Claims
- 1. A compound of the formula ##STR12## wherein R is hydroxy or lower alkoxy;
- R.sub.1, R.sub.2, R.sub.5 and R.sub.6 each is hydrogen or lower alkyl;
- R.sub.3 is hydrogen, lower alkyl or mercapto-lower alkylene;
- R.sub.4 is hydrogen, lower alkanoyl, benzoyl or ##STR13## X is S, SO or SO.sub.2 ; m is 1, 2 or 3; n is 0, 1 or 2 and m+n is 3;
- p is 0 or 1;
- and basic salts thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms.
- 2. A compound as in claim 1 wherein R is hydroxy or lower alkoxy; R.sub.1, R.sub.2, R.sub.5 and R.sub.6 each is hydrogen or lower alkyl; R.sub.3 is hydrogen, lower alkyl or mercapto-lower alkylene; R.sub.4 is hydrogen, lower alkanoyl or benzoyl; X is sulfur; m is 2; n is 1; and p is 0 or 1.
- 3. A compound as in claim 1 wherein R is hydroxy, methoxy or ethoxy; R.sub.1, R.sub.2, R.sub.3, R.sub.5 and R.sub.6 each is hydrogen, methyl or ethyl; R.sub.4 is hydrogen, acetyl or benzoyl; X is sulfur; m is 2; n is 1; and p is 0 or 1.
- 4. A compound as in claim 1 wherein R.sub.4 is hydrogen.
- 5. A compound as in claim 1 wherein R.sub.4 is acetyl.
- 6. A compound as in claim 1 wherein R.sub.4 is benzoyl.
- 7. A compound as in claim 1 wherein R.sub.4 is ##STR14##
- 8. A compound as in claim 1 wherein R is hydroxy.
- 9. A compound as in claim 1 wherein p is 1.
- 10. A compound as in claim 1 wherein X is sulfur.
- 11. A compound as in claim 10 wherein R is hydroxy; R.sub.1, R.sub.2, R.sub.3, R.sub.5 and R.sub.6 each is hydrogen; R.sub.4 is acetyl; m is 2; n is 1 and p is 1.
- 12. A compound as in claim 10 wherein R is hydroxy; R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each is hydrogen; m is 2; n is 1; and p is 1.
- 13. A composition comprising a compound of the formula ##STR15## wherein R is hydroxy or lower alkoxy;
- R.sub.1, R.sub.2, R.sub.5 and R.sub.6 each is hydrogen or lower alkyl;
- R.sub.3 is hydrogen, lower alkyl or mercapto-lower alkylene;
- R.sub.4 is hydrogen, lower alkanoyl, benzoyl or ##STR16## X is S, SO or SO.sub.2 ; m is 1, 2 or 3; n is 0, 1 or 2 and m+n is 3;
- p is 0 or 1;
- and basic salts thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms.
- 14. A method for reducing blood pressure which comprises administering a composition comprising a compound of the formula ##STR17## wherein R is hydroxy or lower alkoxy;
- R.sub.1, R.sub.2, R.sub.5 and R.sub.6 each is hydrogen or lower alkyl;
- R.sub.3 is hydrogen, lower alkyl or mercapto-lower alkylene;
- R.sub.4 is hydrogen, lower alkanoyl, benzoyl or ##STR18## X is S, SO or SO.sub.2 ; m is 1, 2 or 3; n is 0, 1 or 2 and m+n is 3;
- p is 0 or 1;
- and basic salts thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms.
Parent Case Info
This is a division of application Ser. No. 907,452, filed May 22, 1978, now U.S. Pat. No. 4,192,878, which is a continuation-in-part of application Ser. No. 836,107, filed Sept. 23, 1977, now abandoned, which is a continuation-in-part of application Ser. No. 747,281, filed Dec. 3, 1976, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3886149 |
Treuner et al. |
May 1975 |
|
3920639 |
Dolfini |
Nov 1975 |
|
4046889 |
Ondetti et al. |
Sep 1977 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
2138121 |
Feb 1973 |
DEX |
Non-Patent Literature Citations (5)
Entry |
Rosamond et al., Journ. of Med. Chem., 19, (1976), pp. 873-876. |
C. A., 72, (1970), 31780v. |
Funae et al., Japanese Journal of Pharmacology, 28 Suppl., p. 107 P, (1978). |
Chem. Pharm. Bull., 26 (4), pp. 1333-1335, (1978). |
An Internal Report of E. R. Squibb & Sons, Inc. of a Presentation by Ohya et al., at the 90th Annual Meeting of the Pharmaceutical Society of Japan held on Apr. 4, 1978 in Okayama, Japan. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
907452 |
May 1978 |
|
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
836107 |
Sep 1977 |
|
Parent |
747281 |
Dec 1976 |
|