Claims
- 1. A compound of the formula: ##STR249## wherein Y represents sulfonyl (--SO.sub.2 --) ##STR250## (i) R.sup.1 and R.sup.2, which may be the same or different, each represent
- (1) hydrogen,
- (2) an alkyl of up to 16 carbon atoms or an alkyl of up to 16 carbon atoms substituted by carboxy,
- (3) a group of the formula: ##STR251## wherein X represents a single-bond, sulfonyl (--SO.sub.2 --), an alkylene of up to 4 carbon atoms, or an alkylene of up to 4 carbon atoms substituted by --COOH or benzyloxy-carbonyl ##STR252## represents a carbocyclic ring or a heterocyclic ring, n represents an integer of 1 to 5,
- R.sup.4 which may be the same or different represents,
- (1) hydrogen or an alkyl group of up to 8 carbon atoms,
- (2) an alkoxy of up to 14 carbon atoms,
- (3) an alkylthio of up to 6 carbon atoms,
- (4) hydroxy, halogen, nitro or trihalomethyl,
- (5) a group of the formula: --NR.sup.41 R.sup.42 wherein R.sup.41 and R.sup.42, which may be the same or different, each represents hydrogen or alkyl of up to 4 carbon atoms,
- (6) tetrazole,
- (7) sulfonic acid (--SO.sub.3 H) or hydroxymethyl (--CH.sub.2 OH),
- (8) a group of the formula: --SO.sub.2 NR.sup.41 R.sup.42 wherein R.sup.41 and R.sup.42 have the same meanings as described hereinbefore,
- (9) a group of the formula: --Z.sup.41 --COOR.sup.43 wherein Z.sup.41 represents a single-bond, an alkylene of up to 4 carbon atoms, or an alkenylene of from 2 to 4 carbon atoms, R.sup.43 represents hydrogen, an alkyl of up to 4 carbon atoms or benzyl,
- (10) a group of the formula: --CONR.sup.41 R.sup.42 wherein R.sup.41 and R.sup.42 have the same meanings as described hereinbefore,
- (11) a group of the formula: --COO--Z.sup.42 COOR.sup.43 wherein Z.sup.42 represents an alkylene of up to 4 carbon atoms, R.sup.43 represents hydrogen or an alkyl of up to 4 carbon atoms,
- (12) a group of the formula: --COO--Z.sup.42 --CONR.sup.41 R.sup.42 wherein Z.sup.42, R.sup.41 and R.sup.42 have the same meanings as described hereinbefore,
- (13) a group of the formula: --OCO--R.sup.45 wherein R.sup.45 represents an alkyl of up to 8 carbon atoms or p-guanidinophenyl,
- (14) a group of the formula: --CO--R.sup.46 wherein R.sup.46 represents an alkyl of up to 4 carbon atoms,
- (15) a group of the formula: --O--Z.sup.43 --COOR.sup.45 wherein Z.sup.43 represents an alkylene of up to 6 carbon atoms, R.sup.45 represents a hydrogen atom, an alkyl group of up to 8 carbon atoms or a p-guanidinophenyl group,
- (16) a group of the formula: ##STR253## wherein --N--Z.sup.44 --CO represents an amino acid residue, R.sup.48 represents hydrogen or alkyl of up to 4 carbon atoms, and R.sup.49 represents hydroxy, alkoxy of up to 4 carbon atoms, amino unsubstituted or substituted by one or two alkyls of up to 4 carbon atoms, carbamoylmethoxy unsubstituted or substituted by one or two alkyls of up to 4 carbon atoms at nitrogen of carbamoyl, R.sup.47 represents a single-bond or an alkyl of up to 4 carbon atoms, or wherein ##STR254## represents a heterocyclic ring containing 3 to 6 carbon atoms and R.sup.47 and R.sup.49 each has the same meaning as described hereinbefore,
- (ii) R.sup.1, R.sup.2 and nitrogen bonded to R.sup.1 and R.sup.2 together represent a heterocyclic ring containing at least one nitrogen and substituted by --COOH, or an unsubstituted heterocyclic ring containing at least one nitrogen, R.sup.3 represents
- (1) hydrogen,
- (2) hydroxy,
- (3) an alkyl of up to 6 carbon atoms,
- (4) halogen,
- (5) an alkoxy of up to 4 carbon atoms,
- (6) an acyloxy of 2 to 5 carbon atoms, m represents an integer of up to 4, with the proviso that (1) when R.sup.1 and R.sup.2 represent hydrogen atom or alkyl group of up to 16 carbon atoms, and R.sup.3 represents a hydrogen atom or an alkyl group of up to 6 carbon atoms, Y represents carbonyl (--CO--),
- and that (2) the compounds wherein one of R.sup.1 and R.sup.2 represents hydrogen or an alkyl group of up to 16 carbon atoms or 2-carboxyethyl and the other of R.sup.1 and R.sup.2 represents a group of the formula: ##STR255## wherein X has the same meaning as described hereinbefore, ##STR256## represents a pyridine or pyrrole ring, n represents an integer of 1 or 2, R.sup.4 which may be the same or different represents a hydrogen, an alkyl group of up to 8 carbon atoms or a group of the formula: --Z.sup.41 --COOR.sup.43 wherein Z.sup.41 and R.sup.43 have the same meaning as described hereinbefore, m represents an integer of 1 or 2 and Y and R.sup.3 have the same meaning as described hereinbefore, are excluded, or pharmaceutically acceptable salts thereof.
