Claims
- 1. A skin model system comprising a three-dimensional, cross-linked, porous matrix of insoluble collagen containing fibroblast cells therein, and stratified layers of differentiated epidermal cells supported thereon, wherein a layer of said differentiated epidermal cells is in direct contact with a surface of said three-dimensional, cross-linked, porous matrix of insoluble collagen.
- 2. A skin model system of claim 1 wherein said epidermal cells comprise keratinocytes.
- 3. A skin model system of claim 2 wherein said fibroblasts are dermal fibroblasts.
- 4. A skin model system of claim 1 wherein said collagen matrix has been cross-linked by a dehydrothermal method.
- 5. A skin model system of claim 1 which is in the form of a sheet having a thickness of in the range of about 1 to 5 mm.
- 6. A skin model system comprising a three-dimensional, cross-linked, porous matrix of insoluble collagen containing fibroblast cells therein, and a monolayer of differentiated epidermal cells supported thereon in direct contact with a surface of said three-dimensional, cross-linked, porous matrix of insoluble collagen.
- 7. A skin model system of claim 6 wherein said epidermal cells comprise keratinoctyes.
- 8. A skin model system of claim 7 wherein said fibroblasts are dermal fibroblasts.
- 9. A skin model system of claim 6 wherein said collagen matrix has been cross-linked by a dehydrothermal method.
- 10. A skin model system of claim 6 which is in the form of a sheet having a thickness of in the range of about 1 to 5 mm.
Parent Case Info
This is a continuation of application Ser. No. 08/352,979, filed Dec. 9, 1994, now abandoned, which in turn is a continuation of Ser. No. 08/032,373, filed Mar. 17, 1993, now abandoned, which are hereby incorporated by reference.
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Continuations (2)
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Number |
Date |
Country |
Parent |
352979 |
Dec 1994 |
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Parent |
32373 |
Mar 1993 |
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