide is:

Arg 26 GLP-1(8-36); Arg 34 GLP-1(8-36); Arg 26, 34 Lys 36 GLP-1(8-36); Arg 26 GLP-1(8-36)amide; Arg 34 GLP-1(8-36)amide; Arg 26, 34 Lys 36 GLP-1(8-36)amide; Arg 26 GLP-1(8-37); Arg 34 GLP-1(8-37); Arg 26, 34 Lys 36 GLP-1(8-37); Arg 26 GLP-1(8-38); Arg 34 GLP-1(8-38); Arg 26, 34 Lys 38 GLP-1(8-38); Arg 26 GLP-1(8-39); Arg 34 GLP-1(8-39); Arg 26, 34 Lys 39 GLP-1(8-39); Gly 8 Arg 26 GLP-1(8-36); Gly 8 Arg 34 GLP-1(8-36); Gly 8 Arg 26, 34 Lys 36 GLP-1(8-36); Gly 8 Arg 26 GLP-1(8-36)amide; Gly 8 Arg 34 GLP-1(8-36)amide; Gly 8 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Gly 8 Arg 26 GLP-1(8-37); Gly 8 Arg 34 GLP-1(8-37); Gly 8 Arg 26, 34 Lys 36 GLP-1(8-37); Gly 8 Arg 26 GLP-1(8-38); Gly 8 Arg 34 GLP-1(8-38); Gly 8 Arg 26, 34 Lys 38 GLP-1(8-38); Gly 8 Arg 26 GLP-1(8-39); Gly 8 Arg 34 GLP-1(8-39); Gly 8 Arg 26, 34 Lys 39 GLP-1(8-39); Val 8 Arg 26 GLP-1(8-36); Val 8 Arg 34 GLP-1(8-36); Val 8 Arg 26, 34 Lys 36 GLP-1(8-36); Val 8 Arg 26 GLP-1(8-36)amide; Val 8 Arg 34 GLP-1(8-36)amide; Val 8 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Val 8 Arg 26 GLP-1(8-37); Val 8 Arg 34 GLP-1(8-37); Val 8 Arg 26, 34 Lys 36 GLP-1(8-37); Val 8 Arg 26 GLP-1(8-38); Val 8 Arg 34 GLP-1(8-38); Val 8 Arg 26, 34 Lys 38 GLP-1(8-38); Val 8 Arg 26 GLP-1(8-39); Val 8 Arg 34 GLP-1(8-39); Val 8 Arg 26, 34 Lys 39 GLP-1(8-39); Ser 8 Arg 26 GLP-1(8-36); Ser 8 Arg 34 GLP-1(8-36); Ser 8 Arg 26, 34 Lys 36 GLP-1(8-36); Ser 8 Arg 26 GLP-1(8-36)amide; Ser 8 Arg 34 GLP-1(8-36)amide;

Ser 8 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Ser 8 Arg 26 GLP-1(8-37); Ser 8 Arg 34 GLP-1(8-37); Ser 8 Arg 26, 34 Lys 36 GLP-1(8-37); Ser 8 Arg 26 GLP-1(8-38); Ser 8 Arg 34 GLP-1(8-38); Ser 8 Arg 26, 34 Lys 38 GLP-1(8-38); Ser 8 Arg 26 GLP-1(8-39); Ser 8 Arg 34 GLP-1(8-39); Ser 8 Arg 26, 34 Lys 39 GLP-1(8-39); Thr 8 Arg 26 GLP-1(8-36); Thr 8 Arg 34 GLP-1(8-36); Thr 8 Arg 26, 34 Lys 36 GLP-1(8-36); Thr 8 Arg 26 GLP-1(8-36)amide; Thr 8 Arg 34 GLP-1(8-36)amide; Thr 8 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Thr 8 Arg 26 GLP-1(8-37); Thr 8 Arg 34 GLP-1(8-37); Thr 8 Arg 26, 34 Lys 36 GLP-1(8-37); Thr 8 Arg 26 GLP-1(8-38); Thr 8 Arg 34 GLP-1(8-38); Thr 8 Arg 26, 34 Lys 38 GLP-1(8-38); Thr 8 Arg 26 GLP-1(8-39); Thr 8 Arg 34 GLP-1(8-39); Thr 8 Arg 26, 34 Lys 39 GLP-1(8-39); Val 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36); Val 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(8-37); Val 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(8-38); Val 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(8-39); Val 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36); Val 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(8-37); Val 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(8-38); Val 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(8-39); Val 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36); Val 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(8-37); Val 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(8-38); Val 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(8-39); Val 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36); Val 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(8-37); Val 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(8-38); Val 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(8-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Ser 8 Glu36Arg 26, 34 Lys 37 GLP-1(8-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(8-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(8-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(8-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(8-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(8-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36); Ser 8 Asp 37 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(8-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(8-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(8-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(8-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(8-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(8-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(8-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(8-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(8-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(8-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(8-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(8-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(8-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(8-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(8-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(8-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(8-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(8-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(8-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(8-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(8-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 GLP-1(8-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 GLP-1(8-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 GLP-1(8-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(8-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(8-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(8-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 GLP-1(8-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 GLP-1(8-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 GLP-1(8-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 GLP-1(8-39); Arg 26, 34 Lys 18 GLP-1(8-36); Arg 26, 34 Lys 18 GLP-1(8-36)amide; Arg 26, 34 Lys 18 GLP-1(8-37); Arg 26, 34 Lys 18 GLP-1(8-38); Gly 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(8-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(8-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(8-38); Arg 26, 34 Lys 23 GLP-1(8-36); Arg 26, 34 Lys 23 GLP-1(8-36)amide; Arg 26, 34 Lys 23 GLP-1(8-37); Arg 26, 34 Lys 23 GLP-1(8-38); Gly 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-36); Gly 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(8-36); Gly 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-36)amide; Gly 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(8-36)amide; Gly 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-37); Gly 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-38); Gly 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(8-38); Arg 26, 34 Lys 27 GLP-1(8-36); Arg 26, 34 Lys 27 GLP-1(8-36)amide; Arg 26, 34 Lys 27 GLP-1(8-37); Arg 26, 34 Lys 27 GLP-1(8-38); Gly 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-36); Gly 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(8-36); Gly 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-36)amide; Gly 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(8-36)amide; Gly 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-37); Gly 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-38); Gly 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(8-38); Arg 26, 34 Lys 18 GLP-1(8-36); Arg 26, 34 Lys 18 GLP-1(8-36)amide; Arg 26, 34 Lys 18 GLP-1(8-37); Arg 26, 34 Lys 18 GLP-1(8-38); Val 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-36); Val 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(8-36); Val 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(8-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-37); Val 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-38); Val 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(8-38); Arg 26, 34 Lys 23 GLP-1(8-36); Arg 26, 34 Lys 23 GLP-1(8-36)amide; Arg 26, 34 Lys 23 GLP-1(8-37); Arg 26, 34 Lys 23 GLP-1(8-38); Val 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-36); Val 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(8-36); Val 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-36)amide; Val 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(8-36)amide; Val 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-37); Val 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-38); Val 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(8-38); Arg 26, 34 Lys 27 GLP-1(8-36); Arg 26, 34 Lys 27 GLP-1(8-36)amide; Arg 26, 34 Lys 27 GLP-1(8-37); Arg 26, 34 Lys 27 GLP-1(8-38); Val 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-36); Val 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(8-36); Val 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-36)amide; Val 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(8-36)amide; Val 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-37); Val 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-38); Val 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(8-38); Arg 26, 34 Lys 18 GLP-1(8-36); Arg 26, 34 Lys 18 GLP-1(8-36)amide; Arg 26, 34 Lys 18 GLP-1(8-37); Arg 26, 34 Lys 18 GLP-1(8-38); Ser 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(8-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(8-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(8-38); Arg 26, 34 Lys 23 GLP-1(8-36); Arg 26, 34 Lys 23 GLP-1(8-36)amide; Arg 26, 34 Lys 23 GLP-1(8-37); Arg 26, 34 Lys 23 GLP-1(8-38); Ser 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-36); Ser 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(8-36); Ser 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-36)amide; Ser 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(8-36)amide; Ser 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-37); Ser 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-38); Ser 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(8-38); Arg 26, 34 Lys 27 GLP-1(8-36); Arg 26, 34 Lys 27 GLP-1(8-36)amide; Arg 26, 34 Lys 27 GLP-1(8-37); Arg 26, 34 Lys 27 GLP-1(8-38); Ser 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-36); Ser 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(8-36); Ser 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-36)amide; Ser 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(8-36)amide; Ser 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-37); Ser 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-38); Ser 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(8-38); Arg 26, 34 Lys 18 GLP-1(8-36); Arg 26, 34 Lys 18 GLP-1(8-36)amide; Arg 26, 34 Lys 18 GLP-1(8-37); Arg 26, 34 Lys 18 GLP-1(8-38); Thr 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(8-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(8-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 GLP-1(8-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 GLP-1(8-38); Arg 26, 34 Lys 23 GLP-1(8-36); Arg 26, 34 Lys 23 GLP-1(8-36)amide; Arg 26, 34 Lys 23 GLP-1(8-37); Arg 26, 34 Lys 23 GLP-1(8-38); Thr 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-36); Thr 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(8-36); Thr 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-36)amide; Thr 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(8-36)amide; Thr 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-37); Thr 8 Asp 24 Arg 26, 34 Lys 23 GLP-1(8-38); Thr 8 Asp 22 Arg 26, 34 Lys 23 GLP-1(8-38); Arg 26, 34 Lys 27 GLP-1(8-36); Arg 26, 34 Lys 27 GLP-1(8-36)amide; Arg 26, 34 Lys 27 GLP-1(8-37); Arg 26, 34 Lys 27 GLP-1(8-38); Thr 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-36); Thr 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(8-36); Thr 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-36)amide; Thr 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(8-36)amide; Thr 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-37); Thr 8 Asp 28 Arg 26, 34 Lys 27 GLP-1(8-38); or Thr 8 Asp 26 Arg 26, 34 Lys 27 GLP-1(8-38).

In a further preferred embodiment, the present invention relates to a GLP-1 derivative wherein the parent peptide is:

Arg 26 Lys 36 GLP-1(8-36); Arg 34 Lys 36 GLP-1(8-36); Arg 26 Lys 36 GLP-1(8-37); Arg 34 Lys 36 GLP-1(8-37); Arg 26 Lys 37 GLP-1(8-37); Arg 34 Lys 37 GLP-1(8-37); Arg 26 Lys 39 GLP-1(8-39); Arg 34 Lys 39 GLP-1(8-39); Arg 26, 34 Lys 36,39 GLP-1(8-39); Arg 26 Lys 18 GLP-1(8-36); Arg 34 Lys 18 GLP-1(8-36); Arg 26 Lys 18 GLP-1(8-37); Arg 34 Lys 18 GLP-1(8-37); Arg 26 Lys 18 GLP-1(8-38); Arg 34 Lys 18 GLP-1(8-38); Arg 26 Lys 18 GLP-1(8-39); Arg 34 Lys 18 GLP-1(8-39); Arg 26 Lys 23 GLP-1(8-36); Arg 34 Lys 23 GLP-1(8-36); Arg 26 Lys 23 GLP-1(8-37); Arg 34 Lys 23 GLP-1(8-37); Arg 26 Lys 23 GLP-1(8-38); Arg 34 Lys 23 GLP-1(8-38); Arg 26 Lys 23 GLP-1(8-39); Arg 34 Lys 23 GLP-1(8-39); Arg 26 Lys 27 GLP-1(8-36); Arg 34 Lys 27 GLP-1(8-36); Arg 26 Lys 27 GLP-1(8-37); Arg 34 Lys 27 GLP-1(8-37); Arg 26 Lys 27 GLP-1(8-38); Arg 34 Lys 27 GLP-1(8-38); Arg 26 Lys 27 GLP-1(8-39); Arg 34 Lys 27 GLP-1(8-39);

Arg 26, 34 Lys 18,36 GLP-1(8-36); Arg 26, 34 Lys 18 GLP-1(8-37); Arg 26, 34 Lys 18,37 GLP-1(8-37); Arg 26, 34 Lys 18,38 GLP-1(8-38); Arg 26, 34 Lys 18,39 GLP-1(8-39); Arg 26, 34 Lys 23,36 GLP-1(8-36); Arg 26, 34 Lys 23 GLP-1-(8-37); Arg 26, 34 Lys 23,37 GLP-1(8-37); Arg 26, 34 Lys 23,38 GLP-1(8-38); Arg 26 Lys 23,39 GLP-1(8-39); Arg 26, 34 Lys 27,36 GLP-1(8-36); Arg 26, 34 Lys 27 GLP-1(8-37); Arg 26, 34 Lys 27,37 GLP-1(8-37); Arg 26, 34 Lys 23,38 GLP-1(8-38); Arg 26, 34 Lys 27,39 GLP-1(8-39); Gly 8 GLP-1(8-36); Gly 8 GLP-1(8-37); Gly 8 GLP-1(8-38); Gly 8 GLP-1(8-39); Gly 8 Arg 26 Lys 36 GLP-1(8-36); Gly 8 Arg 34 Lys 36 GLP-1(8-36); Gly 8 Arg 26 Lys 36 GLP-1(8-37); Gly 8 Arg 34 Lys 36 GLP-1(8-37); Gly 8 Arg 26 Lys 37 GLP-1(8-37); Gly 8 Arg 34 Lys 37 GLP-1(8-37); Gly 8 Arg 26 Lys 39 GLP-1(8-39); Gly 8 Arg 34 Lys 39 GLP-1(8-39); Gly 8 Arg 26, 34 Lys 36,39 GLP-1(8-39); Gly 8 Arg 26 Lys 18 GLP-1y(8-36); Gly 8 Arg 34 Lys 18 GLP-1((8-36); Gly 8 Arg 26 Lys 18 GLP-1(8-37); Gly 8 Arg 34 Lys 18 GLP-1(8-37); Gly 8 Arg 26 Lys 18 GLP-1(8-38); Gly 8 Arg 34 Lys 18 GLP-1(8-38); Gly 8 Arg 26 Lys 18 GLP-1(8-39); Gly 8 Arg 34 Lys 18 GLP-1(8-39); Gly 8 Arg 26 Lys 23 GLP-1(8-36); Gly 8 Arg 34 Lys 23 GLP-1(8-36); Gly 8 Arg 26 Lys 23 GLP-1(8-37); Gly 8 Arg 34 Lys 23 GLP-1(8-37); Gly 8 Arg 26 Lys 23 GLP-1(8-38); Gly 8 Arg 34 Lys 23 GLP-1(8-38); Gly 8 Arg 26 Lys 23 GLP-1(8-39); Gly 8 Arg 34 Lys 23 GLP-1(8-39); Gly 8 Arg 26 Lys 27 GLP-1(8-36); Gly 8 Arg 34 Lys 27 GLP-1(8-36); Gly 8 Arg 26 Lys 27 GLP-1(8-37); Gly 8 Arg 34 Lys 27 GLP-1(8-37); Gly 8 Arg 26 Lys 27 GLP-1(8-38); Gly 8 Arg 34 Lys 27 GLP-1(8-38); Gly 8 Arg 26 Lys 27 GLP-1(8-39); Gly 8 Arg 34 Lys 27 GLP-1(8-39); Gly 8 Arg 26, 34 Lys 18,36 GLP-1(8-36); Gly 8 Arg 26, 34 Lys 18 GLP-1(8-37); Gly 8 Arg 26, 34 Lys 18,37 GLP-1(8-37); Gly 8 Arg 26, 34 Lys 18,38 GLP-1(8-38); Gly 8 Arg 26, 34 Lys 18,39 GLP-1(8-39); Gly 8 Arg 26, 34 Lys 23,36 GLP-1(8-36); Gly 8 Arg 26, 34 Lys 23 GLP-1(8-37); Gly 8 Arg 26, 34 Lys 23,37 GLP-1(8-37); Gly 8 Arg 26, 34 Lys 23,38 GLP-1(8-38); Gly 8 Arg 26, 34 Lys 23,39 GLP-1(8-39); Gly 8 Arg 26, 34 Lys 27,36 GLP-1(8-36); Gly 8 Arg 26, 34 Lys 27 GLP-1(8-37); Gly 8 Arg 26, 34 Lys 27,37 GLP-1(8-37); Gly 8 Arg 26, 34 Lys 27,38 GLP-1(8-38); Gly 8 Arg 26, 34 Lys 27,39 GLP-1(8-39); Val 8 GLP-1(8-36); Val 8 GLP-1(8-37); Val 8 GLP-1(8-38); Val 8 GLP-1(8-39); Val 8 Arg 26 Lys 36 GLP-1(8-36); Val 8 Arg 34 Lys 36 GLP-1(7-36); Val 8 Arg 26 Lys 36 GLP-1(8-37); Val 8 Arg 34 Lys 36 GLP-1(8-37); Val 8 Arg 26 Lys 37 GLP-1(8-37); Val 8 Arg 34 Lys 37 GLP-1(8-37); Val 8 Arg 26 Lys 39 GLP-1(8-39); Val 8 Arg 34 Lys 39 GLP-1(8-39); Val 8 Arg 26, 34 Lys 36,39 GLP-1(8-39); Val 8 Arg 26 Lys 18 GLP-1(8-36); Val 8 Arg 34 Lys 18 GLP-1(8-36); Val 8 Arg 26 Lys 18 GLP-1(8-37); Val 8 Arg 34 Lys 18 GLP-1(8-37); Val 8 Arg 26 Lys 18 GLP-1(8-38); Val 8 Arg 34 Lys 18 GLP-1(8-38); Val 8 Arg 26 Lys 18 GLP-1(8-39); Val 8 Arg 34 Lys 18 GLP-1(8-39); Val 8 Arg 26 Lys 23 GLP-1(8-36); Val 8 Arg 34 Lys 23 GLP-1(8-36); Val 8 Arg 26 Lys 23 GLP-1(8-37); Val 8 Arg 34 Lys 23 GLP-1(8-37); Val 8 Arg 26 Lys 23 GLP-1(8-38); Val 8 Arg 34 Lys 23 GLP-1(8-38); Val 8 Arg 26 Lys 23 GLP-1(8-39); Val 8 Arg 34 Lys 23 GLP-1(8-39); Val 8 Arg 26 Lys 27 GLP-1(8-36); Val 8 Arg 34 Lys 27 GLP-1(8-36); Val 8 Arg 26 Lys 27 GLP-1(8-37); Val 8 Arg 34 Lys 27 GLP-1(8-37); Val 8 Arg 26 Lys 27 GLP-1(8-38); Val 8 Arg 34 Lys 27 GLP-1(8-38); Val 8 Arg 26 Lys 27 GLP-1(8-39); Val 8 Arg 34 Lys 27 GLP-1(8-39); Val 8 Arg 26, 34 Lys 18,36 GLP-1(8-36); Val 8 Arg 26, 34 Lys 18 GLP-1(8-37); Val 8 Arg 26, 34 Lys 18,37 GLP-1(8-37); Val 8 Arg 26, 34 Lys 18,38 GLP-1(8-38); Val 8 Arg 26, 34 Lys 18,39 GLP-1(8-39); Val 8 Arg 26, 34 Lys 23,36 GLP-1(8-36); Val; 8 Arg 26, 34 Lys 23 GLP-1(8-37); Val 8 Arg 26, 34 Lys 23,37 GLP-1(8-37); Val 8 Arg 26, 34 Lys 23,38 GLP-1(8-38); Val 8 Arg 26, 34 Lys 23,39 GLP-1(8-39); Val 8 Arg 26, 34 Lys 27,36 GLP-1(8-36); Val 8 Arg 26, 34 Lys 27 GLP-1(8-37); Val 8 Arg 26, 34 Lys 27,37 GLP-1(8-37); Val 8 Arg 26, 34 Lys 27,38 GLP-1(8-38); or Val 8 Arg 26, 34 Lys 27,39 GLP-1(8-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -tetradecanoyl) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -tetradecanoyl) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -tetradecanoyl) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -tetradecanoyl) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N′-tetradecanoyl) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -tetradecanoyl) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -tetradecanoyl) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -tetradecanoyl) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -tetradecanoyl) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -tetradecanoyl) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -tetradecanoyl) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -tetradecanoyl) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -tetradecanoyl) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -tetradecanoyl) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -tetradecanoyl) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -tetradecanoyl) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -tetradecanoyl) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -tetradecanoyl) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -tetradecanoyl) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -tetradecanoyl) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -tetradecanoyl) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -tetradecanoyl) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -tetradecanoyl) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -tetradecanoyl) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -tetradecanoyl) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -tetradecanoyl) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -tetradecanoyl) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -tetradecanoyl) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -tetradecanoyl) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N 68 -tetradecanoyl) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -tetradecanoyl) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -tetradecanoyl) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -tetradecanoyl) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -tetradecanoyl) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -tetradecanoyl) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -tetradecanoyl) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -tetradecanoyl)Arg 34 GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -tetradecanoyl)Arg 34 GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -tetradecanoyl) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -tetradecanoyl) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -tetradecanoyl) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -tetradecanoyl)Arg 34 GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -tetradecanoyl)Arg 34 GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -tetradecanoyl) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 38 (N ε -tetradecanoyl) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -tetradecanoyl) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -tetradecanoyl) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -tetradecanoyl)Arg 34 GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -tetradecanoyl)Arg 34 GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -tetradecanoyl) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -tetradecanoyl) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -tetradecanoyl) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -tetradecanoyl)Arg 34 GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -tetradecanoyl)Arg 34 GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -tetradecanoyl) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -tetradecanoyl) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N 68 -(ω-carboxynonadecanoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N-(ω-carboxynonadecanoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N 68 -(ω-carboxynonadecanoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N 68 -(ω-carboxynonadecanoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N 68 -(ω-carboxynonadecanoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(ω-carboxynonadecanoyl))Arg 34 GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(ω-carboxynonadecanoyl))Arg 34 GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(ω-carboxynonadecanoyl))Arg 34 GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(ω-carboxynonadecanoyl))Arg 34 GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 38 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(ω-carboxynonadecanoyl))Arg 34 GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(ω-carboxynonadecanoyl))Arg 34 GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(ω-10 carboxynonadecanoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(ω-carboxynonadecanoyl))Arg 34 GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(ω-carboxynonadecanoyl))Arg 3 4 GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(7-3 0 deoxycholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N 68 -(7-deoxycholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N 68 -(7-deoxycholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(7-deoxycholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(7-deoxycholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(7-deoxycholoyl))Arg 34 GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(7-deoxycholoyl))Arg 3 4 GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(7-deoxycholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(7-10 deoxycholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(choloyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(choloyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(choloyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(choloyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(choloyl)) GLP-20 1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(choloyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(choloyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(7-deoxycholoyl))Arg 34 GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(7-deoxycholoyl))Arg 34 GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(7-deoxycholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 38 (N ε -(7-deoxycholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(7-deoxycholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(choloyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(choloyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N 68 -(choloyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(choloyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(choloyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(choloyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N 68 -(choloyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N 68 -(7-deoxycholoyl))Arg 34 GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(7-deoxycholoyl))Arg 34 GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(7-deoxycholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(7-deoxycholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(choloyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(choloyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(choloyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(choloyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(choloyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(choloyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(choloyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(7-deoxycholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(7-deoxycholoyl))Arg 34 GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(7-deoxycholoyl))Arg 34 GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(7-deoxycholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(7-deoxycholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(choloyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(choloyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(choloyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(choloyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(choloyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N 68 -(choloyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N-(choloyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(choloyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(choloyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(choloyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(choloyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(choloyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(choloyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(choloyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(choloyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(choloyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(choloyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(choloyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N 68 -(choloyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(choloyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(choloyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(choloyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(choloyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(choloyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(choloyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(choloyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(choloyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N 68 -(choloyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(choloyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(choloyl))Arg 34 GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(choloyl))Arg 34 GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(choloyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(choloyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(lithocholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(lithocholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(lithocholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(choloyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(choloyl))Arg 34 GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(choloyl))Arg 34 GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(choloyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 38 (N ε -(choloyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(choloyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(lithocholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(lithocholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(lithocholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(choloyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(choloyl))Arg 34 GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(choloyl))Arg 34 GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(choloyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(choloyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(lithocholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(lithocholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε (lithocholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(lithocholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(choloyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(choloyl))Arg 34 GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(choloyl))Arg 34 GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(choloyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(choloyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(lithocholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N 68 -(lithocholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(lithocholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(lithocholoyl)) GLP-30 1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(lithocholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(lithocholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-36).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(lithocholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(lithocholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(lithocholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-35).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(lithocholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Lys 34 (N ε -(lithocholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(lithocholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26, 34 -bis(N ε -(lithocholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Arg 26 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-36)amide.

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(lithocholoyl))Arg 34 GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(lithocholoyl))Arg 34 GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(lithocholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 38 (N ε -(lithocholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(lithocholoyl)) GLP-1(7-37).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(lithocholoyl))Arg 34 GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(lithocholoyl))Arg 34 GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(lithocholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 38 (N ε -(lithocholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(lithocholoyl)) GLP-1(7-38).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(lithocholoyl))Arg 34 GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(lithocholoyl))Arg 34 GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(lithocholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(lithocholoyl)) GLP-1(7-39).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26 Lys 34 (N ε -(lithocholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Lys 26 (N ε -(lithocholoyl))Arg 34 GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Lys 26 (N ε -(lithocholoyl))Arg 34 GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Arg 26, 34 Lys 36 (N ε -(lithocholoyl)) GLP-1(7-40).

In a further preferred embodiment, the GLP-1 derivative is Gly 8 Arg 26, 34 Lys 36 (N ε -(lithocholoyl)) GLP-1(7-40).

