Claims
- 1. A compound of the formula ##STR12## wherein R is hydroxy or lower alkoxy;
- R.sub.3 is hydrogen, lower alkyl or mercapto-lower alkylene;
- R.sub.4 is hydrogen, lower alkanoyl, benzoyl or ##STR13## X is S, SO or SO.sub.2 ; and p is 0 or 1;
- or a basic salt thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms; and a pharmaceutically acceptable vehicle therefor.
- 2. A compound as in claim 1 wherein R.sub.4 is hydrogen.
- 3. A compound as in claim 1 wherein R.sub.4 is acetyl.
- 4. A compound as in claim 1 wherein R.sub.4 is benzoyl.
- 5. A compound as in claim 1 wherein R.sub.4 is ##STR14##
- 6. A compound as in claim 1 wherein R is hydroxy.
- 7. A compound as in claim 1 wherein p is 1.
- 8. A compound as in claim 1 wherein X is sulfur.
- 9. The compound in accordance with claim 8, 3-(3-acetylthio-2-methylpropanoyl)-2-thiazolidinecarboxylic acid methyl ester.
- 10. The compound in accordance with claim 8, 3-(3-mercapto-2-methylpropanoyl)-2-thiazolidinecarboxylic acid.
- 11. The compound in accordance with claim 8, 3,3'-[dithiobis-(2-methyl-3-propanoyl)]bis-thiazolidine-2-carboxylic acid.
- 12. A composition comprising a compound of the formula ##STR15## wherein R is hydroxy or lower alkoxy;
- R.sub.3 is hydrogen, lower alkyl or mercapto-lower alkylene;
- R.sub.4 is hydrogen, lower alkanoyl, benzoyl or ##STR16## X is S, SO or SO.sub.2 ; and p is 0 or 1;
- or a basic salt thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms; and a pharmaceutically acceptable vehicle therefor.
- 13. A method for reducing blood pressure which comprises administering a composition comprising a compound of the formula ##STR17## wherein R is hydroxy or lower alkoxy;
- R.sub.3 is hydrogen, lower alkyl or mercapto-lower alkylene;
- R.sub.4 is hydrogen, lower alkanoyl, benzoyl or ##STR18## X is S, SO or SO.sub.2 ; and p is 0 or 1;
- or a basic salt thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms; and a pharmaceutically acceptable vehicle therefor.
Parent Case Info
This is a division of application Ser. No. 907,452, filed May 22, 1978, now U.S. Pat. No. 4,192,878, issued Mar. 11, 1980, which is a continuation-in-part of application Ser. No. 836,107, filed Sept. 23, 1977, now abandoned, which is a continuation-in-part of application Ser. No. 747,281, filed Dec. 3, 1976, now abandoned.
US Referenced Citations (4)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2138121 |
Feb 1973 |
DEX |
Non-Patent Literature Citations (5)
Entry |
Rosamond et al., Journ. Med. Chem. 19, 873-876 (1976). |
CA 72, 337, (1970), 31780v. |
Japanese Jour. of Pharmacology, 28 suppl. 107P (1978). |
Chem. Pharm. Bull. 26(4) 1333-1335 (1978). |
Internal Report of E. R. Squibb & Sons, Inc., Presentation by Ohya et al., at 90th Meeting of Pharmaceutical Society of Japan held 4-4-78 in Japan. |
Divisions (1)
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Number |
Date |
Country |
Parent |
907452 |
May 1978 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
836107 |
Sep 1977 |
|
Parent |
747281 |
Dec 1976 |
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