- 2. A compound according to claim 1, wherein Y is sulfonyl (--SO.sub.2 --).
- 3. A compound according to claim 1, wherein ##STR257## is a carbocyclic ring.
- 4. A compound according to claim 1, wherein ##STR258## is phenyl.
- 5. A compound according to claim 1, wherein one of R.sup.4 is an amino acid-residue.
- 6. A compound according to claim 1, wherein an amino acid-residue of R.sup.4 is a glycine-residue.
- 7. A compound according to claim 1, wherein an amino acid-residue of R.sup.4 is alanine-residue.
- 8. A compound according to claim 6, which is selected from the group consisting of:
- N-[o-(p-pivaloyloxybenzene)sulfonylaminobenzoyl]glycine,
- N-[2-(p-pivaloyloxybenzene)sulfonylamino-5-chlorobenzoyl]glycine,
- N-[5-methylthio-2-(p-pivaloyloxybenzene)sulfonylaminobenzoyl]glycine,
- N-[2-(p-pivaloyloxybenzene)sulfonylamino-5-propylthiobenzoyl]glycine,
- N-[5-methyl-2-(p-pivaloyloxybenzene)sulfonylaminobenzoyl]glycine, and
- N-[o-(p-pivaloyloxybenzene)sulfonylaminobenzoyl]glycine methylester.
- 9. A compound according to claim 7, which is selected from the group consisting of:
- N-[o-(3-methyl-4-pivaloyloxybenzene)sulfonylaminobenzoyl]-d 1-alanine,
- N-[o-(3-methyl-4-pivaloyloxybenzene)sulfonylaminobenzoyl]-.beta.-alanine,
- N-[o-(e-methyl-4-pivaloyloxybenzene)sulfonylaminobenzoyl]-l-alanine,
- N-[5-chloro-2-(3-methyl-4-pivaloyloxybenzene)sulfonylaminobenzoyl]-l-alanine and
- N-[5-chloro-2-(3-methyl-4-pivaloyloxybenzene)sulfonylamino-benzoyl]-.beta.-alanine.
- 10. A pharmaceutical composition for the treatment of pulmonary emphysema, atherosclerosis and rheumatoid arthritis, which comprises, as active ingredient, an effective amount of at least one compound of the formula (I) depicted in claim 1, wherein various symbols are as defined in claim 1, together with a pharmaceutically acceptable carrier.
- 11. A method for the treatment of pulmonary emphysema, atherosclerosis and rheumatoid arthritis comprising administering to a patient in need of same, a pharmaceutical composition which comprises, as active ingredient, an effective amount of at least one compound of the formula (I) of claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
63-145450 |
Jun 1988 |
JPX |
|
1-53541 |
Mar 1989 |
JPX |
|
Parent Case Info
This application is a Divisional of Ser. No. 07/960,301, filed Oct. 13, 1992, now U.S. Pat. No. 5,336,681, which is a Continuation of Ser. No. 07/681,364, filed Apr. 8, 1991, now abandoned, which is a Divisional of Ser. No. 07/364,994, filed Jun. 12, 1989, now U.S. Pat. No. 5,017,610.
US Referenced Citations (7)
Foreign Referenced Citations (4)
Number |
Date |
Country |
2109842 |
Sep 1972 |
DEX |
2246403 |
Mar 1973 |
DEX |
1223619 |
Feb 1971 |
GBX |
2136980 |
Sep 1984 |
GBX |
Divisions (2)
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Number |
Date |
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Parent |
960301 |
Oct 1992 |
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Parent |
364994 |
Jun 1989 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
681364 |
Apr 1991 |
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