Other preferred embodiments will be described using the following abbreviations:

Glut=N ε -(γ-L-glutamyl)

Aspa=N ε -(β-L-asparagyl)

Glyc=N ε -glycyl

GAB=N ε -(α-(γ-aminobutanoyl)

ADod=N α -dodecanoyl

ATet=N α -tetradecanoyl

AHex=N α -hexadecanoyl

AOct=N α -octadecanoyl

ALit=N α -lithocholyl

GDod=N γ -dodecanoyl

GTet=N γ -tetradecanoyl

GHex=N γ -hexadecanoyl

GOct=N γ -octadecanoyl

GLit=N γ -lithocholyl

Other preferred GLP-1 derivatives of the present invention are:

Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-36); Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-36)amide; Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-37); Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-37); Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-37); Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-38); Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-38); Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-39); Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-39); Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Glut-ADod) GLP-13(7-38); Gly 8 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-36)amide Val 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-38); Val 8 Arg 34 Lys 26 -((Glut-ADod) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-37); Thr 8 Arg 26 Lys 34 (Glut-ADod) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Glut-ADod) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Glut-ADod) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod)-GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 (Glut-ADod) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ADod) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ADod) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ADod) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-37); Arg 26 Lys 23 -(Glut-ADod) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-37); Arg 26, 34 Lys 18 (Glut-ADod) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 (Glut-ADod) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 (Glut-ADod) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ADod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ADod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ADod) GLP-1(7-38);

Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-36); Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-36)amide; Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-37); Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-37); Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-37); Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-38); Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-38); Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-39); Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-39); Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Glut-ATet) GLP-l (7-38); Gly 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Glut-ATet)-GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Glut-ATet) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Thr 8 Arg 26 Lys 34 (Glut-ATet) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Glut-ATet) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-l (7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1-(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ATet) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ATet) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ATet) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-ATet) GLP-l (7-37); Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ATet)-GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ATet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ATet) GLP-1(7-38);

Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-36); Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-36); Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-36)amide; Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-37); Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-37); Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-38); Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-38); Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-39); Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-39); Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 (Glut-AHex) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Glut-M~ex) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Glut-AHex) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Glut-AHex) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Glut-A~ex) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 (Glut-AHex) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-A-ex) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-S(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex)-1 LP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AHex)GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-31(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AHex) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AHex) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AHex) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AHex) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Glut-AHex) GLP-l (7-36); Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AHex) GLP-1(7-38);

Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-36); Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-36)amide; Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-37); Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-37); Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-38); Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-38); Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-39); Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-39); Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Glut-AOct)-GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-37); Ser 8 Arg 34 Lys 34 -(Glut-AOct) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Glut-AOct) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Glut-AOct) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 (Glut-AOct) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AOct)-GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct)-GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-AOct) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-AOct) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-AOct) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -((Glut-AOct) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-11(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 8 -(Glut-AOct) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-AOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-AOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-AOct) GLP-1(7-38);

Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-36); Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-36)amide; Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-37); Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-37); Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-37); Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-38); Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-38); Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-39); Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-39); Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-36); Gly 3 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Gly 8 Arg 26 Lys 34 (Glut-ALit) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Ser 8 Arg 34 Lys 34 -(Glut-ALit) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 (Glut-ALit) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Glut-ALit) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Glut-ALit) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-l (7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glut-ALit) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glut-ALit) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glut-ALit) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glut-ALit) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-13(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-A~it) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-38);

Arg 26, 34 Lys 27 -Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 1 -(Glut-ALit) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glut-ALit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glut-ALit) GLP-1P(7-38);

Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1((7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glut-ALit) GLP-1(7-38);

Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-36); Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-36)amide; Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-37); Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-37); Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-38); Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-38); Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-39); Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-39); Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-L1(7-36); Gly 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-38); Ser 8 Arg 34 Lys 26 (Aspa-ADod ) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-4(7-39);

Thr 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 6(Aspa-ADod) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Aspa-ADod) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Aspa-ADod) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 (Aspa-ADod) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 (Aspa-ADod) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ADod) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ADod) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ADod) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa -ADod) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-l1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(C7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-37);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ADod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ADod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ADod) GLP-1(7-38); Thr 8 Asp 17 Arg26,34Lys 27 -(Aspa-ADod) GLP-1(7-38);

Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-36); Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-36)amide; Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-37); Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-37); Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-38); Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-38); Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-39); Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-39); Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Asps-ATet) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Aspa-ATet) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Aspa-ATet) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ATet) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ATet) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ATet) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ATet) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 (Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ATet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ATet) GLP-1(7-38);

Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-36); Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-36)amide; Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-37); Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-37); Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-38); Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-38); Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-39); Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-39); Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Aspa-26 ex) GLP-1(7-38), Val 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-A1(7-39);

Ser 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-l (7-36); Thr 8 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Aspa-AHex) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Aspa-AHex) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 (Aspa-AHex) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AHex) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AHex) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AHex) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36); Ser 8 Asp 19 Arg 26,34 Lys 23 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AHex) GLP-1(7-38);

Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-36); Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-36)amide; Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-37); Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-37); Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-37); Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-38); Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-38); Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-39); Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-39); Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Aspa-AOct)9GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 (Aspa-AOct) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Aspa-AOct) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Aspa-AOct) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 (Aspa-AOct) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Val 8 Glu37Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-AOct) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-AOct) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-AOct) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-AOct) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-l (7-37); Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-17(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-37); Ser 8 Asp 19 Arg 26,34 4 Lys 27 -(Aspa-AOct) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-AOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-AOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1p(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-AOct) GLP-1(7-38);

Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-36); Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-36); Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-36)amide; Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-37); Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-37); Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-38); Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-38); Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-39); Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-39); Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-36)amide;

Gly 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 (Aspa-ALit) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Aspa-ALit) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Aspa-ALit) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide;

Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Aspa-ALit) GLP-1(7-36)amide;

Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Aspa-ALit) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Aspa-ALit) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Aspa-ALit) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-38), Val 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-y(7-36); Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 18 (Aspa-ALit) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36) Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36)amide; Ser 8 Asp 27 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36); Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-L (7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-l (7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36); Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Aspa-ALit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-l (7-36); Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Aspa-ALit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36); Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-37); Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Aspa-ALit) GLP-1(7-38);

Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-36); Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-36)amide; Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-37); Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-37); Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-38); Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-38); Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-39); Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-39); Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Glyc-ADod) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Glyc-ADod) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ADod) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ADod) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ADod) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-38); Ser 3 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ADod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ADod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ADod) GLP-1(7-38);

Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-36); Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-36); Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-36)amide; Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-37); Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-37); Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-38); Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-38); Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-39); Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-39); Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-3 (7-36)amide; Gly 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Glyc-ATet)-GLP31(7-38); Val 8 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Glyc-ATet) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Glyc-ATet) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 (Glyc-ATet) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ATet) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ATet) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ATet) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-I(7-36); Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36) Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ATet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ATet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ATet) GLP-1(7-38);

Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-36); Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-36)amide; Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-37); Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-37); Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-37); Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-38); Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-38); Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-39); Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-39); Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Glyc-(ex) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Glyc-AHex) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Glyc-AHex) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-A-ex) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AHex) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AHex) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AHex) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-Hex) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AHex) GLP-1(7-38);

Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-36); Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-36)amide; Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-37); Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-37); Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-38); Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-38); Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-39); Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-39); Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-36); Ser 8 Arg 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Thr 8 Arg 26 Lys 34 (Glyc-AOct) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Glyc-AOct) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Glyc-AOct) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 (Glyc-AOct) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Gly 8 Glu38Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Ser 8 Glu 37 Arg 26,34Lys 38 -(Glyc-AOct) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide;

Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-AOct) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-AOct) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-AOct) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-AOct) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-AOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-l (7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-AOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-AOct) GLP-1(7-38);

Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-36); Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-36)amide; Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-37); Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-37); Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-38); Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-38); Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-39); Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-39); Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-t(7-39); Val 8 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(Glyc-ALit)-GLP1 (7-39);

Thr 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(Glyc-ALit) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(Glyc-ALit) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Val 8 Asp38Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-l (7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide;

Thr 8 Glu 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(Glyc-ALit) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(Glyc-ALit) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(Glyc-ALit) GLP-1(7-39);

Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-38);

Arg 26, 34 Lys 23 (Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 (Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-38);

Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-11(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(Glyc-ALit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(Glyc-ALit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36); Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-37); Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(Glyc-ALit) GLP-1(7-38);

Arg 26 Lys 34 -GAB-GDod) GLP-1(7-36); Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-36); Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-37) Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 26 -(GAB-GDod) GLP-1(7-37); Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-38); Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-38); Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-39); Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-39); Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(GAB-GDod ) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(GAB-GDod) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1((7-38); Thr 8 Arg 26 Lys 34 -(GAB-(GAB-GDod) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(GAB-GDod) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39); Gly 8 Glu35Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39) ;

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Thr 8 Glu37Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GDod) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GDod) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GDod) GLP-1(7-39);

Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36); Val 8 Asp 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB -GDod) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GDod) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GDod) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GDod) GLP-1(7-38);

Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-36); Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-36); Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-36)amide; Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-37); Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-37); Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-38); Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-38); Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-39); Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-39); Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-l (7-38); Val 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-38; Ser 8 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(GAB-GTet) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(GAB-GTet) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-3(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-)1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39);

Thr 8 Glu 35 Arg 26,34 Lys 36 -(GAB-GTet) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GTet) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GTet) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GTet) GLP-1(7-39);

Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-38); Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 (GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36): Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 18 (GAB-GTet) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GTet) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GTet) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GTet) GLP-1(7-38);

Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-36); Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-36)amide; Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-37); Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-37); Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-38); Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-38); Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-39); Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-39); Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(GAB-GHex) GLP-31(7-37); Val 8 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 (GAB-GHex) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-l (7-39);

Thr 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-l (7-38); Thr 8 Arg 26 Lys 34 -(GAB-GHex) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(GAB-GHex) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide;

Ser 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GHex) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GHex) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GHex) GLP-1(7-39);

Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-38);

Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36); Val 18 Asp 17 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-38);

Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-30 1(7-38);

Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-38);

Arg 26, 34 Lys 27 (GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-38);

Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GHex) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-38);

Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GHex) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Asp 17&l Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GHex) GLP-1(7-38);

Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-36); Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-36)amide; Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-37); Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-37); Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-38); Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-38); Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-39); Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-39); Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39); Ser 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-37); Ser 8 Arg 26 Lys 34 (GAB-GOct) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-36); Thr 8 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(GAB-GOct) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(GAB-GOct) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide;

Val 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GOct) GLP-t(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GOct) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GOct) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GOct) GLP-1(7-39); Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GOct)-GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 27 (GAB-GOct) GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-38);

Arg 26, 34 Lys 18 (GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-38);

Arg 26, 34 Lys 23 y(GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GOct) GLP-1(7-38);

Arg 26, 34 Lys 23 (GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GOct) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GOct) GLP-1(7-38);

Arg 26 Lys 34 (GAB-GLit) GLP-1(7-36); Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-36)amide; Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-37); Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-37); Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-38); Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-38); Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-39); Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-39); Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39);

Gly 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-36); Gly 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-36); Gly 8 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Gly 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-36)amide; Gly 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-36)amide; Gly 8 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Gly 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-37); Gly 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-37); Gly 8 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-37); Gly 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-38); Gly 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Gly 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-39); Gly 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39);

Val 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-36); Val 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-36); Val 8 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Val 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-37); Val 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-37); Val 8 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-37); Val 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-38); Val 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-38); Val 8 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Val 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-39); Val 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-39); Val 8 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39);

Ser 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-36); Ser 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-36); Ser 8 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Ser 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-37); Ser 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-37); Ser 8 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-37); Ser 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-38); Ser 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Ser 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-39); Ser 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39);

Thr 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-36); Thr 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Thr 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-37); Thr 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-37); Thr 8 Arg 26, 34 Lys 36 (GAB-GLit) GLP-1(7-37); Thr 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-38); Thr 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Thr 8 Arg 26 Lys 34 -(GAB-GLit) GLP-1(7-39); Thr 8 Arg 34 Lys 26 -(GAB-GLit) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39);

Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Gly 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-L1(7-36)amide; Gly 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Gly 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Gly 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-3(7-39);

Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Gly 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Gly 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Gly 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Gly 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39);

Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Val 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Val 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Val 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39);

Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Val 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Val 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Val 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39);

Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Ser 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Ser 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Ser 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39);

Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Ser 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Ser 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Ser 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39);

Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Thr 8 Glu 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Glu 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Thr 8 Glu 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Thr 8 Glu 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39);

Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36); Thr 8 Asp 35 Arg 26, 34 Lys 36 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Asp 36 Arg 26, 34 Lys 37 -(GAB-GLit) GLP-1(7-37); Thr 8 Asp 37 Arg 26, 34 Lys 38 -(GAB-GLit) GLP-1(7-38); Thr 8 Asp 38 Arg 26, 34 Lys 39 -(GAB-GLit) GLP-1(7-39);

Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1-(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-38); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36)amide; Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36)amide; Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-37); Gly 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-38); Gly 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-38); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36); Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36)amide; Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-37); Val 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-38); Val 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 18 -GAB-GLit) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-38); Arg 26, 34 Lys 23 -(GAB-GLit)-GLP-1 (7-36)

Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-38); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36)amide; Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-37); Ser 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-38); Ser 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-38);

Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys- 18 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 18 -(GAB-GLit) GLP-1(7-38);

Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 23 -(GAB-GLit) GLP-1(7-38);

Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36); Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36)amide; Arg 26, 34 Lys 27 (GAB-GLit) GLP-1(7-37); Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-38); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-36)amide; Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-37); Thr 8 Asp 19 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-38); Thr 8 Asp 17 Arg 26, 34 Lys 27 -(GAB-GLit) GLP-1(7-38);

Other preferred derivatives of GLP-1 analogs of the present invention are:

Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-36); Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-37); Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-38); Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(Glut-ADod) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Glut-ADod) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Glut-ADod) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Glut-ADod) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Glut-ADod) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Glut-ADod) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Glut-ADod) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Glut-ADod) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Glut-ADod) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Glut-ADod) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Glut-ADod) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Glut-ADod) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Glut-ADod) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Glut-ADod) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Glut-ADod) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Glut-ADod) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Glut-ADod) GLP-1(7-39); Arg 26 Lys 23, 34 -bis-(Glut-ADod) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Glut-ADod) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Glut-ADod) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Glut-ADod) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Glut-ADod) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Glut-ADod) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Glut-ADod) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Glut-ADod) GLP-1(7-39); Arg 26 Lys 27, 34 -bis-(Glut-ADod) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Glut-ADod) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Glut-ADod) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Glut-ADod) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Glut-ADod) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Glut-ADod) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Glut-ADod) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Glut-ADod) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-39) Gly 8 Arg 26 Lys 34,36 -bis-(Glut-ADod) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Glut-ADod) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Glut-ADod) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Glut-ADod) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Glut-ADod) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Glut-ADod) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Glut-ADod) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Glut-ADod) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Glut-ADod) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Glut-ADod) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Glut-ADod) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Glut-ADod) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-39) Val 8 Arg 26 Lys 34,36 -bis-(Glut-ADod) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Glut-ADod) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Glut-ADod) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Glut-ADod) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Glut-ADod) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Glut-ADod) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Glut-ADod) GLP-1(8-38); Val 8 Arg 34 Lys 26,38 -bis-(Glut-ADod) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Glut-ADod) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Glut-ADod) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Glut-ADod) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Glut-ADod) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-39) Ser 8 Arg 26 Lys 34,36 -bis-(Glut-ADod) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Glut-ADod) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Glut-ADod) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Glut-ADod) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Glut-ADod) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Glut-ADod) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Glut-ADod) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Glut-ADod) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Glut-ADod) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Glut-ADod) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Glut-ADod) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Glut-ADod) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Glut-ADod) GLP-1(7-39) Thr 8 Arg 26 Lys 34,36 -bis-(Glut-ADod) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Glut-ADod) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Glut-ADod) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Glut-ADod) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Glut-ADod) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Glut-ADod) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Glut-ADod) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Glut-ADod) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Glut-ADod) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Glut-ADod) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Glut-ADod) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Glut-ADod) GLP-1(7-39);

Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-36); Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-37); Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-38); Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(Glut-ATet) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Glut-ATet) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Glut-ATet) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Glut-ATet) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Glut-ATet) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Glut-ATet) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Glut-ATet) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Glut-ATet) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Glut-ATet) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Glut-ATet) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Glut-ATet) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Glut-ATet) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Glut-ATet) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Glut-ATet) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Glut-ATet) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Glut-ATet) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Glut-ATet) GLP-1(7-39); Arg 26 Lys 23, 34 -bis-(Glut-ATet) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Glut-ATet) GLP-1(7-36) Arg 26 Lys 23, 34 -bis-(Glut-ATet) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Glut-ATet) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Glut-ATet) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Glut-ATet) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Glut-ATet) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Glut-ATet) GLP-1(7-39);

Arg 26 Lys 27, 34 -bis-(Glut-ATet) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Glut-ATet) GLP-13(7-36); Arg 26 Lys 27, 34 -bis-(Glut-ATet) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Glut-ATet) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Glut-ATet) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Glut-ATet) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Glut-ATet) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Glut-ATet) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-39) Gly 8 Arg 26 Lys 34,36 -bis-(Glut-ATet) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Glut-ATet) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Glut-ATet) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Glut-ATet) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Glut-ATet) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Glut-ATet) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Glut-ATet) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Glut-ATet) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Glut-ATet) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Glut-ATet) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Glut-ATet) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Glut-ATet) GLP-1(7-39); Val 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(Glut-ATet) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Glut-ATet) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Glut-ATet) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Glut-ATet) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Glut-ATet) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Glut-ATet) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Glut-ATet) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Glut-ATet) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Glut-ATet) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Glut-ATet) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Glut-ATet) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Glut-ATet) GLP-1(7-39); Ser 8 Lys 26,34 =bis-(Glut-ATet) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7- 39)

Ser 8 Arg 26 Lys 34,36 -bis-(Glut-ATet) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Glut-ATet) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Glut-ATet) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Glut-ATet) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Glut-ATet) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Glut-ATet) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Glut-ATet) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Glut-ATet) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Glut-ATet) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Glut-ATet) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Glut-ATet) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Glut-ATet) GLP-1(7-39); Thr 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Glut-ATet) GLP-1(7-39) Thr 8 Arg 26 Lys 34,36 -bis-(Glut-ATet) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Glut-ATet) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Glut-ATet) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Glut-ATet) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Glut-ATet) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Glut-ATet) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Glut-ATet) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Glut-ATet) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Glut-ATet) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Glut-ATet) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Glut-ATet) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Glut-ATet) GLP-1(7-39); Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-36); Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-37); Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-38); Lys 26, 34 -bis-(Glut-AHex) GLP-13(7-39)

Arg 26 Lys 34,36 -bis-(Glut-AHex) GLP-1(7-36); Arg 34 Lys 26 ,36 -bis-(Glut-AHex) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Glut-AHex) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Glut-AHex) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Glut-AHex) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Glut-AHex) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Glut-AHex) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Glut-AHex) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Glut-AHex) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Glut-AHex) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Glut-AHex) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Glut-AHex) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Glut-AHex) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Glut-AHex) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Glut-AHex) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Glut-AHex) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Glut-AHex) GLP-1(7-39); Arg 26 Lys 23, 34 -bis-(Glut-AHex) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Glut-AHex) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Glut-AHex) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Glut-AHex) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Glut-AHex) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Glut-AHex) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Glut-AHex) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Glut-AHex) GLP-1(7-39); Arg 26 Lys 27, 34 -bis-(Glut-AHex) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Glut-AHex) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Glut-AHex) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Glut-AHex) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Glut-AHex) GLP-1(7-38); Arg 34 Lys 27,26 -bis-(Glut-AHex) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Glut-AHex) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Glut-AHex) GLP-1(7-39); Gly 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-39); Gly 8 Arg 26 Lys 34,36 -bis-(Glut-AHex) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Glut-AHex) GLP-1(7-36) Gly 8 Arg 26 Lys 34,36 -bis-(Glut-AHex) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Glut-AHex) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Glut-AHex) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Glut-AHex) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Glut-AHex) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Glut-AHex) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Glut-AHex) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Glut-AHex) GLP-11(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Glut-AHex) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Glut-AHex) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-39) Val 8 Arg 26 Lys 34,36 -bis-(Glut-AHex) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Glut-AHex) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Glut-AHex) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Glut-AHex) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Glut-AHex) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Glut-AHex) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Glut-AHex) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Glut-AHex) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Glut-AHex) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Glut-AHex) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Glut-AHex) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Glut-AHex) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-36); Ser 8 Lys 26,34 bis-(Glut-AHex) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-39) Ser 8 Arg 26 Lys 34,36 -bis-(Glut-AHex) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Glut-AHex) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Glut-AHex) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Glut-AHex) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Glut-AHex) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Glut-AHex) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Glut-AHex) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Glut-AHex) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Glut-AHex) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Glut-AHex) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Glut-AHex) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Glut-AHex) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Glut-AH ex) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Glut-AHex) GLP-1(7-39) Thr 8 Arg 26 Lys 34,36 -bis-(Glut-AHex) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Glut-AHex) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Glut-AHex) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Glut-M~ex) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Glut-AHex) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Glut-AHex) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Glut-AHex) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Glut-AHex) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Glut-AHex) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Glut-AHex) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Glut-AHex) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Glut-AHex) GLP-1(7-39);

Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-36); Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-37); Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-38); Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(Glut-AOct) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Glut-AOct) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Glut-AOct) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Glut-AOct) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Glut-AOct) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Glut-AOct) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Glut-AOct) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Glut-AOct) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Glut-AOct) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Glut-AOct) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Glut-AOct) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Glut-AOct) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Glut-AOct) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Glut-AOct) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Glut-AOct) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Glut-AOct) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Glut-AOct) GLP-1(7-39); Arg 26 Lys 23, 34 -bis-(Glut-AOct) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Glut-AOct) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Glut-AOct) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Glut-AOct) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Glut-AOct) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Glut-AOct) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Glut-AOct) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Glut-AOct) GLP-1(7-39); Arg 26 Lys 27, 34 -bis-(Glut-AOct) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Glut-AOct) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Glut-AOct) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Glut-AOct) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Glut-AOct) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Glut-AOct) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Glut-AOct) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Glut-AOct) GLP-1(7-39);

Gly 8 Lys 26,34 bis-(Glut-AOct) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-39) Gly 8 Arg 26 Lys 34,36 -bis-(Glut-AOct) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Glut-AOct) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Glut-AOct) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Glut-AOct) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Glut-AOct) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Glut-AOct) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Glut-AOct) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Glut-AOct) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Glut-AOct) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Glut-AOct) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Glut-AOct) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Glut-AOct) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-39) Val 8 Arg 26 Lys 34,36 -bis-(Glut-AOct) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Glut-AOct) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Glut-AOct) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Glut-AOct) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Glut-AOct) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Glut-AOct) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Glut-AOct) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Glut-AOct) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Glut-AOct) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Glut-AOct) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Glut-AOct) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Glut-AOct) GLP-1(7-39); Ser 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(Glut-AOct) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Glut-AOct) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Glut-AOct) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Glut-AOct) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Glut-AOct) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Glut-AOct) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Glut-AOct) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Glut-AOct) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Glut-AOct) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Glut-AOct) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Glut-AOct) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Glut-AOct) GLP-1(7-39); Thr 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Glut-AOct) GLP-1(7-39) Thr 8 Arg 26 Lys 34,36 -bis-(Glut-AOct) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Glut-AOct) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Glut-AOct) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Glut-AOct) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Glut-AOct) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Glut-AOct) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Glut-AOct) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Glut-AOct) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Glut-AOct) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Glut-AOct) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Glut-AOct) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Glut-AOct) GLP-1(7-39);

Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-36); Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-37); Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-38); Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(Glut-ALit) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Glut-ALit) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Glut-ALit) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Glut-ALit) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Glut-ALit) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Glut-ALit) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Glut-ALit) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Glut-ALit) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Glut-ALit) GLP-13(7-39);

Arg 26 Lys 18, 34 -bis-(Glut-ALit) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Glut-ALit) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Glut-ALit) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Glut-ALit) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Glut-ALit) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Glut-ALit) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Glut-ALit) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Glut-ALit) GLP-1(7-39); Arg 26 Lys 23, 34 -bis-(Glut-ALit) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Glut-ALit) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Glut-ALit) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Glut-ALit) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Glut-ALit) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Glut-ALit) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Glut-ALit) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Glut-ALit) GLP-1(7-39); Arg 26 Lys 27, 34 -bis-(Glut-ALit) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Glut-ALit) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Glut-ALit) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Glut-ALit) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Glut-ALit) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Glut-ALit) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Glut-ALit) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Glut-ALit) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-39)

Gly 8 Arg 26 Lys 34,36 -bis-(Glut-ALit) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Glut-ALit) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Glut-ALit) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Glut-ALit) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Glut-ALit) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Glut-ALit) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Glut-ALit) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Glut-ALit) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Glut-ALit) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Glut-ALit) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Glut-ALit) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Glut-ALit) GLP-1(7-39); Val 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(Glut-ALit) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Glut-ALit) GLP-1(C7-36); Val 8 Arg 26 Lys 34,36 -bis-(Glut-ALit) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Glut-ALit) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Glut-ALit) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Glut-ALit) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Glut-ALit) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Glut-ALit) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Glut-ALit) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Glut-ALit) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Glut-ALit) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Glut-ALit) GLP-1l(7-39); Ser 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(Glut-ALit) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Glut-ALit) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Glut-ALit) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Glut-ALit) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Glut-ALit) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Glut-ALit) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Glut-ALit) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Glut-ALit) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Glut-ALit) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Glut-ALit) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Glut-ALit) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Glut-ALit) GLP-1(7-39); Thr 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Glut-ALit) GLP-1(7-39)

Thr 8 Arg 26 Lys 34,36 -bis-(Glut-ALit) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Glut-ALit) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Glut-ALit) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Glut-ALit) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Glut-ALit) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Glut-ALit) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Glut-ALit) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Glut-ALit) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Glut-ALit) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Glut-ALit) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Glut-ALit) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Glut-ALit) GLP-1(7-39); Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-36); Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-37); Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-38); Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-39) Arg 26 Lys 34,36 -bis-(Aspa-ADod) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Aspa-ADod) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Aspa-ADod) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Aspa-ADod) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Aspa-ADod) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Aspa-ADod) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Aspa-ADod) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Aspa-ADod) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Aspa-ADod) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Aspa-ADod) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Aspa-ADod) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Aspa-ADod) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Aspa-ADod) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Aspa-ADod) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Aspa-ADod) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Aspa-ADod) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Aspa-ADod) GLP-1(7-39); Arg 26 Lys 23, 34 -bis-(Aspa-ADod) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Aspa-ADod) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Aspa-ADod) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Aspa-ADod) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Aspa-ADod) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Aspa-ADod) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Aspa-ADod) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Aspa-ADod) GLP-1(7-39); Arg 26 Lys 27, 34 -bis-(Aspa-ADod) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Aspa-ADod) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Aspa-ADod) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Aspa-ADod) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Aspa-ADod) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Aspa-ADod) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Aspa-ADod) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Aspa-ADod) GLP-1(7-39); Gly 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-39) Gly 8 Arg 26 Lys 34,36 -bis-(Aspa-ADod) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Aspa-ADod) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Aspa-ADod) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Aspa-ADod) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Aspa-ADod)-GLP)1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Aspa-ADod) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Aspa-ADod) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Aspa-ADod) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ADod) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Aspa-ADod) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Aspa-ADod) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-ADod) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-39) Val 8 Arg 26 Lys 34,36 -bis-(Aspa-ADod) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Aspa-ADod) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Aspa-ADod) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Aspa-ADod) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Aspa-ADod) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Aspa-ADod) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Aspa-ADod) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Aspa-ADod) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ADod) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Aspa-ADod) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Aspa-ADod) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-ADod) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-39) Ser 8 Arg 26 Lys 34,36 -bis-(Aspa-ADod) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Aspa-ADod) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Aspa-ADod) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Aspa-ADod) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Aspa-ADod) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Aspa-ADod) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Aspa-ADod) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Aspa-ADod) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ADod) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Aspa-ADod) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Aspa-ADod) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-ADod) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis(Aspa-ADod) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Aspa-ADod) GLP-1(7-39) Thr 8 Arg 26 Lys 34,36 -bis-(Aspa-ADod) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Aspa-ADod) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Aspa-ADod) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Aspa-ADod) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Aspa-ADod) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Aspa-ADod) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Aspa-ADod) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Aspa-ADod) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ADod) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Aspa-ADod) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Aspa-ADod) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ADod) GLP-1(7-39);

Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-36); Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-37); Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-38); Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(Aspa-ATet) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Aspa-ATet) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Aspa-ATet) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Aspa-ATet) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Aspa-ATet) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Aspa-ATet) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Aspa-ATet) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Aspa-ATet) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Aspa-ATet) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Aspa-ATet) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Aspa-ATet) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Aspa-ATet) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Aspa-ATet) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Aspa-ATet) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Aspa-ATet) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Aspa-ATet) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Aspa-ATet) GLP-1(7-39); Arg 26 Lys 23, 34 -bis-(Aspa-ATet) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Aspa-ATet) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Aspa-ATet) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Aspa-ATet) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Aspa-ATet) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Aspa-ATet) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Aspa-ATet) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Aspa-ATet) GLP-1(7-39);

Arg 26 Lys 27, 34 -bis-(Aspa-ATet) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Aspa-ATet) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Aspa-ATet) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Aspa-ATet) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Aspa-ATet) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Aspa-ATet) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Aspa-ATet) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Aspa-ATet) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-39)

Gly 8 Arg 26 Lys 34,36 -bis-(Aspa-ATet) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Aspa-ATet) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Aspa-ATet) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Aspa-ATet) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Aspa-ATet) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Aspa-ATet) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Aspa-ATet) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Aspa-ATet) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ATet) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Aspa-ATet) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Asps-ATet) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 26, 34 -bis-(Asps-ATet) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-39); Val 8 Arg 26 Lys 34,36 -bis-(Aspa-ATet) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Aspa-ATet) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Aspa-ATet) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Aspa-ATet) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Aspa-ATet) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Aspa-ATet) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Aspa-ATet) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Aspa-ATet) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ATet) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Aspa-ATet) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Aspa-ATet) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-ATet) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(Aspa-ATet) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Aspa-ATet) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Aspa-ATet) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Aspa-ATet) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Aspa-ATet) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Aspa-ATet) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Aspa-ATet) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Aspa-ATet) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ATet) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Aspa-ATet) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Aspa-ATet) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-ATet) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Aspa-ATet) GLP-1(7-39)

Thr 8 Arg 26 Lys 34,36 -bis-(Aspa-ATet) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Aspa-ATet) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Aspa-ATet) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Aspa-ATet) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Aspa-ATet) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Aspa-ATet) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Aspa-ATet) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Aspa-ATet) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ATet) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Aspa-ATet) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Aspa-ATet) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-ATet) GLP-1(7-39);

Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-36); Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-37); Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-38); Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(Aspa-AHex) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Aspa-AHex) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Aspa-AHex) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Aspa-AHex) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Aspa-AHex) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Aspa-AHex) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Aspa-AHex) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Aspa-AHex) GLP-1(7-39); Arg 26 Lys 36,39 -bis-(Aspa-AHex) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Aspa-AHex) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Aspa-AHex) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Aspa-AHex) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Aspa-AHex) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Aspa-AHex) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Aspa-AHex) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Aspa-AHex) GLP-1(7-39); Arg 34 Lys 18,,26 -bis-(Aspa-AHex) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(Aspa-AHex) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Aspa-AHex) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Aspa-AHex) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Aspa-AHex) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Aspa-AHex) GLP-1(7-38); Arg 26 Lys 23,26 -bis-(Aspa-AHex) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Aspa-AHex) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Aspa-AHex) GLP-1(7-39); Arg 26 Lys 27, 34 -bis-(Aspa-AHex) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Aspa-AHex) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Aspa-AHex) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Aspa-AHex) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Aspa-AHex) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Aspa-AHex) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Aspa-AHex) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Aspa-AHex) GLP-1(7-39); Gly 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-39) Gly 8 Arg 26 Lys 34,36 -bis-(Aspa-AHex) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Aspa-AHex) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Aspa-AHex) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Aspa-AHex) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Aspa-AHex) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Aspa-AHex) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Aspa-AHex) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Aspa-AHex) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-AHex) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Aspa-AHex) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Aspa-AHex) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-AHex) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-37); Val 8 Lys 26,34 bis-(Aspa-AHex) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(Aspa-AHex) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Aspa-AHex) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Aspa-AHex) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Aspa-AHex) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Aspa-AHex) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Aspa-AHex) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Aspa-AHex) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Aspa-AHex) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-A ex) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Aspa-AHex) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Aspa-AHex) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-AHex) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(Aspa-AHex) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Aspa-AHex) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Aspa-AHex) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Aspa-AHex) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Aspa-AHex) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Aspa-AHex) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Aspa-AHex) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Aspa-AHex) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-AHex) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Aspa-AHex) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Aspa-AHex) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-AHex) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Aspa-AHex) GLP-1(7-39)

Thr 8 Arg 26 Lys 34,36 -bis(Aspa-AHex) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Aspa-AHex) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Aspa-AHex) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Aspa-AHex) GLP-1(7-37); Thr 8 Arg 26 Lys 34 37 -bis-(Aspa-AHex) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Aspa-AHex) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Aspa-AHex) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Aspa-AHex) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-AHex) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Aspa-AHex) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Aspa-AHex) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-AHex) GLP-1(7-39);

Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-36); Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-37); Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-38); Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(Aspa-AOct) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Aspa-AOct) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Aspa-AOct) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Aspa-AOct) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Aspa-AOct) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Aspa-AOct) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Aspa-AOct) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Aspa-AOct) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Aspa-AOct) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Aspa-AOct) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Aspa-AOct) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Aspa-AOct) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Aspa-AOct) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Aspa-AOct) GLP-1(7-38); Arg 34 Lys 18,26 -bis -(Aspa -AOct )-G LP-1(7-38); Arg 26 Lys 18, 34 -bis-(Aspa-AOct) GLP-1(7-39); Arg 34 Lys 18,26 -bis -(Aspa -AOct) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(Aspa-AOct) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Aspa-AOct) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Aspa-AOct) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Aspa-AOct) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Aspa-AOct) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Aspa-AOct) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Aspa-AOct) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Aspa-AOct)L -1(7-39);

Arg 26 Lys 27, 34 -bis-(Aspa-AOct) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Aspa-AOct) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Aspa-AOct) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Aspa-AOct) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Aspa-AOct) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Aspa-AOct) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Aspa-AOct) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Aspa-AOct) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-39)

