Claims
- 1. A compound of the formula ##STR12## wherein R is hydroxy or lower alkoxy;
- R.sub.1, R.sub.2, R.sub.5 and R.sub.6 each is hydrogen or lower alkyl;
- R.sub.3 is hydrogen, lower alkyl or mercapto-lower alkylene;
- R.sub.4 is hydrogen, lower alkanoyl, benzoyl or ##STR13## X is S, SO, or SO.sub.2 ; and p is 0 or 1;
- and basic salts thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms.
- 2. A compound as in claim 1 wherein R.sub.5 and R.sub.6 each is hydrogen.
- 3. A compound as in claim 2 wherein X is sulfur.
- 4. A compound as in claim 1 wherein R.sub.4 is ##STR14##
- 5. A compound as in claim 1 wherein R is hydroxy, methoxy or ethoxy; R.sub.1, R.sub.2, R.sub.3, R.sub.5 and R.sub.6 each is hydrogen, methyl or ethyl; R.sub.4 is hydrogen, acetyl or benzoyl; X is sulfur; and p is 0 or 1.
- 6. A compound as in claim 1 wherein R.sub.4 is hydrogen.
- 7. A compound as in claim 1 wherein R.sub.4 is acetyl.
- 8. A compound as in claim 1 wherein R.sub.4 is benzoyl.
- 9. A compound as in claim 1 wherein R is hydroxy.
- 10. A compound as in claim 1 wherein p is 1.
- 11. A compound as in claim 1 wherein X is sulfur.
- 12. A compound as in claim 11 wherein R is hydroxy; R.sub.1, R.sub.2, R.sub.3, R.sub.5 and R.sub.6 each is hydrogen; R.sub.4 is benzoyl; and p is 1.
- 13. A compound as in claim 11 wherein R is hydroxy; R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each is hydrogen; and p is 1.
- 14. A compound as in claim 11 wherein R is hydroxy; R.sub.1, R.sub.2, R.sub.4, R.sub.5 and R.sub.6 each is hydrogen; R.sub.3 is methyl; and p is 1.
- 15. The compound of claim 13 in which the thiazolidine is in the L-form.
- 16. The compound of claim 14 in which the thiazolidine is in the L-form.
- 17. A composition comprising a compound of the formula ##STR15## wherein R is hydroxy or lower alkoxy;
- R.sub.1, R.sub.2, R.sub.5 and R.sub.6 each is hydrogen or lower alkyl;
- R.sub.3 is hydrogen, lower alkyl or mercapto-lower alkylene;
- R.sub.4 is hydrogen, lower alkanoyl, benzoyl or ##STR16## X is S, SO, or SO.sub.2 ; and p is 0 or 1;
- or a basic salt thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms; and a pharmaceutically acceptable vehicle therefor.
- 18. A composition as in claim 17 comprising a compound of the formula ##STR17## and a pharmaceutically acceptable vehicle therefor.
- 19. A composition as in claim 18 comprising a compound of the formula ##STR18## and a pharmaceutically acceptable vehicle therefor.
- 20. A method for reducing blood pressure which comprises administering a composition comprising a compound of the formula ##STR19## wherein R is hydroxy or lower alkoxy;
- R.sub.1, R.sub.2, R.sub.5 and R.sub.6 each is hydrogen or lower alkyl;
- R.sub.3 is hydrogen, lower alkyl or mercapto-lower alkylene;
- R.sub.4 is hydrogen, lower alkanoyl, benzoyl or ##STR20## X is S, SO, or SO.sub.2 ; and p is 0 or 1;
- or a basic salt thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms; and a pharmaceutically acceptable vehicle therefor.
- 21. A method for reducing blood pressure as in claim 20 which comprises administering a composition comprising a compound of the formula ##STR21## and a pharmaceutically acceptable vehicle therefor.
- 22. A method for reducing blood pressure as in claim 20 which comprises administering a composition comprising a compound of the formula ##STR22## and a pharmaceutically acceptable vehicle therefor.
- 23. A compound as in claim 11 wherein R is hydroxy; R.sub.1, R.sub.2, R.sub.5 and R.sub.6 each is hydrogen; R.sub.3 is methyl; R.sub.4 is acetyl; and p is 1.
Parent Case Info
This application is a continuation-in-part of application Ser. No. 836,107 filed Sept. 23, 1977, now abandoned, which in turn is a continuation-in-part of application Ser. No. 747,281, filed Dec. 2, 1976, now abandoned.
US Referenced Citations (3)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2138121 |
Feb 1973 |
DEX |
Non-Patent Literature Citations (5)
Entry |
Japanese Journal of Pharmacology, 28 Suppl. 107P, (1978). |
Chem. Pharm. Bull., 26 (4), 1333-1335, (1978). |
Internal report of E. R. Squibb & Sons, Inc., of a presentation by Ohya, et al., at the 90th Annual Meeting of the Pharmaceutical Society of Japan held on Apr. 4, 1978 in Okayama, Japan. |
Rosamond, et al., Jour. Med. Chem., 19 (1976), pp. 873-876. |
C.A., 72 (1970), 31780v. |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
836107 |
Sep 1977 |
|
Parent |
747281 |
Dec 1976 |
|