Gly 8 Arg 26 Lys 34,36 -bis-(Aspa-AOct) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Aspa-AOct) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Aspa-AOct) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Aspa-AOct) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Aspa-AOct) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Aspa-AOct) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Aspa-AOct) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Aspa-AOct) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-AOct) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Aspa-AOct) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Aspa-AOct) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-AOct) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-39) Val 8 Arg 26 Lys 34,36 -bis-(Aspa-AOct) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Aspa-AOct) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Aspa-AOct) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Aspa-AOct) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Aspa-AOct) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Aspa-AOct) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Aspa-AOct) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Aspa-AOct) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-AOct) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Aspa-AOct) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Aspa-AOct) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-AOct) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(Aspa-AOct) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Aspa-AOct) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Aspa-AOct) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Aspa-AOct) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Aspa-AOct) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Aspa-AOct) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Aspa-AOct) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Aspa-AOct) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-AOct) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Aspa-AOct) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Aspa-AOct) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-AOct) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Aspa-AOct) GLP-1(7-39) Thr 8 Arg 26 Lys 34,36 -bis-(Aspa-AOct) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Aspa-AOct) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Aspa-AOct) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Aspa-AOct) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Aspa-AOct) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Aspa-AOct) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Aspa-AOct) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Aspa-AOct) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-AOct) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Aspa-AOct) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Aspa-AOct) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-AOct) GLP-1(7-39);

Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-36); Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-37); Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-38); Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(Aspa-ALit) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Aspa-ALit) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Aspa-ALit) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Aspa-ALit) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Aspa-ALit) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Aspa-ALit) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Aspa-ALit) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Aspa-ALit) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Aspa-ALit) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Aspa-ALit) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Aspa-ALit) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Aspa-ALit) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Aspa-ALit) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Aspa-ALit) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Aspa-ALit) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Aspa-ALit) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Aspa-ALit) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(Aspa-ALit) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Aspa-ALit) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Aspa-ALit) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Aspa-ALit) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Aspa-ALit) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Aspa-ALit) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Aspa-ALit) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Aspa-ALit) GLP-1(7-39);

Arg 26 Lys 27, 34 -bis-(Aspa-ALit) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Aspa-ALit) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Aspa-ALit) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Aspa-ALit) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Aspa-ALit) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Aspa-ALit) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Aspa-ALit) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Aspa-ALit) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-39) Gly 8 Arg 26 Lys 34,36 -bis-(Aspa-ALit) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Aspa-ALit) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Aspa-ALit) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Aspa-ALit) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Aspa-ALit) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Aspa-ALit) GLP-1(7-38); Gly 8 Arg 26 Lys 34,38 -bis-(Aspa-ALit) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Aspa-ALit) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ALit) GLP-1(7-38); Gly 8 Arg 26 Lys 34,39 bis-(Aspa-ALit) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Aspa-ALit) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-ALit) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(Aspa-ALit) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Aspa-ALit) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Aspa-ALit) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Aspa-ALit) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Aspa-ALit) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Aspa-ALit) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Aspa-ALit) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Aspa-ALit) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ALit) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Aspa-ALit) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Aspa-ALit) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-ALit) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-39)

Ser 8 Arg 26 Lys 34 36 -bis-(Aspa-ALit) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Aspa-ALit) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Aspa-ALit) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Aspa-ALit) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Aspa-ALit) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Aspa-ALit) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Aspa-ALit) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Aspa-ALit) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ALit) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Aspa-ALit) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Aspa-ALit) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-ALit) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Aspa-ALit) GLP-1(7-39)

Thr 8 Arg 26 Lys 34,36 -bis-(Aspa-ALit) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Aspa-ALit) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Aspa-ALit) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Aspa-ALit) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Aspa-ALit) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Aspa-ALit) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Aspa-ALit) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Aspa-ALit) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Aspa-ALit) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Aspa-ALit) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Aspa-ALit) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Aspa-ALit) GLP-1(7-39);

Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-36); Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-37); Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-38); Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(Glyc-ADod) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Glyc-ADod) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Glyc-ADod) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Glyc-ADod) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Glyc-ADod) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Glyc-ADod) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Glyc-ADod) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Glyc-ADod) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Glyc-ADod) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Glyc-ADod) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Glyc-ADod) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Glyc-ADod) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Glyc-ADod) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Glyc-ADod) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Glyc-ADod) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Glyc-ADod) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Glyc-ADod) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(Glyc-ADod) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Glyc-ADod) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Glyc-ADod) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Glyc-ADod) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Glyc-ADod) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Glyc-ADod) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Glyc-ADod) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Glyc-ADod) GLP-1(7-39);

Arg 26 Lys 27, 34 -bis-(Glyc-ADod) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Glyc-ADod) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Glyc-ADod) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Glyc-ADod) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Glyc-ADod) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Glyc-ADod) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Glyc-ADod) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Glyc-ADod) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-39) Gly 8 Arg 26 Lys 34,36 -bis-(Glyc-ADod) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Glyc-ADod) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Glyc-ADod) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Glyc-ADod) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Glyc-ADod) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Glyc-ADod) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Glyc-ADod) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Glyc-ADod) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-ADod) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Glyc-ADod) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Glyc-ADod) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-ADod) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1-(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(Glyc-ADod) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Glyc-ADod) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Glyc-ADod) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Glyc-ADod) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Glyc-ADod) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Glyc-ADod) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Glyc-ADod) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Glyc-ADod) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-ADod) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Glyc-ADod) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Glyc-ADod) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-ADod) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-39) Ser 8 Arg 26 Lys 34,36 -bis-(Glyc-ADod) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Glyc-ADod) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Glyc-ADod) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Glyc-ADod) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Glyc-ADod) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Glyc-ADod) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Glyc-ADod) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Glyc-ADod) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-ADod) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Glyc-ADod) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Glyc-ADod) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-ADod) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-I(7-37); Thr 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Glyc-ADod) GLP-1(7-39) Thr 8 Arg 26 Lys 34,36 -bis-(Glyc-ADod) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Glyc-ADod) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Glyc-ADod) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Glyc-ADod) GLP-5 1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Glyc-ADod) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Glyc-ADod) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Glyc-ADod) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Glyc-ADod) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-ADod) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Glyc-ADod) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Glyc-ADod) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-ADod) GLP-1(7-39);

Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-36); Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-37); Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-38); Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(Glyc-ATet) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Glyc-ATet) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Glyc-ATet) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Glyc-ATet) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Glyc-ATet) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Glyc-ATet) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Glyc-ATet) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Glyc-ATet) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Glyc-ATet) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Glyc-ATet) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Glyc-ATet) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Glyc-ATet) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Glyc-ATet) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Glyc-ATet) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Glyc-ATet) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Glyc-ATet) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Glyc-ATet) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(Glyc-ATet) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Glyc-ATet) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Glyc-ATet) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Glyc-ATet) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Glyc-ATet) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Glyc-ATet) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Glyc-ATet) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Glyc-ATet) GLP-1(7-39);

Arg 26 Lys 27, 34 -bis-(Glyc-ATet) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Glyc-ATet) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Glyc-ATet) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Glyc-ATet) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Glyc-ATet) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Glyc-ATet) GLP-1(7-38); Arg 26 Lys 27,34 bis-(Glyc-ATet) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Glyc-ATet) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-36); Gly 8 Lys 26, 34 -bis -(Glyc-ATet) GLP-1(7-37) ; Gly 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-39)

Gly 8 Arg 26 Lys 34,36 -bis-(Glyc-ATet) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Glyc-ATet) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Glyc-ATet) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Glyc-ATet) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Glyc-ATet) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Glyc-ATet) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Glyc-ATet) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Glyc-ATet) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-ATet) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Glyc-ATet) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Glyc-ATet) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-ATet) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(Glyc-ATet) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Glyc-ATet) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Glyc-ATet) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Glyc-ATet) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Glyc-ATet) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Glyc-ATet) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Glyc-ATet) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Glyc-ATet) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-ATet) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Glyc-ATet) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Glyc-ATet) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-ATet) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(Glyc-ATet) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Glyc-ATet) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Glyc-ATet) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Glyc-ATet) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Glyc-ATet) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Glyc-ATet) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Glyc-ATet) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Glyc-ATet) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-ATet) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Glyc-ATet) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Glyc-ATet) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-ATet) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Glyc-ATet) GLP-1(7-39)

Thr 8 Arg 26 Lys 34,36 -bis-(Glyc-ATet) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Glyc-ATet) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Glyc-ATet) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Glyc-ATet) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Glyc-ATet) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Glyc-ATet) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Glyc-ATet) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Glyc-ATet) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-ATet) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Glyc-ATet) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Glyc-ATet) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-ATet) GLP-1(7-39);

Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-36); Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-37); Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-38); Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-39)

Arg 26 Lys 34,36 bis-(Glyc-AHex) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Glyc-AHex) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Glyc-AHex) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Glyc-AHex) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Glyc-AHex) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Glyc-AHex) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Glyc-AHex) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Glyc-AHex) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Glyc-AHex) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Glyc-AHex) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Glyc-AHex) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Glyc-AHex) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Glyc-AHex) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Glyc-AHex) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Glyc-AHex) GLP-1(7-38); Arg 26 Lys 18 34 -bis-(Glyc-AHex) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Glyc-AHex) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(Glyc-AHex) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Glyc-AHex) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Glyc-AHex) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Glyc-AHex) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Glyc-AHex) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Glyc-AHex) GLP-1(7-38); Arg 26 Lys 23,34 bis-(Glyc-AHex) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Glyc-AHex) GLP-1(7-39);

Arg 26 Lys 27, 34 -bis-(Glyc-AHex) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Glyc-AHex) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Glyc-AHex) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Glyc-AHex) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Glyc-AHex) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Glyc-AHex) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Glyc-AHex) GLP-1(7-39); Arg 34 Lys 27, 26 -bis -(Glyc-AHex) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-39)

Gly 8 Arg 26 Lys 34,36 -bis-(Glyc-AHex) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Glyc-AHex) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Glyc-AHex) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Glyc-AHex) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Glyc-AHex) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Glyc-AHex) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Glyc-AHex) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Glyc-AHex) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-AHex) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Glyc-AHex) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Glyc-AHex) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-AHex) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-)(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(Glyc-AHex) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Glyc-AHex) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Glyc-AHex) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Glyc-AHex) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Glyc-AHex) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Glyc-AHex) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Glyc-AHex) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Glyc-AHex) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-AHex) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Glyc-AHex) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Glyc-AHex) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-AHex) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(Glyc-AHex) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Glyc-AHex) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Glyc-AHex) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Glyc-AHex) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Glyc-AHex) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Glyc-AHex) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Glyc-AHex) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Glyc-AHex) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-AHex) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Glyc-AHex) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Glyc-AHex) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-AHex) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Glyc-AHex) GLP-1(7-39)

Thr 8 Arg 26 Lys 34,36 -bis-(Glyc-AHex) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Glyc-AHex) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Glyc-AHex) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Glyc-AHex) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Glyc-AHex) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Glyc-AHex) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Glyc-AHex) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Glyc-AHex) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-AHex) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Glyc-AHex) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Glyc-AHex) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-AHex) GLP-1(7-39);

Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-36); Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-37); Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-38); Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(Glyc-AOct) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Glyc-AOct) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Glyc-AOct) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Glyc-AOct) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Glyc-AOct) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Glyc-AOct) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Glyc-AOct) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Glyc-AOct) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Glyc-AOct) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Glyc-AOct) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Glyc-AOct) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Glyc-AOct) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Glyc-AOct) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Glyc-AOct) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Glyc-AOct) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Glyc-AOct) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Glyc-AOct) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(Glyc-AOct) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Glyc-AOct) GLP-l (7-36); Arg 26 Lys 23, 34 -bis-(Glyc-AOct) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Glyc-AOct) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Glyc-AOct) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Glyc-AOct) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Glyc-AOct) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Glyc-AOct) GLP-1(7-39);

Arg 26 Lys 27, 34 -bis-(Glyc-AOct) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Glyc-AOct) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Glyc-AOct) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Glyc-AOct) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Glyc-AOct) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Glyc-AOct) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Glyc-AOct) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Glyc-AOct) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-39)

Gly 8 Arg 26 Lys 34,36 -bis-(Glyc-AOct) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Glyc-AOct) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Glyc-AOct) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Glyc-AOct) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Glyc-AOct) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Glyc-AOct) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Glyc-AOct) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Glyc-AOct) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-AOct) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Glyc-AOct) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Glyc-AOct) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-AOct) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(Glyc-AOct) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Glyc-AOct) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Glyc-AOct) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Glyc-AOct) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Glyc-AOct) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Glyc-AOct) GLP-1(7-37); Val 8 Arg 26 Lys 34 38 -bis-(Glyc-AOct) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Glyc-AOct) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-AOct) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Glyc-AOct) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Glyc-AOct) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-AOct) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(Glyc-AOct) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Glyc-AOct) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Glyc-AOct) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Glyc-AOct) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Glyc-AOct) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Glyc-AOct) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Glyc-AOct) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Glyc-AOct) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-AOct) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Glyc-AOct) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Glyc-AOct) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-AOct) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Glyc-AOct) GLP-1(7-39)

Thr 8 Arg 26 Lys 34,36 -bis-(Glyc-AOct) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Glyc-AOct) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Glyc-AOct) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Glyc-AOct) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Glyc-AOct) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Glyc-AOct) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Glyc-AOct) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Glyc-AOct) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-AOct) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Glyc-AOct) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Glyc-AOct) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-AOct) GLP-1(7-39);

Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-36); Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-37); Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-38); Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(Glyc-ALit) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(Glyc-ALit) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(Glyc-ALit) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(Glyc-ALit) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(Glyc-ALit) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(Glyc-ALit) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(Glyc-ALit) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(Glyc-ALit) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(Glyc-ALit) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(Glyc-ALit) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(Glyc-ALit) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(Glyc-ALit) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(Glyc-ALit) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(Glyc-ALit) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(Glyc-ALit) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(Glyc-ALit) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(Glyc-ALit) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(Glyc-ALit) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(Glyc-ALit) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(Glyc-ALit) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(Glyc-ALit) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(Glyc-ALit) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(Glyc-ALit) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(Glyc-ALit) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(Glyc-ALit) GLP-1(7-39);

Arg 26 Lys 27 34 -bis-(Glyc-ALit) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(Glyc-ALit) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(Glyc-ALit) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(Glyc-ALit) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(Glyc-ALit) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(Glyc-ALit) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(Glyc-ALit) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(Glyc-ALit) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-39)

Gly 8 Arg 26 Lys 34,36 -bis-(Glyc-ALit) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(Glyc-ALit) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(Glyc-ALit) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(Glyc-ALit) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(Glyc-ALit) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(Glyc-ALit) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(Glyc-ALit) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(Glyc-ALit) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-ALit) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(Glyc-ALit) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(Glyc-ALit) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-ALit) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(Glyc-ALit) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(Glyc-ALit) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(Glyc-ALit) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(Glyc-ALit) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(Glyc-ALit) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(Glyc-ALit) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(Glyc-ALit) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(Glyc-ALit) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-ALit) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(Glyc-ALit) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(Glyc-ALit) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-ALit) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(Glyc-ALit) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(Glyc-ALit) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(Glyc-ALit) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(Glyc-ALit) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(Glyc-ALit) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(Glyc-ALit) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(Glyc-ALit) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(Glyc-ALit) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-ALit) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(Glyc-ALit) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(Glyc-ALit) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-ALit) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(Glyc-ALit) GLP-1(7-39) Thr 8 Arg 26 Lys 34,36 -bis-(Glyc-ALit) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(Glyc-ALit) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(Glyc-ALit) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(Glyc-ALit) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(Glyc-ALit) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(Glyc-ALit) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(Glyc-ALit) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(Glyc-ALit) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(Glyc-ALit) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(Glyc-ALit) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(Glyc-ALit) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(Glyc-ALit) GLP-1(7-39);

Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-36); Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-37); Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-38); Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(GAB-GDod) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(GAB-GDod) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(GAB-GDod) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(GAB-GDod) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(GAB-GDod) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(GAB-GDod) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(GAB-GDod) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(GAB-GDod) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(GAB-GDod) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(GAB-GDod) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(GAB-GDod) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(GAB-GDod) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(GAB-GDod) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(GAB-GDod) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(GAB-GDod) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(GAB-GDod) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(GAB-GDod) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(GAB-GDod) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(GAB-GDod) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(GAB-GDod) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(GAB-GDod) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(GAB-GDod) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(GAB-GDod) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(GAB-GDod) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(GAB-GDod) GLP-1(7-39);

Arg 26 Lys 27, 34 -bis-(GAB-GDod) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(GAB-GDod) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(GAB-GDod) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(GAB-GDod) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(GAB-GDod) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(GAB-GDod) GLP-1(7-38); Arg 26 Lys 27,34 bis-(GAB-GDod) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(GAB-GDod) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-39)

Gly 8 Arg 26 Lys 34,36 -bis-(GAB-GDod) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(GAB-GDod) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(GAB-GDod) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(GAB-GDod) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(GAB-GDod) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(GAB-GDod) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(GAB-GDod) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(GAB-GDod) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GDod) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(GAB-GDod) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(GAB-GDod) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GDod) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-39) Val 8 Arg 26 Lys 34,36 -bis-(GAB-GDod) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(GAB-GDod) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(GAB-GDod) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(GAB-GDod) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(GAB-GDod) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(GAB-GDod) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(GAB-GDod) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(GAB-GDod) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GDod) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(GAB-GDod) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(GAB-GDod) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GDod) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(GAB-GDod) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(GAB-GDod) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(GAB-GDod) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(GAB-GDod) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(GAB-GDod) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(GAB-GDod) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(GAB-GDod) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(GAB-GDod) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GDod) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(GAB-GDod) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(GAB-GDod) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GDod) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(GAB-GDod) GLP-1(7-39)

Thr 8 Arg 26 Lys 34,36 -bis-(GAB-GDod) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(GAB-GDod) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(GAB-GDod) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(GAB-GDod) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(GAB-GDod) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(GAB-GDod) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(GAB-GDod) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(GAB-GDod) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GDod) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(GAB-GDod) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(GAB-GDod) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GDod) GLP-1(7-39);

Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-36); Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-37); Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-38); Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(GAB-GTet) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(GAB-GTet) GLP-1(7 36); Arg 26 Lys 34,36 -bis-(GAB-GTet) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(GAB-GTet) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(GAB-GTet) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(GAB-GTet) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(GAB-GTet) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(GAB-GTet) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(GAB-GTet) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(GAB-GTet) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(GAB-GTet) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(GAB-GTet) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(GAB-GTet) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(GAB-GTet) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(GAB-GTet) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(GAB-GTet) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(GAB-GTet) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(GAB-GTet) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(GAB-GTet) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(GAB-GTet) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(GAB-GTet) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(GAB-GTet) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(GAB-GTet) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(GAB-GTet) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(GAB-GTet) GLP-1(7-39);

Arg 26 Lys 27, 34 -bis-(GAB-GTet) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(GAB-GTet) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(GAB-GTet) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(GAB-GTet) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(GAB-GTet) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(GAB-GTet) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(GAB-GTet) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(GAB-GTet) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-39)

Gly 8 Arg 26 Lys 34,36 -bis-(GAB-GTet) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(GAB-GTet) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(GAB-GTet) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(GAB-GTet) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(GAB-GTet) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(GAB-GTet) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(GAB-GTet) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(GAB-GTet) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GTet) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(GAB-GTet) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(GAB-GTet) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GTet) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(GAB-GTet) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(GAB-GTet) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(GAB-GTet) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(GAB-GTet) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(GAB-GTet GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(GAB-GTet) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(GAB-GTet) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(GAB-GTet) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GTet) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(GAB-GTet) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(GAB-GTet) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GTet) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(GAB-GTet) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(GAB-GTet) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(GAB-GTet) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(GAB-GTet) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(GAB-GTet) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(GAB-GTet) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(GAB-GTet) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(GAB-GTet) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GTet) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(GAB-GTet) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(GAB-GTet) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GTet) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(GAB-GTet) GLP-1(7-39)

Thr 8 Arg 26 Lys 34,36 -bis-(GAB-GTet) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(GAB-GTet) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(GAB-GTet) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(GAB-GTet) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(GAB-GTet) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(GAB-GTet) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(GAB-GTet) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(GAB-GTet) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GTet) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(GAB-GTet) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(GAB-GTet) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GTet) GLP-1(7-39);

Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-36); Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-37); Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-38); Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(GAB-GHex) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(GAB-GHex) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(GAB-GHex) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(GAB-GHex) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(GAB-GHex) GLP-1(7-37); Arg 34 Lys 26,37 bis-(GAB-GHex) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(GAB-GHex) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(GAB-GHex) GLP-i(7-39); Arg 26, 34 Lys 36,39 -bis-(GAB-GHex) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(GAB-GHex) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(GAB-GHex) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(GAB-GHex) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(GAB-GHex) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(GAB-GHex) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(GAB-GHex) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(GAB-GHex) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(GAB-GHex) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(GAB-GHex) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(GAB-GHex) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(GAB-GHex) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(GAB-GHex) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(GAB-GHex) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(GAB-GHex) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(GAB-GHex) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(GAB-GHex) GLP-1(7-39);

Arg 26 Lys 27, 34 -bis-(GAB-GHex) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(GAB-GHex) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(GAB-GHex) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(GAB-GHex) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(GAB-GHex) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(GAB-GHex) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(GAB-GHex) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(GAB-GHex) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-36); Gly 8 Lys 26,34 bis-(GAB-GHex) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-39)

Gly 8 Arg 26 Lys 34,36 -bis-(GAB-GHex) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(GAB-GHex) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(GAB-GHex) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(GAB-GHex) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(GAB-GHex) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(GAB-GHex) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(GAB-GHex) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(GAB-GHex) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GHex) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(GAB-GHex) GLP-1(7-39); Gly 8 Arg 34 Lys- 26,39 -bis-(GAB-GHex) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GHex) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(GAB-GHex) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(GAB-GHex) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(GAB-GHex) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(GAB-GHex) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(GAB-GHex) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(GAB-GHex) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(GAB-GHex) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(GAB-GHex) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GHex) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(GAB-GHex) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(GAB-GHex) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GHex) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-39) Ser 8 Arg 26 Lys 34,36 -bis-(GAB-GHex) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(GAB-GHex) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(GAB-GHex) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(GAB-GHex) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(GAB-GHex) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(GAB-GHex) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(GAB-GHex) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(GAB-GHex) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GHex) GLP-1(7-38); Ser 8 Arg 34 Lys 34, 39 -bis-(GAB-GHex) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(GAB-GHex) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GHex) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(GAB-GHex) GLP-1(7-39) Thr 8 Arg 26 Lys 34,36 -bis-(GAB-GHex) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(GAB-GHex) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(GAB-GHex) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(GAB-GHex) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(GAB-GHex) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(GAB-GHex) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 bis-(GAB-GHex) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(GAB-GHex) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GHex) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(GAB-GHex) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(GAB-GHex) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GHex) GLP-1(7-39);

Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-36); Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-37); Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-38); Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(GAB-GOct) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(GAB-GOct) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(GAB-GOct) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(GAB-GOct) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(GAB-GOct) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(GAB-GOct) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(GAB-GOct) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(GAB-GOct) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(GAB-GOct) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(GAB-GOct) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(GAB-GOct) GLP-1(7-36); Arg 26 Lys 18,34 bis-(GAB-GOct) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(GAB-GOct) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(GAB-GOct) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(GAB-GOct) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(GAB-GOct) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(GAB-GOct) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(GAB-GOct) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(GAB-GOct) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(GAB-GOct) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(GAB-GOct) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(GAB-GOct) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(GAB-GOct) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(GAB-GOct) GLP-1(7-39); Arg 34 Lys 23,26 -bis-(GAB-GOct) GLP-1(7-39);

Arg 26 Lys 27, 34 -bis-(GAB-GOct) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(GAB-GOct) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(GAB-GOct) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(GAB-GOct) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(GAB-GOct) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(GAB-GOct) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(GAB-GOct) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(GAB-GOct) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-39)

Gly 8 Arg 26 Lys 34,36 -bis-(GAB-GOct) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(GAB-GOct) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(GAB-GOct) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(GAB-GOct-GG1P-3(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(GAB-GOct) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(GAB-GOct) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(GAB-GOct) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(GAB-GOct) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GOct) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(GAB-GOct) GLP-1(7-39); Gly 8 Arg 34 Lys 26,39 -bis-(GAB-GOct) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GOct) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(GAB-GOct) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(GAB-GOct) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(GAB-GOct) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(GAB-GOct) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(GAB-GOct) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(GAB-GOct) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(GAB-GOct) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(GAB-GOct) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GOct) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(GAB-GOct) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(GAB-GOct) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GOct) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(GAB-GOct) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(GAB-GOct) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(GAB-GOct) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(GAB-GOct) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(GAB-GOct) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(GAB-GOct) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(GAB-GOct) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(GAB-GOct) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GOct) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(GAB-GOct) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(GAB-GOct) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GOct) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(GAB-GOct) GLP-1(7-39)

Thr 8 Arg 26 Lys 34,36 -bis-(GAB-GOct) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(GAB-GOct) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(GAB-GOct) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(GAB-GOct) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(GAB-GOct) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(GAB-GOct) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(GAB-GOct) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(GAB-GOct) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GOct) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(GAB-GOct) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(GAB-GOct) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GOct) GLP-1(7-39);

Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-36); Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-37); Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-38); Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-39)

Arg 26 Lys 34,36 -bis-(GAB-GLit) GLP-1(7-36); Arg 34 Lys 26, 36 -bis-(GAB-GLit) GLP-1(7-36); Arg 26 Lys 34,36 -bis-(GAB-GLit) GLP-1(7-37); Arg 34 Lys 26, 36 -bis-(GAB-GLit) GLP-1(7-37); Arg 26 Lys 34,37 -bis-(GAB-GLit) GLP-1(7-37); Arg 34 Lys 26,37 -bis-(GAB-GLit) GLP-1(7-37); Arg 26 Lys 34, 39 -bis-(GAB-GLit) GLP-1(7-39); Arg 34 Lys 26,39 -bis-(GAB-GLit) GLP-1(7-39); Arg 26, 34 Lys 36,39 -bis-(GAB-GLit) GLP-1(7-39);

Arg 26 Lys 18, 34 -bis-(GAB-GLit) GLP-1(7-36); Arg 34 Lys 18,26 -bis-(GAB-GLit) GLP-1(7-36); Arg 26 Lys 18, 34 -bis-(GAB-GLit) GLP-1(7-37); Arg 34 Lys 18,26 -bis-(GAB-GLit) GLP-1(7-37); Arg 26 Lys 18, 34 -bis-(GAB-GLit) GLP-1(7-38); Arg 34 Lys 18,26 -bis-(GAB-GLit) GLP-1(7-38); Arg 26 Lys 18, 34 -bis-(GAB-GLit) GLP-1(7-39); Arg 34 Lys 18,26 -bis-(GAB-GLit) GLP-1(7-39);

Arg 26 Lys 23, 34 -bis-(GAB-GLit) GLP-1(7-36); Arg 34 Lys 23,26 -bis-(GAB-GLit) GLP-1(7-36); Arg 26 Lys 23, 34 -bis-(GAB-GLit) GLP-1(7-37); Arg 34 Lys 23,26 -bis-(GAB-GLit) GLP-1(7-37); Arg 26 Lys 23, 34 -bis-(GAB-GLit) GLP-1(7-38); Arg 34 Lys 23,26 -bis-(GAB-GLit) GLP-1(7-38); Arg 26 Lys 23, 34 -bis-(GAB-GLit) GLP-1(7-39); Arg 34 Lys 23,26 -bis2(GAB-GLit) GLP-1(7-39);

Arg 26 Lys 27, 34 -bis-(GAB-GLit) GLP-1(7-36); Arg 34 Lys 27, 26 -bis-(GAB-GLit) GLP-1(7-36); Arg 26 Lys 27, 34 -bis-(GAB-GLit) GLP-1(7-37); Arg 34 Lys 27, 26 -bis-(GAB-GLit) GLP-1(7-37); Arg 26 Lys 27, 34 -bis-(GAB-GLit) GLP-1(7-38); Arg 34 Lys 27, 26 -bis-(GAB-GLit) GLP-1(7-38); Arg 26 Lys 27, 34 -bis-(GAB-GLit) GLP-1(7-39); Arg 34 Lys 27, 26 -bis-(GAB-G Lit) GLP-1(7-39);

Gly 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-36); Gly 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-37); Gly 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-38); Gly 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-39)

Gly 8 Arg 26 Lys 34,36 -bis-(GAB-GLit) GLP-1(7-36); Gly 8 Arg 34 Lys 26, 36 -bis-(GAB-GLit) GLP-1(7-36); Gly 8 Arg 26 Lys 34,36 -bis-(GAB-GLit) GLP-1(7-37); Gly 8 Arg 34 Lys 26, 36 -bis-(GAB-GLit) GLP-1(7-37); Gly 8 Arg 26 Lys 34,37 -bis-(GAB-GLit) GLP-1(7-37); Gly 8 Arg 34 Lys 26,37 -bis-(GAB-GLit) GLP-1(7-37); Gly 8 Arg 26 Lys 34,38 -bis-(GAB-GLit) GLP-1(7-38); Gly 8 Arg 34 Lys 26,38 -bis-(GAB-GLit) GLP-1(7-38); Gly 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GLit) GLP-1(7-38); Gly 8 Arg 26 Lys 34, 39 -bis-(GAB-GLit) GLP-1(7l-39); Gly 8 Arg 34 Lys 26,39 -bis-(GAB-GLit) GLP-1(7-39); Gly 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GLit) GLP-1(7-39);

Val 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-36); Val 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-37); Val 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-38); Val 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-39)

Val 8 Arg 26 Lys 34,36 -bis-(GAB-GLit) GLP-1(7-36); Val 8 Arg 34 Lys 26, 36 -bis-(GAB-GLit) GLP-1(7-36); Val 8 Arg 26 Lys 34,36 -bis-(GAB-GLit) GLP-1(7-37); Val 8 Arg 34 Lys 26, 36 -bis-(GAB-GLit) GLP-1(7-37); Val 8 Arg 26 Lys 34,37 -bis-(GAB-GLit) GLP-1(7-37); Val 8 Arg 34 Lys 26,37 -bis-(GAB-GLit) GLP-1(7-37); Val 8 Arg 26 Lys 34,38 -bis-(GAB-GLit) GLP-1(7-38); Val 8 Arg 34 Lys 26,38 -bis-(GAB-GLit) GLP-1(7-38); Val 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GLit) GLP-1(7-38); Val 8 Arg 26 Lys 34, 39 -bis-(GAB-GLit) GLP-1(7-39); Val 8 Arg 34 Lys 26,39 -bis-(GAB-GLit) GLP-1(7-39); Val 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GLit) GLP-1(7-39);

Ser 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-36); Ser 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-37); Ser 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-38); Ser 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-39)

Ser 8 Arg 26 Lys 34,36 -bis-(GAB-GLit) GLP-1(7-36); Ser 8 Arg 34 Lys 26, 36 -bis-(GAB-GLit) GLP-1(7-36); Ser 8 Arg 26 Lys 34,36 -bis-(GAB-GLit) GLP-1(7-37); Ser 8 Arg 34 Lys 26, 36 -bis-(GAB-GLit) GLP-1(7-37); Ser 8 Arg 26 Lys 34,37 -bis-(GAB-GLit) GLP-1(7-37); Ser 8 Arg 34 Lys 26,37 -bis-(GAB-GLit) GLP-1(7-37); Ser 8 Arg 26 Lys 34,38 -bis-(GAB-GLit) GLP-1(7-38); Ser 8 Arg 34 Lys 26,38 -bis-(GAB-GLit) GLP-1(7-38); Ser 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GLit) GLP-1(7-38); Ser 8 Arg 26 Lys 34, 39 -bis-(GAB-GLit) GLP-1(7-39); Ser 8 Arg 34 Lys 26,39 -bis-(GAB-GLit) GLP-1(7-39); Ser 8 Arg 26, 34 Lys 36,39 bis-(GAB-GLit) GLP-1(7-39);

Thr 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-36); Thr 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-37); Thr 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-38); Thr 8 Lys 26, 34 -bis-(GAB-GLit) GLP-1(7-39)

Thr 8 Arg 26 Lys 34,36 -bis-(GAB-GLit) GLP-1(7-36); Thr 8 Arg 34 Lys 26, 36 -bis-(GAB-GLit) GLP-1(7-36); Thr 8 Arg 26 Lys 34,36 -bis-(GAB-GLit) GLP-1(7-37); Thr 8 Arg 34 Lys 26, 36 -bis-(GAB-GLit) GLP-1(7-37); Thr 8 Arg 26 Lys 34,37 -bis-(GAB-GLit) GLP-1(7-37); Thr 8 Arg 34 Lys 26,37 -bis-(GAB-GLit) GLP-1(7-37); Thr 8 Arg 26 Lys 34,38 -bis-(GAB-GLit) GLP-1(7-38); Thr 8 Arg 34 Lys 26,38 -bis-(GAB-GLit) GLP-1(7-38); Thr 8 Arg 26, 34 Lys 36,38 -bis-(GAB-GLit) GLP-1(7-38); Thr 8 Arg 26 Lys 34, 39 -bis-(GAB-GLit) GLP-1(7-39); Thr 8 Arg 34 Lys 26,39 -bis-(GAB-GLit) GLP-1(7-39); Thr 8 Arg 26, 34 Lys 36,39 -bis-(GAB-GLit) GLP-1(7-39).

Pharmaceutical Compositions

The present invention also relates to pharmaceutical compositions comprising a GLP-1 derivative of the present invention and a pharmaceutically acceptable vehicle or carrier.

Preferably, the pharmaceutical compositions comprise an isotonic agent, a preservative and a buffer. Examples of isotonic agents are sodium chloride, mannitol and glycerol. Examples of preservatives are phenol, m-cresol, methyl p-hydroxybenzoate and benzyl alcohol. Suitable buffers include sodium acetate and sodium phosphate.

The pharmaceutical compositions preferably further comprise a surfactant in order to improve the solubility and/or the stability of the GLP-1 derivative. Individual embodiments of the surfactant, such as a detergent, for use in the pharmaceutical composition of the invention include ethoxylated castor oil, polyglycolyzed glycerides, acetylated monoglycerides, sorbitan fatty acid esters, poloxamers, such as 188 and 407, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene derivatives such as alkylated and alkoxylated derivatives (tweens, e.g. Tween-20), monoglycerides or ethoxylated derivatives thereof, diglycerides or polyoxyethylene derivatives thereof, glycerol, cholic acid or derivatives thereof, lecithins, alcohols and phospholipids, glycerophospholipids (lecithins, kephalins, phosphatidyl serine), glyceroglycolipids (galactopyransoide), sphingophospholipids (sphingomyelin), and sphingoglycolipids (ceramides, gangliosides), DSS (docusate sodium, CAS registry no [577-11-7]), docusate calcium, CAS registry no [128-49-4]), docusate potassium, CAS registry no [7491-09-0]), SDS (sodium dodecyl sulfate or sodium lauryl sulfate), dipalmitoyl phosphatidic acid, sodium caprylate, bile acids and salts thereof and glycine or taurine conjugates, ursodeoxycholic acid, sodium cholate, sodium deoxycholate, sodium taurocholate, sodium glycocholate, N-Hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate, anionic (alkyl-aryl-sulphonates) monovalent surfactants, palmitoyl lysophosphatidyl-L-serine, lysophospholipids (e.g. 1-acyl-sn-glycero-3-phosphate esters of ethanolamine, choline, serine or threonine), alkyl, alkoxyl (alkyl ester), alkoxy (alkyl ether)-derivatives of lysophosphatidyl and phosphatidylcholines, e.g. lauroyl and myristoyl derivatives of lysophosphatidylcholine, dipalmitoylphosphatidylcholine, and modifications of the polar head group, that is cholines, ethanolamines, phosphatidic acid, serines, threonines, glycerol, inositol, and the postively charged DODAC, DOTMA, DCP, BISHOP, lysophosphatidylserine and lysophosphatidylthreonine, zwitterionic surfactants (e.g. N-alkyl-N,N-dimethylammonio-1-propanesulfonates, 3-cholamido-1-propyldimethylammonio-1-propanesulfonate, dodecylphosphocholine, myristoyl lysophosphatidylcholine, hen egg lysolecithin), cationic surfactants (quarternary ammonium bases) (e.g. cetyltrimethylammonium bromide, cetylpyridinium chloride), non-ionic surfactants, polyethyleneoxide/polypropyleneoxide block copolymers (Pluronics/Tetronics, Triton X-100, Dodecyl β-D-glucopyranoside) or polymeric surfactants (Tween-40, Tween-80, Brij-35). Other preferred surfactants include fusidic acid derivatives-(e.g. sodium tauro-dihydrofusidate etc.), long-chain fatty acids and salts thereof C6-C12(eg. oleic acid and caprylic acid), acylcarnitines and derivatives, N α -acylated derivatives of lysine, arginine or histidine, or side-chain acylated derivatives of lysine or arginine, N α -acylated derivatives of dipeptides comprising any combination of lysine, arginine or histidine and a neutral or acidic amino acid, N α -acylated derivative of a tripeptide comprising any combination of a neutral amino acid and two charged amino acids, or the surfactant may be selected from the group of imidazoline derivatives.

One group of preferred surfactants consists of zwitterionic surfactants, cationic surfactants, non-ionic surfactants and polymeric surfactants.

Another group of preferred surfactants consists of SDS, sodium caprylate, sodium cholate, sodium deoxycholate, sodium taurocholate and sodium glycocholate.

A further group of preferred surfactants consists of lauroyl lysophosphatidylcholine, palmitoyl lysophosphatidyl-L-serine, myristoyl lysophosphatidylcholine and N-Hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate.

The pharmaceutical compositions preferably also comprise zinc.

The pharmaceutial compositions preferably further comprise another antidiabetic agent. The term “antidiabetic agent” includes compounds for the treatment and/or prophylaxis of insulin resistance and diseases wherein insulin resistance is the pathophysiological mechanism.

In one embodiment of this invention, the antidiabetic agent is an insulin, more preferably human insulin.

In another embodiment the antidiabetic agent is a hypoglycaemic agent, preferably an oral hypoglycaemic agent. Oral hypoglycaemic agents are preferably selected from the group consisting of sulfonylureas, biguanides, thiazolidinediones, glucosidase inhibitors, glucagon antagonists, GLP-1 agonists, potasium channel openers, insulin sensitizers, hepatic enzyme inhibitors, glucose uptake modulators, compounds modifying the lipid metabolism, compounds lowering food intake, and agents acting on the ATP-dependent potassium channel of the β-cells.

Preferred sulfonylureas are tolbutamide, glibenclamide, glipizide and gliclazide. A preferred biguanide is metformin. Preferred thiazolidinediones are troglitazone and ciglitazone. A preferred glucosidase inhibitors is acarbose. Preferred agents acting on the ATP-dependent potassium channel of the β-cells are: glibenclamide, glipizide, gliclazide, and repaglinide.

The pharmaceutical compositions of the present invention may further comprise another antiobesity agent.

In one embodiment of this invention, the antiobesity agent is leptin.

In another embodiment the antiobesity agent is amphetamin.

In another embodiment the antiobesity agent is dexfenfluramine.

In another embodiment the antiobesity agent is sibutramine.

In another embodiment the antiobesity agent is orlistat.

In another embodiment the antiobesity agent is selected from a group of CART agonists, NPY antagonists, orexin antagonists, H3-antagonists, TNF agonists, CRF agonists, CRF BP antagonists, urocortin agonists, β3 agonists, MSH agonists, CCK agonists, serotonin re-uptake inhibitors, mixed serotonin and noradrenergic compounds, 5HT agonists, bombesin agonists, galanin antagonists, growth hormone, growth hormone releasing compounds, glucagon, TRH agonists, uncoupling protein 2 or 3 modulators, leptin agonists, DA agonists (Bromocriptin, Doprexin), lipase/amylase inhibitors, PPAR modulators, PXR modulators or TR P agonists.

The present invention also relates to pharmaceutical compositions comprising water and a GLP-1 derivative which has a helix content as measured by CD at 222 nm in H 2 O at 22±2° C. exceeding 25%, preferably in the range of 25% to 50%, at a peptide concentration of about 10 μM. The size of the partially helical, micelle-like aggregates may be estimated by size-exclusion chromatography. Similarly, the apparent (critical micelle concentrations) CMC's of the peptides may be estimated from the concentration dependent fluorescence in the presence of appropriate dyes (e.g. Brito, R. & Vaz, W. (1986) Anal. Biochem. 152, 250-255).

That the derivatives have a partially structured micellar-like aggregate conformation in aqueous solutions makes them more soluble and stable in solution as compared to the native peptide. The increased solubility and stability can be seen by comparing the solubility after 9 days of standing for a derivative and native GLP-1(7-37) in a pharmaceutical formulation, e.g. 5 mM phosphate buffer, pH 6.9 added 0.1 M NaCl.

Circular Dichroism (CD) can be used to show that the GLP-1 derivatives have a certain partially structured conformation independent of their concentration. In contrast, for native GLP-1(7-37) an increase in the helix content is seen with increasing concentration, from 10-15% to 30-35% (at 500 μM concentration) in parallel with peptide self-association. For the GLP-1 derivatives forming partially structured micellar-like aggregates in aqueous solution the helix content remains constant above 30% at concentrations of 10 μM. The aggregated structured conformation is an inherent property of the derivative present in water or dilute aqueous buffer without the need for any additional structure-inducing components.

The pharmaceutical compositions of the present invention may be prepared by conventional techniques, e.g. as described in Remington's Pharmaceutical Sciences, 1985 or in Remington: The Science and Practice of Pharmacy, 19th edition, 1995.

For example, injectable compositions of the GLP-1 derivative of the invention can be prepared using the conventional techniques of the pharmaceutical industry which involves dissolving and mixing the ingredients as appropriate to give the desired end product.

A composition for nasal administration of certain peptides may, for example, be prepared as described in European Patent No. 272097(to Novo Nordisk A/S) or in WO 93/18785.

In a preferred embodiment of the present invention, the GLP-1 derivative is provided in the form of a composition suitable for administration by injection. Such a composition can either be an injectable solution ready for use or it can be an amount of a solid composition, e.g. a lyophilised product, which has to be dissolved in a solvent before it can be injected. The injectable solution preferably contains not less than about 2 mg/ml, preferably not less than about 5 mg/ml, more preferred not less than about 10 mg/ml of the GLP-1 derivative and, preferably, not more than about 100 mg/ml of the GLP-1 derivative.

Uses

The present invention also relates to the use of a GLP-1 derivative of the invention for the preparation of a medicament which has a protracted profile of action relative to GLP-1(7-37).

The present invention relates also to the use of a GLP-1 derivative of the invention for the preparation of a medicament with protracted effect for the treatment of non-insulin dependent diabetes mellitus.

The present invention also relates to the use of a GLP-1 derivative of the invention for the preparation of a medicament with protracted effect for the treatment of insulin dependent diabetes mellitus.

The present invention also relates to the use of a GLP-1 derivative of the invention for the preparation of a medicament with protracted effect for the treatment of obesity.

The present invention also relates to the use of a GLP-1 derivative of the present invention for treating insulin resistance.

The present invention also relates to the use of a GLP-1 derivative of the present invention for the preparation of a medicament with protracted effect for the treatment of obesity.

The present invention relates to a method of treating insulin dependent or non-insulin dependent diabetes mellitus in a patient in need of such a treatment, comprising administering to the patient a therapeutically effective amount of a GLP-1 derivative of the present invention together with a pharmaceutically acceptable carrier.

The present invention relates to a method of treating obesity in a patient in need of such a treatment, comprising administering to the patient a therapeutically effective amount of a GLP-1 derivative of the present invention together with a pharmaceutically acceptable carrier.

The particular GLP-1 derivative to be used and the optimal dose level for any patient will depend on the disease to be treated and on a variety of factors including the efficacy of the specific peptide derivative employed, the age, body weight, physical activity, and diet of the patient, on a possible combination with other drugs, and on the severity of the case.

The pharmaceutical compositions of the present invention may be administered parenterally to patients in need of such a treatment. Parenteral administration may be performed by subcutaneous, intramuscular or intravenous injection by means of a syringe, optionally a pen-like syringe. Alternatively, parenteral administration can be performed by means of an infusion pump. A further option is a composition which may be a powder or a liquid for the administration of the GLP-1 derivative in the form of a nasal or pulmonal spray. As a still further option, the GLP-1 derivatives of the invention can also be administered transdermally, e.g. from a patch, optionally a iontophoretic patch, or transmucosally, e.g. bucally.

Methods of Production

The parent peptide can be produced by a method which comprises culturing a host cell containing a DNA sequence encoding the polypeptide and capable of expressing the polypeptide in a suitable nutrient medium under conditions permitting the expression of the peptide, after which the resulting peptide is recovered from the culture.

The medium used to culture the cells may be any conventional medium suitable for growing the host cells, such as minimal or complex media containing appropriate supplements. Suitable media are available from commercial suppliers or may be prepared of published recipes (e.g. in catalogues of the American Type Culture Collection). The peptide produced by the cells may then be recovered from the culture medium by conventional procedures including separating the host cells from the medium by centrifugation or filtration, precipitating the proteinaceous components of the supernatant or filtrate by means of a salt, e.g. ammonium sulphate, purification by a variety of chromatographic procedures, e.g. ion exchange chromatography, gel filtration chromatography, affinity chromatography, or the like, dependent on the type of peptide in question.

The DNA sequence encoding the parent peptide may suitably be of genomic or cDNA origin, for instance obtained by preparing a genomic or cDNA library and screening for DNA sequences coding for all or part of the peptide by hybridisation using synthetic oligonucleotide probes in accordance with standard techniques (see, for example, Sambrook, J, Fritsch, EF and Maniatis, T, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, New York, 1989). The DNA sequence encoding the peptide may also be prepared synthetically by established standard methods, e.g. the phosphoamidite method described by Beaucage and Caruthers, Tetrahedron Letters 22(1981), 1859-1869, or the method described by Matthes et al., EMBO Journal 3(1984), 801-805. The DNA sequence may also be prepared by polymerase chain reaction using specific primers, for instance as described in U.S. Pat. No. 4,683,202 or Saiki et al., Science 239(1988), 487-491.

The DNA sequence may be inserted into any vector which may conveniently be subjected to recombinant DNA procedures, and the choice of vector will often depend on the host cell into which it is to be introduced. Thus, the vector may be an autonomously replicating vector, i.e. a vector which exists as an extrachromosomal entity, the replication of which is independent of chromosomal replication, e.g. a plasmid. Alternatively, the vector may be one which, when introduced into a host cell, is integrated into the host cell genome and replicated together with the chromosome(s) into which it has been integrated.

The vector is preferably an expression vector in which the DNA sequence encoding the peptide is operably linked to additional segments required for transcription of the DNA, such as a promoter. The promoter may be any DNA sequence which shows transcriptional activity in the host cell of choice and may be derived from genes encoding proteins either homologous or heterologous to the host cell. Examples of suitable promoters for directing the transcription of the DNA encoding the peptide of the invention in a variety of host cells are well known in the art, cf. for instance Sambrook et al., supra.

The DNA sequence encoding the peptide may also, if necessary, be operably connected to a suitable terminator, polyadenylation signals, transcriptional enhancer sequences, and translational enhancer sequences. The recombinant vector of the invention may further comprise a DNA sequence enabling the vector to replicate in the host cell in question.

The vector may also comprise a selectable marker, e.g. a gene the product of which complements a defect in the host cell or one which confers resistance to a drug, e.g. ampicillin, kanamycin, tetracyclin, chloramphenicol, neomycin, hygromycin or methotrexate.

To direct a parent peptide of the present invention into the secretory pathway of the host cells, a secretory signal sequence (also known as a leader sequence, prepro sequence or pre sequence) may be provided in the recombinant vector. The secretory signal sequence is joined to the DNA sequence encoding the peptide in the correct reading frame. Secretory signal sequences are commonly positioned 5′ to the DNA sequence encoding the peptide. The secretory signal sequence may be that normally associated with the peptide or may be from a gene encoding another secreted protein.

The procedures used to ligate the DNA sequences coding for the present peptide, the promoter and optionally the terminator and/or secretory signal sequence, respectively, and to insert them into suitable vectors containing the information necessary for replication, are well known to persons skilled in the art (cf., for instance, Sambrook et al., supra).

The host cell into which the DNA sequence or the recombinant vector is introduced may be any cell which is capable of producing the present peptide and includes bacteria, yeast, fungi and higher eukaryotic cells. Examples of suitable host cells well known and used in the art are, without limitation, E. coli, Saccharomyces cerevisiae, or mammalian BHK or CHO cell lines.

The GLP-1 derivatives of this invention can be used in the treatment of various diseases.

The particular GLP-1 derivative to be used and the optimal dose level for any patient will depend on the disease to be treated and on a variety of factors including the efficacy of the specific peptide derivative employed, the age, body weight, physical activity, and diet of the patient, on a possible combination with other drugs, and on the severity of the case. It is recommended that the dosage of the GLP-1 derivative of this invention be determined for each individual patient by those skilled in the art.

In particular, it is envisaged that the GLP-1 derivative will be useful for the preparation of a medicament with a protracted profile of action for the treatment of non-insulin dependent diabetes mellitus and/or for the treatment of obesity.

The present invention is further illustrated by the following examples which, however, are not to be construed as limiting the scope of protection. The features disclosed in the foregoing description and in the following examples may, both separately and in any combination thereof, be material for realising the invention in diverse forms thereof.

EXAMPLES

The following acronyms for commercially available chemicals are used:

DMF: N,N-Dimethylformamide

DCC: N,N-Dicyclohexylcarbodiimide

NMP: N-Methyl-2-pyrrolidone

EDPA: N-Ethyl-N,N-diisopropylamine

EGTA: Ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid

GTP: Guanosine 5′-triphosphate

TFA: Trifluoroacetic acid

THF: Tetrahydrofuran

H-Glu(OH)-OBu t : L-Glutamic acid α-tert-butyl ester

Cac-ONSu: Decanoic acid 2,5-dioxopyrrolidin-1-yl ester

Cap-ONSu: Octanoic acid 2,5-dioxopyrrolidin-1-yl ester

Lau-ONSu: Dodecanoic acid 2,5-dioxopyrrolidin-1-yl ester

Myr-ONSu: Tetradecanoic acid 2,5-dioxopyrrolidin-1-yl ester

Pal-ONSu: Hexadecanoic acid 2,5-dioxopyrrolidin-1-yl ester

Ste-ONSu Octadecanoic acid 2,5-dioxopyrrolidin-1-yl ester

Abbreviations:

PDMS: Plasma Desorption Mass Spectrometry

MALDI-MS: Matrix Assisted Laser Desorptiont/Ionisation Mass Spectrometry

HPLC: High Performance Liquid Chromatography

amu: atomic mass units

Lit-Glu(ONSu)-OBu t : N α -Lithochoyl-L-glutamic acid α-t-butyl ester γ-2,5-dioxopyrrolidin-1-yl ester

Cap-Glu(ONSu)-OBu t : N α -Octanoyl-L-glutamic acid α-t-butyl ester γ-2,5-dioxopyrrolidin-1-yl ester

Cac-Glu(ONSu)-OBu t : N α -Decanoyl-L-glutamic acid α-t-butyl ester γ-2,5-dioxopyrrolidin-1-yl ester

Lau-Glu(ONSu)-OBu t : N α -Dodecanoyl-L-glutamic acid α-t-butyl ester γ-2,5-dioxopyrrolidin-1-yl ester

Myr-Glu(ONSu)-OBu t : N α -Tetradecanoyl-L-glutamic acid α-t-butyl ester γ-2,5-dioxopyrrolidin-1-yl ester

Pal-Glu(ONSu)-OBu t : N α -Hexadecanoyl-(L)-glutamic acid α-t-butyl-γ-2,5-dioxopyrrolidin-1-yl diester

Ste-Glu(ONSu)-OBu t : N α -Octadecanoyl-(L)-glutamic acid α-t-butyl-γ-2,5-dioxopyrrolidin-1-yl diester

Lau-β-Ala-ONSu: N β -Dodecanoyl-β-alanine 2,5-dioxopyrrolidin-1-yl ester

Pal-β-Ala-ONSu: N β -Hexadecanoyl-β-alanine 2,5-dioxopyrrolidin-1-yl ester

Lau-GABA-ONSu: N γ -Dodecanoyl-γ-aminobutyric acid 2,5-dioxopyrrolidin-1-yl ester

Myr-GABA-ONSu: N γ -Tetradecanoyl-γ-aminobutyric acid 2,5-dioxopyrrolidin-1-yl ester

Pal-GABA-ONSu: N γ -Hexadecanoyl-γ-aminobutyric acid 2,5-dioxopyrrolidin-1-yl ester

Ste-GABA-ONSu: N γ -Octadecanoyl-γ-aminobutyric acid 2,5-dioxopyrrolidin-1-yl ester

Pal-Isonip-ONSu: N-Hexadecanoyl-piperidine-4-carboxylic acid 2,5-dioxopyrrolidin-1-yl ester

Pal-Glu(OBu t )-ONSu: N α -Hexadecanoyl-L-glutamic acid α-2,5-dioxopyrrolidin-1-yl ester γ-t-butyl ester

HOOC—(CH 2 ) 6 —COONSu: ω-Carboxyheptanoic acid 2,5-dioxopyrrolidin-1-yl ester

HOOC—(CH 2 ) 10 —COONSu: ω-Carboxyundecanoic acid 2,5-dioxopyrrolidin-1-yl ester

HOOC—(CH 2 ) 12 —COONSu: ω-Carboxytridecanoic acid 2,5-dioxopyrrolidin-1-yl ester

HOOC—(CH 2 ) 14 —COONSu: ω-Carboxypentadecanoic acid 2,5-dioxopyrrolidin-1-yl ester

HOOC—(CH 2 ) 16 —COONSu: ω-Carboxyheptadecanoic acid 2,5-dioxopyrrolidin-1-yl ester

HOOC—(CH 2 ) 18 —COONSu: ω-Carboxynonadecanoic acid 2,5-dioxopyrrolidin-1-yl ester

N α -alkanoyl-Glu(ONSu)-OBu t : N α -Alkanoyl-(L)-glutamic acid α-t-butyl-γ-2,5-dioxopyrrolidin-1-yl diester

Analytical

Plasma Desorption Mass Spectrometry

Sample Preparation:

The sample is dissolved in 0.1% TFA/EtOH (1:1) at a concentration of 1 μg/μl. The sample solution (5-10 μl) is placed on a nitrocellulose target (Bio-ion AB, Uppsala, Sweden) and allowed to adsorb to the target surface for 2 minutes. The target is subsequently rinsed with 2×25 μl 0.1% TFA and spin-dried. Finally, the nitrocellulose target is placed in a target carrousel and introduced into the mass spectrometer.

MS Analysis:

PDMS analysis was carried out using a Bio-ion 20 time-of flight instrument (Bio-ion Nordic AB, Uppsala, Sweden). An acceleration voltage of 15 kV was applied and molecular ions formed by bombardment of the nitrocellulose surface with 252-Cf fission fragments were accelerated towards a stop detector. The resulting time-of-flight spectrum was calibrated into a true mass spectrum using the H + and NO + ions at m/z 1 and 30, respectively. Mass spectra were generally accumulated for 1.0×10 6 fission events corresponding to 15-20 minutes. Resulting assigned masses all correspond to isotopically averaged molecular masses. The accuracy of mass assignment is generally better than 0.1%.

MALDI-MS

MALDI-TOF MS analysis was carried out using a Voyager RP instrument (PerSeptive Biosystems Inc., Framingham, Mass.) equipped with delayed extraction and operated in linear mode. Alpha-cyano-4-hydroxy-cinnamic acid was used as matrix, and mass assignments were based on external calibration.

Example 1

Synthesis of Lys 26 (N ε -tetradecanoyl) GLP-1(7-37)

The title compound was synthesised from GLP-1(7-37). A mixture of GLP-1(7-37) (25 mg, 7.45 μm), EDPA (26.7 mg, 208 μm), NMP (520 μl) and water (260 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of Myr-ONSu (2.5 mg, 7.67 μm) in NMP (62.5 μl), the reaction mixture was gently shaken for 5 min. at room temperature and then allowed to stand for 20 min. An additional amount of Myr-ONSu (2.5 mg, 7.67 μm) in NMP (62.5 μl) was added and the resulting mixture gently shaken for 5 min. After a total reaction time of 40 min. the reaction was quenched by the addition of a solution of glycine (12.5 mg, 166 μmol) in 50% aqueous ethanol (12.5 ml). The title compound was isolated from the reaction mixture by HPLC using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system, yield: 1.3 mg (corresponding to 4.9% of the theoretical yield). The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The isolated product was analysed by PDMS and the m/z value for the protonated molecular ion was found to be 3567.9±3. The resulting molecular weight was thus 3566.9±3 amu (theoretical value: 3565.9 amu). The position of acylation (Lys26) was verified by enzymatic cleavage of the title compound with Staphylococcus aureus V8 protease and subsequent mass determination of the peptide fragments by PDMS.

In addition to the title compound two other GLP-1derivatives were isolated from the reaction mixture by using the same chromatographic column and a more shallow gradient (35-38% acetonitrile in 60 minutes), see Examples 2 and 3.

Example 2

Synthesis of Lys 34 (N ε -tetradecanoyl) GLP-1(7-37)

The title compound was isolated by HPLC from the reaction mixture described in Example 1. PDMS analysis yielded a protonated molecular ion at m/z 3567.7±3. The molecular weight was found to be 3566.7±3 amu (theoretical value: 3565.9 amu). The acylation site was determined on the basis of the fragmentation pattern.

Example 3

Synthesis of Lys 26, 34 -bis(N ε -tetradecanoyl) GLP-1(7-37)

The title compound was isolated by HPLC from the reaction mixture described in Example 1. PDMS analysis yielded a protonated molecular ion at m/z 3778.4±3. The molecular weight was found to be 3777.4±3 amu (theoretical value: 3776.1 amu).

Example 4

Synthesis of Lys 26 (N ε -tetradecanoyl)Arg 34 GLP-1(7-37)

The title compound was synthesised from Arg 34 GLP-1(7-37). A mixture of Arg 34 GLP-1(7-37) (5 mg, 1.47 μm), EDPA (5.3 mg, 41.1 μm), NMP (105 μl) and water (50 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of Myr-ONSu (0.71 mg, 2.2 μm) in NMP (17.8 μl), the reaction mixture was gently shaken for 5 min. at room temperature and then allowed to stand for 20 min. After a total reaction time of 30 min. the reaction was quenched by the addition of a solution of glycine (25 mg, 33.3 μm) in 50% aqueous ethanol (2.5 ml). The reaction mixture was purified by HPLC as described in Example 1. PDMS analysis yielded a protonated molecular ion at m/z 3594.9±3. The molecular weight was found to be 3593.9±3 amu (theoretical value: 3593.9 amu).

Example 5

Synthesis of Gly 8 Arg 26, 34 Lys 36 (N ε -tetradecanoyl) GLP-1(7-37)

The title compound was synthesised from Gly 8 Arg 26, 34 Lys 36 GLP-1(7-37) which was purchased from QCB. A mixture of Gly 8 Arg 26, 34 Lys 36 GLP-1(7-37) (1.3 mg, 0.39 μm), EDPA (1.3 mg, 10 μm), NMP (125 μl) and water (30 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of Myr-ONSu (0.14 mg, 0.44 μm) in NMP (3.6 ml), the reaction mixture was gently shaken for 15 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (0.1 mg, 1.33 μm) in 50% aqueous ethanol (10 μl). The reaction mixture was purified by HPLC, and the title compound (60 μg, 4%) was isolated.

Example 6

Synthesis of Arg 26, 34 Lys 36 (N ε -tetradecanoyl) GLP-1(7-37)-OH

A mixture of Arg 26, 34 Lys 36 GLP-1(7-37)-OH (5.0 mg, 1.477 μmol), EDPA (5.4 mg, 41.78 μmol), NMP (105 μl) and water (50 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of Myr-ONSu (0.721 mg, 2.215 μmol) in NMP (18 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 45 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (2.5 mg, 33.3 μmol) in 50% aqueous ethanol (250 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (1.49 mg, 28%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3595±3. The resulting molecular weight was thus 3594±3 amu (theoretical value 3594 amu).

Example 7

Synthesis of Lys 26,34 bis(N ε -(ω-carboxynonadecanoyl)) GLP-1(7-37)-OH

A mixture of GLP-1(7-37)-OH (70 mg, 20.85 μmol), EDPA (75.71 mg, 585.8 μmol), NMP (1.47 ml) and water (700 μL) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution of HOOC—(CH 2 ) 18 —COONSu (27.44 mg, 62.42 μmol) in NMP (686 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 50 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (34.43 mg, 458.7 μmol) in 50% aqueous ethanol (3.44 ml). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (8.6 mg, 10%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 4006±3. The resulting molecular weight was thus 4005±3 amu (theoretical value 4005 amu).

Example 8

Synthesis of Arg 26, 34 Lys 36 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-36)-OH

A mixture of Arg 26, 34 Lys 36 GLP-1(7-36)-OH (5.06 mg, 1.52 μmol), EDPA (5.5 mg, 42.58 μmol), NMP (106 μl) and water (100 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of HOOC—(CH 2 ) 18 —COONSu (1.33 mg, 3.04 μmol) in NMP (33.2 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 2.5 h at room temperature. The reaction was quenched by the addition of a solution of glycine (2.50 mg, 33.34 μmol) in 50% aqueous ethanol (250 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.46 mg, 8%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3652±3. The resulting molecular weight was thus 3651±3 amu (theoretical value 3651 amu).

Example 9

Synthesis of Arg 26, 34 Lys 38 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-38)-OH

A mixture of Arg 26, 34 Lys 38 GLP-1(7-38)-OH (5.556 mg, 1.57 μmol), EDPA (5.68 mg, 43.96 μmol), NMP (116.6 μl) and water (50 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 18 —COONSu (1.38 mg, 3.14 μmol) in NMP (34.5 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 2.5 h at room temperature. The reaction was quenched by the addition of a solution of glycine (2.5 mg, 33.3 μmol) in 50% aqueous ethanol (250 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.7 mg, 12%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3866±3. The resulting molecular weight was thus 3865±3 amu (theoretical value 3865 amu).

Example 10

Synthesis of Arg 34 Lys 26 (N ε -(ω-carboxynonadecanoyl)) GLP-1(7-37)-OH

A mixture of Arg 34 GLP-1(7-37)-OH (5.04 mg, 1.489 μmol), EDPA (5.39 mg, 41.70 μmol), NMP (105 μl) and water (50 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 18 —COONSu (1.31 mg, 2.97 μmol) in NMP (32.8 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 30 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (2.46 mg, 32.75 μmol) in 50% aqueous ethanol (246 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (1.2 mg, 22%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3709±3. The resulting molecular weight was thus 3708±3 amu (theoretical value 3708 amu).

Example 11

Synthesis of Arg 34 Lys 26 (N ε -(ω-carboxyheptadecanoyl)) GLP-1(7-37)-OH

A mixture of Arg 34 GLP-1(7-37)-OH (5.8 mg, 1.714 μmol), EDPA (6.20 mg, 47.99 μmol), NMP (121.8 μl) and water (58 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 16 —COONSu (2.11 mg, 5.142 μmol) in NMP (52.8 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (2.83 mg, 37.70 μmol) in 50% aqueous ethanol (283 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.81 mg, 13%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3681±3. The resulting molecular weight was thus 3680±3 amu (theoretical value 3680 amu).

Example 12

Synthesis of Arg 26, 34 Lys 36 (N ε -(ω-carboxyheptadecanoyl)) GLP-1(7-37)-OH

A mixture of Arg 26, 34 Lys 36 GLP-1(7-37)-OH (3.51 mg, 1.036 μmol), EDPA (3.75 mg, 29.03 μmol), NMP (73.8 μl) and water (35 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 16 —COONSu (1.27 mg, 3.10 μmol) in NMP (31.8 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 2 h and 10 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (1.71 mg, 22.79 μmol) in 50% aqueous ethanol (171 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.8 mg, 21%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3682±3. The resulting molecular weight was thus 3681±3 amu (theoretical value 3681 amu).

Example 13

Synthesis of Arg 26,34 Lys 38 (N 68 -(ω-carboxylheptadecanoyl)) GLP-1(7-38)-OH

A mixture of Arg 26, 34 Lys 38 GLP-1(7-38)-OH (5.168 mg, 1.459 μmol), EDPA (5.28 mg, 40.85 μmol), NMP (108.6 μl) and water (51.8 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 16 —COONSu (1.80 mg, 4.37 μmol) in NMP (45 μl), the reaction mixture was gently shaken for 10 min. at room temperature, and then allowed to stand for an additional 2 h and 15 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (2.41 mg, 32.09 μmol) in 50% aqueous ethanol (241 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.8 mg, 14%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3838±3. The resulting molecular weight was thus 3837±3 amu (theoretical value 3837 amu).

Example 14

Synthesis of Arg 26, 34 Lys 36 (N ε -(ω-carboxyheptadecanoyl)) GLP-1(7-36)-OH

A mixture of Arg 26, 34 Lys 36 GLP-1(7-36)-OH (24.44 mg, 7.34 μmol), EDPA (26.56 mg, 205.52 μmol), NMP (513 μl) and water (244.4 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 16 —COONSu (9.06 mg, 22.02 μmol) in NMP (1.21 ml), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 30 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (12.12 mg, 161.48 μmol) in 50% aqueous ethanol (1.21 ml). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (7.5 mg, 28%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3625±3. The resulting molecular weight was thus 3624±3 amu (theoretical value 3624 amu).

Example 15

Synthesis of Arg 26, 34 Lys 36 (N ε -(ω-carboxyundecanoyl)) GLP-1(7-37)-OH

A mixture of Arg 26, 34 Lys 36 GLP-1(7-37)-OH (4.2 mg, 1.24 μmol), EDPA (4.49 mg, 34.72 μmol), NMP (88.2 μl) and water (42 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 10 —COONSu (1.21 mg, 3.72 μmol) in NMP (30.25 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 40 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (2.04 mg, 27.28 μmol) in 50% aqueous ethanol (204 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.8 mg, 18%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3598±3. The resulting molecular weight was thus 3597±3 amu (theoretical value 3597 amu).

Example 16

Synthesis of Arg 26, 34 Lys 38 (N ε -(ω-carboxyundecanoyl)) GLP-1(7-38)-OH

A mixture of Arg 26, 34 Lys 38 GLP-1(7-38)-OH (5.168 mg, 1.46 μmol), EDPA (5.28 mg, 40.88 μmol), NMP (108.6 μl) and water (51.7 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 10 —COONSu (1.43 mg, 4.38 μmol) in NMP (35.8 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 50 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (2.41 mg, 32.12 μmol) in 50% aqueous ethanol (241 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.85 mg, 16%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3753±3. The resulting molecular weight was thus 3752±3 amu (theoretical value 3752 amu).

Example 17

Synthesis of Lys 26,34 bis(N ε -(ω-carboxyundecanoyl)) GLP-1(7-37)-OH

A mixture of GLP-1(7-37)-OH (10.0 mg, 2.98 μmol), EDPA (10.8 mg, 83.43 μmol), NMP (210 μl) and water (100 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 10 —COONSu (2.92 mg, 8.94 μmol) in NMP (73 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 50 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (4.92 mg, 65.56 μmol) in 50% aqueous ethanol (492 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (1.0 mg, 9%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3781±3. The resulting molecular weight was thus 3780±3 amu (theoretical value 3780 amu).

Example 18

Synthesis of Arg 26, 34 Lys 36 (N 68 -(ω-carboxyundecanoyl)) GLP-1(7-36)-OH

A mixture of Arg 26, 34 Lys 36 GLP-1(7-36)-OH (15.04 mg, 4.52 μmol), EDPA (16.35 mg, 126.56 μmol), NMP (315.8 μl) and water (150.4 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 10 —COONSu (4.44 mg, 13.56 μmol) in NMP (111 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 40 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (7.5 mg, 99.44 μmol) in 50% aqueous ethanol (750 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (3.45 mg, 22%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3540±3. The resulting molecular weight was thus 3539±3 amu (theoretical value 3539 amu).

Example 19

Synthesis of Arg 34 Lys 26 (N ε -(ω-carboxyundecanoyl)) GLP-1(7-37)-OH

A mixture of Arg 34 GLP-1(7-37)-OH (5.87 mg, 1.73 μmol), EDPA (6.27 mg, 48.57 μmol), NMP (123.3 μl) and water (58.7 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 10 —COONSu (1.70 mg, 5.20 μmol) in NMP (42.5 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 40 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (2.86 mg, 286 μmol) in 50% aqueous ethanol (286 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C., and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (1.27 mg, 20%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3597±3. The resulting molecular weight was thus 3596±3 amu (theoretical value 3596 amu).

Example 20

Synthesis of Arg 34 Lys 26 (N ε -(ω-carboxyheptanoyl)) GLP-1(7-37)-OH

A mixture of Arg 34 GLP-1(7-37)-OH (4.472 mg, 1.32 μmol), EDPA (4.78 mg, 36.96 μmol), NMP (94 μl) and water (44.8 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 6 —COONSu (1.07 mg, 3.96 μmol) in NMP (26.8 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 1 h and 50 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (2.18 mg, 29.04 μmol) in 50% aqueous ethanol (218 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.5 mg, 11%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3540±3. The resulting molecular weight was thus 3539±3 amu (theoretical value 3539 amu).

Example 21

Synthesis of Arg 26, 34 Lys 38 (N ε -(ω-carboxyheptanoyl)) GLP-1(7-38)-OH

A mixture of Arg 26, 34 Lys 38 GLP-1(7-38)-OH (5.168 mg, 1.459 μmol), EDPA (5.28 mg, 40.85 μmol), NMP (108.6 μl) and water (51.6 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 6 —COONSu (1.18 mg, 4.37 μmol) in NMP (29.5 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 1 h and 50 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (2.40 mg, 32.09 μmol) in 50% aqueous ethanol (240 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.5 mg, 9%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3697±3. The resulting molecular weight was thus 3695±3 amu (theoretical value 3695 amu).

Example 22

Synthesis of Arg 26, 34 Lys 36 (N ε -(ω-carboxyheptanoyl)) GLP-1(7-37)-OH

A mixture of Arg 26, 34 Lys 36 GLP-1(7-37)-OH (5.00 mg, 1.47 μmol), EDPA (5.32 mg, 41.16 μmol), NMP (105 μl) and water (50 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 6 —COONSu (1.19 mg, 4.41 μmol) in NMP (29.8 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (2.42 mg, 32.34 μmol) in 50% aqueous ethanol (242 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.78 mg, 15%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3542±3. The resulting molecular weight was thus 3541±3 amu (theoretical value 3541 amu).

Example 23

Synthesis of Arg 26, 34 Lys 36 (N ε -carboxyheptanoyl)) GLP-1(7-36)-OH

A mixture of Arg 26, 34 Lys 36 GLP-1(7-36)-OH (5.00 mg, 1.50 μmol), EDPA (5.44 mg, 42.08 μmol), NMP (210 μl) and water (50 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 6 13 COONSu (1.22 mg, 4.5 μmol) in NMP (30.5 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (2.47 mg, 33.0 μmol) in 50% aqueous ethanol (247 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.71 mg, 14%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3484±3. The resulting molecular weight was thus 3483±3 amu (theoretical value 3483 amu).

Example 24

Synthesis of Lys 26,34 bis(N ε -(ω-carboxyheptanoyl)) GLP-1(7-37)-OH

A mixture of GLP-1(7-37)-OH (10 mg, 2.5 μmol), EDPA (10.8 mg, 83.56 μmol), NMP (210 μl) and water (100 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2) 6 —COONSu (2.42 mg, 8.92 μmol) in NMP (60.5 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 2 h and 35 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (4.92 mg, 65.54 μmol) in 50% aqueous ethanol (492 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (2.16 mg, 24%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3669±3. The resulting molecular weight was thus 3668±3 amu (theoretical value 3668 amu).

Example 25

Synthesis of Arg 34 Lys 26 (N ε -(ω-carboxypentadecanoyl)) GLP-1(7-37)-OH

A mixture of Arg 34 GLP-1(7-37)-OH (4.472 mg, 1.321 μmol), EDPA (4.78 mg, 36.99 μmol), NMP (93.9 μl) and water (44.7 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 14 —COONSu (1.519 mg, 3.963 μmol) in NMP (38 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 1 h at room temperature. The reaction was quenched by the addition of a solution of glycine (2.18 mg, 29.06 μmol) in 50% aqueous ethanol (218 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.58 mg, 12%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3654±3. The resulting molecular weight was thus 3653±3 amu (theoretical value 3653 amu).

Example 26

Synthesis of Arg 26, 34 Lys 36 (N ε -(ω-carboxyheptanoyl)) GLP-1(7-36)-OH

A mixture of Arg 26, 34 Lys 36 GLP-1(7-36)-OH (5.00 mg, 1.50 μmol), EDPA (5.44 mg, 42.08 μmol), NMP (210 μl) and water (50 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 14 —COONSu (1.72 mg, 4.5 μmol) in NMP (43 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 1 h at room temperature. The reaction was quenched by the addition of a solution of glycine (2.48 mg, 33 μmol) in 50% aqueous ethanol (248 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.58 mg, 11%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3596±3. The resulting molecular weight was thus 3595±3 amu (theoretical value 3595 amu).

Example 27

Synthesis of Lithocholic Acid 2,5-dioxo-pyrrolidin-1-yl Ester

To a mixture of lithocholic acid (5.44 g, 14.34 mmol), N-hydroxysuccinimide (1.78 g, 15.0 mmol), anhydrous THF (120 ml) and anhydrous acetonitrile (30 ml), kept at to 10° C., was added a solution of N,N′-dicyclohexylcarbodiimide (3.44 g, 16.67 mmol) in anhydrous THF. The reaction mixture was stirred at ambient temperature for 16 h, filtered and concentrated in vacuo. The residue was dissolved in dichloromethane (450 ml), washed with a 10% aqueous Na 2 CO 3 solution (2×150 ml) and water (2×150 ml), and dried (MgSO 4 ). Filtered and the filtrate concentrated in vacuo to give a crystalline residue. The residue was recrystallised from a mixture of dichloromethane (30 ml) and n-heptane (30 ml to give the title compound (3.46 g, 51%) as a crystalline solid.

Example 28

Synthesis of Arg 34 Lys 26 (N ε -lithocholyl) GLP-1(7-37)-OH

A mixture of Arg 34 GLP-1(7-37)-OH (4.472 mg, 1.32 μmol), EDPA (4.78 mg, 36.96 μmol), NMP (94 μl) and water (44.8 μl) was gently shaken for 10 min. at room temperature. To the resulting mixture was added a solution of lithocholic acid 2,5-dioxo-pyrrolidin-1-yl ester (1.87 mg, 3.96 μmol) in NMP (46.8 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 1 h at room temperature. The reaction was quenched by the addition of a solution of glycine (2.18 mg, 29.04 μmol) in 50% aqueous ethanol (218 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (1.25 mg, 25%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3744±3. The resulting molecular weight was thus 3743±3 amu (theoretical value 3743 amu).

Example 29

Synthesis of N α -tetradecanoyl-Glu(ONSu)-OBu t

To a suspension of H-Glu(OH)-OBu t (2.5 g, 12.3 μmmol), DMF (283 ml) and EDPA (1.58 g, 12.3 mmol) was added drop by drop a solution of Myr-ONSu (4.0 g, 12.3 mmol) in DMF (59 ml). The reaction mixture was stirred for 16 h at room temperature and then concentrated in vacuo to a total volume of 20 ml. The residue was partitioned between 5% aqueous citric acid (250 ml) and ethyl acetate (150 ml), and the phases were separated. The organic phase was concentrated in vacuo and the residue dissolved in DMF (40 ml). The resulting solution was added drop by drop to a 10% aqueous solution of citric acid (300 ml) kept at 0° C. The precipitated compound was collected and washed with iced water and dried in a vacuum drying oven. The dried compound was dissolved in DMF (23 ml) and HONSu (1.5 g, 13 mmol) was added. To the resulting mixture was added a solution of N,N′-dicyclohexylcarbodiimide (2.44 g, 11.9 mmol) in dichloromethane (47 ml). The reaction mixture was stirred for 16 h at room temperature, and the precipitated compound was filtered off. The precipitate was recrystallised from n-heptane/2-propanol to give the title compound (3.03 g, 50%).

Example 30

Synthesis of Glu 22,23,30 Arg 26, 34 Lys 38 (N ε -(γ-glutamyl(N α -tetradecanoyl))) GLP-1(7-38)-OH

A mixture of Glu 22,23,30 Arg 26, 34 Lys 38 -GLP1(7-38)-OH (1.0 mg, 0.272 μmol), EDPA, (0.98 mg, 7.62 μmol), NMP (70 μl) and water (70 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of N α -tetradecanoyl-Glu(ONSu)-OBu t , prepared as described in Example 29,(0.41 mg, 0.816 μmol) in NMP (10.4 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 45 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (0.448 mg, 5.98 μmol) in 50% aqueous ethanol (45 μl). A 0.5% aqueous solution of ammonium acetate (0.9 ml) was added, and the resulting mixture was immobilised on a Varian 500 mg C8 Mega Bond Elut® cartridge, the immobilised compound washed with 5% aqueous acetonitrile (10 ml), and finally liberated from the cartridge by elution with TFA (10 ml). The eluate was concentrated in vacuo, and the reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.35 mg, 32%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 4012±3. The resulting molecular weight was thus 4011±3 amu (theoretical value 4011 amu).

Example 31

Synthesis of Glu 23,26 Arg 34 Lys 38 (N ε -(γ-glutamyl(N α -tetradecanoyl))) GLP-1(7-38)-OH

A mixture of Glu 23,26 Arg 34 Lys 38 GLP-1(7-38)-OH (6.07 mg, 1.727 μmol), EDPA (6.25 mg, 48.36 μmol), NMP (425 μl) and water (425 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of N α -tetradecanoyl-Glu(ONSu)-OBu t , prepared as described in example 29,(2.65 mg, 5.18 μmol) in NMP (66.3 μl), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 45 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (2.85 mg, 38.0 μmol) in 50% aqueous ethanol (285 μl). A 0.5% aqueous solution of ammonium acetate (5.4 ml) was added, and the resulting mixture was immobilised on a Varian 500 mg C8 Mega Bond Elut® cartridge, the immobilised compound washed with 5% aqueous acetonitrile (10 ml), and finally liberated from the cartridge by elution with TFA (10 ml). The eluate was concentrated in vacuo, and the reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.78 mg, 12%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3854±3. The resulting molecular weight was thus 3853±3 amu (theoretical value 3853 amu).

Example 32

Synthesis of Lys 26, 34 -bis(N ε -(ω-carboxytridecanoyl)) GLP-1(7-37)-OH

A mixture of GLP-1(7-37)-OH (30 mg, 8.9 μmol), EDPA (32.3 mg, 250 μmol), NMP (2.1 ml) and water (2.1 ml) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 12 —COONSu (12.7 mg, 35.8 μmol) in NMP (318 μl), the reaction mixture was gently shaken for 1 h and 40 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (3.4 mg, 44.7 μmol) in 50% aqueous ethanol (335 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (10 mg, 29%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3840±3. The resulting molecular weight was thus 3839±3 amu (theoretical value 3839 amu).

Example 33

Synthesis of Lys 26, 34 -bis(N ε -(γ-glutamyl(N α -tetradecanoyl))) GLP-1(7-37)-OH

A mixture of GLP-1(7-37)-OH (300 mg, 79.8 μmol), EDPA (288.9 mg, 2.24 mmol), NMP (21 ml) and water (21 ml) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of N α -tetradecanoyl-Glu(ONSu)-OBu t , prepared as described in Example 29,(163 mg, 319.3 μmol) in NMP (4.08 ml), the reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 1 h at room temperature. The reaction was quenched by the addition of a solution of glycine (131.8 mg, 1.76 mmol) in 50% aqueous ethanol (13.2 ml). A 0.5% aqueous solution of ammonium-acetate (250 ml) was added, and the resulting mixture was divided into four equal portions. Each portion was eluted onto a Varian 500 mg C8 Mega Bond Elut® cartridge, the immobilised compound washed with 0.1% aqueous TFA (3.5 ml), and finally liberated from the cartridge by elution with 70% aqueous acetonitrile (4 ml). The combined eluates were diluted with 0.1% aqueous TFA (300 ml). The precipitated compound was collected by centrifugation, washed with 0.1% aqueous TFA (50 ml), and finally isolated by centrifugation. To the precipitate was added TFA (60 ml), and the resulting reaction mixture was stirred for 1 h and 30 min. at room temperature. Excess TFA was removed in vacuo, and the residue was poured into water (50 ml). The precipitated compound was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (27.3 mg, 8%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 4036±3. The resulting molecular weight was thus 4035±3 amu (theoretical value 4035 amu).

Example 34

Synthesis of Arg 26, 34 Lys 38 (N ε -(ω-carboxypentadecanoyl)) GLP-1(7-38)-OH

A mixture of Arg 26, 34 Lys 38 GLP-1(7-38)-OH (30 mg, 8.9 μmol), EDPA (32.3 mg, 250 μmol), NMP (2.1 ml) and water (2.1 ml) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution HOOC—(CH 2 ) 14 —COONSu (13.7 mg, 35.8 μmol) in NMP (343 μl), the reaction mixture was gently shaken for 1 h at room temperature. The reaction was quenched by the addition of a solution of glycine (3.4 mg, 44.7 μmol) in 50% aqueous ethanol (335 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (4.8 mg, 14%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3894±3. The resulting molecular weight was thus 3893±3 amu (theoretical value 3893 amu).

Example 35

Synthesis of N α -hexadecanoyl-Glu(ONSu)-OBu t

To a suspension of H-Glu(OH)-OBu t (4.2 g, 20.6 mmol), DMF (500 ml) and EDPA (2.65 g, 20.6 mmol) was added drop by drop a solution of Pal-ONSu (7.3 g, 20.6 mmol) in DMF (100 ml). The reaction mixture was stirred for 64 h at room temperature and then concentrated in vacuo to a total volume of 20 ml. The residue was partitioned between 10% aqueous citric acid (300 ml) and ethyl acetate (250 ml), and the phases were separated. The organic phase was concentrated in vacuo and the residue dissolved in DMF (50 ml). The resulting solution was added drop by drop to a 10% aqueous solution of citric acid (500 ml) kept at 0° C. The precipitated compound was collected and washed with iced water and dried in a vacuum drying oven. The dried compound was dissolved in DMF (45 ml) and HONSu (2.15 g, 18.7 mmol) was added. To the resulting mixture was added a solution of N,N′-dicyclohexylcarbodiimide (3.5 g, 17 mmol) in dichloromethane (67 ml). The reaction mixture was stirred for 16 h at room temperature, and the precipitated compound was filtered off. The precipitate was recrystallised from n-heptane/2-propanol to give the title compound (6.6 g, 72%).

Example 36

Synthesis of Lys 26, 34 -bis(N ε -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-37)-OH

A mixture of GLP-1(7-37)-OH (10 mg, 2.9 μmol), EDPA (10.8 mg, 83.4 μmol), NMP (0.7 ml) and water (0.7 ml) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of N α -hexadecanoyl-Glu(ONSu)-OBu t , prepared as described in Example 33,(163 mg, 319.3 μmol) in NMP (4.08 ml), the reaction mixture was gently shaken 1 h and 20 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (4.9 mg, 65.6 μmol) in 50% aqueous ethanol (492 μl). A 0.5% aqueous solution of ammonium-acetate (9 ml) was added, and the resulting mixture eluted onto a Varian 1 g C8 Mega Bond Elut® cartridge, the immobilised compound washed with 5% aqueous acetonitrile (10 ml), and finally liberated from the cartridge by elution with TFA (10 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (2.4 mg, 20%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 4092±3. The resulting molecular weight was thus 4091±3 amu (theoretical value 4091 amu).

Example 37

Synthesis of Arg 34 Lys 26 (N ε -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-37)-OH

A mixture of Arg 34 GLP-1(7-37)-OH (3.7 mg, 1.1 μmol), EDPA (4.0 mg, 30.8 μmol), acetonitrile (260 μl) and water (260 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of N α -hexadecanoyl-Glu(ONSu)-OBu t , prepared as described in Example 35,(1.8 mg, 3.3 μmol) in acetonitrile (44.2 μl), and the reaction mixture was gently shaken for 1 h and 20 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (1.8 mg, 24.2 μmol) in 50% aqueous ethanol (181 μl). A 0.5% aqueous solution of ammonium-acetate (12 ml) and NMP (300 μl) were added, and the resulting mixture eluted onto a Varian 1 g C8 Mega Bond Elut® cartridge, the immobilised compound washed with 5% aqueous acetonitrile (10 ml), and finally liberated from the cartridge by elution with TFA (6 ml). The eluate was allowed to stand for 2 h at room temperature and then concentrated in vacuo. The residue was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.23 mg, 6 %) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3752±3. The resulting molecular weight was thus 3751±3 amu (theoretical value 3751 amu).

Example 38

Synthesis of Arg 26, 34 Lys 38 (N ε -(γ-glutamyl(N α -tetradecanoyl))) GLP-1(7-38)-OH

A mixture of Arg 26, 34 Lys 38 GLP-1(7-38)-OH (14 mg, 4.0 μmol), EDPA (14.3 mg, 110.6 μmol), NMP (980 μl) and water (980 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of N- α tetradecanoyl-Glu(ONSu)-OBu t , prepared as described in Example 29,(12.1 mg, 23.7 μmol) in NMP (303 μl), and the reaction mixture was gently shaken for 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (6.5 mg, 86.9 mmol) in 50% aqueous ethanol (652 μl). A 0.5% aqueous solution of ammonium-acetate (50 ml) was added, and the resulting mixture eluted onto a Varian 1 g C8 Mega Bond Elut® cartridge, the immobilised compound washed with 5% aqueous acetonitrile (15 ml), and finally liberated from the cartridge by elution with TFA (6 ml). The eluate was allowed to stand for 1 h and 45 min. at room temperature and then concentrated in vacuo. The residue was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (3.9 mg, 26%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3881±3. The resulting molecular weight was thus 3880±3 amu (theoretical value 3880 amu).

Example 39

Synthesis of Arg 26, 34 Lys 38 (N ε -(ω-carboxypentadecanoyl)) GLP-1(7-38)-OH

A mixture of Arg 26, 34 Lys 38 GLP-1(7-38)-OH (14 mg, 4.0 μmol), EDPA (14.3 mg, 111 μmol), NMP (980 μl) and water (980 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of HOOC—(CH 2 ) 14 —COONSu (4.5 mg, 11.9 μmol) in NMP (114 μl), the reaction mixture was gently shaken for 1 h and 45 min. at room temperature. An additional solution of HOOC—(CH 2 ) 14 —COONSu (4.0 mg, 10.4 μmol) in NMP (100 μl) was added, and the resulting mixture was gently shaken for an additional 1 h and 30 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (1.5 mg, 19.8 μmol) in 50% aqueous ethanol (148 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (3.9 mg, 26%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3809±3. The resulting molecular weight was thus 3808±3 amu (theoretical value 3808 amu).

Example 40

Synthesis of Arg 26, 34 Lys 38 (N 68 -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-38)-OH

A mixture of Arg 26, 34 Lys 38 GLP-1(7-38)-OH (14 mg, 4.0 μmol), EDPA (14.3 mg, 110.6 μmol), NMP (980 μl) and water (980 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of N α -hexadecanoyl-Glu(ONSu)-OBu t , prepared as described in Example 35,(6.4 mg, 11.9 μmol) in NMP (160 μl), and the reaction mixture was gently shaken for 1 h and 20 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (6.5 mg, 87 mmol) in 50% aqueous ethanol (653 μl). A 0.5% aqueous solution of ammonium-acetate (50 ml) was added, and the resulting mixture eluted onto a Varian 1 g C8 Mega Bond Elut® cartridge, the immobilised compound washed with 5% aqueous acetonitrile (10 ml), and finally liberated from the cartridge by elution with TFA (6 ml). The =eluate was allowed to stand for 1 h and 30 min. at room temperature and then concentrated in vacuo. The residue was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (7.2 mg, 47%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3881±3. The resulting molecular weight was thus 3880±3 amu (theoretical value 3880 amu).

Example 41

Synthesis of Arg 18,23,26,30,34 Lys 38 (N ε -hexadecanoyl) GLP-1(7-38)-OH

A mixture of Arg 18,23,26,30,34 Lys 38 GLP-1(7-38)-OH (1.0 mg, 0.27 μmol), EDPA (0.34 mg, 2.7 μmol) and DMSO (600 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of Pal-ONSu (0.28 mg, 0.8 μmol) in NMP (7 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 6 h at room temperature. The reaction was quenched by the addition of a solution of glycine (1.6 mg, 21.7 μmol) in 50% aqueous ethanol (163 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (0.17 mg, 16%) was isolated, and the product was analysed by MALDI-MS. The m/z value for the protonated molecular ion was found to be 3961±3. The resulting molecular weight was thus 3960±3 amu (theoretical value 3960 amu).

Example 42

Synthesis of Arg 26, 34 Lys 38 (N ε -(ω-carboxytridecanoyl)) GLP-1(7-38)-OH

A mixture of Arg 26, 34 Lys 38 GLP-1(7-38)-OH (14 mg, 4.0 μmol), EDPA (14.3 mg, 111 μmol), NMP (980 μl) and water (980 μl) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of HOOC—(CH 2 ) 12 —COONSu (4.2 mg, 11.9 μmol) in NMP (105 μl), the reaction mixture was gently shaken for 1 h and 50 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (6.5 mg, 87 μmol) in 50% aqueous ethanol (652 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (5.8 mg, 39%) was isolated, and the product was analysed by MALDI-MS. The m/z value for the protonated molecular ion was found to be 3780±3. The resulting molecular weight was thus 3779±3 amu (theoretical value 3781 amu).

Example 43

Synthesis of Arg 34 Lys 26 (N ε -(γ-glutamyl(N α -tetradecanoyl))) GLP-1(7-37)-OH

A mixture of Arg 34 GLP-1(7-37)-OH (15 mg, 4.4 μmol), EDPA (16 mg, 124 μmol), NMP (2 ml) and water (4.8 ml) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of N α -tetradecanoyl-Glu(ONSu)-OBu t , prepared as described in Example 29, (12.1 mg, 23.7 μmol) in NMP (303 μl), and the reaction mixture was gently shaken for 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (6.5 mg, 86.9 μmol) in 50% aqueous ethanol (652 μl). A 0.5% aqueous solution of ammonium-acetate (50 ml) was added, and the resulting mixture eluted onto a Varian 1 g C8 Mega Bond Elut® cartridge, the immobilised compound washed with 5% aqueous acetonitrile (15 ml), and finally liberated from the cartridge by elution with TFA (6 ml). The eluate was allowed to stand for 1 h and 45 min. at room temperature and then concentrated in vacuo. The residue was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (3.9 mg, 26%) was isolated, and the product was analysed by MALDI-MS. The m/z value for the protonated molecular ion was found to be 3723±3. The resulting molecular weight was thus 3722±3 amu (theoretical value 3723 amu).

Example 44

Synthesis of N α -octadecanoyl-Glu(ONSu)-OBu t

To a suspension of H-Glu(OH)-OBu t (2.82 g, 13.9 mmol), DMF (370 ml) and EDPA (1.79 g, 13.9 mmol) was added drop by drop a solution of Ste-ONSu (5.3 g, 13.9 mmol) in DMF (60 ml). Dichloromethane (35 ml) was added, and the reaction mixture was stirred for 24 h at room temperature and then concentrated in vacuo. The residue was partitioned between 10% aqueous citric acid (330 ml) and ethyl acetate (200 ml), and the phases were separated. The organic phase was concentrated in vacuo and the residue dissolved in DMF (60 ml). The resulting solution was added drop by drop to a 10% aqueous solution of citric acid (400 ml) kept at 0° C. The precipitated compound was collected and washed with iced water and dried in a vacuum drying oven. The dried compound was dissolved in DMF (40 ml) and HONSu (1.63 g, 14.2 mmol) was added. To the resulting mixture was added a solution of DCC (2.66 g, 12.9 mmol) in dichloromethane (51 ml). The reaction mixture was stirred for 64 h at room temperature, and the precipitated compound was filtered off. The precipitate was recrystallised from n-heptane/2-propanol to give the title compound (4.96 g, 68%).

Example 45

Synthesis of Arg 26, 34 Lys 38 (N ε -(γ-glutamyl(N α -octadecanoyl))) GLP-1(7-38)-OH

A mixture of Arg 26,34 GLP-1(7-38)-OH (28 mg, 7.9 μmol), EDPA (28.6 mg, 221.5 μmol), NMP (1.96 ml) and water (1.96 ml) was gently shaken for 5 min. at room temperature. To the resulting mixture was added a solution of N α -octadecanoyl-Glu(ONSu)-OBu t (17.93 g, 31.6 μmol), prepared as described in Example 44, in NMP (448 μl), and the reaction mixture was gently shaken for 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (13.1 mg, 174 μmol) in 50% aqueous ethanol (1.3 ml). A 0.5% aqueous solution of ammonium-acetate (120 ml) was added, and the resulting mixture was divided into two equal portions. Each portion was eluted onto a Varian 5 g C8 Mega Bond Elut® cartridge, the immobilised compound washed with 5% aqueous acetonitrile (25 ml), and finally liberated from the cartridge by elution TFA (25 ml). The combined eluates were allowed to stand for 1 h and 25 min. at room temperature and then concentrated in vacuo. The residue was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The column was heated to 65° C. and the acetonitrile gradient was 0-100% in 60 minutes. The title compound (3.6 mg, 11%) was isolated, and the product was analysed by MALDI-MS. The m/z value for the protonated molecular ion was found to be 3940±3. The resulting molecular weight was thus 3939±3 amu (theoretical value 3937 amu).

BIOLOGICAL FINDINGS

Protraction of GLP-1 Derivatives After s.c. Administration

The protraction of a number GLP-1 derivatives of the invention was determined by monitoring the concentration thereof in plasma after sc administration to healthy pigs, using the method described below. For comparison also the concentration in plasma of GLP-1(7-37) after sc. administration was followed. The results are given in Table 1. The protraction of other GLP-1 derivatives of the invention can be determined in the same way.

Pigs (50% Duroc, 25% Yorkshire, 25% Danish Landrace, app 40 kg) were fasted from the beginning of the experiment. To each pig 0.5 nmol of test compound per kg body weight was administered in a 50 μM isotonic solution (5 mM phosphate, pH 7.4, 0.02% Tween®-20(Merck), 45 mg/ml mannitol (pyrogen free, Novo Nordisk). Blood samples were drawn from a catheter in vena jugularis at the hours indicated in Table 1. 5 ml of the blood samples were poured into chilled glasses containing 175 μl of the following solution: 0.18 M EDTA, 1500 KIE/ml aprotinin (Novo Nordisk) and 3% bacitracin (Sigma), pH 7.4. Within 30 min, the samples were centrifuged for 10 min at 5-6000*g. Temperature was kept at 4° C. The supernatant was pipetted into different glasses and kept at minus 20 ° C. until use.

The plasma concentrations of the peptides were determined by RIA using a monoclonal antibody specific for the N-terminal region of GLP-1(7-37). The cross reactivities were less than 1% with GLP-1(1-37) and GLP-1(8-36)amide and <0.1% with GLP-1(9-37), GLP-1(10-36)amide and GLP-1(11-36)amide. The entire procedure was carried out at 4° C.

The assay was carried out as follows: 100 μl plasma was mixed with 271 μl 96% ethanol, mixed using a vortex mixer and centrifuged at 2600*g for 30 min. The supernatant was decanted into Minisorp tubes and evaporated completely (Savant Speedvac AS290). The evaporation residue was reconstituted in the assay buffer consisting of 80 mM NaH 2 PO 4 /Na 2 HPO 4 , 0.1% HSA (Orpha 20/21, Behring), 10 mM EDTA, 0.6 mM thiomersal (Sigma), pH 7.5. Samples were reconstituted in volumes suitable for their expected concentrations, and were allowed to reconstitute for 30 min. To 300 μl sample, 100 μl antibody solution in dilution buffer containing 40 mM NaH 2 PO 4 /Na 2 HPO 4 , 0.1% HSA, 0.6 mM thiomersal, pH 7.5, was added. A non-specific sample was prepared by mixing 300 μl buffer with 100 μl dilution buffer. Individual standards were prepared from freeze dried stocks, dissolved in 300 μl assay buffer. All samples were pre-incubated in Minisorp tubes with antibody as described above for 72 h. 200 μl tracer in dilution buffer containing 6-7000 CPM was added, samples were mixed and incubated for 48 h. 1.5 ml of a suspension of 200 ml per liter of heparin-stabilised bovine plasma and 18 g per liter of activated carbon (Merck) in 40 mM NaH 2 PO 4 /Na 2 HPO 4 , 0.6 mM thiomersal, pH 7.5, was added to each tube. Before use, the suspension was mixed and allowed to stand for 2 h at 4° C. All samples were incubated for 1 h at 4° C. and then centrifuged at 3400*g for 25 min. Immediately after the centrifugation, the supernatant was decanted and counted in a γ-counter. The concentration in the samples was calculated from individual standard curves. The following plasma concentrations were found, calculated as % of the maximum concentration for the individual compounds (n=2):

TABLE 1
Test	Hours after sc. Administration
compound* )	0.75	1	2	4	6	8	10	12	24
GLP-1(7-37)		100	9	1
Example 25	73	92	100	98	82	24	16	16	16
Example 17	76	71	91	100	84	68	30		9
Example 43		39	71	93	100	91	59	50	17
Example 37		26	38	97	100	71	81	80	45
Example 11	24	47	59	71	100	94	100		94
Example 12	36	54	65	94	80	100	85		93
Example 32	55	53	90	83	88	70	98	100	100
Example 14	18	25	32	47	98	83	97		100
Example 13	15	22	38	59	97	85	100		76
Example 38	60	53	100	66	48	39	25	29	0
Example 39	38	100	70	47	33	33	18	27	14
Example 40	47	19	50	100	51	56	34	14	0
Example 34	19	32	44	84	59	66	83	84	100
* ) The test compounds are the title compounds of the examples with the numbers given

Table 1 shows that the GLP-1 derivatives of the invention have a protracted profile of action relative to GLP-1(7-37) and are much more persistent in plasma than GLP-1(7-37). It also appears from Table 1 that the time at which the peak concentration in plasma is achieved varies within wide limits, depending on the particular GLP-1 derivative selected.

Stimulation of cAMP Formation in a Cell Line Expressing the Cloned Human GLP-1 Receptor

In order to demonstrate efficacy of the GLP-1 derivatives, their ability to stimulate formation of cAMP in a cell line expressing the cloned human GLP-1 receptor was tested. An EC 50 was calculated from the dose-response curve.

Baby hamster kidney (BHK) cells expressing the human pancreatic GLP-1 receptor were used (Knudsen and Pridal, 1996, Eur. J. Pharm. 318, 429-435). Plasma membranes were prepared (Adelhorst et al, 1994, J. Biol. Chem. 269, 6275) by homogenisation in buffer (10 mmol/l Tris-HCl and 30 mmol/l NaCl pH 7.4, containing, in addition, 1 mmol/l dithiothreitol, 5 mg/l leupeptin (Sigma, St. Louis, Mo., USA), 5 mg/l pepstatin (Sigma, St. Louis, Mo., USA), 100 mg/l bacitracin (Sigma, St. Louis, Mo., USA), and 16 mg/l aprotinin (Novo Nordisk A/S, Bagsvaerd, Denmark)). The homogenate was centrifuged on top of a layer of 41 w/v % sucrose. The white band between the two layers was diluted in buffer and centrifuged. Plasma membranes were stored at −80° C. until used.

The assay was carried out in 96-well microtiter plates in a total volume of 140 μl. The buffer used was 50 mmol/l Tris-HCl, pH 7.4 with the addition of 1 mmol/l EGTA, 1.5 mmol/l MgSO 4 , 1.7 mmol/l ATP, 20 mM GTP, 2 mmol/l 3-isobutyl-1-methylxanthine, 0.01% Tween-20 and 0.1% human serum albumin (Reinst, Behringwerke AG, Marburg, Germany). Compounds to be tested for agonist activity were dissolved and diluted in buffer, added to the membrane preparation and the mixture was incubated for 2 h at 37° C. The reaction was stopped by the addition of 25 μl of 0.05 mol/l HCl. Samples were diluted 10 fold before analysis for cAMP by a scintillation proximity assay (RPA 538, Amersham, UK). The following results were obtained:

	Test Compound* )	EC 50 , pM	Test Compound* )	EC 50 , pM
	GLP-1(7-37)	61	Example 31	96
	Example 45	120	Example 30	41
	Example 43	24	Example 26	8.8
	Example 40	55	Example 25	99
	Example 39	5.1	Example 19	79
	Example 38	54	Example 16	3.5
	Example 37	60
	* ) The test compounds are the title compounds of the examples with the numbers given.

Example 46

Synthesis of Arg 26,34 ,Lys 36 (N ε -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-36)-OH

To a mixture of Arg 26,34 ,Lys 36 GLP-1(7-36)-OH (12.2 mg, 3.67 μmol), EDPA (13.3 mg, 103 μmol), NMP (1.71 ml) and water (855 μl) was added a solution of Pal-Glu(ONSu)-OBu t (5.94 mg, 11 μmol), prepared as described in PCT application no. PCT/DK97/00340, in NMP (148 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 90 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (6 mg, 81 μmol) in water (0.6 ml). A 0.5% aqueous solution of ammonium-acetate (38 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (20 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (3.1 mg, 23%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3695±3. The resulting molecular weight was thus 3694±3 amu (theoretical value 3694 amu).

Example 47

Synthesis of Arg 26,34 ,Lys 36 (N ε -(γ-glutamyl(N α -octadecanoyl))) GLP-1(7-36)-OH

To a mixture of Arg 26,34 ,Lys 36 GLP-1(7-36)-OH (12.2 mg, 3.7 μmol), EDPA (13.3 mg, 103 μmol), NMP (1.71 ml) and water (855 μl) was added a solution of Ste-Glu(ONSu)-OBu t (6.25 mg, 11 μmol), prepared as described in PCT application no. PCT/DK97/00340, in NMP (1 ml). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 90 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (6 mg, 81 μmol) in water (0.6 ml). A 0.5% aqueous solution of ammonium acetate (54 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (20 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (3.7 mg, 27%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3723±3. The resulting molecular weight was thus 3722±3 amu (theoretical value 3722 amu).

Example 48

Synthesis of Lithocholic Acid 2,5-dioxopyrrolidin-1-yl Ester

To a solution of lithocholic acid (5.44 g, 14.3 mmol) in a mixture of anhydrous THF (120 ml) and anhydrous acetonitril (30 ml) was added N-hydroxysuccinimide (1.78 g, 15 mmol). The mixture was cooled to 10° C., a solution of DCC (3.44 g, 16.7 mmol) in anhydrous THF (30 ml) was added drop wise, and the resulting reaction mixture stirred for 16 h at room temperature. The reaction mixture was filtered and partitioned between dichloromethane (450 ml) and 10% aqueous Na 2 CO 3 (150 ml). The phases were separated, and the organic phase washed with 10% aqueous Na 2 CO 3 (150 ml), water (2×150 ml), and dried (MgSO 4 ). The solvent was concentrated in vacuo. The residue was crystallised from a mixture of dichloromethane (30 ml) and n-heptane (30 ml). The precipitate was dried in a vacuum drying oven for 36 h to give the title compound (3.46 g, 51%).

Example 49

Synthesis of Lit-Glu(ONSu)-OBu t

A suspension of H-Glu(OH)-OBu t (1.28 g, 6.33 mmol), DMF (88 ml) and EDPA (0.82 g, 6.33 mmol) and lithocholic acid 2,5-dioxopyrrolidin-1-yl ester, prepared as described in example 48, was stirred for 16 h at room temperature. The reaction mixture was concentrated in vacuo and the residue dissolved in ethyl acetate (40 ml). The resulting solution was washed with 5% aqueous citric acid (2×25 ml), brine (10 ml), and filtered). The solvent was concentrated in vacuo and the residue dissolved in DMF (12 ml). The resulting solution was added drop wise to a 10% aqueous solution of citric acid whereby the product precipitates. The precipitate was collected and washed with iced water, and dried in vacuo. The crude product was recrystallised from a mixture of n-heptane (40 ml) and 2-propanol (17 ml). The precipitate was dried in a vacuum drying oven for 4 h to give the free acid intermediate.

To a solution of the free acid intermediate in DMF (18 ml) was added hydroxysuccinimide (0.45 g, 3.91 mmol), followed by a solution of DCC (0.73 g, 3.56 mmol) in dichloromethane (18 ml). The resulting mixture was stirred at ambient temperature for 18 h, and then filtered. The filtrate was concentrated in vacuo to a solid, and the residue was dissolved in dichloromethane (25 ml), and the filtration repeated, the solvent removed in vacuo to give a foam. The residue was dissolved in refluxing n-heptane (35 ml), and the product crystallised b addition of 2-propanol. The precipitate was collected, washed with cold n-heptane, dried at 35° C. in vacuo to give the title compound (1.34 g, 57%).

Example 50

Synthesis of Arg 34, Lys 26 (N ε -(γ-glutamyl(N α -lithochoyl))) GLP-1(7-37)-OH

To a mixture of Arg 34 ,Lys 26 GLP-1(7-37)-OH (41.1 mg, 12.2 μmol), EDPA (44 mg, 340 μmol), NMP (5.76 ml) and water (2.88 ml) was added a solution of Lit-Glu(ONSu)-OBu t (24 mg, 37 μmol), prepared as described in example 49, in NMP (600 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 75 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (20 mg, 268 μmol) in water (2 ml). A 0.5% aqueous solution of ammonium acetate (128 ml) was added, and the resulting mixture divided into two equal portions, and each portion eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (2×25 ml), and finally liberated from the cartridge by elution with TFA (2×25 ml). The combined eluates were concentrated in vacuo, and the residue purified by column chromato-graphy using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (5 mg, 11%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3872±3. The resulting molecular weight was thus 3871±3 amu (theoretical value 3871 amu).

Example 51

Synthesis of Arg 26 ,Lys 34 (N ε -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-37)-OH

To a mixture of Arg 26 ,Lys 34 GLP-1(7-37)-OH (18 mg, 5.3 μmol), EDPA (19.3 mg, 149 μmol), NMP (2.52 ml) and water (1.26 ml) was added a solution of Pal-Glu(ONSu)-OBu t (8.6 mg, 16 μmol) in NMP (215 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 90 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (8.8 mg, 117 μmol) in water (0.88 ml). A 0.5% aqueous solution of ammonium acetate (50 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (6 mg, 30%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3752±3. The resulting molecular weight was thus 3751±3 amu (theoretical value 3751 amu).

Example 52

Synthesis of Desamino-His 7 ,Arg 26 ,Lys 34 (N ε -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-37)-OH

To a mixture of desamino-His 7 ,Arg 26 ,Lys 34 GLP-1(7-37)-OH (14.3 mg, 4.2 μmol), EDPA (15.3 mg, 119 μmol), NMP (2 ml) and water (1 ml) was added a solution of Pal-Glu(ONSu)-OBu t (6.84 mg, 12.7 μmol) in NMP (171 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 50 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (7 mg, 99 μmol) in water (700 μl). A 0.5% aqueous solution of ammonium acetate (42 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (5.6 mg, 35%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3738±3. The resulting molecular weight was thus 3737±3 amu (theoretical value 3737 amu).

Example 53

Synthesis of Gly 8 ,Arg 26,34 ,Lys 38 (N 68 -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-38)-OH

To a mixture of Gly 8 ,Arg 26,34 ,Lys 38 GLP-1(7-38)-OH (11.8 mg, 3.4 μmol), EDPA (12.1 mg, 94 μmol), NMP (1.65 ml) and water (0.83 ml) was added a solution of Pal-Glu(ONSu)-OBu t (5.4 mg, 10 μmol) in NMP (135 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 75 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (5.5 mg, 73.7 μmol) in water (553 μl). A 0.5% aqueous solution of ammonium acetate (36 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (5 mg, 38%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3895±3. The resulting molecular weight was thus 3894±3 amu (theoretical value 3894 amu).

Example 54

Synthesis of Gly 8 ,Glu 37 ,Arg 26,34 ,Lys 38 (N ε -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-38)-OH

To a mixture of Gly 8 ,Glu 37 ,Arg 26,34 ,Lys 38 GLP-1(7-38)-OH (9 mg, 2.48 μmol), EDPA (9 mg, 69.4 μmol), NMP (1.25 ml) and water (0.63 ml) was added a solution of Pal-Glu(ONSu)-OBu t (4 mg, 7.4 μmol) in NMP (100 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 105 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (4.1 mg, 54.6 μmol) in water (410 μl). A 0.5% aqueous solution of ammonium acetate (27 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (15 ml), and finally liberated from the cartridge by elution with TFA (15 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (2.9 mg, 29%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3967±3. The resulting molecular weight was thus 3966±3 amu (theoretical value 3967 amu).

Example 55

Synthesis of Gly 8 ,Glu 37 ,Arg 26,34 ,Lys 38 (N ε -(γ-glutamyl(N α -octadecanoyl))) GLP-1(7-38)-OH

To a mixture of Gly 8 ,Glu 37 ,Arg 26,34 ,Lys 38 GLP-1(7-38)-OH (9 mg, 2.5 μmol), EDPA (9 mg, 69.4 μmol), NMP (1.25 ml) and water (0.63 ml) was added a solution of Ste-Glu(ONSu)-OBu t (4.2 mg, 7.4 μmol in NMP (105 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 105 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (4.1 mg, 54.6 μmol) in water (409 μl). A 0.5% aqueous solution of ammonium acetate (27 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (15 ml), and finally liberated from the cartridge by elution with TFA (15 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (3.2 mg, 32%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3995±3. The resulting molecular weight was thus 3994±3 amu (theoretical value 3995 amu).

Example 56

Synthesis of Cap-Glu(ONSu)-OBu t

To a solution of octanoic acid (5 g, 34.7 mmol) and N-hydroxysuccinimide (4 g, 34.7 mmol) in anhydrous acetonitril (10 ml) was added a solution of DCC (7.15 g, 34.7 mmol) in anhydrous dichloromethane (15 ml), and the resulting reaction mixture stirred for 16 h at room temperature. The precipitated solid was filtered off and recrystallised from a mixture of n-heptane (40 ml) and 2-propanol (2 ml). The precipitate was dried in a vacuum drying oven for 16 h to give the intermediate Cap-ONSu. A suspension of the crude ester intermediate (3.9 g, 16.2 mmol), (L)-H-Glu(OH)-OBu t (3.28 g, 16.2 mmol), DMF (268 ml) and EDPA (2.1 g, 16.2 mmol) was stirred for 64 h at room temperature. The reaction mixture was concentrated in vacuo and the residue dissolved in ethyl acetate (50 ml). The resulting solution was washed with 5% aqueous citric acid (2×25 ml). The solvent was concentrated in vacuo and the residue dissolved in DMF (36 ml). The resulting solution was added drop wise to a 10% aqueous solution of citric acid (357 ml) and extracted with ethyl acetate (200 ml), and dried (MgSO 4 ). The solvent was concentrated in vacuo to give the crude glutamic acid intermediate. To a mixture of the crude glutamic acid intermediate, N-hydroxysuccinimide (1.85 g, 16.1 mmol) and DMF (25 ml) was added a solution of DCC (3.32 g, 16.1 mmol) in dichloromethane (15 ml). The resulting mixture was stirred at ambient temperature for 20 h. The reaction mixture was filtered and the solvent concentrated in vacuo. The residue was purified on a silica gel column (40-63μ), eluted with a mixture of dichloromethane and acetonitril (1:1) to give the title compound (0.63 g, 6% over all).

Example 57

Synthesis of Desamino-His 7 ,Arg 26 ,Lys 34 (N ε -(γ-glutamyl(N α -octanoyl))) GLP-1(7-37)-OH

To a mixture of desamino-His 7 ,Arg 26 ,Lys 34 GLP-1(7-37)-OH (14.3 mg, 4.2 μmol), EDPA (15.3 mg, 119 μmol), NMP (2 ml) and water (1 ml) was added a solution of Cap-Glu(ONSu)-OBu t (6.8 mg, 12.7 μmol), prepared as described in example 56, in NMP (135 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (7 mg, 93 μmol) in water (698 μl). A 0.5% aqueous solution of ammonium acetate (42 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (4.1 mg, 27%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3626±3. The resulting molecular weight was thus 3625±3 amu (theoretical value 3625 amu).

Example 58

Synthesis of Glu 37 ,Arg 26,34 ,Lys 38 (N ε -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-38)-OH

To a mixture of Glu 37 ,Arg 26,34 ,Lys 38 GLP-1(7-38)-OH (17.6 mg, 4.9 μmol), EDPA (17.6 mg, 136 μmol), NMP (1.23 ml) and water (2.46 ml) was added a solution of Pal-Glu(ONSu)OBu t (7.9 mg, 14.6 μmol) in NMP (197 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (8 mg, 107 μmol) in water (804 μl). A 0.5% aqueous solution of ammonium acetate (49 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (5.1 mg, 26%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3981±3. The resulting molecular weight was thus 3980±3 amu (theoretical value 3981 amu).

Example 59

Synthesis of Arg 34 ,Lys 26 (N ε -(γ-glutamyl(N α -octadecanoyl))) GLP-1(7-37)-OH

To a mixture of Arg 34 GLP-1(7-37)-OH (41.1 mg, 12.2 μmol), EDPA (44 mg, 341 μmol), NMP (5.76 ml) and water (2.88 ml) was added a solution of Ste-Glu(ONSu)-OBu t (20.7 mg, 36.5 μmol in NMP (517 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (20.1 mg, 268 μmol) in water (2.01 ml). A 0.5% aqueous solution of ammonium-acetate (120 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (15.4 mg, 34%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3781±3. The resulting molecular weight was thus 3780±3 amu (theoretical value 3779 amu).

Example 60

Synthesis of Arg 34 ,Lys 26 (N ε -decanoyl) GLP-1(7-37)

To a mixture of Arg 34 GLP-1(7-37)-OH (20 mg, 5.9 μmol), EDPA (21.4 mg, 165 μmol), NMP (2.8 ml) and water (1.4 ml) was added a solution of Cac-ONSu (4.8 mg, 17.7 μmol) in NMP (119 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (9.8 mg, 130 μmol) in water (98 μl). The resulting mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (7.4 mg, 35%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3539.6±3. The resulting molecular weight was thus 3538.6±3 amu (theoretical value 3538 amu).

Example 61

Synthesis of Arg 34 ,Lys 26 (N ε -(hexadecanoyl)) GLP-1(7-37)-OH

To a mixture of Arg 34 GLP-1(7-37)-OH (41.1 mg, 12.2 μmol), EDPA (44 mg, 340 μmol), NMP (2.88 ml) and water (2.88 ml) was added a solution of Pal-ONSu (12.9 mg, 36.5 μmol) in NMP (3.3 ml). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 110 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (20.1 mg, 268 μmol) in water (201 μl). The solvent was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (15 mg, 34%) was isolated, and the product was analysed by PDMS.

Example 62

Synthesis of Arg 26,34 ,Lys 27 (N ε -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-37)-OH

To a mixture of Arg 26,34 , Lys 27 GLP-1(7-37)-OH (11.6 mg, 3.4 μmol), EDPA (12.3 mg, 94.9 μmol), NMP (1.6 ml) and water (0.8 ml) was added a solution of Pal-Glu(ONSu)-OBu t (5.5 mg, 10.2 μmol) in NMP (137 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 90 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (5.6 mg, 74.6 μmol) in water (560 μl ). A 0.5% aqueous solution of ammonium acetate (34 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (15 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The solvent was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (2.1 mg, 16%) was isolated, and the product was analysed by PDMS.

Example 63

Synthesis of Arg 26,34 ,Lys 23 (N ε -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-37)-OH

To a mixture of Arg 26,34, Lys 23 GLP-1(7-37)-OH (11.6 mg, 3.4 μmol), EDPA (12.3 mg, 94.9 μmol), NMP (1.6 ml) and water (0.8 ml) was added a solution of Pal-Glu(ONSu)-OBu t (5.5 mg, 10.2 μmol) in NMP (137 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 90 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (5.6 mg, 74.6 μmol) in water (560 μl). A 0.5% aqueous solution of ammonium acetate (34 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (15 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The solvent was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (3.1 mg, 24%) was isolated, and the product was analysed by PDMS.

Example 64

Synthesis of Arg 26,34 ,Lys 18 (N ε -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-37)-OH

To a mixture of Arg 26,34 ,Lys 18 GLP-1(7-37)-OH (11.7 mg, 3.4 μmol), EDPA (12.2 mg, 94.6 μmol), NMP (1.6 ml) and water (0.8 ml) was added a solution of Pal-Glu(ONSu)-OBu t (5.5 mg, 10.2 μmol) in NMP (137 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 90 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (5.6 mg, 74.6 μmol) in water (560 μl). A 0.5% aqueous solution of ammonium acetate (34 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The solvent was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (1.9 mg, 15%) was isolated, and the product was analysed by PDMS.

Example 65

Synthesis of Arg 34 ,Lys 26 (N ε -(octanoyl)) GLP-1(7-37)-OH

To a mixture of Arg 34 GLP-1(7-37)-OH (41.1 mg, 12.2 μmol), EDPA (44 mg, 341 μmol), NMP (5.76 ml) and water (2.88 ml) was added a solution of Cap-ONSu (8.8 mg, 36.5 μmol), prepared as described in example 56, in NMP (106 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 115 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (20 mg, 268 μmol) in water (200 μl). The solvent was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (18.8 mg, 44%) was isolated, and the product was analysed by PDMS.

Example 66

Synthesis of Arg 34 ,Lys 26 (N 68 -(dodecanoyl)) GLP-1(7-37)-OH

To a mixture of Arg 34 GLP-1(7-37)-OH (41.1 mg, 12.2 μmol), EDPA (44 mg, 341 μmol), NMP (5.76 ml) and water (2.88 ml) was added a solution of Lau-ONSu (8.8 mg, 36.5 μmol), prepared in a similar manner as described for Cap-ONSu in example 56), in NMP (271 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 100 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (20.1 mg, 268 μmol) in water (200 μl). The solvent was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (18 mg, 42%) was isolated, and the product was analysed by PDMS.

Example 67

Synthesis of Pal-GABA-ONSu

A mixture of Pal-ONSu (3 g, 8.48 mmol), γ-aminobutyric acid (0.87 g, 8.48 mmol) in DMF (200 ml) was stirred at room temperature for 60 h. The reaction mixture was filtered and the filtrate was added drop wise to 10% aqueous citric acid (500 ml). The precipitated N-acylated intermediate was collected and dried in vacuo. To a suspension of the dried intermediate in DMF (35 ml) was added a solution of DCC (1.45 g, 7.0 mmol) in dichloromethane (20 ml). The resulting mixture was stirred at room temperature for 20 h, and then filtered. The solvent was removed in vacuo to give a solid residue. The residue was recrystallised from a mixture of n-heptane (50 ml) and 2-propanol (2.5 ml) to give the title compound (2.5 g, 75%).

Example 68

Synthesis of Arg 34 ,Lys 26 (N ε -(γ-aminobutyroyl(N γ -hexadecanoyl))) GLP-1(7-37)-OH

To a mixture of Arg 34 , Lys 26 GLP-1(7-37)-OH (41.1 mg, 12.2 μmol), EDPA (44 mg, 341 μmol), NMP (5.76 ml) and water (2.88 ml) was added a solution of Pal-GABA-ONSu (16 mg, 36.5 μmol), prepared as described in example 67) in NMP (400 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 100 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (20 mg, 268 μmol) in water (200 μl). The solvent was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (15.8 mg, 35%) was isolated, and the product was analysed by PDMS.

Example 69

Synthesis of N α -hexadecanoyl-D-glutamic acid α-t-butyl ester-γ-2,5-dioxopyrrolidin-1-yl ester

A mixture of Pal-ONSu (6.64 g, 18.8 mmol), D-glutamic acid α-tert-butyl ester (4.5 g, 18.8 mmol) and EDPA (4.85 g, 37.5 mmol) in DMF (538 ml) was stirred at room temperature for 60 h. The solvent was removed and the residue dissolved in ethyl acetate (175 ml). The resulting solution was extracted with 10% aqueous citric acid (2×125 ml), and the organic phase concentrated in vacuo. The residue was dissolved in DMF (60 ml), and the resulting mixture slowly added to 10% aqueous citric acid (500 ml). The precipitated compound was collected and dried in vacuo, to give the crude N-acylated glutamic acid intermediate. The crude intermediate was dissolved in DMF (35 ml), and a solution of DCC (3.5 g, 17 mmol) in dichloromethane (70 ml) was added. The resulting mixture was stirred at room temperature for 20 h, and then filtered. The filtrate was concentrated in vacuo, and the solid residue recrystallised from a mixture of n-heptane (75 ml) and 2-propanol (5 ml), to give the title compound (5.2 g, 50%).

Example 70

Synthesis of Arg 34 ,Lys 26 (N ε -(γ-D-glutamyl(N α -hexadecanoyl))) GLP-1(7-37)-OH

To a mixture of Arg 34 , Lys 26 GLP-1(7-37)-OH (41.1 mg, 12.2 μmol), EDPA (44 mg, 341 μmol), NMP (5.76 ml) and water (2.88 ml) was added a solution of N α -hexadecanoyl-D-glutamic acid α-t-butyl ester-γ-2,5-dioxopyrrolidin-1-yl ester (19.7 mg, 36.5 μmol) in NMP (491 μl). The reaction mixture was gently shaken for 5 min. at room temperature, and then allowed to stand for an additional 95 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (20 mg, 268 μmol) in water (2 ml). A 0.5% aqueous solution of ammonium acetate (120 ml) was added, and the resulting mixture divided into to equal portions, and each portion eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The combined eluates were concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (10.5 mg, 23%) was isolated, and the product was analysed by PDMS.

Example 71

Synthesis of Lys 34 (N ε -(γ-glutamyl(N α -tetradecanoyl))) GLP-1(7-37)

To a mixture of GLP-1(7-37)-OH (33.6 mg, 8.9 μmol), EDPA (32.4 mg, 250 μmol), NMP (2.1 ml) and water (2.1 ml) was added a solution of Myr-Glu(ONSu)-OBu t (9.1 mg, 17.9 μmol), prepared as described above, in NMP (228 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 80 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (14.8 mg, 197 μmol) in water (1.47 ml). A 0.5% aqueous solution of ammonium acetate (100 ml) was added, and the resulting mixture divided into two equal portions, and each portion eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (2×25 ml), and finally liberated from the cartridge by elution with TFA (2×25 ml). The combined eluates were concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (0.19 mg, 0.6%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3693±3. The resulting molecular weight was thus 3692±3 amu (theoretical value 3695 amu).

Example 72

Synthesis of Arg 26,34 ,Lys 8 (N ε -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-37)

To a mixture of Arg 26, 34 Lys 8 GLP-1(7-37)-OH (10.3 mg, 3 μmol), EDPA (10.8 mg, 83 μmol), NMP (1.44 ml) and water (0.72 ml) was added a solution of Pal-Glu(ONSu)-OBu t (4.8 mg, 8.9 μmol), prepared as described above, in NMP (120 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 70 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (4.9 mg, 65.3 μmol) in water (490 μl). A 0.5% aqueous solution of ammonium acetate (30 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (3.2 mg, 28%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3836±3. The resulting molecular weight was thus 3835±3 AMU (theoretical value 3836 AMU).

Example 73

Synthesis of Lau-Glu(ONSu)-OBu t

To a solution of H-Glu-OBu t (3 g, 15 mmol) in DMF (344 ml) was added EDPA (2.58 ml, 15 mmol) and a solution of Lau-ONSu (4.5 g, 15 mmol), prepared in a similar manner as described for Cap-ONSu in example 56, in DMF (74 ml). The resulting mixture was stirred at ambient temperature for 18 h, and the solvent removed in vacuo. The oily residue was partitioned between ethyl acetate (150 ml) and 5% aqueous citric acid (250 ml). The organic phase was concentrated in vacuo. The residue was dissolved in DMF (40 ml) and the solution added drop by drop to a 10% aqueous citric acid solution (350 ml). The precipitated product was collected, washed with water and dried in vacuo for 18 h to give the intermediate free acid. To solution of the free acid intermediate in DMF (25 ml) was added N-hydroxysuccinimide (1.7 g, 14.8 mmol) and a solution of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide (2.58 g, 13.5 mmol) in dichloromethane (52 ml). The resulting mixture was stirred at room temperature for 18 h, and the solvents removed in vacuo. The oily residue was partitioned between dichloromethane (80 ml) and water (80 ml). The organic phase was washed with 5% aqueous citric acid, dried (MgSO 4 ), and concentrated in vacuo to a solid. The solid residue was crystallised from a mixture of n-heptane (77 ml) and 2-propanol (50 ml), and finally recrystallised from n-heptane (76 ml) to give the title compound (2.96 g, 46%).

Example 74

Synthesis of Arg 34 ,Lys 26 (N ε -(γ-glutamyl(N α -dodecanoyl))) GLP-1(7-37)

To a mixture of Arg 34 GLP-1(7-37)-OH (20.6 mg, 6.1 μmol), EDPA (22 mg, 171 μmol), NMP (2.88 ml) and water (1.44 ml) was added a solution Lau-Glu(ONSu)-OBu t (10.2 mg, 21.2 μmol), prepared as described in example 73, in NMP (255 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 75 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (10 mg, 134 μmol) in water (100 μl). A 0.5% aqueous solution of ammonium acetate (61 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (8.2 mg, 36%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3693±3. The resulting molecular weight is 3692±3 AMU (theoretical value 3693 AMU).

Example 75

Synthesis of Lau-β-Ala-ONSu

To a solution of Lau-ONSu (4.25 g, 14.3 mmol), prepared in a similar manner to in DMF (400 ml) was added EDPA (1.84 g, 14.3 mmol) and β-alanine (1.27 g, 14.3 mmol). The resulting mixture was stirred at ambient temperature for 18 h. Water (250 ml) and DMF (50 ml) were added and the solution stirred for 1 h at room temperature. The solvents were removed in vacuo to give a solid. The solid residue was dissolved in DMF (50 ml) and the solution added drop by drop to a 5% aqueous solution of citric acid (200 ml). The precipitate collected, washed with water (50 ml) and dried in vacuo to give the title compound (3.6 g, 93%).

Example 76

Synthesis of Pal-β-Ala-ONSu

To a solution of Pal-ONSu (4.25 g, 14.3 mmol) in DMF (400 ml) was added EDPA (1.84 g, 14.3 mmol) and β-alanine (1.27 g, 14.3 mmol). The resulting mixture was stirred at ambient temperature for 18 h. Water (250 ml) and DMF (50 ml) were added and the solution stirred for 1 h at room temperature. The solvents were removed in vacuo to give a solid. The solid residue was dissolved in DMF (50 ml) and the solution added drop by drop to a 5% aqueous solution of citric acid (200 ml). The precipitate collected, washed with water (50 ml) and dried in vacuo to give the title compound (3.6 g, 93%).

Example 77

Synthesis of Myr-GABA-ONSu

To a solution of Myr-ONSu (4 g, 12.3 mmol) in DMF (350 ml) was added EDPA (1.58 g, 12.3 mmol) and γ-aminobutyric acid (1.26 g, 12.3 mmol). The resulting mixture was stirred at ambient temperature for 18 h. Water (50 ml) was added and the solution stirred for 1 h at room temperature. The solvents were removed in vacuo to give a solid. The solid residue was dissolved in DMF (75 ml) and the solution added drop by drop to a 5% aqueous solution of citric acid (250 ml). The precipitate collected, washed with water (100 ml) and dried in vacuo to give the free acid intermediate (3.65 g, 95%). To a solution of the free acid intermediate (3 g, 9.6 mmol), N-hydroxysuccinimide (1.65 g, 14.4 mmol) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (3.67 g, 19.1 mmol) in DMF (330 ml) was stirred for 18 h at room temperature, and the solvent removed in vacuo to give a solid. The solid residue was dissolved in dichloromethane (100 ml) and washed with brine (100 ml). The organic phase was dried (MgSO 4 ) and concentrated in vacuo to give a solid. The solid residue was recrystallised from n-heptane (75 ml) to give the title compound (2.8 g, 71%).

Example 78

Synthesis of Pal-β-Ala-ONSu

To a solution of Pal-ONSu (0.9 g, 2.8 mmol) in DMF (100 ml) were added N-hydroxysuccinimide (0.35 g, 3 mmol) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide (0.79 g, 4.1 mmol). The resulting mixture was stirred at ambient temperature for 40 h, and the solvent removed in vacuo. The solid residue was partitioned between water (50 ml) and dichloromethane (50 ml). The organic phase was separated, dried (MgSO 4 ) and the solvent removed in vacuo to give the title compound (1.1 g, 94%)

Example 79

Synthesis of Arg 34 ,Lys 26 (N 68 -(β-alanyl(N α -hexadecanoyl))) GLP-1(7-37)

To a mixture of Arg 34 GLP-1(7-37)-OH (19.2 mg, 5.7 μmol), EDPA (20.5 mg, 159 μmol), NMP (2.7 ml) and water (1.35 ml) was added a solution Pal-β-Ala-ONSu (7.2 mg, 17 μmol), prepared as described in example 79, in NMP (181 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 90 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (9.3 mg, 125 μmol) in water (93 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (11.6 mg, 55%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3694±3. The resulting molecular weight was thus 3693±3 AMU (theoretical value 3693 AMU).

Example 80

Synthesis of Pal-Glu(OBu t )-ONSu

To a solution of H-Glu(OH)-OBu t (2.7 g, 11.3 mmol) and Pal-ONSu (3.98 g, 11.3 mmol) in DMF (300 ml) was added EDPA (3.2 g, 24.8 mmol). The resulting mixture was stirred at ambient temperature for 18 h, and the solvent concentrated in vacuo to give an oil. The oily residue was dissolved in DMF (60 ml) and the solution added drop by drop to a 10% aqueous solution of citric acid (300 ml) whereby a precipitate was formed. The precipitate was collected, washed with cold water (25 ml), and dried in vacuo to give free acid intermediate (4.44 g, 89%). The free acid intermediate (4 g, 9.1 mmol) was dissolved in DMF (50 ml) and N-hydroxysuccinimide (1.15 g, 10 mmol) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (2.6 g, 13.6 mmol) were added. The resulting mixture was stirred at room temperature for 60 h, the solvent concentrated in vacuo to give the crude title compound (8.2 g).

Example 81

Synthesis of Arg 34 ,Lys 26 (N ε -(α-glutamyl(N α -hexadecanoyl))) GLP-1(7-37)

To a mixture of Arg 34 GLP-1(7-37)-OH (25.6 mg, 7.6 μmol), EDPA (27.4 mg, 212 μmol), NMP (3.5 ml) and water (1.75 ml) was added a solution of Pal-Glu(OBu t )-ONSu (12.2 mg, 22.7 μmol), prepared as described in example 80, in NMP (305 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 100 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (12.5 mg, 168 μmol) in water (125 μl). A 0.5% aqueous solution of ammonium acetate (72.5 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (30 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (6.1 mg, 22%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3751±3. The resulting molecular weight was thus 3750±3 AMU (theoretical value 3751 AMU).

Example 82

Synthesis of Ste-GABA-ONSu

To a solution of Ste-ONSu (3 g, 7.9 mmol) in DMF (270 ml) was added EDPA (1 g, 7.9 mmol) and a solution of γ-aminobutyric acid (0.81 g, 7.9 mmol) in water (40 ml). The resulting suspension was stirred at ambient temperature for 18 h, and then concentrated in vacuo to a final volume of 50 ml. The resulting suspension was added to a 5% aqueous solution of citric acid (500 ml) whereby a precipitate is formed. The precipitate was collected and washed with water (50 ml), and dried in vacuo for 4 h to give the free acid intermediate (2.8 g, 97%). To a mixture of the free acid intermediate (2.6 g, 7 mmol), N-hydroxysuccinimide (1.21 g, 10.5 mmol) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (2.69 g, 14 mmol) in NMP (300 ml) was stirred for 70 h, and the solvent removed in vacuo to give a solid. The solid residue was dissolved in dichloromethane (100 ml) and washed with brine (2×100 ml). The organic phase was dried (MgSO 4 ) and concentrated in vacuo to give a solid. The solid residue was recrystallised from n-heptane (75 ml) to give the title compound (2.2 g, 67%).

Example 83

Synthesis of Pal-Isonip-ONSu

To a suspension of 1-hexadecanoylbenzotriazole (3 g, 8.4 mmol), prepared as described in the literature (Kreutzberger; van der Goot, Arch. Pharm., 307, 1974), in DMF (350 ml) were added EDPA (1.08 g, 8.4 mmol) and a solution of piperidine-4-carboxylic acid in water (20 ml). The resulting suspension was stirred at room temperature for 12d, and then concentrated in vacuo to an oil. The oily residue was added drop by drop to a 5% aqueous solution of citric acid (300 ml) whereby a precipitate was formed. The precipitate was collected and washed with water (50 ml), dried in vacuo for 2 h to give the free acid intermediate (3 g, 97%). To a solution of the free acid intermediate (2.8 g, 7.6 mmol), N-hydroxysuccinimide (1.31 g, 11.4 mmol) in DMF (250 ml) was added N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (2.92 g, 15.2 mmol). The resulting mixture was stirred at ambient temperature for 18 h, and the solvent removed in vacuo to give an oil. The oily residue was dissolved in dichloromethane (100 ml), washed with brine (50 ml), dried (MgSO 4 ) and concentrated in vacuo to give the crude title compound (4.1 g, quant.).

Example 84

Synthesis of Arg 34 ,Lys 26 (N ε -(piperidinyl-4-carbonyl(N-hexadecanoyl))) GLP-1(7-37)

To a mixture of Arg 34 GLP-1(7-37)-OH (25 mg, 7.4 μmol), EDPA (26.7 mg, 207 μmol), NMP (3.5 ml) and water (1.75 ml) was added a solution Pal-Isonip-ONSu (13.7 mg, 30 μmol), prepared as described in example 83 in NMP (343 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 90 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (12.2 mg, 163 μmol) in water (122 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (12 mg, 44%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3734±3. The resulting molecular weight was thus 3733±3 amu (theoretical value 3733 amu).

Example 85

Synthesis of Arg 34 ,Lys 26 (N ε -(γ-glutamyl(N α -decanoyl))) GLP-1(7-37)

To a mixture of Arg 34 GLP-1(7-37)-OH (25 mg, 7.4 μmol), EDPA (26.7 mg, 207 μmol), NMP (3.5 ml) and water (1.75 ml) was added a solution of Cac-Glu(ONSu)-OBu t (10 mg, 22.1 μmol) in NMP (252 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 140 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (12.2 mg, 162 μmol) in water (122 μl). A 0.5% aqueous solution of ammonium acetate (73 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (12.2 mg, 45%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3669.7±3. The resulting molecular weight was thus 3668.7±3 amu (theoretical value 3667 amu).

Example 86

General Method A

Synthesis of Alkanoic Acid 2,5-dioxopyrrolidin-1-yl Ester

To a solution of the alkanoic acid (34.7 mmol) and N-hydroxysuccinimide (4 g, 34.7 mmol) in anhydrous acetonitril (10 ml) was added a solution of DCC (7.15 g, 34.7 mmol) in anhydrous dichloromethane (15 ml), and the resulting reaction mixture was stirred for 16 h at room temperature. The precipitated solid was filtered off and recrystallised from a mixture of n-heptane and 2-propanol. The precipitate was dried in vacuo for 16 h to give the title compound.

Synthesis of Lys(N ε -alkanoyl)-peptide

To a mixture of the peptide (5.9 μmol), EDPA (21 mg, 164 μmol), NMP (5.8 ml) and water (2.9 ml) was added a solution of the alkanoic acid 2,5-dioxopyrrolidin-1-yl ester (37 μmol), prepared as described above, in NMP (0.5 ml). The reaction mixture was gently shaken for 5 min at room temperature, and then allowed to stand for an additional 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (9.7 mg, 129 μmol) in water (97 μl). The solvent was removed in vacuo, and the residue was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% for 60 minutes.

Coupling of a desired group A comprising the 5- or 6-membered ring system Y to the N-terminal end of the peptide may be performed using solid phase protein synthesis techniques as explained above.

Example 87

General Method B

Synthesis of N α -alkanoyl-(L)-glutamic acid α-tert-butyl-γ-(2,5-dioxopyrrolidin-1-yl) Diester

A suspension of the alkanoic acid 2,5-dioxopyrrolidin-1-yl ester (16.2 mmol), prepared as described under General method A, (L)-glutamic acid α-tert-butyl ester (3.28 g, 16.2 mmol), DMF (268 ml) and EDPA (2.1 g, 16.2 mmol) was stirred for 64 h at room temperature. The reaction mixture was concentrated in vacuo and the residue was dissolved in ethyl acetate (50 ml). The resulting solution was washed with 5% aqueous citric acid (2×25 ml). The solvent was concentrated removed in vacuo and the residue dissolved in DMF (36 ml). The resulting solution was carefully added to a 10% aqueous solution of citric acid (357 ml) and extracted with ethyl acetate (200 ml) and dried (MgSO 4 ). The solvent was concentrated removed in vacuo to give the crude glutamic diester intermediate. To a mixture of the crude diester, N-hydroxysuccinimide (1.85 g, 16.1 mmol) and anhydrous DMF (25 ml) was added a solution of DCC (3.32 g, 16.1 mmol) in anhydrous dichloromethane (15 ml). The resulting mixture was stirred at ambient temperature for 20 h. The reaction mixture was filtered and the solvent was concentrated removed in vacuo. The residue was purified on a silica gel column (40-63 μM) and eluted with a mixture of dichloromethane and acetonitril (1:1) to give the title compound.

Synthesis of Lys(N ε -(γ-glutamyl(N α -alkanoyl)))peptide

To a mixture of the peptide (4.2 μmol), EDPA (15.3 mg, 119 μmol), NMP (2 ml) and water (1 ml) was added a solution of N α -alkanoyl-(L)-glutamic acid α-tert-butyl-γ-(2,5-dioxopyrrolidin-1-yl) diester (12.7 μmol), prepared as described above, in NMP (135 ml). The reaction mixture was gently shaken for 5 min at room temperature and then allowed to stand for an additional 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (7 mg, 93 μmol) in water (698 μl). A 0.5% aqueous solution of ammonium acetate (42 ml) was added, and the resulting mixture was eluted onto a Varian 5 g C8 Mega Bond Elut® cartridge, the immobilised compound was washed with 5% aqueous acetonitril (25 ml) and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% for 60 minutes.

Coupling of a desired group A comprising the 5- or 6-membered ring system Y to the N-terminal end of the peptide may be performed using solid phase protein synthesis techniques as explained above.

Example 88

Synthesis of N-terminal Modified Peptides

Peptides were synthesised according to the Fmoc strategy on an Applied Biosystems 431A peptide synthesiser in 0.25 mmol scale using the manufacturer supplied FastMoc UV protocols starting with a Fmoc-Gly-Wang resin (NovaBiochem). The protected amino acid derivatives used were commercially obtained Fmoc amino acids, and Adoc-Imidazolylpropionic acid. The derivatives used where side chain protection was needed were: Fmoc-Arg(Pmc), Fmoc-Trp(Boc), Fmoc-Glu(OBut), Fmoc-Lys(Boc), Fmoc-Gln(Trt), Fmoc-Tyr(But), Fmoc-Ser(But), Fmoc-Thr(But), Fmoc-His(Trt) and Fmoc-Asp(OBut), and Adoc-Imidazolylpropionic acid.

The peptides were cleaved from the resin and side chain deprotected in TFA/phenol/thioanisole/water/ethanedithiol (83.25:6.25:4.25:4.25:2.00) for 180 min. The cleavage mixture was filtered and the filtrate was concentrated by a stream of nitrogen. The crude peptide was precipitated from this oil with diethyl ether and washed twice with diethyl ether. After drying the crude peptide was dissolved in 50% aqueous acetic acid and diluted to 10% acetic acid with water and purified by semipreparative HPLC on a 25 mm×250 mm column packed with 7 m μC-18 silica. The column was eluted with a gradient of acetonitril against 0.05 M (NH 4 ) 2 SO 4 , pH 2.5 at 10 ml/min. at 40° C. The peptide-containing fractions were collected, diluted with 3 volumes of water and applied to a Sep-Pak® C18 cartridge (Waters part. 51910) which was equilibrated with 0.1% TFA. The peptide was eluted from the Sep-Pak® cartridge with 70% acetonitrile/0.1% TFA, water and isolated from the eluate by lyophilization after dilution with water. The final product obtained was characterised by amino acid analysis, analytical RP-HPLC and by PDMS. Amino acid analysis and mass spectrometry agreed with the expected structure within the experimental error of the method (mass spectrometry +/−2 amu, amino acid analysis +/− 10%, RP-HPLC showed a peptide purity >95%).

The RP-HPLC analysis was performed using UV detection at 214 nm and a Vydac 218TP54 4.6 mm×250 mm, 5 μm C-18 silica column which was eluted at 1 ml/min. at 42° C. Two different elution conditions were used: a gradient of 5-60% acetonitrile/0.1 M ammonium sulfate, water pH 2.5; and a gradient of 5-60% acetonitrile, 0.1% TFA/0.1% TFA, water.

Example 89

Synthesis of Cap-Glu(ONSu)-OBu t

To a solution of octanoic acid (5 g, 34.7 mmol) and N-hydroxysuccinimide (4 g, 34.7 mmol) in anhydrous acetonitril (10 ml) was added a solution of DCC (7.15 g, 34.7 mmol) in anhydrous dichloromethane (15 ml), and the resulting reaction mixture stirred for 16 h at room temperature. The precipitated solid was filtered off and recrystallised from a mixture of n-heptane (40 ml) and 2-propanol (2 ml). The precipitate was dried in a vacuum drying oven for 16 h to give the intermediate Cap-ONSu. A suspension of the crude ester intermediate (3.9 g, 16.2 mmol), (L)-H-Glu(OH)-OBu t (3.28 g, 16.2 mmol), DMF (268 ml) and EDPA (2.1 g, 16.2 mmol) was stirred for 64 h at room temperature. The reaction mixture was concentrated in vacuo and the residue dissolved in ethyl acetate (50 ml). The resulting solution was washed with 5% aqueous citric acid (2×25 ml). The solvent was concentrated in vacuo and the residue dissolved in DMF (36 ml). The resulting solution was added drop wise to a 10% aqueous solution of citric acid (357 ml) and extracted with ethyl acetate (200 ml), and dried (MgSO 4 ). The solvent was concentrated in vacuo to give the crude glutamic acid intermediate. To a mixture of the crude glutamic acid intermediate, N-hydroxysuccinimide (1.85 g, 16.1 mmol) and DMF (25 ml) was added a solution of DCC (3.32 g, 16.1 mmol) in dichloromethane (15 ml). The resulting mixture was stirred at ambient temperature for 20 h. The reaction mixture was filtered and the solvent concentrated in vacuo. The residue was purified on a silica gel column (40-63 μm), eluted with a mixture of dichloromethane and acetonitril (1:1) to give the title compound (0.63 g, 6% over all).

Example 90

Synthesis of Desamino-His 7 ,Arg 34 ,Lys 26 (N ε -(γ-glutamyl(N α -hexadecanoyl))) GLP-1(7-37)

To a mixture of desamino-His 7 ,Arg 34 GLP-1(7-37)-OH (20 mg, 5.9 μmol), EDPA (21.5 mg, 166 μmol), NMP (2.8 ml) and water (1.4 ml) was added a solution Pal-Glu(ONSu)-OBu t (9.6 mg, 17.8 μmol in NMP (240 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 75 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (9.8 mg, 130 μmol) in water (979 μl). A 0.5% aqueous solution of ammonium acetate (58 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (9.1 mg, 41%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3739±3. The resulting molecular weight was thus 3738±3 amu (theoretical value 3736 amu).

Example 91

Synthesis of Myr-GABA-ONSu

To a solution of Myr-ONSu (4 g, 12.3 mmol) in DMF (350 ml) was added EDPA (1.58 g, 12.3 mmol) and γ-aminobutyric acid (1.26 g, 12.3 mmol). The resulting mixture was stirred at ambient temperature for 18 h. Water (50 ml) was added and the solution stirred for 1 h at room temperature. The solvents were removed in vacuo to give a solid. The solid residue was dissolved in DMF (75 ml) and the solution added drop by drop to a 5% aqueous solution of citric acid (250 ml). The precipitate collected, washed with water (100 ml) and dried in vacuo to give the free acid intermediate (3.65 g, 95%). To a solution of the free acid intermediate (3 g, 9.6 mmol), N-hydroxysuccinimide (1.65 g, 14.4 mmol) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (3.67 g, 19.1 mmol) in DMF (330 ml) was stirred for 18 h at room temperature, and the solvent removed in vacuo to give a solid. The solid residue was dissolved in dichloromethane (100 ml) and washed with brine (100 ml). The organic phase was dried (MgSO 4 ) and concentrated in vacuo to give a solid. The solid residue was recrystallised from n-heptane (75 ml) to give the title compound (2.8 g, 71%).

Example 92

Synthesis of Desamino-His 7 ,Arg 34 ,Lys 26 (N ε -(γ-aminobutyroyl(N γ -hexadecanoyl))) GLP-1(7-37)

To a mixture of desamino-His 7 ,Arg 34 GLP-1(7-37)-OH (20 mg, 8.9 μmol), EDPA (21.5 mg, 166 μmol), NMP (2.8 ml) and water (1.4 ml) was added a solution Pal-GABA-ONSu (7.8 mg, 17.8 μmol) in NMP (181 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 90 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (9.3 mg, 125 μmol) in water (93 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (11.6 mg, 55%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3692±3. The resulting molecular weight was thus 3691±3 amu (theoretical value 3693 amu).

Example 93

Synthesis of Desamino-His 7 ,Arg 34 ,Lys 26 (N ε -(β-alanyl(N γ -hexadecanoyl))) GLP-1(7-37)

To a mixture of desamino-His 7 ,Arg 34 GLP-1(7-37)-OH (25 mg, 7.4 μmol), EDPA (26.8 mg, 208 μmol), NMP (3.5 ml) and water (1.75 ml) was added a solution Pal-β-Ala-ONSu (9.4 mg, 22.2 μmol) in NMP (236 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 130 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (12.2 mg, 163 μmol) in water (122 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (13.4 mg, 49%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3681±3. The resulting molecular weight was thus 3680±3 amu (theoretical value 3678 amu).

Example 94

Synthesis of Ste-GABA-ONSu

To a solution of Ste-ONSu (3 g, 7.9 mmol) in DMF (270 ml) was added EDPA (1 g, 7.9 mmol) and a solution of γ-aminobutyric acid (0.81 g, 7.9 mmol) in water (40 ml). The resulting suspension was stirred at ambient temperature for 18 h, and then concentrated in vacuo to a final volume of 50 ml. The resulting suspension was added to a 5% aqueous solution of citric acid (500 ml) whereby a precipitate is formed. The precipitate was collected and washed with water (50 ml), and dried in vacuo for 4 h to give the free acid intermediate (2.8 g, 97%). To a mixture of the free acid intermediate (2.6 g, 7 mmol), N-hydroxysuccinimide (1.21 g, 10.5 mmol) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (2.69 g, 14 mmol) in NMP (300 ml) was stirred for 70 h, and the solvent removed in vacuo to give a solid. The solid residue was dissolved in dichloromethane (100 ml) and washed with brine (2×100 ml). The organic phase was dried (MgSO 4 ) and concentrated in vacuo to give a solid. The solid residue was recrystallised from n-heptane (75 ml) to give the title compound (2.2 g, 67%).

Example 95

Synthesis of Arg 34 ,Ala 8 (N α -(imidazol-4-ylprop-2-enoyl),Lys 26 (N ε -(γ-aminobutyroyl(N γ -hexadecanoyl))) GLP-1(8-37)

To a mixture of Arg 34 ,Ala 8 (N α -(imidazol-4-ylprop-2-enoyl) GLP-1(8-37)-OH (5.6 mg, 1.7 μmol), EDPA (6 mg, 46.2 μmol), NMP (0.78 ml) and water (0.39 ml) was added a solution Pal-GABA-ONSu (2.2 mg, 5 μmol) in NMP (54 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 80 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (2.7 mg, 36 μmol) in water (27 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (1.9 mg, 31%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3690±3. The resulting molecular weight was thus 3689±3 amu (theoretical value 3690 amu).

Example 96

Synthesis of Arg 34 ,Ala 8 (N α -(imidazol-4-ylacetyl),Lys 26 (N ε -(γ-aminobutyroyl(N γ -hexadecanoyl))) GLP-1(8-37)

To a mixture of Arg 34 ,Ala 8 (N α -(imidazol-4-ylacetyl) GLP-1(8-37)-OH (5.3 mg, 1.6 μmol), EDPA (5.7 mg, 43.9 μmol), NMP (0.74 ml) and water (0.37 ml) was added a solution Pal-GABA-ONSu (2 mg, 4.7 μmol) in NMP (52 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 80 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (2.6 mg, 34 μmol) in water (26 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (2.2 mg, 38%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3676±3. The resulting molecular weight was thus be 3675±3 amu (theoretical value 3678 amu).

Example 97

Synthesis of Desamino-His 7 ,Arg 34 ,Lys 26 (N ε -(γ-aminobutyroyl(N γ -tetradecanoyl))) GLP-1(7-37)

To a mixture of desamino-His 7 ,Arg 34 GLP-1(7-37)-OH (25 mg, 7.4 μmol), EDPA (26.9 mg, 208 μmol), NMP (3.5 ml) and water (1.75 ml) was added a solution Myr-GABA-ONSu (9.1 mg, 22.2 μmol), prepared as described in example 91, in NMP (228 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 90 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (12.2 mg, 163 μmol) in water (122 μl). The reaction mixture was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (10.5 mg, 39%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3667±3. The resulting molecular weight was thus 3664±3 amu (theoretical value 3662 amu).

Example 98

Synthesis of Desamino-His 7 ,Arg 34 ,Lys 26 (N ε -(γ-aminobutyroyl(N γ -octadecanoyl))) GLP-1(7-37)

To a mixture of desamino-His 7 ,Arg 34 GLP-1(7-37)-OH (25 mg, 7.4 μmol), EDPA (26.8 mg, 207 μmol), NMP (3.5 ml) and water (1.75 ml) was added a solution Ste-GABA-ONSu (10.4 mg, 22.2 μmol), prepared as described in example 94, in NMP (259 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 170 min. at room temperature. The reaction was quenched by the addition of a solution of glycine (12.2 mg, 163 μmol) in water (122 μl) and the reaction mixture purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (7 mg, 25%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3719±3. The resulting molecular weight was thus 3718±3 amu (theoretical value 3720 amu).

Example 99

General Method A

Synthesis of Alkanoic Acid 2,5-dioxopyrrolidin-1-yl Ester

To a solution of the alkanoic acid (34.7 mmol) and N-hydroxysuccinimide (4 g, 34.7 mmol) in anhydrous acetonitril (10 ml) was added a solution of DCC (7.15 g, 34.7 mmol) in anhydrous dichloromethane (15 ml), and the resulting reaction mixture was stirred for 16 h at room temperature. The precipitated solid was filtered off and recrystallised from a mixture of n-heptane and 2-propanol. The precipitate was dried in vacuo for 16 h to give the title compound.

Synthesis of Lys(N ε -alkanoyl)-peptide

To a mixture of the desired parent peptide (5.9 μmol), EDPA (21 mg, 164 μmol), NMP (5.8 ml) and water (2.9 ml) was added a solution of the alkanoic acid 2,5-dioxopyrrolidin-1-yl ester (37 μmol), prepared as described above, in NMP (0.5 ml). The reaction mixture was gently shaken for 5 min at room temperature, and then allowed to stand for an additional 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (9.7 mg, 129 μmol) in water (97 μl). The solvent was removed in vacuo, and the residue was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient is 0-100% for 60 minutes.

General Method B

Synthesis of N α -alkanoyl-(L)-glutamic Acid α-tert-butyl-γ-(2,5-dioxopyrrolidin-1-yl) Diester

A suspension of the alkanoic acid 2,5-dioxopyrrolidin-1-yl ester (16.2 mmol), prepared as described under General method A, (L)-glutamic acid α-tert-butyl ester (3.28 g, 16.2 mmol), DMF (268 ml) and EDPA (2.1 g, 16.2 mmol) was stirred for 64 h at room temperature. The reaction mixture was concentrated in vacuo and the residue was dissolved in ethyl acetate (50 ml). The resulting solution was washed with 5% aqueous citric acid (2×25 ml). The solvent was removed in vacuo and the residue dissolved in DMF (36 ml). The resulting solution was carefully added to a 10% aqueous solution of citric acid (357 ml) and extracted with ethyl acetate (200 ml) and dried (MgSO 4 ). The solvent was removed in vacuo to give the crude glutamic diester intermediate. To a mixture of the crude diester, N-hydroxysuccinimide (1.85 g, 16.1 mmol) and anhydrous DMF (25 ml) was added a solution of DCC (3.32 g, 16.1 mmol) in anhydrous dichloromethane (15 ml). The resulting mixture was stirred at ambient temperature for 20 h. The reaction mixture was filtered and the solvent was removed in vacuo. The residue was purified on a silica gel column (40-63 μm) and eluted with a mixture of dichloromethane and acetonitril (1:1) to give the title compound.

Synthesis of Lys(N ε -(γ-glutamyl(N α -alkanoyl)))peptide

To a mixture of the desired parent peptide (4.2 μmol), EDPA (15.3 mg, 119 μmol), NMP (2 ml) and water (1 ml) was added a solution of N α -alkanoyl-(L)-glutamic acid α-tert-butyl-γ-(2,5-dioxopyrrolidin-1-yl) diester (12.7 μmol), prepared as described above, in NMP (135 ml). The reaction mixture was gently shaken for 5 min at room temperature and then allowed to stand for an additional 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (7 mg, 93 μmol) in water (698 μl). A 0.5% aqueous solution of ammonium acetate (42 ml) was added, and the resulting mixture was eluted onto a Varian 5 g C8 Mega Bond Elut® cartridge, the immobilised compound was washed with 5% aqueous acetonitril (25 ml) and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue was purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient is 0-100% for 60 minutes.

Example 100

Synthesis of Arg 34 ,Lys 26 (N ε -(γ-glutamyl(N α -tetradecanoyl))) GLP-1(9-37)

To a mixture of Arg 34 GLP-1(9-37)-OH (22.4 mg, 7.1 μmol), EDPA (25.5 mg, 197 μmol), NMP (3.14 ml) and water (1.57 ml) was added a solution of Myr-Glu(ONSu)-OBu t (10.8 mg, 21.2 μmol) in NMP (270 μl). The reaction mixture was gently shaken for 5 min., and then allowed to stand for an additional 2 h at room temperature. The reaction was quenched by the addition of a solution of glycine (11.6 mg, 155 μmol) in water (116 μl). A 0.5% aqueous solution of ammonium acetate (67 ml) was added, and the resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut®, the immobilised compound washed with 5% aqueous acetonitril (25 ml), and finally liberated from the cartridge by elution with TFA (25 ml). The eluate was concentrated in vacuo, and the residue purified by column chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column was heated to 65° C. and the acetonitril gradient was 0-100% in 60 minutes. The title compound (2.3 mg, 9.2%) was isolated, and the product was analysed by PDMS. The m/z value for the protonated molecular ion was found to be 3516.0±3. The resulting molecular weight was thus 3515.0±3 amu (theoretical value 3515 amu).

Example 101

In this example and examples 102 and 103,

the phrase “8 mM phosphate buffer of pH 7.4” means 4 mM NaH 2 PO 4 , 2H 2 O and 4 mM Na 2 HPO 4 , 2H 2 O pH adjusted to 7.4 (using Sodium Hydroxide and/or Hydrochloric acid).

the term “Compound 1” means Arg 34 ,Lys 26 (N ε -( γ -Glu(N α -tetradecanoyl))) GLP-1(7-37).

the term “Compound 2” means Arg 34 ,Lys 26 (N ε -( γ -Glu(N α -hexadecanoyl))) GLP-1(7-37).

the term “Compound 3” means Arg 26,34 ,Lys 36 (N ε -( γ -Glu(N α -hexadecanoyl))) GLP-1(7-36).

the term “Compound 4” means Arg 26 ,Lys 34 (N ε ( γ -Glu(N α -hexadecanoyl))) GLP-1(7-37).

the term “Compound 5” means Gly 8 ,Glu 37 ,Arg 26,34 ,Lys 38 (N ε -( γ -Glu(N α -hexadecanoyl))) GLP-1(7-38).

General Example 101
	Compound	2-7.5	mg/ml
	Mannitol	34-50	mg/ml
	Phenol	5-7.5	mg/ml
	8 mM phosphate buffer of pH 7.4

Mannitol and phenol were dissolved in the phosphate buffer preadjusted to pH 7.4. The compound was then dissolved under slow stirring. The pH was adjusted to 7.4 using sodium hydroxide and/or hydrochloric acid. Finally, the formulation was sterilised by filtration through an appropriate filter.

The following specific formulations were produced using this procedure:

	Example 101-A
	Compound 1	2.0	mg/ml
	Mannitol	38	mg/ml
	Phenol	5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 101-B
	Compound 1	5	mg/ml
	Mannitol	36.9	mg/ml
	Phenol	5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 101-C
	Compound 1	7.5	mg/ml
	Mannitol	34	mg/ml
	Phenol	7.5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 101-D
	Compound 2	2.0	mg/ml
	Mannitol	38	mg/ml
	Phenol	5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 101-E
	Compound 2	5	mg/ml
	Mannitol	36.9	mg/ml
	Phenol	5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 101-F
	Compound 2	7.5	mg/ml
	Mannitol	34	mg/ml
	Phenol	7.5	mg/ml
	8 mm phosphate	ad 100	ml
	buffer of pH 7.4
	Example 101-G
	Compound 3	2.0	mg/ml
	Mannitol	38	mg/ml
	Phenol	5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 101-H
	Compound 3	5	mg/ml
	Mannitol	36.9	mg/ml
	Phenol	5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 101-I
	Compound 3	7.5	mg/ml
	Mannitol	34	mg/ml
	Phenol	7.5	mg/ml
	8 mm phosphate	ad 100	ml
	buffer of pH 7.4
	Example 101-J
	Compound 4	2.0	mg/ml
	Mannitol	38	mg/ml
	Phenol	5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 101-K
	Compound 4	5	mg/ml
	Mannitol	36.9	mg/ml
	Phenol	5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 101-L
	Compound 4	7.5	mg/ml
	Mannitol	34	mg/ml
	Phenol	7.5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 102
	Compound	2-7.5	mg/ml
	Mannitol	19-25	mg/ml
	Benzyl Alcohol	14-18	mg/ml
	8 mM phosphate buffer of pH 7.4

Mannitol and benzyl alcohol were dissolved in the phosphate buffer preadjusted to pH 7.4. The compound was then dissolved under slow stirring. The pH was adjusted to 7.4 using sodium hydroxide and/or hydrochloric acid. Finally, the formulation was sterilised by filtration through an appropriate filter.

The following specific formulations were produced using this procedure:

	Example 102-A
	Compound 1	2.0	mg/ml
	Mannitol	25	mg/ml
	Benzyl alcohol	14	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 102-B
	Compound 1	7.5	mg/ml
	Mannitol	19	mg/ml
	Benzyl alcohol	18	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 102-C
	Compound 2	2.0	mg/ml
	Mannitol	25	mg/ml
	Benzyl alcohol	14	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 102-D
	Compound 2	7.5	mg/ml
	Mannitol	19	mg/ml
	Benzyl alcohol	18	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 102-E
	Compound 3	2.0	mg/ml
	Mannitol	25	mg/ml
	Benzyl alcohol	14	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 102-F
	Compound 3	7.5	mg/ml
	Mannitol	19	mg/ml
	Benzyl alcohol	18	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 102-G
	Compound 5	2.0	mg/ml
	Mannitol	25	mg/ml
	Benzyl alcohol	14	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 102-H
	Compound 5	7.5	mg/ml
	Mannitol	19	mg/ml
	Benzyl alcohol	18	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 103
	Compound	2-7.5	mg/ml
	Mannitol	42-44	mg/ml
	Metacresol	2.5-4.0	mg/ml
	8 mM phosphate buffer of pH 7.4

Mannitol and metacresol were dissolved in the phosphate buffer preadjusted to pH 7.4. The compound was then dissolved under slow stirring. The pH was adjusted to 7.4 using sodium hydroxide and/or hydrochloric acid. Finally, the formulation was sterilised by filtration through an appropriate filter.

The following specific formulations were produced using this:

	Example 103-A
	Compound 1	2.0	mg/ml
	Mannitol	44	mg/ml
	Metacresol	2.5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 103-B
	Compound 1	7.5	mg/ml
	Mannitol	42	mg/ml
	Metacresol	4	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 103-C
	Compound 2	2.0	mg/ml
	Mannitol	44	mg/ml
	Metacresol	2.5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 103-D
	Compound 2	7.5	mg/ml
	Mannitol	42	mg/ml
	Metacresol	4	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 103-E
	Compound 3	2.0	mg/ml
	Mannitol	44	mg/ml
	Metacresol	2.5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 103-F
	Compound 3	7.5	mg/ml
	Mannitol	42	mg/ml
	Metacresol	4	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 103-G
	Compound 5	2.0	mg/ml
	Mannitol	44	mg/ml
	Metacresol	2.5	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4
	Example 103-H
	Compound 5	7.5	mg/ml
	Mannitol	42	mg/ml
	Metacresol	4	mg/ml
	8 mM phosphate	ad 100	ml
	buffer of pH 7.4

Example 104

Circular Dichroism (CD) at 222 nm as a function of peptide concentration for peptides dissolved in 10 mM tris buffer, pH 8, and 23° C. was measured for native GLP-1(7-37) and the following eight GLP-1 derivatives of the present invention:

(a) Example 37

(b) Example 50

(c) Example 63

(d) Example 51

(e) Example 55

(f) Example 61

(g) Example 68

(h) Example 64

The results are shown in FIG. 1 . Note that the CD signal is proportional to the average content of α-helix in the peptides, i.e., a CD value of −1 corresponds to 10% α-helix content under these conditions. The figure shows that, as the concentration of native GLP-1(7-37) is raised between 25 and 1000 μM, the content of α-helix increases from about 15% to about 30-35% in parallel with the formation of higher oligomers. In contrast with this concentration dependent behaviour, the figure shows that the helix content remains high and essentially independent of the concentration in the 1-200 μM range for the GLP-1 derivatives of the present invention forming partially structured micelle-like aggregates under the same conditions.

Example 105

Equilibrium Solubility

For pH-solubility profiles, solutions containing the peptide and additives (surfactant and, where indicated, other excipients) at the appropriate concentrations were prepared at pH 9-10. The solutions were filtered, samples were withdrawn, and the pH was adjusted to the desired value in the range of 3-8. The samples were left for 24 hours at 23° C. to attain solubility equilibrium. After centrifugation (20,000 g for 20 minutes, 23° C.) of each sample, the pH was measured, and the solubility was determined from measurement of the absorbance at 276 nm of the supernatant.

Long Term Physical Stability

acylated GLP-1(7-37) analogue were dissolved at twice the desired final concentration and incubated briefly (<10 minutes) at pH 11.5, 23° C. before filtration and mixing with an equal volume of a filtered solution containing all the excipients in twice the desired final concentration. The pH was then measured and adjusted as needed. The solution was transferred to pen-fill cartridges containing a small glass ball (to allow visual determination of changes in solution viscosity). The containers were sealed and incubated at the desired temperature between 4° C. and 37° C. At appropriate time intervals, the samples were gently turned and visually examined using a light box. When physical changes were apparent (precipitation, crystallization or gelation), the sample was centrifuged and the absorbance was measured in the supernatant to determine whether the component coming out of solution was the peptide or not.

Equilibrium solubility was determined as a function of pH for 1 mg/ml solutions of the acylated GLP-1(7-37) analogue N ε -hexadecanoyl-γ-glutamyl-Lys26,Art34GLP-1(7-37) in the absence of additives and in the presence of increasing amounts of the surfactant LPCL (lauroyl lysophosphatidyl choline). The results show that 1 mM and 2 mM LPCL enhance solubility relative to the reference composition, while full solubility is obtained in the presence of 5 mM LPCL.

96 1 31 PRT Artificial Sequence derivatives of human GLP-1 1His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 20 25 30 2 31 PRT Artificial Sequence mutagen 2His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30 3 31 PRT Artificial Sequence mutagen 3His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Lys Gly 20 25 30 4 31 PRT Artificial Sequence mutagen 4His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly 20 25 30 5 32 PRT Artificial Sequence mutagen 5His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Arg 20 25 30 6 33 PRT Artificial Sequence mutagen 6His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Lys 7 34 PRT Artificial Sequence mutagen 7His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Arg Lys 8 31 PRT Artificial Sequence mutagen 8His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Lys Gly 20 25 30 9 31 PRT Artificial Sequence mutagen 9His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly 20 25 30 10 33 PRT Artificial Sequence mutagen 10His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Arg 20 25 30Lys 11 34 PRT Artificial Sequence mutagen 11His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Arg Lys 12 33 PRT Artificial Sequence mutagen 12His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Arg 20 25 30Lys 13 34 PRT Artificial Sequence mutagen 13His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Arg 20 25 30Arg Lys 14 31 PRT Artificial Sequence mutagen 14His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 20 25 30 15 31 PRT Artificial Sequence mutagen 15His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30 16 31 PRT Artificial Sequence mutagen 16His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Lys Gly 20 25 30 17 31 PRT Artificial Sequence mutagen 17His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly 20 25 30 18 33 PRT Artificial Sequence mutagen 18His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Lys 19 34 PRT Artificial Sequence mutagen 19His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Arg Lys 20 31 PRT Artificial Sequence mutagen 20His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Lys Gly 20 25 30 21 31 PRT Artificial Sequence mutagen 21His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly 20 25 30 22 33 PRT Artificial Sequence mutagen 22His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Arg 20 25 30Lys 23 34 PRT Artificial Sequence mutagen 23His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Arg Lys 24 33 PRT Artificial Sequence mutagen 24His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Arg 20 25 30Lys 25 34 PRT Artificial Sequence mutagen 25His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Arg 20 25 30Arg Lys 26 32 PRT Artificial Sequence mutagen 26His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Lys 20 25 30 27 33 PRT Artificial Sequence mutagen 27His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Lys 28 34 PRT Artificial Sequence mutagen 28His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Arg Lys 29 35 PRT Artificial Sequence mutagen 29His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Arg Glu Lys 35 30 36 PRT Artificial Sequence mutagen 30His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Arg Glu Phe Lys 35 31 37 PRT Artificial Sequence mutagen 31His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Arg Glu Phe Pro Lys 35 32 38 PRT Artificial Sequence mutagen 32His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Arg Glu Phe Pro Glu Lys 35 33 39 PRT Artificial Sequence mutagen 33His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Arg Glu Phe Pro Glu Glu Lys 35 34 38 PRT Artificial Sequence mutagen 34His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30Val Arg Gly Arg Gly Lys 35 35 39 PRT Artificial Sequence mutagen 35His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30Val Arg Gly Arg Gly Arg Lys 35 36 40 PRT Artificial Sequence mutagen 36His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30Val Arg Gly Arg Gly Arg Arg Lys 35 40 37 41 PRT Artificial Sequence mutagen 37His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30Val Arg Gly Arg Gly Arg Arg Glu Lys 35 40 38 42 PRT Artificial Sequence mutagen 38His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30Val Arg Gly Arg Gly Arg Arg Glu Phe Lys 35 40 39 43 PRT Artificial Sequence mutagen 39His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30Val Arg Gly Arg Gly Arg Arg Glu Phe Pro Lys 35 40 40 44 PRT Artificial Sequence mutagen 40His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30Val Arg Gly Arg Gly Arg Arg Glu Phe Pro Glu Lys 35 40 41 45 PRT Artificial Sequence mutagen 41His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30Val Arg Gly Arg Gly Arg Arg Glu Phe Pro Glu Glu Lys 35 40 45 42 37 PRT Artificial Sequence mutagen 42Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 1 5 10 15Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val 20 25 30Arg Gly Arg Gly Lys 35 43 38 PRT Artificial Sequence mutagen 43Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 1 5 10 15Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val 20 25 30Arg Gly Arg Gly Arg Lys 35 44 39 PRT Artificial Sequence mutagen 44Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 1 5 10 15Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val 20 25 30Arg Gly Arg Gly Arg Arg Lys 35 45 40 PRT Artificial Sequence mutagen 45Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 1 5 10 15Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val 20 25 30Arg Gly Arg Gly Arg Arg Glu Lys 35 40 46 41 PRT Artificial Sequence mutagen 46Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 1 5 10 15Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val 20 25 30Arg Gly Arg Gly Arg Arg Glu Phe Lys 35 40 47 42 PRT Artificial Sequence mutagen 47Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 1 5 10 15Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val 20 25 30Arg Gly Arg Gly Arg Arg Glu Phe Pro Lys 35 40 48 43 PRT Artificial Sequence mutagen 48Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 1 5 10 15Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val 20 25 30Arg Gly Arg Gly Arg Arg Glu Phe Pro Glu Lys 35 40 49 44 PRT Artificial Sequence mutagen 49Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 1 5 10 15Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val 20 25 30Arg Gly Arg Gly Arg Arg Glu Phe Pro Glu Glu Lys 35 40 50 36 PRT Artificial Sequence mutagen 50Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20 25 30Gly Arg Gly Lys 35 51 37 PRT Artificial Sequence mutagen 51Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20 25 30Gly Arg Gly Arg Lys 35 52 38 PRT Artificial Sequence mutagen 52Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20 25 30Gly Arg Gly Arg Arg Lys 35 53 39 PRT Artificial Sequence mutagen 53Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20 25 30Gly Arg Gly Arg Arg Glu Lys 35 54 40 PRT Artificial Sequence mutagen 54Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20 25 30Gly Arg Gly Arg Arg Glu Phe Lys 35 40 55 41 PRT Artificial Sequence mutagen 55Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20 25 30Gly Arg Gly Arg Arg Glu Phe Pro Lys 35 40 56 42 PRT Artificial Sequence mutagen 56Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20 25 30Gly Arg Gly Arg Arg Glu Phe Pro Glu Lys 35 40 57 43 PRT Artificial Sequence mutagen 57Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20 25 30Gly Arg Gly Arg Arg Glu Phe Pro Glu Glu Lys 35 40 58 35 PRT Artificial Sequence mutagen 58Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 1 5 10 15Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 20 25 30Arg Gly Lys 35 59 36 PRT Artificial Sequence mutagen 59Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 1 5 10 15Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 20 25 30Arg Gly Arg Lys 35 60 37 PRT Artificial Sequence mutagen 60Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 1 5 10 15Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 20 25 30Arg Gly Arg Arg Lys 35 61 38 PRT Artificial Sequence mutagen 61Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 1 5 10 15Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 20 25 30Arg Gly Arg Arg Glu Lys 35 62 39 PRT Artificial Sequence mutagen 62Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 1 5 10 15Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 20 25 30Arg Gly Arg Arg Glu Phe Lys 35 63 40 PRT Artificial Sequence mutagen 63Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 1 5 10 15Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 20 25 30Arg Gly Arg Arg Glu Phe Pro Lys 35 40 64 41 PRT Artificial Sequence mutagen 64Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 1 5 10 15Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 20 25 30Arg Gly Arg Arg Glu Phe Pro Glu Lys 35 40 65 42 PRT Artificial Sequence mutagen 65Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 1 5 10 15Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 20 25 30Arg Gly Arg Arg Glu Phe Pro Glu Glu Lys 35 40 66 34 PRT Artificial Sequence mutagen 66Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 1 5 10 15Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 20 25 30Gly Lys 67 35 PRT Artificial Sequence mutagen 67Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 1 5 10 15Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 20 25 30Gly Arg Lys 35 68 36 PRT Artificial Sequence mutagen 68Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 1 5 10 15Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 20 25 30Gly Arg Arg Lys 35 69 37 PRT Artificial Sequence mutagen 69Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 1 5 10 15Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 20 25 30Gly Arg Arg Glu Lys 35 70 38 PRT Artificial Sequence mutagen 70Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 1 5 10 15Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 20 25 30Gly Arg Arg Glu Phe Lys 35 71 39 PRT Artificial Sequence mutagen 71Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 1 5 10 15Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 20 25 30Gly Arg Arg Glu Phe Pro Lys 35 72 40 PRT Artificial Sequence mutagen 72Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 1 5 10 15Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 20 25 30Gly Arg Arg Glu Phe Pro Glu Lys 35 40 73 41 PRT Artificial Sequence mutagen 73Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 1 5 10 15Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 20 25 30Gly Arg Arg Glu Phe Pro Glu Glu Lys 35 40 74 33 PRT Artificial Sequence mutagen 74Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30Lys 75 34 PRT Artificial Sequence mutagen 75Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30Arg Lys 76 35 PRT Artificial Sequence mutagen 76Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30Arg Arg Lys 35 77 36 PRT Artificial Sequence mutagen 77Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30Arg Arg Glu Lys 35 78 37 PRT Artificial Sequence mutagen 78Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30Arg Arg Glu Phe Lys 35 79 38 PRT Artificial Sequence mutagen 79Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30Arg Arg Glu Phe Pro Lys 35 80 39 PRT Artificial Sequence mutagen 80Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30Arg Arg Glu Phe Pro Glu Lys 35 81 40 PRT Artificial Sequence mutagen 81Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30Arg Arg Glu Phe Pro Glu Glu Lys 35 40 82 38 PRT Artificial Sequence mutagen 82His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30Val Lys Gly Arg Gly Lys 35 83 38 PRT Artificial Sequence mutagen 83His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu 20 25 30Val Arg Gly Arg Gly Lys 35 84 38 PRT Artificial Sequence mutagen 84His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30Val Arg Gly Lys Gly Lys 35 85 32 PRT Artificial Sequence mutagen 85His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Lys 20 25 30 86 32 PRT Artificial Sequence mutagen 86His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Lys 20 25 30 87 32 PRT Artificial Sequence mutagen 87His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Lys 20 25 30 88 32 PRT Artificial Sequence mutagen 88His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Lys 20 25 30 89 39 PRT Artificial Sequence mutagen 89His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30Val Lys Gly Arg Gly Arg Lys 35 90 39 PRT Artificial Sequence mutagen 90His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu 20 25 30Val Arg Gly Arg Gly Arg Lys 35 91 39 PRT Artificial Sequence mutagen 91His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30Val Arg Gly Lys Gly Arg Lys 35 92 33 PRT Artificial Sequence mutagen 92His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Arg 20 25 30Lys 93 33 PRT Artificial Sequence mutagen 93His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30Lys 94 33 PRT Artificial Sequence mutagen 94His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Arg 20 25 30Lys 95 32 PRT Artificial Sequence mutagen 95His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Lys 20 25 30 96 32 PRT Artificial Sequence mutagen 96His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Lys 20 25 30

Claims

1. A glucagon-like peptide-1 (GLP-1) derivative of formula I (SEQ ID NO:2): 7   8   9   10  11  12  13  14  15  16  17His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-18  19  20  21  22  23  24  25  26  27  28Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-29  30  31  32  33  34  35  36  37Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gluwherein(a) the ε-amino group of Lys at position 26 is substituted with a lipophilic substituent optionally via a spacer, and (b) the lipophilic substituent is (i) CH3(CH2)nCO— wherein n is 6, 8, 10, 12, 14, 16, 18, 20 or 22 (ii) HOOC(CH2)mCO— wherein m is 10, 12, 14, 16, 18, 20 or 22, or (iii) lithocholyl, and (c) the spacer is an amino acid residue except Cys, or the spacer is γ-aminobutanoyl.

2. The GLP-1 derivative of claim 1, wherein the lipophilic substituent is linked to the ε-amino group of Lys via a spacer.

3. The GLP-1 derivative of claim 2, wherein the spacer is is γ-glutamyl.

4. The GLP-1 derivative of claim 2, wherein the spacer is β-asparagyl.

5. The GLP-1 derivative of claim 2, wherein the spacer is glycyl.

6. The GLP-1 derivative of claim 2, wherein the spacer is γ-aminobutanoyl.

7. The GLP-1 derivative of claim 2, wherein the spacer is β-alanyl.

8. A pharmaceutical composition comprising a GLP-1 derivative of claim 1 and a pharmaceutically acceptable vehicle or carrier.

9. The pharmaceutical composition of claim 8, further comprising an isotonic agent, a preservative and a buffer.

10. The pharmaceutical composition of claim 9, wherein the isotonic agent is sodium chloride, mannitol and glycerol.

11. The pharmaceutical composition of claim 9, wherein the preservative is phenol, m-cresol, methyl p-hydroxybenzoate or benzyl alcohol.

12. The pharmaceutical composition of claim 9, wherein the buffer is sodium acetate or sodium phosphate.

13. The pharmaceutical composition of claim 8, further comprising a surfactant.

14. The pharmaceutical composition of claim 8, further comprising zinc.

15. The pharmaceutical composition of claim 8, further comprising an antidiabetic agent.

16. The pharmaceutical composition of claim 15, wherein the antidiabetic agent is human insulin.

17. The pharmaceutical composition of claim 15, wherein the antidiabetic agent is a hypoglycemic agent.

18. The pharmaceutical composition of claim 8, further comprising an antiobesity agent.

19. A method of treating diabetes, comprising adminstering to a patient a therapeutically effective amount of a GLP-1 derivative of claim 1.

20. A method of treating obesity, comprising administering to a patient a therapeutically effective amount of a GLP-1 derivative of claim 1.